Hub : Genes

GIT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.1530	0.0630	2.3e-04	0.063	NA	0.024	NA	0.057	1.1e-02	NA	8.1e-02	NA	1.4e-02
2	GTEx	Testis	0.1180	0.0620	2.1e-04	0.171	NA	0.124	NA	0.131	4.8e-08	NA	4.1e-06	NA	2.1e-06
3	GTEx	Thyroid	0.0610	0.0260	4.7e-06	0.082	NA	0.079	NA	0.087	7.4e-07	NA	1.1e-06	NA	3.7e-07
4	YFS	Blood	0.1141	0.0353	0.0e+00	0.077	0.076	0.080	0.075	0.086	5.6e-24	1.3e-23	9.8e-25	2.6e-23	8.8e-27
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0926	0.0445	3.4e-03	0.009	0.006	0.011	NA	0.011	2.7e-02	6.6e-02	2.0e-02	NA	1.6e-02
6	TCGA	Thyroid Carcinoma	0.0590	0.0250	9.7e-05	0.055	0.054	0.038	NA	0.052	4.8e-06	5.2e-06	1.2e-04	NA	8.0e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	3.6	5.8	14.7	-1.9	-2.3	1.5	-2.9	-3.8	0.5
Bipolar Disorder or Schizophrenia	1.5	3.6	8.1	-1.6	-1.4	1.6	-2.2	-2.9	1.2
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	0.2	-0.6	-0.9	0.3	0.9	-0.4
Depression (Nagel 2018)	0.2	0.3	0.8	-0.6	-0.6	-0.2	-0.9	-0.7	-0.4
Intelligence (Savage-Jansen 2018)	4.7	14.4	25.4	5.0	3.4	-4.6	3.5	0.9	-3.9
Neuroticism (Nagel 2018)	0.0	0.1	0.4	0.2	-0.6	-0.4	0.0	0.1	-0.1
Schizophrenia (2018)	0.2	0.5	1.2	-0.6	-0.0	0.8	-0.5	-0.6	1.1
Schizophrenia vs Biploar Disorder	2.2	2.9	4.7	2.0	2.2	-1.3	1.9	1.7	-0.7
Worry (Nagel 2018)	0.2	0.5	2.3	-0.0	-0.1	0.5	-0.1	-1.5	0.4
Alzheimer’s Disease (in mother)	4.9	5.7	8.9	-2.9	-1.5	2.3	-2.5	-3.0	1.9
Alzheimer’s Disease (in father)	1.8	2.0	4.7	-2.2	-0.4	1.7	-0.6	-0.7	1.8
Alzheimer’s Disease (including proxy)	7.6	11.1	16.6	-4.1	-2.5	3.6	-3.3	-3.1	3.2
Crohns Disease (2017)	0.4	0.8	2.0	-1.1	0.4	1.1	0.3	-0.2	1.4
Irritable Bowel Disease (IBD)	0.8	2.0	4.5	1.1	1.7	-0.8	2.1	1.7	0.0
Ulcerative Colitis (UC)	2.9	5.5	8.1	2.6	2.2	-2.1	2.9	2.8	-1.1
Major Depression (MDD)	1.8	2.2	4.1	-1.3	-2.0	0.9	-1.9	-1.6	0.5
Reaction Time	0.2	0.4	1.4	-0.1	-0.0	-0.8	0.1	-0.8	-1.2
Verbal and Numeric Reasoning (VNR)	2.4	5.6	10.3	3.2	1.8	-3.1	1.9	0.0	-2.7
Breast Cancer	1.6	3.9	8.5	2.9	2.0	-1.8	2.5	-0.3	-1.1
Ovarian Cancer	0.5	0.6	2.0	-0.6	-1.4	0.5	-0.8	-0.3	0.5
Prostate Cancer	0.6	0.9	2.6	1.0	1.6	0.0	1.4	-0.0	0.2
Age at First Birth	0.5	0.8	2.5	0.1	0.5	-0.5	1.6	1.2	0.3
Bipolar Disorder (2011)	8.3	8.1	12.5	-2.6	-3.3	2.5	-3.5	-3.5	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	-0.4	-0.5	-0.6	-0.1	-1.0	-0.8
Coronary Artery Disease (CAD)	2.9	3.5	8.4	2.9	1.2	-2.1	1.9	1.0	-1.3
Crohns Disease (2012)	0.7	1.2	2.4	-1.3	-0.7	1.4	-0.5	0.4	1.6
Mean Putamen Volume	2.5	2.8	5.7	2.4	1.0	-1.6	1.7	1.8	-1.3
Fasting Glucose	1.8	2.1	4.5	-1.1	0.4	2.1	-0.9	-1.9	1.6
HbA1C	0.3	0.3	0.8	-0.1	0.6	0.6	0.6	0.9	0.4
HDL Cholesterol	1.2	2.0	4.7	-0.6	-1.0	1.8	-1.2	-1.0	2.2
LDL Cholesterol	0.3	0.5	1.3	1.2	-0.1	-0.9	0.3	0.4	-0.8
Lupus	0.3	0.5	1.1	-1.0	0.4	-0.5	-0.6	-0.8	-0.6
Neuroticism (2016)	0.4	0.6	1.9	-0.3	-1.4	0.3	-1.0	0.1	0.4
Primary Biliary Cirrhosis	1.7	2.4	3.9	-1.6	-1.7	1.4	-2.0	-1.4	1.0
Rheumatoid Arthritis	0.2	0.3	0.5	0.4	-0.6	-0.7	-0.3	-0.1	-0.6
Schizophrenia (2014)	0.0	0.1	0.2	-0.0	0.3	0.2	-0.0	-0.4	0.5
Triglycerides	0.1	0.2	0.5	-0.4	-0.5	0.4	-0.7	-0.5	0.2
