TWAS
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Traits
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Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
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chr6:25,266,147-26,689,223
Best TWAS P=8.51e-12 · Best GWAS P=3.43e-14 conditioned to 0.294
25.2M
25.4M
25.6M
25.8M
26M
26.2M
26.4M
26.6M
0
5
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Artery Tibial
U91328.21
0.09
0.01
lasso
8
0.01
0.0300
2.87
6.8
8.5e-12
-0.51
0.14
0.57
TRUE
4
GTEx
Skin Sun Exposed Lower leg
TRIM38
0.09
0.00
enet
21
0.02
0.0063
1.66
5.8
7.3e-09
-0.52
0.13
0.60
TRUE
1
GTEx
Artery Aorta
U91328.21
0.18
0.00
lasso
11
0.02
0.0353
-0.52
5.7
1.2e-08
-0.31
0.10
0.48
TRUE
2
GTEx
Artery Tibial
TRIM38
0.08
0.00
lasso
9
0.00
0.3730
4.13
5.1
2.8e-07
-0.21
0.18
0.42
FALSE