Hub : Genes

GIT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Spleen 0.1530 0.0630 2.3e-04 0.063 NA 0.024 NA 0.057 1.1e-02 NA 8.1e-02 NA 1.4e-02
2 GTEx Testis 0.1180 0.0620 2.1e-04 0.171 NA 0.124 NA 0.131 4.8e-08 NA 4.1e-06 NA 2.1e-06
3 GTEx Thyroid 0.0610 0.0260 4.7e-06 0.082 NA 0.079 NA 0.087 7.4e-07 NA 1.1e-06 NA 3.7e-07
4 YFS Blood 0.1141 0.0353 0.0e+00 0.077 0.076 0.080 0.075 0.086 5.6e-24 1.3e-23 9.8e-25 2.6e-23 8.8e-27
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0926 0.0445 3.4e-03 0.009 0.006 0.011 NA 0.011 2.7e-02 6.6e-02 2.0e-02 NA 1.6e-02
6 TCGA Thyroid Carcinoma 0.0590 0.0250 9.7e-05 0.055 0.054 0.038 NA 0.052 4.8e-06 5.2e-06 1.2e-04 NA 8.0e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 3.6 5.8 14.7 -1.9 -2.3 1.5 -2.9 -3.8 0.5
Bipolar Disorder or Schizophrenia 1.5 3.6 8.1 -1.6 -1.4 1.6 -2.2 -2.9 1.2
Depressed Affect (Nagel 2018) 0.2 0.4 0.8 0.2 -0.6 -0.9 0.3 0.9 -0.4
Depression (Nagel 2018) 0.2 0.3 0.8 -0.6 -0.6 -0.2 -0.9 -0.7 -0.4
Intelligence (Savage-Jansen 2018) 4.7 14.4 25.4 5.0 3.4 -4.6 3.5 0.9 -3.9
Neuroticism (Nagel 2018) 0.0 0.1 0.4 0.2 -0.6 -0.4 0.0 0.1 -0.1
Schizophrenia (2018) 0.2 0.5 1.2 -0.6 -0.0 0.8 -0.5 -0.6 1.1
Schizophrenia vs Biploar Disorder 2.2 2.9 4.7 2.0 2.2 -1.3 1.9 1.7 -0.7
Worry (Nagel 2018) 0.2 0.5 2.3 -0.0 -0.1 0.5 -0.1 -1.5 0.4
Alzheimer’s Disease (in mother) 4.9 5.7 8.9 -2.9 -1.5 2.3 -2.5 -3.0 1.9
Alzheimer’s Disease (in father) 1.8 2.0 4.7 -2.2 -0.4 1.7 -0.6 -0.7 1.8
Alzheimer’s Disease (including proxy) 7.6 11.1 16.6 -4.1 -2.5 3.6 -3.3 -3.1 3.2
Crohns Disease (2017) 0.4 0.8 2.0 -1.1 0.4 1.1 0.3 -0.2 1.4
Irritable Bowel Disease (IBD) 0.8 2.0 4.5 1.1 1.7 -0.8 2.1 1.7 0.0
Ulcerative Colitis (UC) 2.9 5.5 8.1 2.6 2.2 -2.1 2.9 2.8 -1.1
Major Depression (MDD) 1.8 2.2 4.1 -1.3 -2.0 0.9 -1.9 -1.6 0.5
Reaction Time 0.2 0.4 1.4 -0.1 -0.0 -0.8 0.1 -0.8 -1.2
Verbal and Numeric Reasoning (VNR) 2.4 5.6 10.3 3.2 1.8 -3.1 1.9 0.0 -2.7
Breast Cancer 1.6 3.9 8.5 2.9 2.0 -1.8 2.5 -0.3 -1.1
Ovarian Cancer 0.5 0.6 2.0 -0.6 -1.4 0.5 -0.8 -0.3 0.5
Prostate Cancer 0.6 0.9 2.6 1.0 1.6 0.0 1.4 -0.0 0.2
Age at First Birth 0.5 0.8 2.5 0.1 0.5 -0.5 1.6 1.2 0.3
Bipolar Disorder (2011) 8.3 8.1 12.5 -2.6 -3.3 2.5 -3.5 -3.5 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.1 -0.4 -0.5 -0.6 -0.1 -1.0 -0.8
Coronary Artery Disease (CAD) 2.9 3.5 8.4 2.9 1.2 -2.1 1.9 1.0 -1.3
Crohns Disease (2012) 0.7 1.2 2.4 -1.3 -0.7 1.4 -0.5 0.4 1.6
Mean Putamen Volume 2.5 2.8 5.7 2.4 1.0 -1.6 1.7 1.8 -1.3
Fasting Glucose 1.8 2.1 4.5 -1.1 0.4 2.1 -0.9 -1.9 1.6
HbA1C 0.3 0.3 0.8 -0.1 0.6 0.6 0.6 0.9 0.4
HDL Cholesterol 1.2 2.0 4.7 -0.6 -1.0 1.8 -1.2 -1.0 2.2
LDL Cholesterol 0.3 0.5 1.3 1.2 -0.1 -0.9 0.3 0.4 -0.8
Lupus 0.3 0.5 1.1 -1.0 0.4 -0.5 -0.6 -0.8 -0.6
Neuroticism (2016) 0.4 0.6 1.9 -0.3 -1.4 0.3 -1.0 0.1 0.4
Primary Biliary Cirrhosis 1.7 2.4 3.9 -1.6 -1.7 1.4 -2.0 -1.4 1.0
Rheumatoid Arthritis 0.2 0.3 0.5 0.4 -0.6 -0.7 -0.3 -0.1 -0.6
Schizophrenia (2014) 0.0 0.1 0.2 -0.0 0.3 0.2 -0.0 -0.4 0.5
Triglycerides 0.1 0.2 0.5 -0.4 -0.5 0.4 -0.7 -0.5 0.2
