Best TWAS P=4.48e-12 · Best GWAS P=1.08e-12 conditioned to 0.0129
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFGEF2 | 0.09 | 0.05 | lasso | 8 | 0.10 | 9.2e-13 | 7.0 | -6.9 | 4.5e-12 | -0.83 | 0.00 | 1.00 | TRUE |
| 6 | METSIM | Adipose | ARFGEF2 | 0.04 | 0.03 | lasso | 12 | 0.02 | 9.8e-05 | 7.1 | -6.5 | 9.5e-11 | -0.97 | 0.02 | 0.98 | FALSE |
| 7 | NTR | Blood | SNORD12B | 0.03 | 0.05 | lasso | 8 | 0.05 | 1.9e-14 | 5.9 | -6.4 | 1.9e-10 | -0.95 | 0.09 | 0.91 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARFGEF2 | 0.05 | 0.04 | lasso | 5 | 0.05 | 3.2e-06 | 7.0 | -6.4 | 2.0e-10 | -0.95 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Testis | ARFGEF2 | 0.20 | 0.20 | lasso | 7 | 0.24 | 5.4e-11 | 4.6 | -6.1 | 1.4e-09 | -0.93 | 0.02 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C20orf199 | 0.05 | 0.06 | lasso | 4 | 0.06 | 1.0e-04 | 5.9 | 5.9 | 3.9e-09 | 0.91 | 0.00 | 0.96 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | STAU1 | 0.08 | 0.03 | lasso | 6 | 0.02 | 2.3e-02 | 4.6 | 5.5 | 5.0e-08 | 0.85 | 0.03 | 0.91 | FALSE |
| 3 | GTEx | Colon Sigmoid | CSE1L | 0.18 | 0.12 | lasso | 11 | 0.09 | 4.4e-04 | 5.2 | -5.3 | 9.6e-08 | -0.81 | 0.14 | 0.80 | FALSE |
| 4 | GTEx | Colon Transverse | ARFGEF2 | 0.11 | 0.07 | enet | 12 | 0.09 | 2.9e-05 | -2.0 | -5.1 | 2.8e-07 | -0.80 | 0.04 | 0.94 | FALSE |