Best TWAS P=7.8e-27 · Best GWAS P=1.1e-23 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FANCE | 0.03 | 0.02 | bslmm | 420 | 0.01 | 1.7e-02 | -9.4 | -10.4 | 1.7e-25 | 0.01 | 0.24 | 0.37 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RPL10A | 0.21 | 0.09 | enet | 30 | 0.11 | 2.6e-13 | -8.7 | -6.0 | 2.7e-09 | -0.01 | 0.90 | 0.10 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RPL10A | 0.06 | 0.02 | enet | 27 | 0.03 | 2.6e-03 | -7.5 | -7.3 | 2.8e-13 | -0.08 | 0.21 | 0.38 | TRUE |
| 4 | GTEx | Artery Aorta | RPL10A | 0.20 | 0.12 | lasso | 5 | 0.11 | 8.8e-07 | -8.8 | -9.0 | 3.0e-19 | -0.05 | 0.93 | 0.03 | FALSE |
| 5 | GTEx | Artery Tibial | C6orf106 | 0.07 | 0.02 | lasso | 4 | 0.02 | 8.8e-03 | -6.2 | 6.6 | 4.4e-11 | -0.07 | 0.09 | 0.14 | FALSE |
| 6 | GTEx | Artery Tibial | RPL10A | 0.11 | 0.08 | lasso | 2 | 0.09 | 1.5e-07 | -8.7 | -8.4 | 6.2e-17 | -0.07 | 0.99 | 0.01 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | TEAD3 | 0.36 | 0.29 | enet | 27 | 0.32 | 8.4e-25 | 4.6 | -7.6 | 3.1e-14 | -0.01 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Colon Transverse | RPL10A | 0.12 | 0.05 | lasso | 4 | 0.05 | 2.5e-03 | -8.7 | -9.4 | 8.0e-21 | -0.04 | 0.20 | 0.32 | FALSE |
| 9 | GTEx | Esophagus Mucosa | RPL10A | 0.14 | 0.10 | enet | 17 | 0.09 | 2.1e-06 | -8.7 | -8.4 | 2.9e-17 | -0.09 | 0.93 | 0.02 | FALSE |
| 10 | GTEx | Esophagus Muscularis | TAF11 | 0.13 | 0.02 | lasso | 6 | 0.00 | 1.6e-01 | -4.8 | 5.3 | 8.9e-08 | -0.03 | 0.06 | 0.14 | FALSE |
| 11 | GTEx | Esophagus Muscularis | RPL10A | 0.31 | 0.19 | lasso | 5 | 0.18 | 4.6e-11 | -8.8 | -8.8 | 1.4e-18 | -0.03 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Heart Atrial Appendage | MAPK13 | 0.12 | 0.00 | lasso | 5 | 0.00 | 3.1e-01 | -6.0 | 5.3 | 1.1e-07 | 0.02 | 0.06 | 0.20 | TRUE |
| 13 | GTEx | Lung | RPL10A | 0.21 | 0.09 | enet | 53 | 0.09 | 1.2e-07 | -8.8 | -7.7 | 1.1e-14 | -0.03 | 0.92 | 0.04 | FALSE |
| 14 | GTEx | Muscle Skeletal | RPL10A | 0.10 | 0.05 | enet | 17 | 0.04 | 3.9e-05 | -8.7 | -7.2 | 5.7e-13 | -0.05 | 0.58 | 0.22 | FALSE |
| 15 | GTEx | Nerve Tibial | DEF6 | 0.15 | 0.00 | lasso | 8 | 0.00 | 1.6e-01 | -7.8 | 7.6 | 3.7e-14 | 0.00 | 0.17 | 0.07 | FALSE |
| 16 | GTEx | Nerve Tibial | C6orf106 | 0.11 | 0.07 | enet | 17 | 0.07 | 1.3e-05 | 4.2 | 6.0 | 1.9e-09 | 0.12 | 0.71 | 0.02 | FALSE |
| 17 | GTEx | Nerve Tibial | RPL10A | 0.14 | 0.12 | lasso | 3 | 0.12 | 9.7e-09 | -8.8 | -8.4 | 3.6e-17 | -0.03 | 0.99 | 0.00 | FALSE |
| 18 | GTEx | Skin Not Sun Exposed Suprapubic | TEAD3 | 0.15 | 0.06 | lasso | 5 | 0.08 | 2.5e-05 | -7.6 | -8.6 | 6.6e-18 | -0.09 | 0.58 | 0.27 | FALSE |
| 19 | GTEx | Skin Sun Exposed Lower leg | C6orf106 | 0.09 | 0.04 | enet | 25 | 0.02 | 4.6e-03 | -5.6 | 7.3 | 2.6e-13 | 0.08 | 0.38 | 0.02 | FALSE |
| 20 | GTEx | Testis | ZNF76 | 0.15 | 0.14 | enet | 8 | 0.12 | 4.4e-06 | -7.1 | 7.9 | 3.6e-15 | 0.03 | 0.53 | 0.44 | TRUE |