Type 2 Diabetes (T2D) (2012) 3.8 4.4 6.7 1.7 1.7 -2.6 2.5 1.6 -2.2
Ulcerative Colitis 1.3 1.9 3.6 1.9 1.2 -1.5 1.5 0.8 -1.3
Blood Eosinophil Count 0.1 1.0 3.2 0.6 -0.3 -1.4 -0.6 -0.4 -1.8
Blood Platelet Count 13.7 158.6 380.2 19.5 18.2 -4.9 14.1 4.1 0.7
Blood Red Count 3.6 34.3 47.9 6.8 4.6 -6.9 5.3 3.9 -6.9
Blood White Count 7.5 55.7 90.8 -9.5 -5.5 8.7 -8.2 -4.8 6.9
Heel T-Score 7.8 62.4 174.2 -6.6 -2.1 11.0 -4.8 -3.0 13.2
BMI 3.7 21.2 34.6 4.5 3.7 -5.3 4.2 3.5 -5.9
Height 2.4 45.7 74.0 -6.8 -3.1 8.1 -8.6 -7.6 4.7
Waist Hip Ratio (WHR) 0.4 1.9 6.0 1.9 2.5 -0.2 1.2 -0.4 -0.0
Systolic Blood Pressure 0.2 1.2 2.9 0.3 1.4 -1.3 0.9 0.3 -1.7
Smoking Status 1.0 2.4 4.5 -1.7 -1.8 1.7 -2.1 -0.1 0.9
Allergy or Eczema 1.2 3.1 5.5 2.3 2.0 -2.0 1.9 0.3 -1.0
Cardiovascular Disease 5.6 18.3 26.9 4.5 3.1 -5.0 4.0 3.5 -5.2
Hypothyroidism (self reported) 3.8 8.8 19.8 2.6 1.8 -4.5 1.8 0.6 -4.4
Respiratory disease 0.6 1.3 3.9 -1.1 -1.4 0.7 -2.0 -0.6 0.3
Type 2 Diabetes (T2D) (2018) 1.2 2.3 3.5 1.9 1.6 -1.6 1.8 1.0 -1.0
Lung FEV1/FVC ratio 26.2 132.7 201.6 12.5 8.1 -14.2 11.7 8.5 -12.8
Lung FVC 1.6 8.3 19.8 -2.3 -2.8 3.6 -2.0 0.4 4.5
Neuroticism 0.5 1.1 2.5 -1.1 -1.6 1.0 -1.0 -0.0 1.1
Chronotype (morning person) 0.4 0.9 2.3 0.0 -0.8 -0.8 -1.1 -1.0 -1.5
Hair Pigment 0.4 12.3 20.5 -2.5 -4.5 3.1 -4.4 -3.4 2.5
Tanning 0.2 2.0 3.5 -1.9 -0.9 0.9 -1.8 -1.9 -0.1
Hand grip strength (left) 0.2 0.6 1.4 -0.2 -0.5 1.2 -1.0 -0.8 0.8
Number of treatments/medications taken 2.8 5.1 8.6 2.0 1.4 -2.7 1.6 2.4 -2.9
Average weekly spirits intake 0.6 0.8 1.4 -0.9 -0.7 1.2 -0.8 -0.4 1.1
Sensitivity / hurt feelings 1.6 2.7 4.8 -1.3 -2.2 1.5 -2.0 -1.0 1.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.5 -0.2 -0.5 -0.5 -0.5 -0.7 -0.7
Hearing difficulty/problems: Yes 1.2 1.8 4.5 1.3 0.3 -1.4 1.4 2.1 -0.6
Relative age of first facial hair 0.1 0.2 0.8 0.9 0.0 -0.3 0.3 0.6 0.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.6 -0.6 1.1 -0.8 0.9 0.6 -1.3
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.5 -0.6 -0.0 0.7 0.0 0.3 1.2
Ever had hysterectomy (womb removed) 1.1 1.2 2.7 1.0 1.7 -1.0 1.2 -0.4 -1.1
Systolic blood pressure, automated reading 1.0 2.9 10.1 0.7 3.2 -1.1 1.9 0.3 -1.5
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.2 0.1 0.0 -0.0 -0.4 -0.1 0.0
Angina 6.7 8.8 13.8 3.0 1.9 -3.6 2.8 2.3 -3.7
Medication for hormone replacement therapy 0.4 0.5 0.9 -0.7 0.4 1.0 -0.0 0.8 0.9
Vitamin and mineral supplements 0.4 0.5 1.3 -1.1 0.5 0.9 -0.4 -0.2 0.6
Supplements: Zinc 3.5 3.8 5.6 2.4 1.2 -2.2 2.3 1.8 -1.5
Medication: Co-codamol 0.2 0.3 0.8 -0.7 0.4 0.5 -0.9 0.2 -0.0
Medication: Metformin 3.8 5.3 8.2 2.7 2.1 -2.4 2.9 1.9 -1.7
Diabetes (father) 0.4 0.5 1.5 -0.1 0.0 -0.4 -0.2 -1.2 -1.1
Diabetes (mother) 1.5 1.9 2.7 1.6 1.4 -1.5 1.1 0.6 -1.6
Severe depression (siblings) 0.4 0.4 1.4 0.1 1.2 -0.1 0.7 -0.4 0.6
Pack years adult smoking proportion 0.8 1.3 3.4 -1.9 -1.1 -0.4 -0.9 0.0 -1.4
Impedance of leg (right) 0.1 0.4 0.9 -0.4 0.3 -0.7 0.9 -0.9 0.2