Type 2 Diabetes (T2D) (2012)	3.8	4.4	6.7	1.7	1.7	-2.6	2.5	1.6	-2.2
Ulcerative Colitis	1.3	1.9	3.6	1.9	1.2	-1.5	1.5	0.8	-1.3
Blood Eosinophil Count	0.1	1.0	3.2	0.6	-0.3	-1.4	-0.6	-0.4	-1.8
Blood Platelet Count	13.7	158.6	380.2	19.5	18.2	-4.9	14.1	4.1	0.7
Blood Red Count	3.6	34.3	47.9	6.8	4.6	-6.9	5.3	3.9	-6.9
Blood White Count	7.5	55.7	90.8	-9.5	-5.5	8.7	-8.2	-4.8	6.9
Heel T-Score	7.8	62.4	174.2	-6.6	-2.1	11.0	-4.8	-3.0	13.2
BMI	3.7	21.2	34.6	4.5	3.7	-5.3	4.2	3.5	-5.9
Height	2.4	45.7	74.0	-6.8	-3.1	8.1	-8.6	-7.6	4.7
Waist Hip Ratio (WHR)	0.4	1.9	6.0	1.9	2.5	-0.2	1.2	-0.4	-0.0
Systolic Blood Pressure	0.2	1.2	2.9	0.3	1.4	-1.3	0.9	0.3	-1.7
Smoking Status	1.0	2.4	4.5	-1.7	-1.8	1.7	-2.1	-0.1	0.9
Allergy or Eczema	1.2	3.1	5.5	2.3	2.0	-2.0	1.9	0.3	-1.0
Cardiovascular Disease	5.6	18.3	26.9	4.5	3.1	-5.0	4.0	3.5	-5.2
Hypothyroidism (self reported)	3.8	8.8	19.8	2.6	1.8	-4.5	1.8	0.6	-4.4
Respiratory disease	0.6	1.3	3.9	-1.1	-1.4	0.7	-2.0	-0.6	0.3
Type 2 Diabetes (T2D) (2018)	1.2	2.3	3.5	1.9	1.6	-1.6	1.8	1.0	-1.0
Lung FEV1/FVC ratio	26.2	132.7	201.6	12.5	8.1	-14.2	11.7	8.5	-12.8
Lung FVC	1.6	8.3	19.8	-2.3	-2.8	3.6	-2.0	0.4	4.5
Neuroticism	0.5	1.1	2.5	-1.1	-1.6	1.0	-1.0	-0.0	1.1
Chronotype (morning person)	0.4	0.9	2.3	0.0	-0.8	-0.8	-1.1	-1.0	-1.5
Hair Pigment	0.4	12.3	20.5	-2.5	-4.5	3.1	-4.4	-3.4	2.5
Tanning	0.2	2.0	3.5	-1.9	-0.9	0.9	-1.8	-1.9	-0.1
Hand grip strength (left)	0.2	0.6	1.4	-0.2	-0.5	1.2	-1.0	-0.8	0.8
Number of treatments/medications taken	2.8	5.1	8.6	2.0	1.4	-2.7	1.6	2.4	-2.9
Average weekly spirits intake	0.6	0.8	1.4	-0.9	-0.7	1.2	-0.8	-0.4	1.1
Sensitivity / hurt feelings	1.6	2.7	4.8	-1.3	-2.2	1.5	-2.0	-1.0	1.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.2	-0.5	-0.5	-0.5	-0.7	-0.7
Hearing difficulty/problems: Yes	1.2	1.8	4.5	1.3	0.3	-1.4	1.4	2.1	-0.6
Relative age of first facial hair	0.1	0.2	0.8	0.9	0.0	-0.3	0.3	0.6	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.6	-0.6	1.1	-0.8	0.9	0.6	-1.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.5	-0.6	-0.0	0.7	0.0	0.3	1.2
Ever had hysterectomy (womb removed)	1.1	1.2	2.7	1.0	1.7	-1.0	1.2	-0.4	-1.1
Systolic blood pressure, automated reading	1.0	2.9	10.1	0.7	3.2	-1.1	1.9	0.3	-1.5
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.2	0.1	0.0	-0.0	-0.4	-0.1	0.0
Angina	6.7	8.8	13.8	3.0	1.9	-3.6	2.8	2.3	-3.7
Medication for hormone replacement therapy	0.4	0.5	0.9	-0.7	0.4	1.0	-0.0	0.8	0.9
Vitamin and mineral supplements	0.4	0.5	1.3	-1.1	0.5	0.9	-0.4	-0.2	0.6
Supplements: Zinc	3.5	3.8	5.6	2.4	1.2	-2.2	2.3	1.8	-1.5
Medication: Co-codamol	0.2	0.3	0.8	-0.7	0.4	0.5	-0.9	0.2	-0.0
Medication: Metformin	3.8	5.3	8.2	2.7	2.1	-2.4	2.9	1.9	-1.7
Diabetes (father)	0.4	0.5	1.5	-0.1	0.0	-0.4	-0.2	-1.2	-1.1
Diabetes (mother)	1.5	1.9	2.7	1.6	1.4	-1.5	1.1	0.6	-1.6
Severe depression (siblings)	0.4	0.4	1.4	0.1	1.2	-0.1	0.7	-0.4	0.6
Pack years adult smoking proportion	0.8	1.3	3.4	-1.9	-1.1	-0.4	-0.9	0.0	-1.4
Impedance of leg (right)	0.1	0.4	0.9	-0.4	0.3	-0.7	0.9	-0.9	0.2