| 21 | GTEx | Thyroid | RPL10A | 0.16 | 0.09 | lasso | 11 | 0.07 | 8.9e-06 | -7.0 | -7.2 | 5.8e-13 | -0.11 | 0.88 | 0.02 | FALSE |
| 22 | GTEx | Whole Blood | DEF6 | 0.14 | 0.05 | lasso | 4 | 0.03 | 9.9e-04 | -7.4 | 6.7 | 2.0e-11 | -0.07 | 0.82 | 0.06 | FALSE |
| 23 | METSIM | Adipose | RPL10A | 0.18 | 0.13 | lasso | 15 | 0.13 | 3.4e-19 | -8.8 | -8.3 | 1.1e-16 | -0.03 | 1.00 | 0.00 | FALSE |
| 24 | NTR | Blood | C6orf106 | 0.03 | 0.02 | lasso | 6 | 0.02 | 7.2e-07 | 4.5 | 5.4 | 6.4e-08 | 0.09 | 1.00 | 0.00 | FALSE |
| 25 | NTR | Blood | ZNF76 | 0.01 | 0.00 | blup | 424 | 0.00 | 3.8e-02 | -8.0 | 10.7 | 7.8e-27 | -0.08 | 0.08 | 0.68 | TRUE |
| 26 | ROSMAP | Brain Pre-frontal Cortex | DEF6 | 0.04 | 0.02 | bslmm | 421 | 0.02 | 1.8e-03 | -9.3 | 8.4 | 3.1e-17 | -0.09 | 0.25 | 0.70 | FALSE |
| 27 | ROSMAP | Brain Pre-frontal Cortex | ZNF76 | 0.04 | 0.00 | blup | 424 | 0.02 | 2.1e-03 | -7.8 | 7.6 | 3.8e-14 | -0.08 | 0.36 | 0.34 | FALSE |
| 28 | ROSMAP | Brain Pre-frontal Cortex | PACSIN1 | 0.09 | 0.00 | blup | 359 | 0.02 | 4.5e-04 | 4.6 | 6.8 | 1.4e-11 | 0.31 | 0.18 | 0.07 | FALSE |
| 29 | ROSMAP | Brain Pre-frontal Cortex | C6orf106 | 0.30 | 0.26 | bslmm | 372 | 0.33 | 9.3e-44 | 4.5 | 7.4 | 1.5e-13 | 0.06 | 1.00 | 0.00 | TRUE |
| 30 | ROSMAP | Brain Pre-frontal Cortex | RPL10A | 0.30 | 0.18 | bslmm | 409 | 0.19 | 2.6e-24 | -8.7 | -6.0 | 1.8e-09 | 0.09 | 1.00 | 0.00 | FALSE |
| 31 | YFS | Blood | RPL10A | 0.24 | 0.11 | lasso | 11 | 0.13 | 4.4e-39 | -8.8 | -7.9 | 3.8e-15 | -0.02 | 1.00 | 0.00 | FALSE |
| 32 | YFS | Blood | ZNF76 | 0.05 | 0.08 | lasso | 4 | 0.07 | 6.7e-23 | -7.8 | 7.7 | 1.2e-14 | -0.08 | 1.00 | 0.00 | FALSE |
| 33 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RPL10A | 0.03 | 0.00 | blup | 54 | 0.02 | 6.0e-03 | -9.5 | -10.6 | 3.8e-26 | 0.01 | 0.01 | 0.80 | FALSE |
| 34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPL10A | 0.03 | 0.00 | blup | 55 | 0.01 | 1.4e-03 | -8.8 | -6.7 | 1.5e-11 | -0.04 | 0.05 | 0.09 | FALSE |
| 35 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TCP11 | 0.03 | 0.03 | blup | 49 | 0.04 | 6.6e-08 | -8.7 | -10.0 | 1.1e-23 | 0.01 | 0.02 | 0.98 | FALSE |
| 36 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TCP11 | 0.07 | 0.01 | enet | 8 | 0.01 | 8.2e-02 | -9.5 | -8.5 | 1.3e-17 | -0.02 | 0.01 | 0.85 | FALSE |
| 37 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TCP11 | 0.03 | 0.00 | blup | 49 | 0.01 | 8.8e-03 | -9.7 | -9.0 | 2.0e-19 | 0.02 | 0.01 | 0.89 | FALSE |
| 38 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C6orf106 | 0.04 | 0.01 | blup | 68 | 0.01 | 2.4e-02 | 4.5 | 5.4 | 7.8e-08 | 0.11 | 0.03 | 0.20 | TRUE |
| 39 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPL10A | 0.07 | 0.07 | lasso | 2 | 0.06 | 9.9e-08 | -8.7 | -8.8 | 1.0e-18 | -0.04 | 0.86 | 0.14 | TRUE |