Leg fat-free mass (left) 0.2 0.8 2.5 -0.5 0.5 1.1 -1.6 -0.2 -0.7
Trunk fat percentage 2.6 10.6 18.1 3.3 2.8 -3.6 2.7 2.6 -4.2
Hand grip strength (right) 0.6 1.7 3.4 -0.9 -1.0 1.8 -1.2 -1.3 1.5
Townsend deprivation index at recruitment 2.8 3.9 11.0 -3.3 -2.1 1.8 -2.1 0.3 0.8
Current tobacco smoking 0.7 1.1 2.8 -1.7 -1.4 0.7 -1.1 -0.5 0.0
Average weekly fortified wine intake 0.9 1.1 2.6 -0.6 -0.1 1.5 -0.5 -1.0 1.6
Maternal smoking around birth 1.0 1.5 3.4 -1.2 -1.9 0.5 -1.7 -0.6 -0.5
Fed-up feelings 0.6 1.1 3.1 -0.9 -1.8 -0.3 -1.5 -0.0 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 2.0 -1.4 0.0 0.5 -1.0 -0.4 0.2
Relative age voice broke 0.7 1.1 2.9 -1.1 -0.8 1.1 -0.6 -0.2 1.7
Taking other prescription medications 2.8 4.3 7.8 1.9 1.5 -2.8 1.6 1.4 -2.8
Age when periods started (menarche) 0.4 1.0 1.9 -1.2 -0.8 1.2 -1.4 -0.3 0.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.7 0.7 -0.2 -0.8 -0.3 -0.2 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 5.4 12.2 32.0 -4.0 -0.6 4.7 -1.6 -0.5 5.7
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 3.9 2.0 -0.0 -1.0 1.0 1.0 -0.5
Qualifications: CSEs or equivalent 1.4 1.9 3.8 -1.5 0.1 1.7 -0.6 -1.9 1.4
Serious illness, injury or assault to yourself 1.0 1.2 2.6 0.5 1.6 -0.9 0.9 -0.7 -1.6
High blood pressure 4.7 13.1 15.0 3.9 3.6 -3.7 3.9 3.0 -3.7
Hayfever, allergic rhinitis or eczema 1.9 4.1 6.5 2.5 2.4 -2.2 2.4 1.0 -1.1
Multivitamins +/- minerals 1.2 1.5 2.8 1.5 0.7 -1.7 1.4 0.0 -1.2
Stomach or abdominal pain in last month 2.9 3.6 6.7 1.9 1.1 -2.6 2.0 0.9 -2.2
Supplements: Glucosamine 0.2 0.2 0.6 0.8 0.4 -0.4 0.2 -0.5 -0.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.3 0.1 1.1 -0.6 0.6 -0.8 -0.6
Medication: Atenolol 1.4 1.7 2.4 1.2 1.0 -1.5 1.4 1.1 -1.6
Medication: Levothyroxine sodium 0.6 1.1 2.4 0.9 0.1 -1.6 -0.2 -0.8 -1.6
Sitting height 1.2 8.5 14.7 -3.2 -1.5 3.2 -3.8 -3.2 1.8
Chronic bronchitis/emphysema (father) 0.2 0.3 0.6 -0.8 -0.3 0.5 -0.4 0.6 0.4
High blood pressure (mother) 1.5 2.0 6.0 1.3 0.5 -2.0 0.2 -0.3 -2.5
Body mass index (BMI) 3.1 13.1 23.3 3.8 2.8 -3.9 2.9 3.1 -4.8
Impedance of leg (left) 0.2 1.0 3.1 -1.0 -0.2 0.5 0.1 -1.8 1.3
Leg predicted mass (left) 0.2 0.9 2.8 -0.6 0.5 1.2 -1.7 -0.4 -0.6
Trunk fat mass 1.7 7.2 13.7 2.6 2.7 -2.6 2.0 2.1 -3.7
Waist circumference 2.9 10.8 18.6 3.7 3.5 -3.2 2.6 1.8 -4.3
Number of incorrect matches in round 5.0 8.3 15.7 -3.7 -1.6 4.0 -2.6 -1.2 3.2
Past tobacco smoking 0.2 0.3 0.8 -0.1 0.4 -0.7 0.9 -0.6 -0.4
Alcohol usually taken with meals 0.5 0.9 3.3 -0.4 -0.0 1.2 -0.3 -0.1 1.8
Nervous feelings 0.4 0.7 1.7 -1.1 0.2 1.0 -0.1 -0.3 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.1 0.5 1.1 -0.4 0.8 0.3 -0.2
Hearing difficulty/problems with background noise 0.6 0.9 3.3 1.8 -0.9 -0.9 0.3 0.5 -0.2
Hair/balding pattern: Pattern 2 0.6 0.8 2.2 -0.5 -0.4 1.0 -0.3 -1.5 1.1
Had menopause 3.6 4.4 6.0 2.3 2.2 -2.1 2.4 1.7 -1.9
Had other major operations 0.3 0.4 0.6 0.7 0.6 -0.7 0.4 -0.2 -0.8
Forced vital capacity (FVC) 5.4 20.8 32.6 -4.7 -3.2 5.7 -5.1 -2.8 5.0