Leg fat-free mass (left)	0.2	0.8	2.5	-0.5	0.5	1.1	-1.6	-0.2	-0.7
Trunk fat percentage	2.6	10.6	18.1	3.3	2.8	-3.6	2.7	2.6	-4.2
Hand grip strength (right)	0.6	1.7	3.4	-0.9	-1.0	1.8	-1.2	-1.3	1.5
Townsend deprivation index at recruitment	2.8	3.9	11.0	-3.3	-2.1	1.8	-2.1	0.3	0.8
Current tobacco smoking	0.7	1.1	2.8	-1.7	-1.4	0.7	-1.1	-0.5	0.0
Average weekly fortified wine intake	0.9	1.1	2.6	-0.6	-0.1	1.5	-0.5	-1.0	1.6
Maternal smoking around birth	1.0	1.5	3.4	-1.2	-1.9	0.5	-1.7	-0.6	-0.5
Fed-up feelings	0.6	1.1	3.1	-0.9	-1.8	-0.3	-1.5	-0.0	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.0	-1.4	0.0	0.5	-1.0	-0.4	0.2
Relative age voice broke	0.7	1.1	2.9	-1.1	-0.8	1.1	-0.6	-0.2	1.7
Taking other prescription medications	2.8	4.3	7.8	1.9	1.5	-2.8	1.6	1.4	-2.8
Age when periods started (menarche)	0.4	1.0	1.9	-1.2	-0.8	1.2	-1.4	-0.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	0.7	-0.2	-0.8	-0.3	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	5.4	12.2	32.0	-4.0	-0.6	4.7	-1.6	-0.5	5.7
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.9	2.0	-0.0	-1.0	1.0	1.0	-0.5
Qualifications: CSEs or equivalent	1.4	1.9	3.8	-1.5	0.1	1.7	-0.6	-1.9	1.4
Serious illness, injury or assault to yourself	1.0	1.2	2.6	0.5	1.6	-0.9	0.9	-0.7	-1.6
High blood pressure	4.7	13.1	15.0	3.9	3.6	-3.7	3.9	3.0	-3.7
Hayfever, allergic rhinitis or eczema	1.9	4.1	6.5	2.5	2.4	-2.2	2.4	1.0	-1.1
Multivitamins +/- minerals	1.2	1.5	2.8	1.5	0.7	-1.7	1.4	0.0	-1.2
Stomach or abdominal pain in last month	2.9	3.6	6.7	1.9	1.1	-2.6	2.0	0.9	-2.2
Supplements: Glucosamine	0.2	0.2	0.6	0.8	0.4	-0.4	0.2	-0.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	0.1	1.1	-0.6	0.6	-0.8	-0.6
Medication: Atenolol	1.4	1.7	2.4	1.2	1.0	-1.5	1.4	1.1	-1.6
Medication: Levothyroxine sodium	0.6	1.1	2.4	0.9	0.1	-1.6	-0.2	-0.8	-1.6
Sitting height	1.2	8.5	14.7	-3.2	-1.5	3.2	-3.8	-3.2	1.8
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.8	-0.3	0.5	-0.4	0.6	0.4
High blood pressure (mother)	1.5	2.0	6.0	1.3	0.5	-2.0	0.2	-0.3	-2.5
Body mass index (BMI)	3.1	13.1	23.3	3.8	2.8	-3.9	2.9	3.1	-4.8
Impedance of leg (left)	0.2	1.0	3.1	-1.0	-0.2	0.5	0.1	-1.8	1.3
Leg predicted mass (left)	0.2	0.9	2.8	-0.6	0.5	1.2	-1.7	-0.4	-0.6
Trunk fat mass	1.7	7.2	13.7	2.6	2.7	-2.6	2.0	2.1	-3.7
Waist circumference	2.9	10.8	18.6	3.7	3.5	-3.2	2.6	1.8	-4.3
Number of incorrect matches in round	5.0	8.3	15.7	-3.7	-1.6	4.0	-2.6	-1.2	3.2
Past tobacco smoking	0.2	0.3	0.8	-0.1	0.4	-0.7	0.9	-0.6	-0.4
Alcohol usually taken with meals	0.5	0.9	3.3	-0.4	-0.0	1.2	-0.3	-0.1	1.8
Nervous feelings	0.4	0.7	1.7	-1.1	0.2	1.0	-0.1	-0.3	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.1	0.5	1.1	-0.4	0.8	0.3	-0.2
Hearing difficulty/problems with background noise	0.6	0.9	3.3	1.8	-0.9	-0.9	0.3	0.5	-0.2
Hair/balding pattern: Pattern 2	0.6	0.8	2.2	-0.5	-0.4	1.0	-0.3	-1.5	1.1
Had menopause	3.6	4.4	6.0	2.3	2.2	-2.1	2.4	1.7	-1.9
Had other major operations	0.3	0.4	0.6	0.7	0.6	-0.7	0.4	-0.2	-0.8
Forced vital capacity (FVC)	5.4	20.8	32.6	-4.7	-3.2	5.7	-5.1	-2.8	5.0