| 40 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TCP11 | 0.03 | 0.02 | blup | 49 | 0.02 | 1.7e-03 | -7.6 | -9.8 | 1.1e-22 | -0.03 | 0.06 | 0.84 | FALSE |
| 41 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PPARD | 0.07 | 0.06 | lasso | 3 | 0.04 | 2.5e-03 | -5.2 | -5.5 | 4.7e-08 | 0.10 | 0.14 | 0.31 | FALSE |
| 42 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DEF6 | 0.04 | 0.01 | blup | 50 | 0.03 | 6.2e-04 | -7.8 | 6.1 | 1.0e-09 | -0.13 | 0.06 | 0.73 | FALSE |
| 43 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TCP11 | 0.05 | 0.04 | blup | 49 | 0.06 | 1.3e-07 | -9.7 | -9.8 | 1.3e-22 | -0.03 | 0.01 | 0.99 | FALSE |
| 44 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ZNF76 | 0.08 | 0.05 | lasso | 10 | 0.07 | 4.9e-04 | -8.0 | -6.7 | 1.9e-11 | -0.01 | 0.03 | 0.58 | FALSE |
| 45 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf126 | 0.03 | 0.00 | enet | 8 | 0.01 | 1.8e-02 | 4.9 | 5.5 | 3.2e-08 | 0.02 | 0.01 | 0.41 | TRUE |
| 46 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf81 | 0.05 | 0.00 | blup | 43 | 0.02 | 8.9e-04 | 5.7 | -7.8 | 6.2e-15 | 0.02 | 0.02 | 0.34 | FALSE |
| 47 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPL10A | 0.02 | 0.02 | lasso | 2 | 0.02 | 3.8e-03 | -9.2 | -9.2 | 3.7e-20 | -0.02 | 0.07 | 0.18 | FALSE |
| 48 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TCP11 | 0.03 | 0.03 | blup | 49 | 0.03 | 3.5e-04 | -9.7 | -10.2 | 1.5e-24 | -0.03 | 0.01 | 0.97 | FALSE |
| 49 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TCP11 | 0.05 | 0.07 | lasso | 2 | 0.07 | 1.9e-05 | -9.4 | -9.4 | 3.4e-21 | -0.02 | 0.02 | 0.96 | FALSE |
| 50 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TCP11 | 0.08 | 0.11 | lasso | 2 | 0.11 | 3.4e-05 | -9.4 | -9.5 | 1.7e-21 | -0.02 | 0.01 | 0.95 | FALSE |
| 51 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPL10A | 0.09 | 0.03 | enet | 19 | 0.07 | 1.1e-07 | -8.8 | -8.2 | 2.8e-16 | -0.01 | 0.75 | 0.21 | FALSE |
| 52 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TCP11 | 0.03 | 0.03 | lasso | 3 | 0.04 | 3.8e-05 | -8.7 | -8.7 | 2.3e-18 | 0.04 | 0.02 | 0.93 | FALSE |
| 53 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF76 | 0.03 | 0.02 | lasso | 3 | 0.02 | 3.5e-03 | -6.6 | 7.2 | 8.2e-13 | -0.01 | 0.16 | 0.49 | TRUE |
| 54 | The Cancer Genome Atlas | Thyroid Carcinoma | C6orf106 | 0.08 | 0.00 | enet | 15 | 0.05 | 2.5e-05 | -5.9 | 8.2 | 2.1e-16 | 0.00 | 0.01 | 0.74 | FALSE |
| 55 | The Cancer Genome Atlas | Thyroid Carcinoma | RPL10A | 0.05 | 0.07 | enet | 4 | 0.04 | 1.2e-04 | -8.8 | -9.1 | 9.0e-20 | -0.05 | 0.69 | 0.14 | FALSE |
| 56 | The Cancer Genome Atlas | Thyroid Carcinoma | SCUBE3 | 0.03 | 0.01 | blup | 62 | 0.03 | 8.9e-04 | -8.0 | 6.8 | 8.7e-12 | -0.03 | 0.05 | 0.64 | TRUE |
| 57 | The Cancer Genome Atlas | Thyroid Carcinoma | TCP11 | 0.03 | 0.02 | blup | 49 | 0.02 | 1.6e-03 | -9.4 | -9.9 | 3.8e-23 | -0.05 | 0.02 | 0.77 | FALSE |