Heel bone mineral density (BMD) T-score, automated (right) 3.8 8.8 27.6 -3.0 0.3 3.9 -0.6 -0.0 5.3
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 2.6 0.7 -0.1 -1.2 0.6 1.6 -1.4
Qualifications: None of the above 0.9 1.9 4.3 -1.4 -2.1 1.1 -1.8 0.4 0.6
Financial difficulties in last 2 years 0.4 0.6 1.8 -0.4 -0.7 0.4 -0.9 -1.4 -0.2
Mouth/teeth dental problems 0.3 0.5 0.9 -0.4 0.8 0.7 0.5 0.9 0.7
Heart attack 8.6 11.0 14.9 3.8 3.2 -3.6 2.8 2.2 -3.9
Allergy 1.4 3.2 4.7 -2.2 -2.1 1.4 -1.8 -2.1 0.5
Pain all over the body in last month 0.2 0.3 0.5 -0.6 0.6 -0.4 0.1 -0.2 -0.7
Diabetes (self-reported) 3.4 5.3 8.1 2.8 2.0 -2.5 2.5 1.8 -1.9
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.5 1.3 1.1 -0.9 1.9 1.3 -0.2
Medication: Ramipril 0.6 0.8 2.8 0.8 0.1 -0.8 0.7 1.7 -0.5
Medication: Simvastatin 2.2 3.3 5.9 2.0 0.8 -2.3 1.5 1.4 -2.4
Fluid intelligence score 2.6 5.3 10.3 2.6 1.8 -3.2 2.3 0.3 -2.4
Illnesses of siblings 11.3 15.8 25.7 -4.7 -2.6 5.1 -3.7 -2.3 4.6
Neuroticism score 0.8 1.6 2.3 -1.5 -1.5 1.0 -1.2 -0.8 1.4
Weight 0.4 1.9 5.8 1.1 1.8 -0.7 0.1 0.8 -2.4
Impedance of arm (right) 0.3 1.2 3.1 -0.8 -1.4 0.9 -0.4 -0.7 1.8
Arm fat percentage (right) 3.8 14.9 22.4 4.2 2.5 -4.3 3.4 3.6 -4.7
Trunk fat-free mass 0.6 3.7 7.2 -1.8 0.2 2.7 -2.7 -2.0 0.7
Hip circumference 0.6 2.6 7.3 0.9 2.2 -1.1 0.6 1.2 -2.7
Time employed in main current job 0.2 0.2 0.5 -0.3 0.1 0.5 0.7 -0.0 0.6
Alcohol intake versus 10 years previously 0.8 1.1 2.7 0.4 -1.5 -1.2 -0.3 -0.6 -1.6
Father’s age at death 0.6 0.9 1.1 -0.6 -1.0 1.0 -1.0 -1.1 0.8
Worrier / anxious feelings 0.1 0.1 0.2 -0.4 0.0 0.1 0.5 -0.3 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.7 0.5 -0.1 -0.6 -0.3 0.4 -0.9
Falls in the last year 0.9 1.2 3.0 -1.7 -1.0 1.3 -0.7 0.2 1.1
Hair/balding pattern: Pattern 3 0.4 0.6 1.7 1.3 0.7 -1.0 0.2 0.0 -0.6
Number of live births 0.1 0.2 0.6 -0.1 0.7 0.3 0.2 0.8 0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.6 -0.7 -0.6 1.2 -1.3 -0.3 1.1
Pulse rate 0.1 0.2 0.4 -0.5 0.6 -0.0 -0.3 0.5 -0.6
Happiness 0.3 0.4 1.5 -0.6 -1.2 -0.2 -0.6 -0.0 -0.3
Noisy workplace 3.3 4.1 6.5 -2.2 -2.6 2.1 -2.2 -0.3 2.0
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.8 0.3 0.4 -0.2 1.3 1.1 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.6 0.5 1.6 -0.9 1.2 0.6 -0.8
Mouth/teeth dental problems: Dentures 0.2 0.3 0.8 -0.9 0.8 0.1 0.0 -0.7 -0.1
Asthma 0.8 1.6 4.1 -1.5 -1.0 1.2 -2.0 0.2 0.9
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 3.7 -0.5 -1.9 0.7 -1.6 0.5 0.1
Medication: Cholesterol lowering 1.9 2.9 5.0 1.8 1.1 -2.2 1.2 1.4 -2.2
Depression (self-reported) 0.3 0.4 0.7 0.2 0.7 -0.6 0.4 -0.6 -0.8
Medication: Lansoprazole 0.7 0.9 3.0 0.5 1.7 -0.4 0.9 -0.3 -0.9
Prospective memory result 5.5 6.8 14.1 -2.7 -2.9 2.6 -3.7 -1.8 1.2
Lung cancer (father) 0.7 0.8 1.7 -1.3 -0.3 1.1 -0.8 -0.9 0.5
Illnesses of mother 3.9 4.8 12.2 -2.2 -1.1 3.0 -1.3 -0.4 3.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.1 -0.1 -0.7 0.6 -1.1 0.1 0.5
Pulse wave Arterial Stiffness index 0.5 0.6 2.3 -0.5 -0.1 0.6 -0.3 -1.5 0.6
