Best TWAS P=2.15e-09 · Best GWAS P=2.71e-08 conditioned to 0.815
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SERPINF1 | 0.19 | 0.05 | lasso | 6 | 0.02 | 6.3e-03 | 5.6 | -5.6 | 2.1e-08 | -0.96 | 0.00 | 0.99 | FALSE |
| 2 | GTEx | Brain Cortex | SMYD4 | 0.34 | 0.17 | lasso | 4 | 0.23 | 5.3e-07 | 4.3 | -5.4 | 8.5e-08 | -0.80 | 0.05 | 0.80 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | SERPINF1 | 0.20 | 0.11 | lasso | 3 | 0.16 | 5.6e-12 | 5.6 | -6.0 | 2.1e-09 | -0.91 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Colon Sigmoid | SMYD4 | 0.33 | 0.24 | lasso | 7 | 0.24 | 5.0e-09 | 4.7 | -5.2 | 2.6e-07 | -0.96 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Esophagus Muscularis | SMYD4 | 0.24 | 0.16 | lasso | 3 | 0.18 | 3.1e-11 | 4.9 | -5.2 | 1.7e-07 | -0.96 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | SMYD4 | 0.28 | 0.06 | enet | 36 | 0.12 | 5.8e-07 | 4.9 | -5.2 | 1.7e-07 | -0.58 | 0.03 | 0.94 | FALSE |
| 7 | GTEx | Thyroid | SMYD4 | 0.32 | 0.13 | enet | 11 | 0.23 | 1.5e-17 | 4.9 | -5.3 | 1.0e-07 | -0.88 | 0.03 | 0.97 | FALSE |
| 8 | YFS | Blood | WDR81 | 0.17 | 0.16 | enet | 22 | 0.18 | 1.3e-57 | 5.6 | 5.2 | 2.3e-07 | 0.92 | 0.00 | 1.00 | FALSE |