Heel bone mineral density (BMD) T-score, automated (right)	3.8	8.8	27.6	-3.0	0.3	3.9	-0.6	-0.0	5.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.6	0.7	-0.1	-1.2	0.6	1.6	-1.4
Qualifications: None of the above	0.9	1.9	4.3	-1.4	-2.1	1.1	-1.8	0.4	0.6
Financial difficulties in last 2 years	0.4	0.6	1.8	-0.4	-0.7	0.4	-0.9	-1.4	-0.2
Mouth/teeth dental problems	0.3	0.5	0.9	-0.4	0.8	0.7	0.5	0.9	0.7
Heart attack	8.6	11.0	14.9	3.8	3.2	-3.6	2.8	2.2	-3.9
Allergy	1.4	3.2	4.7	-2.2	-2.1	1.4	-1.8	-2.1	0.5
Pain all over the body in last month	0.2	0.3	0.5	-0.6	0.6	-0.4	0.1	-0.2	-0.7
Diabetes (self-reported)	3.4	5.3	8.1	2.8	2.0	-2.5	2.5	1.8	-1.9
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.5	1.3	1.1	-0.9	1.9	1.3	-0.2
Medication: Ramipril	0.6	0.8	2.8	0.8	0.1	-0.8	0.7	1.7	-0.5
Medication: Simvastatin	2.2	3.3	5.9	2.0	0.8	-2.3	1.5	1.4	-2.4
Fluid intelligence score	2.6	5.3	10.3	2.6	1.8	-3.2	2.3	0.3	-2.4
Illnesses of siblings	11.3	15.8	25.7	-4.7	-2.6	5.1	-3.7	-2.3	4.6
Neuroticism score	0.8	1.6	2.3	-1.5	-1.5	1.0	-1.2	-0.8	1.4
Weight	0.4	1.9	5.8	1.1	1.8	-0.7	0.1	0.8	-2.4
Impedance of arm (right)	0.3	1.2	3.1	-0.8	-1.4	0.9	-0.4	-0.7	1.8
Arm fat percentage (right)	3.8	14.9	22.4	4.2	2.5	-4.3	3.4	3.6	-4.7
Trunk fat-free mass	0.6	3.7	7.2	-1.8	0.2	2.7	-2.7	-2.0	0.7
Hip circumference	0.6	2.6	7.3	0.9	2.2	-1.1	0.6	1.2	-2.7
Time employed in main current job	0.2	0.2	0.5	-0.3	0.1	0.5	0.7	-0.0	0.6
Alcohol intake versus 10 years previously	0.8	1.1	2.7	0.4	-1.5	-1.2	-0.3	-0.6	-1.6
Father’s age at death	0.6	0.9	1.1	-0.6	-1.0	1.0	-1.0	-1.1	0.8
Worrier / anxious feelings	0.1	0.1	0.2	-0.4	0.0	0.1	0.5	-0.3	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.5	-0.1	-0.6	-0.3	0.4	-0.9
Falls in the last year	0.9	1.2	3.0	-1.7	-1.0	1.3	-0.7	0.2	1.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.7	1.3	0.7	-1.0	0.2	0.0	-0.6
Number of live births	0.1	0.2	0.6	-0.1	0.7	0.3	0.2	0.8	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.6	-0.7	-0.6	1.2	-1.3	-0.3	1.1
Pulse rate	0.1	0.2	0.4	-0.5	0.6	-0.0	-0.3	0.5	-0.6
Happiness	0.3	0.4	1.5	-0.6	-1.2	-0.2	-0.6	-0.0	-0.3
Noisy workplace	3.3	4.1	6.5	-2.2	-2.6	2.1	-2.2	-0.3	2.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.8	0.3	0.4	-0.2	1.3	1.1	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.6	0.5	1.6	-0.9	1.2	0.6	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.9	0.8	0.1	0.0	-0.7	-0.1
Asthma	0.8	1.6	4.1	-1.5	-1.0	1.2	-2.0	0.2	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.7	-0.5	-1.9	0.7	-1.6	0.5	0.1
Medication: Cholesterol lowering	1.9	2.9	5.0	1.8	1.1	-2.2	1.2	1.4	-2.2
Depression (self-reported)	0.3	0.4	0.7	0.2	0.7	-0.6	0.4	-0.6	-0.8
Medication: Lansoprazole	0.7	0.9	3.0	0.5	1.7	-0.4	0.9	-0.3	-0.9
Prospective memory result	5.5	6.8	14.1	-2.7	-2.9	2.6	-3.7	-1.8	1.2
Lung cancer (father)	0.7	0.8	1.7	-1.3	-0.3	1.1	-0.8	-0.9	0.5
Illnesses of mother	3.9	4.8	12.2	-2.2	-1.1	3.0	-1.3	-0.4	3.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.1	-0.1	-0.7	0.6	-1.1	0.1	0.5
Pulse wave Arterial Stiffness index	0.5	0.6	2.3	-0.5	-0.1	0.6	-0.3	-1.5	0.6