Impedance of arm (left) 0.3 1.5 2.8 -1.3 -1.6 1.0 -0.8 -0.7 1.7
Arm fat mass (right) 2.5 10.3 18.7 3.4 2.8 -3.3 2.5 2.7 -4.3
Trunk predicted mass 0.6 3.4 6.6 -1.7 0.3 2.6 -2.6 -2.0 0.6
Standing height 2.7 26.3 45.8 -5.4 -1.7 6.8 -5.7 -4.8 5.0
Length of working week for main job 0.7 0.8 1.3 -0.6 0.4 1.1 -0.6 -1.1 1.1
Exposure to tobacco smoke at home 1.1 1.2 2.3 -1.5 0.5 1.5 -0.5 0.0 1.5
Breastfed as a baby 1.6 1.9 4.4 1.1 1.6 -1.1 2.1 1.3 -0.7
Tense / ‘highly strung’ 0.3 0.4 1.9 -0.5 0.5 0.3 0.1 -1.4 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.6 0.3 1.5 -1.4 1.9 -0.2 -1.1
Hair/balding pattern: Pattern 4 0.2 0.4 1.3 -0.3 -0.5 0.5 -0.5 1.1 0.4
Birth weight of first child 2.0 3.6 7.1 -1.2 -1.3 2.7 -2.1 -0.1 2.6
Peak expiratory flow (PEF) 3.9 9.1 15.4 3.9 1.6 -3.6 2.7 2.4 -3.2
Pulse wave reflection index 0.3 0.3 1.6 -0.3 -1.3 -0.1 -0.4 -0.1 0.0
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.6 -0.1 -1.1 -0.2 -0.3 1.3 -0.0
Loud music exposure frequency 0.9 0.9 2.2 0.8 1.5 0.1 1.2 1.0 0.6
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.5 0.6 0.6 -0.1 0.7 0.1 0.3
Mouth/teeth dental problems: Bleeding gums 1.8 2.3 4.0 -0.8 -1.9 1.3 -1.8 -2.0 0.9
Blood clot in the leg (DVT) 5.3 6.9 9.4 3.0 3.1 -2.4 3.0 2.2 -1.9
Medication: Paracetamol 0.5 0.8 2.0 0.7 -1.1 -0.2 -1.4 -0.2 -0.9
Headache pain in last month 0.6 1.0 3.0 -0.2 -1.6 0.1 -1.7 -0.3 -0.7
Medication for cholesterol, blood pressure or diabetes 5.8 9.5 13.3 -3.1 -1.8 3.7 -3.0 -3.4 3.3
Glaucoma (self-reported) 0.4 0.5 1.2 0.5 -0.3 -0.9 -0.2 -0.7 -1.1
Gout (self-reported) 0.5 0.6 1.6 0.1 0.6 -1.1 0.8 -0.1 -1.3
Hypothyroidism/myxoedema (self-reported) 2.4 4.6 10.9 2.0 1.2 -3.3 1.1 0.2 -3.1
Medication: Amlodipine 2.0 2.7 6.5 0.9 -0.2 -2.3 1.3 1.5 -2.6
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.5 -0.1 -0.3 0.4 -0.7 -0.1 0.3
Birth weight 2.7 5.9 13.4 -2.1 -3.7 1.9 -3.4 -1.2 1.0
Chronic bronchitis/emphysema (mother) 1.5 1.8 3.3 1.5 1.1 -1.4 1.4 -0.0 -1.8
High blood pressure (siblings) 8.4 12.1 20.9 4.4 1.7 -4.6 3.0 1.4 -4.3
Forced vital capacity (FVC), Best measure 4.9 17.8 27.0 -4.0 -3.5 5.0 -5.2 -2.7 4.3
Body fat percentage 3.7 14.8 23.0 3.8 3.3 -4.2 3.5 3.1 -4.8
Leg fat percentage (right) 5.9 21.5 32.9 4.5 3.8 -5.3 4.3 3.8 -5.7
Arm fat-free mass (right) 0.3 1.3 2.5 -1.0 1.1 1.4 -1.6 -1.0 -0.6
Exposure to tobacco smoke outside home 0.3 0.3 1.3 0.4 -0.1 -0.2 -0.2 -1.1 -0.7
Comparative body size at age 10 1.3 3.5 9.0 3.0 1.8 -1.7 1.4 0.1 -1.9
Number of full brothers 1.0 1.2 2.7 -1.3 -1.5 0.8 -1.6 -0.1 0.4
Worry too long after embarrassment 2.8 4.8 6.3 -2.1 -2.2 2.2 -2.5 -2.0 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.9 -0.9 0.9 0.2 0.6 -0.8 0.8
Wheeze or whistling in the chest in last year 0.9 1.6 4.4 0.9 -0.0 -1.6 0.3 1.3 -2.1
Number of children fathered 0.4 0.5 0.7 0.8 0.8 -0.6 0.8 0.0 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 5.4 -0.1 0.3 -0.2 1.2 2.3 0.3
Age at first live birth 1.6 2.9 5.5 1.8 1.2 -1.5 2.3 2.1 -0.1
Pulse wave peak to peak time 0.2 0.2 1.2 0.2 0.1 -0.1 0.0 1.1 -0.3
