TWAS
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Traits
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Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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chr2:168,949,234-170,419,444
Best TWAS P=3.29e-08 · Best GWAS P=2.8e-09 conditioned to 1.49e-06
169M
169.2M
169.4M
169.6M
169.8M
170M
170.2M
170.4M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adrenal Gland
NOSTRIN
0.21
0.09
lasso
4
0.09
4.1e-04
5.5
5.5
3.3e-08
0.23
0.09
0.83
TRUE
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
NOSTRIN
0.03
0.01
blup
55
0.02
9.5e-05
-4.7
5.4
8.5e-08
0.24
0.03
0.91
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
NOSTRIN
0.12
0.13
lasso
7
0.14
4.5e-15
-4.7
5.2
1.5e-07
0.20
0.04
0.95
FALSE