Best TWAS P=8.56e-09 · Best GWAS P=5.83e-08 conditioned to 0.337
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Lung | ANKRD13B | 0.13 | 0.09 | lasso | 6 | 0.08 | 6.8e-07 | -4.6 | -5.4 | 7.6e-08 | -0.70 | 0.24 | 0.76 | FALSE |
| 2 | METSIM | Adipose | ANKRD13B | 0.04 | 0.03 | lasso | 3 | 0.05 | 1.4e-07 | 5.3 | -5.8 | 8.6e-09 | -0.86 | 0.08 | 0.92 | TRUE |
| 3 | YFS | Blood | GIT1 | 0.11 | 0.08 | lasso | 8 | 0.09 | 8.7e-27 | 4.1 | -5.2 | 2.0e-07 | -0.79 | 0.85 | 0.13 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SSH2 | 0.01 | 0.01 | blup | 111 | 0.01 | 1.0e-03 | -5.0 | 5.2 | 2.0e-07 | 0.96 | 0.05 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SSH2 | 0.03 | 0.02 | blup | 112 | 0.03 | 2.4e-04 | 5.4 | 5.3 | 1.4e-07 | 0.97 | 0.04 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | SSH2 | 0.06 | 0.03 | blup | 112 | 0.05 | 2.5e-06 | -4.9 | 5.4 | 5.7e-08 | 0.94 | 0.06 | 0.93 | FALSE |