Health satisfaction 1.1 1.5 3.0 1.2 0.9 -1.5 0.9 0.8 -1.7
Shortness of breath walking on level ground 0.3 0.3 1.2 0.2 -1.1 -0.5 -0.6 0.0 -0.5
Qualifications: College or University degree 0.8 2.5 4.4 1.1 2.1 -0.1 2.0 1.7 1.6
Eye problems/disorders: None of the above 0.3 0.4 1.0 0.8 -0.4 -0.6 0.3 1.0 -0.3
Mouth/teeth dental problems: Loose teeth 1.2 1.5 3.7 -1.2 -1.9 0.7 -1.7 -0.3 -0.2
Emphysema/chronic bronchitis 0.1 0.1 0.4 -0.3 -0.1 0.1 -0.1 -0.2 -0.6
Medication for pain relief, constipation, heartburn 1.6 2.7 5.7 -1.7 0.0 1.7 0.1 -2.1 2.4
Neck or shoulder pain in last month 0.9 1.3 3.8 0.4 0.1 -1.8 0.5 0.7 -1.9
Medication: Blood pressure 7.1 12.5 15.1 2.8 2.9 -3.8 3.8 3.9 -3.7
Angina (self-reported) 6.3 8.3 12.9 2.9 2.0 -3.5 2.7 2.1 -3.6
Migraine (self-reported) 1.3 1.6 3.7 -1.3 -1.0 1.9 -1.0 -0.0 1.5
Medication: Ibuprofen 0.8 1.0 3.3 -0.5 -1.3 0.7 -1.8 -0.1 -0.2
Medication: Allopurinol 1.3 1.7 3.1 0.3 1.6 -1.5 1.4 -0.1 -1.8
Medication: Omeprazole 0.5 0.6 2.5 -0.0 0.1 -0.7 0.4 1.6 -0.8
Medication: Seretide 50 evohaler 0.8 0.9 1.8 -0.7 -1.3 0.1 -1.2 -1.3 -0.2
Mean time to correctly identify matches 1.1 2.0 3.1 1.5 1.3 -1.6 1.5 0.6 -1.8
Heart disease (mother) 2.3 2.8 5.7 1.9 0.9 -2.0 1.1 1.3 -2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 1.0 0.2 0.6 -0.0 -0.0 -1.0 -0.2
Whole body fat mass 2.4 9.8 18.7 3.0 3.0 -3.2 2.4 2.4 -4.3
Leg fat mass (right) 4.0 15.4 26.1 3.8 3.6 -4.2 3.4 3.2 -5.1
Arm predicted mass (right) 0.3 1.4 2.7 -1.1 1.0 1.5 -1.6 -1.1 -0.4
Pulse rate, automated reading 0.1 0.4 1.1 -1.1 -0.0 0.7 -0.5 0.6 0.4
Alcohol intake frequency. 1.3 3.0 8.6 -2.9 -1.3 1.2 -2.0 -1.5 -0.4
Comparative height size at age 10 2.0 11.0 19.8 -4.0 -1.1 4.5 -3.8 -2.6 2.8
Number of full sisters 1.0 1.2 3.6 -0.7 -1.9 0.0 -1.7 -0.3 -0.5
Suffer from ‘nerves’ 0.8 1.3 4.1 -0.6 -1.2 0.6 -0.7 -2.0 0.9
Overall health rating 0.6 1.3 3.6 0.1 0.3 -1.5 0.8 1.1 -1.9
Chest pain or discomfort 5.6 8.1 12.2 2.2 1.4 -3.5 2.7 3.3 -3.4
Had major operations 0.3 0.4 1.7 -0.2 -0.0 0.2 0.6 1.3 0.4
Age at last live birth 0.2 0.3 0.6 -0.6 -0.7 0.4 -0.5 0.2 0.8
Family relationship satisfaction 0.8 1.0 2.5 1.1 -0.2 -1.4 0.4 -0.3 -1.6
Leg pain on walking 0.1 0.2 1.0 -0.1 0.1 -0.1 -0.2 0.1 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.5 0.2 0.0 0.1 -0.1 -0.3
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.9 -0.1 -0.2 0.6 -0.6 -1.0 0.6
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.4 -0.5 -0.4 0.8 -0.5 0.2 1.2
Medication: Aspirin 10.4 13.7 22.0 4.7 1.9 -4.2 3.0 3.9 -3.9
Supplements: Vitamin C 0.8 0.9 1.6 1.2 -0.6 -1.3 0.4 0.9 -1.1
Knee pain experienced in last month 1.6 2.5 4.9 1.7 1.4 -1.8 1.0 -0.8 -2.2
Hypertension (Self-reported) 4.8 13.2 16.1 4.0 3.3 -3.9 3.7 2.8 -3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.0 0.9 2.0 -0.5 1.7 -0.6 -0.4
Illnesses of father: Heart disease 3.7 5.1 10.1 3.2 1.9 -2.1 2.4 2.2 -1.3
Illnesses of siblings: Diabetes 0.0 0.0 0.1 -0.2 -0.0 0.3 0.2 -0.0 0.2
Smoking status: Previous 0.3 0.4 1.4 0.3 -0.7 0.5 -1.2 0.5 0.0