Impedance of arm (left)	0.3	1.5	2.8	-1.3	-1.6	1.0	-0.8	-0.7	1.7
Arm fat mass (right)	2.5	10.3	18.7	3.4	2.8	-3.3	2.5	2.7	-4.3
Trunk predicted mass	0.6	3.4	6.6	-1.7	0.3	2.6	-2.6	-2.0	0.6
Standing height	2.7	26.3	45.8	-5.4	-1.7	6.8	-5.7	-4.8	5.0
Length of working week for main job	0.7	0.8	1.3	-0.6	0.4	1.1	-0.6	-1.1	1.1
Exposure to tobacco smoke at home	1.1	1.2	2.3	-1.5	0.5	1.5	-0.5	0.0	1.5
Breastfed as a baby	1.6	1.9	4.4	1.1	1.6	-1.1	2.1	1.3	-0.7
Tense / ‘highly strung’	0.3	0.4	1.9	-0.5	0.5	0.3	0.1	-1.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.6	0.3	1.5	-1.4	1.9	-0.2	-1.1
Hair/balding pattern: Pattern 4	0.2	0.4	1.3	-0.3	-0.5	0.5	-0.5	1.1	0.4
Birth weight of first child	2.0	3.6	7.1	-1.2	-1.3	2.7	-2.1	-0.1	2.6
Peak expiratory flow (PEF)	3.9	9.1	15.4	3.9	1.6	-3.6	2.7	2.4	-3.2
Pulse wave reflection index	0.3	0.3	1.6	-0.3	-1.3	-0.1	-0.4	-0.1	0.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.6	-0.1	-1.1	-0.2	-0.3	1.3	-0.0
Loud music exposure frequency	0.9	0.9	2.2	0.8	1.5	0.1	1.2	1.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.6	0.6	-0.1	0.7	0.1	0.3
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.0	-0.8	-1.9	1.3	-1.8	-2.0	0.9
Blood clot in the leg (DVT)	5.3	6.9	9.4	3.0	3.1	-2.4	3.0	2.2	-1.9
Medication: Paracetamol	0.5	0.8	2.0	0.7	-1.1	-0.2	-1.4	-0.2	-0.9
Headache pain in last month	0.6	1.0	3.0	-0.2	-1.6	0.1	-1.7	-0.3	-0.7
Medication for cholesterol, blood pressure or diabetes	5.8	9.5	13.3	-3.1	-1.8	3.7	-3.0	-3.4	3.3
Glaucoma (self-reported)	0.4	0.5	1.2	0.5	-0.3	-0.9	-0.2	-0.7	-1.1
Gout (self-reported)	0.5	0.6	1.6	0.1	0.6	-1.1	0.8	-0.1	-1.3
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	10.9	2.0	1.2	-3.3	1.1	0.2	-3.1
Medication: Amlodipine	2.0	2.7	6.5	0.9	-0.2	-2.3	1.3	1.5	-2.6
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	-0.1	-0.3	0.4	-0.7	-0.1	0.3
Birth weight	2.7	5.9	13.4	-2.1	-3.7	1.9	-3.4	-1.2	1.0
Chronic bronchitis/emphysema (mother)	1.5	1.8	3.3	1.5	1.1	-1.4	1.4	-0.0	-1.8
High blood pressure (siblings)	8.4	12.1	20.9	4.4	1.7	-4.6	3.0	1.4	-4.3
Forced vital capacity (FVC), Best measure	4.9	17.8	27.0	-4.0	-3.5	5.0	-5.2	-2.7	4.3
Body fat percentage	3.7	14.8	23.0	3.8	3.3	-4.2	3.5	3.1	-4.8
Leg fat percentage (right)	5.9	21.5	32.9	4.5	3.8	-5.3	4.3	3.8	-5.7
Arm fat-free mass (right)	0.3	1.3	2.5	-1.0	1.1	1.4	-1.6	-1.0	-0.6
Exposure to tobacco smoke outside home	0.3	0.3	1.3	0.4	-0.1	-0.2	-0.2	-1.1	-0.7
Comparative body size at age 10	1.3	3.5	9.0	3.0	1.8	-1.7	1.4	0.1	-1.9
Number of full brothers	1.0	1.2	2.7	-1.3	-1.5	0.8	-1.6	-0.1	0.4
Worry too long after embarrassment	2.8	4.8	6.3	-2.1	-2.2	2.2	-2.5	-2.0	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	-0.9	0.9	0.2	0.6	-0.8	0.8
Wheeze or whistling in the chest in last year	0.9	1.6	4.4	0.9	-0.0	-1.6	0.3	1.3	-2.1
Number of children fathered	0.4	0.5	0.7	0.8	0.8	-0.6	0.8	0.0	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	5.4	-0.1	0.3	-0.2	1.2	2.3	0.3
Age at first live birth	1.6	2.9	5.5	1.8	1.2	-1.5	2.3	2.1	-0.1
Pulse wave peak to peak time	0.2	0.2	1.2	0.2	0.1	-0.1	0.0	1.1	-0.3
