[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure :

chr2:135,898,023-137,435,625

Best TWAS P=5.27e-11 · Best GWAS P=1.47e-08 conditioned to 0.0097

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Esophagus Mucosa DARS 0.12 0.05 lasso 4 0.04 9.0e-04 5.3 5.4 5.6e-08 -0.49 0.05 0.89 FALSE
2 GTEx Esophagus Muscularis DARS 0.12 0.11 lasso 3 0.09 3.5e-06 5.3 5.4 8.4e-08 -0.48 0.04 0.96 FALSE
3 GTEx Lung DARS 0.07 0.05 lasso 4 0.05 5.8e-05 5.3 5.4 8.0e-08 -0.48 0.04 0.95 FALSE
4 GTEx Nerve Tibial DARS 0.13 0.06 lasso 5 0.05 3.2e-04 5.4 5.3 9.6e-08 -0.49 0.04 0.94 FALSE
5 GTEx Skin Not Sun Exposed Suprapubic DARS 0.15 0.11 enet 4 0.10 3.0e-06 5.3 5.5 4.2e-08 -0.48 0.04 0.95 FALSE
6 GTEx Skin Sun Exposed Lower leg DARS 0.10 0.12 lasso 1 0.11 1.7e-09 5.3 5.3 1.3e-07 -0.46 0.05 0.95 FALSE
7 GTEx Thyroid DARS 0.20 0.13 lasso 3 0.15 1.3e-11 5.3 5.5 3.6e-08 -0.50 0.05 0.95 FALSE
8 METSIM Adipose DARS 0.09 0.07 blup 311 0.09 4.6e-13 5.3 5.2 2.2e-07 -0.38 0.05 0.95 FALSE
9 NTR Blood MCM6 0.02 0.02 lasso 2 0.03 1.2e-08 4.3 5.2 1.7e-07 -0.55 0.09 0.91 FALSE
10 YFS Blood DARS 0.17 0.19 enet 36 0.19 8.2e-60 5.3 6.6 5.3e-11 -0.53 0.06 0.94 TRUE
11 The Cancer Genome Atlas Breast Invasive Carcinoma LCT 0.02 0.02 enet 3 0.03 7.6e-07 4.6 -5.2 2.0e-07 0.55 0.04 0.96 FALSE
12 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DARS 0.04 0.05 lasso 2 0.05 3.5e-06 5.0 5.1 2.7e-07 -0.47 0.02 0.98 FALSE
13 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DARS 0.10 0.08 enet 14 0.11 5.5e-12 5.3 5.3 9.3e-08 -0.48 0.02 0.98 FALSE
14 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DARS 0.02 0.02 lasso 2 0.02 3.9e-03 5.3 5.3 9.1e-08 -0.48 0.01 0.93 FALSE
15 The Cancer Genome Atlas Pancreatic Adenocarcinoma DARS 0.08 0.10 lasso 4 0.09 8.8e-05 5.4 5.4 7.2e-08 -0.49 0.02 0.94 FALSE
16 The Cancer Genome Atlas Prostate Adenocarcinoma DARS 0.04 0.02 blup 40 0.01 2.1e-02 5.3 5.9 3.7e-09 -0.52 0.02 0.93 FALSE
17 The Cancer Genome Atlas Soft Tissue Sarcoma DARS 0.04 0.04 blup 40 0.04 1.6e-03 5.3 5.6 2.3e-08 -0.53 0.02 0.93 FALSE
18 The Cancer Genome Atlas Thyroid Carcinoma DARS 0.22 0.15 enet 13 0.19 4.1e-18 5.2 5.6 2.5e-08 -0.39 0.02 0.97 FALSE