Forced expiratory volume in 1-second (FEV1), predicted 3.2 6.7 10.2 -2.9 -1.1 3.0 -2.5 -3.2 2.3
Whole body fat-free mass 0.4 2.3 5.7 -1.4 0.3 2.1 -2.4 -1.3 0.1
Leg fat-free mass (right) 0.4 2.2 5.9 -1.3 -0.1 2.2 -2.4 -0.8 0.3
Arm fat percentage (left) 3.8 15.2 23.8 4.1 2.6 -4.5 3.4 3.6 -4.9
Average weekly red wine intake 0.3 0.4 0.8 -0.1 -0.9 0.5 -0.6 0.5 0.9
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.8 0.6 -0.0 0.1 -0.6 -1.7 0.6
Mood swings 0.7 1.2 2.2 0.2 -1.0 -1.4 0.4 1.5 -1.4
Loneliness, isolation 0.2 0.3 1.0 -0.6 -0.2 -0.4 0.3 -1.0 0.2
Long-standing illness, disability or infirmity 0.2 0.3 1.2 -0.3 1.1 -0.4 0.7 -0.1 -0.4
Ever had bowel cancer screening 4.4 5.1 8.1 2.6 2.6 -1.9 2.8 2.0 -1.2
Diabetes diagnosed by doctor 3.0 5.0 7.3 2.7 2.0 -2.5 2.6 1.9 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.3 -0.2 -0.5 0.5 -0.6 0.5 0.4
Friendships satisfaction 0.3 0.4 0.7 0.4 -0.8 -0.8 -0.0 0.4 -0.8
Qualifications: nursing, teaching 1.6 2.4 6.1 1.1 1.8 -1.0 2.5 1.7 -0.1
Commuting to job workplace: Walk 0.7 0.7 1.6 0.1 1.3 -0.6 0.5 -1.2 -0.7
Eye problems/disorders: Cataract 1.9 2.2 5.4 1.3 2.0 -1.0 2.3 0.8 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 2.1 1.4 0.9 -1.4 1.4 0.5 -0.6
Medication for cholesterol 3.2 4.9 5.3 -2.1 -2.1 2.1 -2.3 -2.3 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 3.4 1.7 0.8 -1.6 0.8 -0.2 -1.8
Back pain experienced in last month 4.9 7.2 13.6 2.7 2.0 -3.5 2.2 0.7 -3.7
Mineral and other dietary supplements 0.6 0.9 1.3 -1.1 -0.6 1.1 -1.0 -0.9 0.7
Breast cancer (self-reported) 1.1 1.3 2.6 -1.4 -1.4 1.0 -1.6 -0.5 0.2
Asthma (self-reported) 0.5 1.0 3.0 -1.2 -0.8 0.8 -1.7 0.3 0.5
Osteoporosis (self-reported) 0.4 0.4 1.7 0.2 0.6 -0.0 1.3 0.4 0.5
Osteoarthritis (self-reported) 2.2 2.9 6.2 -1.9 -0.0 1.8 -1.6 -2.5 1.3
Medication: Aspirin 9.6 12.5 19.2 4.4 1.9 -3.9 3.0 4.0 -3.5
Medication: Gliclazide 3.7 4.2 9.5 3.1 2.6 -1.3 1.9 1.3 -1.2
Illnesses of father: None of the above (group 1) 3.1 3.9 5.2 -2.0 -1.9 2.3 -2.1 -1.7 1.9
Smoking status: Current 0.6 1.0 3.0 -1.7 -1.0 0.9 -0.9 -0.5 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.2 1.5 0.3 -1.2 1.2 0.8 -0.5
Whole body water mass 0.4 2.3 5.4 -1.4 0.3 2.1 -2.3 -1.4 0.2
Leg predicted mass (right) 0.4 2.2 5.8 -1.4 -0.1 2.2 -2.4 -0.9 0.3
Arm fat mass (left) 2.5 10.2 19.2 3.3 2.6 -3.3 2.4 2.7 -4.4
Number of self-reported non-cancer illnesses 6.2 10.7 15.4 3.4 2.7 -3.9 3.3 2.1 -3.9
Average weekly champagne plus white wine intake 0.5 0.6 1.4 1.2 -0.2 -1.2 0.8 0.5 -0.4
Miserableness 0.2 0.4 1.1 -1.1 -0.6 -0.0 -0.1 0.3 0.8
Guilty feelings 0.2 0.3 0.6 -0.7 -0.8 0.4 -0.4 -0.0 0.5
Wears glasses or contact lenses 1.5 1.8 2.6 1.5 1.5 -1.1 1.6 0.8 -1.3
Ever taken oral contraceptive pill 1.3 1.4 2.3 -1.4 -1.5 0.9 -1.3 -1.0 0.9
Hearing aid user 0.5 0.6 1.2 -0.7 0.9 1.0 -0.2 0.2 1.1
Mother’s age at death 0.3 0.4 0.9 0.8 0.1 -0.4 0.9 0.9 -0.5
Financial situation satisfaction 0.2 0.3 0.8 -0.1 -0.9 0.3 -0.8 -0.3 -0.1
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.4 -0.1 -1.5 -0.3 -1.1 -1.1 -0.3