Health satisfaction	1.1	1.5	3.0	1.2	0.9	-1.5	0.9	0.8	-1.7
Shortness of breath walking on level ground	0.3	0.3	1.2	0.2	-1.1	-0.5	-0.6	0.0	-0.5
Qualifications: College or University degree	0.8	2.5	4.4	1.1	2.1	-0.1	2.0	1.7	1.6
Eye problems/disorders: None of the above	0.3	0.4	1.0	0.8	-0.4	-0.6	0.3	1.0	-0.3
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.7	-1.2	-1.9	0.7	-1.7	-0.3	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.4	-0.3	-0.1	0.1	-0.1	-0.2	-0.6
Medication for pain relief, constipation, heartburn	1.6	2.7	5.7	-1.7	0.0	1.7	0.1	-2.1	2.4
Neck or shoulder pain in last month	0.9	1.3	3.8	0.4	0.1	-1.8	0.5	0.7	-1.9
Medication: Blood pressure	7.1	12.5	15.1	2.8	2.9	-3.8	3.8	3.9	-3.7
Angina (self-reported)	6.3	8.3	12.9	2.9	2.0	-3.5	2.7	2.1	-3.6
Migraine (self-reported)	1.3	1.6	3.7	-1.3	-1.0	1.9	-1.0	-0.0	1.5
Medication: Ibuprofen	0.8	1.0	3.3	-0.5	-1.3	0.7	-1.8	-0.1	-0.2
Medication: Allopurinol	1.3	1.7	3.1	0.3	1.6	-1.5	1.4	-0.1	-1.8
Medication: Omeprazole	0.5	0.6	2.5	-0.0	0.1	-0.7	0.4	1.6	-0.8
Medication: Seretide 50 evohaler	0.8	0.9	1.8	-0.7	-1.3	0.1	-1.2	-1.3	-0.2
Mean time to correctly identify matches	1.1	2.0	3.1	1.5	1.3	-1.6	1.5	0.6	-1.8
Heart disease (mother)	2.3	2.8	5.7	1.9	0.9	-2.0	1.1	1.3	-2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	1.0	0.2	0.6	-0.0	-0.0	-1.0	-0.2
Whole body fat mass	2.4	9.8	18.7	3.0	3.0	-3.2	2.4	2.4	-4.3
Leg fat mass (right)	4.0	15.4	26.1	3.8	3.6	-4.2	3.4	3.2	-5.1
Arm predicted mass (right)	0.3	1.4	2.7	-1.1	1.0	1.5	-1.6	-1.1	-0.4
Pulse rate, automated reading	0.1	0.4	1.1	-1.1	-0.0	0.7	-0.5	0.6	0.4
Alcohol intake frequency.	1.3	3.0	8.6	-2.9	-1.3	1.2	-2.0	-1.5	-0.4
Comparative height size at age 10	2.0	11.0	19.8	-4.0	-1.1	4.5	-3.8	-2.6	2.8
Number of full sisters	1.0	1.2	3.6	-0.7	-1.9	0.0	-1.7	-0.3	-0.5
Suffer from ‘nerves’	0.8	1.3	4.1	-0.6	-1.2	0.6	-0.7	-2.0	0.9
Overall health rating	0.6	1.3	3.6	0.1	0.3	-1.5	0.8	1.1	-1.9
Chest pain or discomfort	5.6	8.1	12.2	2.2	1.4	-3.5	2.7	3.3	-3.4
Had major operations	0.3	0.4	1.7	-0.2	-0.0	0.2	0.6	1.3	0.4
Age at last live birth	0.2	0.3	0.6	-0.6	-0.7	0.4	-0.5	0.2	0.8
Family relationship satisfaction	0.8	1.0	2.5	1.1	-0.2	-1.4	0.4	-0.3	-1.6
Leg pain on walking	0.1	0.2	1.0	-0.1	0.1	-0.1	-0.2	0.1	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.5	0.2	0.0	0.1	-0.1	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.9	-0.1	-0.2	0.6	-0.6	-1.0	0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.4	-0.5	-0.4	0.8	-0.5	0.2	1.2
Medication: Aspirin	10.4	13.7	22.0	4.7	1.9	-4.2	3.0	3.9	-3.9
Supplements: Vitamin C	0.8	0.9	1.6	1.2	-0.6	-1.3	0.4	0.9	-1.1
Knee pain experienced in last month	1.6	2.5	4.9	1.7	1.4	-1.8	1.0	-0.8	-2.2
Hypertension (Self-reported)	4.8	13.2	16.1	4.0	3.3	-3.9	3.7	2.8	-3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.0	0.9	2.0	-0.5	1.7	-0.6	-0.4
Illnesses of father: Heart disease	3.7	5.1	10.1	3.2	1.9	-2.1	2.4	2.2	-1.3
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.2	-0.0	0.3	0.2	-0.0	0.2
