Best TWAS P=6.13e-10 · Best GWAS P=1.11e-12 conditioned to 0.00044
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pituitary | LHFPL2 | 0.38 | 0.02 | lasso | 9 | 0.04 | 0.0402 | 2.0 | -5.5 | 4.0e-08 | 0.52 | 0.04 | 0.47 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3B1 | 0.02 | 0.00 | blup | 126 | 0.01 | 0.0182 | -6.9 | -6.2 | 6.1e-10 | 0.86 | 0.02 | 0.86 | TRUE |
| 3 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP3B1 | 0.05 | 0.02 | blup | 126 | 0.03 | 0.0005 | 2.8 | -5.5 | 3.4e-08 | 0.80 | 0.02 | 0.92 | FALSE |