TWAS
hub
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Models
Genes
Traits
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Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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chr5:77,052,232-78,753,539
Best TWAS P=6.13e-10 · Best GWAS P=1.11e-12 conditioned to 0.00044
77M
77.2M
77.4M
77.6M
77.8M
78M
78.2M
78.4M
78.6M
78.8M
0
2
4
6
8
10
12
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
AP3B1
0.02
0.00
blup
126
0.01
0.0182
-6.9
-6.2
6.1e-10
0.86
0.02
0.86
TRUE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
AP3B1
0.05
0.02
blup
126
0.03
0.0005
2.8
-5.5
3.4e-08
0.80
0.02
0.92
FALSE
1
GTEx
Pituitary
LHFPL2
0.38
0.02
lasso
9
0.04
0.0402
2.0
-5.5
4.0e-08
0.52
0.04
0.47
FALSE