Smoking status: Previous	0.3	0.4	1.4	0.3	-0.7	0.5	-1.2	0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.7	10.2	-2.9	-1.1	3.0	-2.5	-3.2	2.3
Whole body fat-free mass	0.4	2.3	5.7	-1.4	0.3	2.1	-2.4	-1.3	0.1
Leg fat-free mass (right)	0.4	2.2	5.9	-1.3	-0.1	2.2	-2.4	-0.8	0.3
Arm fat percentage (left)	3.8	15.2	23.8	4.1	2.6	-4.5	3.4	3.6	-4.9
Average weekly red wine intake	0.3	0.4	0.8	-0.1	-0.9	0.5	-0.6	0.5	0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.8	0.6	-0.0	0.1	-0.6	-1.7	0.6
Mood swings	0.7	1.2	2.2	0.2	-1.0	-1.4	0.4	1.5	-1.4
Loneliness, isolation	0.2	0.3	1.0	-0.6	-0.2	-0.4	0.3	-1.0	0.2
Long-standing illness, disability or infirmity	0.2	0.3	1.2	-0.3	1.1	-0.4	0.7	-0.1	-0.4
Ever had bowel cancer screening	4.4	5.1	8.1	2.6	2.6	-1.9	2.8	2.0	-1.2
Diabetes diagnosed by doctor	3.0	5.0	7.3	2.7	2.0	-2.5	2.6	1.9	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.2	-0.5	0.5	-0.6	0.5	0.4
Friendships satisfaction	0.3	0.4	0.7	0.4	-0.8	-0.8	-0.0	0.4	-0.8
Qualifications: nursing, teaching	1.6	2.4	6.1	1.1	1.8	-1.0	2.5	1.7	-0.1
Commuting to job workplace: Walk	0.7	0.7	1.6	0.1	1.3	-0.6	0.5	-1.2	-0.7
Eye problems/disorders: Cataract	1.9	2.2	5.4	1.3	2.0	-1.0	2.3	0.8	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.1	1.4	0.9	-1.4	1.4	0.5	-0.6
Medication for cholesterol	3.2	4.9	5.3	-2.1	-2.1	2.1	-2.3	-2.3	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.4	1.7	0.8	-1.6	0.8	-0.2	-1.8
Back pain experienced in last month	4.9	7.2	13.6	2.7	2.0	-3.5	2.2	0.7	-3.7
Mineral and other dietary supplements	0.6	0.9	1.3	-1.1	-0.6	1.1	-1.0	-0.9	0.7
Breast cancer (self-reported)	1.1	1.3	2.6	-1.4	-1.4	1.0	-1.6	-0.5	0.2
Asthma (self-reported)	0.5	1.0	3.0	-1.2	-0.8	0.8	-1.7	0.3	0.5
Osteoporosis (self-reported)	0.4	0.4	1.7	0.2	0.6	-0.0	1.3	0.4	0.5
Osteoarthritis (self-reported)	2.2	2.9	6.2	-1.9	-0.0	1.8	-1.6	-2.5	1.3
Medication: Aspirin	9.6	12.5	19.2	4.4	1.9	-3.9	3.0	4.0	-3.5
Medication: Gliclazide	3.7	4.2	9.5	3.1	2.6	-1.3	1.9	1.3	-1.2
Illnesses of father: None of the above (group 1)	3.1	3.9	5.2	-2.0	-1.9	2.3	-2.1	-1.7	1.9
Smoking status: Current	0.6	1.0	3.0	-1.7	-1.0	0.9	-0.9	-0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	1.5	0.3	-1.2	1.2	0.8	-0.5
Whole body water mass	0.4	2.3	5.4	-1.4	0.3	2.1	-2.3	-1.4	0.2
Leg predicted mass (right)	0.4	2.2	5.8	-1.4	-0.1	2.2	-2.4	-0.9	0.3
Arm fat mass (left)	2.5	10.2	19.2	3.3	2.6	-3.3	2.4	2.7	-4.4
Number of self-reported non-cancer illnesses	6.2	10.7	15.4	3.4	2.7	-3.9	3.3	2.1	-3.9
Average weekly champagne plus white wine intake	0.5	0.6	1.4	1.2	-0.2	-1.2	0.8	0.5	-0.4
Miserableness	0.2	0.4	1.1	-1.1	-0.6	-0.0	-0.1	0.3	0.8
Guilty feelings	0.2	0.3	0.6	-0.7	-0.8	0.4	-0.4	-0.0	0.5
Wears glasses or contact lenses	1.5	1.8	2.6	1.5	1.5	-1.1	1.6	0.8	-1.3
Ever taken oral contraceptive pill	1.3	1.4	2.3	-1.4	-1.5	0.9	-1.3	-1.0	0.9
Hearing aid user	0.5	0.6	1.2	-0.7	0.9	1.0	-0.2	0.2	1.1
Mother’s age at death	0.3	0.4	0.9	0.8	0.1	-0.4	0.9	0.9	-0.5
Financial situation satisfaction	0.2	0.3	0.8	-0.1	-0.9	0.3	-0.8	-0.3	-0.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.4	-0.1	-1.5	-0.3	-1.1	-1.1	-0.3