Commuting to job workplace: Public transport 1.1 1.3 7.0 -0.3 0.6 -0.0 0.4 2.6 -0.3
Eye problems/disorders: Glaucoma 0.5 0.6 1.5 -0.7 -0.7 0.3 -1.2 -1.1 -0.2
Medication: Blood pressure 1.6 3.1 3.8 1.9 1.4 -1.8 1.8 1.8 -1.9
Pain type(s) experienced in last month: Hip pain 2.6 3.3 6.5 1.3 1.5 -2.4 1.6 1.0 -2.5
Supplements: Fish oil (including cod liver oil) 0.3 0.5 0.9 0.7 0.8 -0.6 0.9 0.5 -0.3
High cholesterol (Self-reported) 2.9 5.2 8.1 2.8 1.0 -2.9 2.2 2.0 -2.3
Medication: Bendroflumethiazide 0.4 0.6 2.3 0.6 0.1 -0.4 0.8 1.5 -0.3
Medication: Paracetamol 0.4 0.6 2.1 0.6 -0.7 0.2 -1.5 -0.7 -0.6
Medication: Lisinopril 4.3 5.5 7.6 2.5 2.5 -2.3 2.8 1.6 -2.2
Medication: Atorvastatin 2.5 3.0 4.5 1.9 1.5 -2.1 1.9 1.5 -1.4
Illnesses of father: High blood pressure 1.9 2.4 4.6 1.2 1.7 -1.8 2.1 0.6 -1.2
Alcohol drinker status: Never 0.2 0.2 0.8 -0.9 -0.4 0.2 -0.1 0.6 0.0
Ever smoked 0.2 0.4 1.8 0.3 0.2 0.3 0.3 1.3 0.5
Basal metabolic rate 0.2 1.3 3.3 -0.8 0.6 1.5 -1.8 -0.9 -0.4
Leg fat percentage (left) 4.3 15.7 24.7 3.9 3.4 -4.4 3.7 3.2 -5.0
Arm fat-free mass (left) 0.2 1.2 2.4 -0.5 1.0 1.2 -1.6 -1.1 -0.8
Number of operations (self-reported) 1.6 2.4 3.6 1.7 0.7 -1.5 1.7 1.9 -1.5
Average weekly beer plus cider intake 0.1 0.1 0.3 -0.4 0.1 -0.4 0.6 0.2 -0.4
Irritability 1.5 2.5 5.1 1.4 0.3 -2.1 1.1 1.4 -2.3
Risk taking 0.6 0.9 2.4 -0.0 -1.6 -0.9 -0.7 -0.7 -1.1
Ever had prostate specific antigen (PSA) test 1.1 1.2 2.3 1.5 1.1 -1.1 1.5 0.6 -0.4
Fractured/broken bones in last 5 years 1.9 2.5 5.8 1.0 1.1 -2.0 1.4 0.9 -2.4
Age started oral contraceptive pill 2.0 2.4 4.5 1.6 1.8 -1.1 2.1 1.7 -0.6
Diastolic blood pressure, automated reading 1.5 4.5 9.3 1.5 3.0 -2.2 1.8 0.4 -2.8
Ever depressed for a whole week 0.3 0.4 0.9 0.6 -1.0 -0.5 -0.7 -0.1 -0.5
Unable to work because of sickness or disability 2.0 2.7 7.5 -2.7 -1.5 1.1 -1.9 -1.2 0.4
Commuting to job workplace: Cycle 0.8 1.0 2.7 0.8 -1.6 -0.6 0.0 1.5 -0.3
Myopia 0.2 0.3 0.8 0.0 -0.9 -0.5 0.2 0.8 -0.1
Vascular/heart problems diagnosed by doctor 5.3 14.3 17.4 -4.2 -3.2 4.2 -3.9 -3.1 4.1
Cholesterol lowering medication 16.6 24.4 31.7 5.3 4.2 -5.6 5.5 4.0 -4.9
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.2 -0.1 0.0 -0.1 -0.0 0.5 -0.2
Pain experienced in last month 3.2 5.3 13.2 -2.2 -1.2 3.2 -1.5 -0.4 3.6
Supplements: Calcium 0.7 0.8 1.7 1.0 0.3 -0.7 1.3 1.1 0.1
Basal cell carcinoma (self-reported) 0.6 0.7 1.4 -0.1 -1.0 0.7 -1.1 -1.2 -0.0
Heart attack/myocardial infarction (self-reported) 7.5 9.6 13.2 3.6 3.0 -3.4 2.6 2.2 -3.6
Deep venous thrombosis (DVT) (self-reported) 5.3 6.8 10.6 2.8 3.3 -2.2 3.0 2.3 -1.8
Heart disease (siblings) 6.6 8.1 10.4 2.7 2.4 -3.2 3.2 3.0 -2.5
Alcohol drinker status: Previous 1.1 1.3 2.9 -1.7 -1.5 1.3 -1.0 0.1 0.5
Pack years of smoking 0.7 1.1 3.0 -1.2 -0.9 -0.8 -0.5 0.5 -1.7
Impedance of whole body 0.2 0.8 2.0 -0.9 -0.6 0.5 0.0 -1.1 1.4
Leg fat mass (left) 3.1 12.1 21.4 3.4 3.4 -3.6 2.9 2.7 -4.6
Arm predicted mass (left) 0.2 1.1 1.7 -0.2 1.2 1.0 -1.3 -1.2 -1.0