Commuting to job workplace: Public transport	1.1	1.3	7.0	-0.3	0.6	-0.0	0.4	2.6	-0.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.5	-0.7	-0.7	0.3	-1.2	-1.1	-0.2
Medication: Blood pressure	1.6	3.1	3.8	1.9	1.4	-1.8	1.8	1.8	-1.9
Pain type(s) experienced in last month: Hip pain	2.6	3.3	6.5	1.3	1.5	-2.4	1.6	1.0	-2.5
Supplements: Fish oil (including cod liver oil)	0.3	0.5	0.9	0.7	0.8	-0.6	0.9	0.5	-0.3
High cholesterol (Self-reported)	2.9	5.2	8.1	2.8	1.0	-2.9	2.2	2.0	-2.3
Medication: Bendroflumethiazide	0.4	0.6	2.3	0.6	0.1	-0.4	0.8	1.5	-0.3
Medication: Paracetamol	0.4	0.6	2.1	0.6	-0.7	0.2	-1.5	-0.7	-0.6
Medication: Lisinopril	4.3	5.5	7.6	2.5	2.5	-2.3	2.8	1.6	-2.2
Medication: Atorvastatin	2.5	3.0	4.5	1.9	1.5	-2.1	1.9	1.5	-1.4
Illnesses of father: High blood pressure	1.9	2.4	4.6	1.2	1.7	-1.8	2.1	0.6	-1.2
Alcohol drinker status: Never	0.2	0.2	0.8	-0.9	-0.4	0.2	-0.1	0.6	0.0
Ever smoked	0.2	0.4	1.8	0.3	0.2	0.3	0.3	1.3	0.5
Basal metabolic rate	0.2	1.3	3.3	-0.8	0.6	1.5	-1.8	-0.9	-0.4
Leg fat percentage (left)	4.3	15.7	24.7	3.9	3.4	-4.4	3.7	3.2	-5.0
Arm fat-free mass (left)	0.2	1.2	2.4	-0.5	1.0	1.2	-1.6	-1.1	-0.8
Number of operations (self-reported)	1.6	2.4	3.6	1.7	0.7	-1.5	1.7	1.9	-1.5
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.4	0.1	-0.4	0.6	0.2	-0.4
Irritability	1.5	2.5	5.1	1.4	0.3	-2.1	1.1	1.4	-2.3
Risk taking	0.6	0.9	2.4	-0.0	-1.6	-0.9	-0.7	-0.7	-1.1
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.3	1.5	1.1	-1.1	1.5	0.6	-0.4
Fractured/broken bones in last 5 years	1.9	2.5	5.8	1.0	1.1	-2.0	1.4	0.9	-2.4
Age started oral contraceptive pill	2.0	2.4	4.5	1.6	1.8	-1.1	2.1	1.7	-0.6
Diastolic blood pressure, automated reading	1.5	4.5	9.3	1.5	3.0	-2.2	1.8	0.4	-2.8
Ever depressed for a whole week	0.3	0.4	0.9	0.6	-1.0	-0.5	-0.7	-0.1	-0.5
Unable to work because of sickness or disability	2.0	2.7	7.5	-2.7	-1.5	1.1	-1.9	-1.2	0.4
Commuting to job workplace: Cycle	0.8	1.0	2.7	0.8	-1.6	-0.6	0.0	1.5	-0.3
Myopia	0.2	0.3	0.8	0.0	-0.9	-0.5	0.2	0.8	-0.1
Vascular/heart problems diagnosed by doctor	5.3	14.3	17.4	-4.2	-3.2	4.2	-3.9	-3.1	4.1
Cholesterol lowering medication	16.6	24.4	31.7	5.3	4.2	-5.6	5.5	4.0	-4.9
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.2	-0.1	0.0	-0.1	-0.0	0.5	-0.2
Pain experienced in last month	3.2	5.3	13.2	-2.2	-1.2	3.2	-1.5	-0.4	3.6
Supplements: Calcium	0.7	0.8	1.7	1.0	0.3	-0.7	1.3	1.1	0.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	-0.1	-1.0	0.7	-1.1	-1.2	-0.0
Heart attack/myocardial infarction (self-reported)	7.5	9.6	13.2	3.6	3.0	-3.4	2.6	2.2	-3.6
Deep venous thrombosis (DVT) (self-reported)	5.3	6.8	10.6	2.8	3.3	-2.2	3.0	2.3	-1.8
Heart disease (siblings)	6.6	8.1	10.4	2.7	2.4	-3.2	3.2	3.0	-2.5
Alcohol drinker status: Previous	1.1	1.3	2.9	-1.7	-1.5	1.3	-1.0	0.1	0.5
Pack years of smoking	0.7	1.1	3.0	-1.2	-0.9	-0.8	-0.5	0.5	-1.7
Impedance of whole body	0.2	0.8	2.0	-0.9	-0.6	0.5	0.0	-1.1	1.4
Leg fat mass (left)	3.1	12.1	21.4	3.4	3.4	-3.6	2.9	2.7	-4.6
Arm predicted mass (left)	0.2	1.1	1.7	-0.2	1.2	1.0	-1.3	-1.2	-1.0