Best TWAS P=3.86e-11 · Best GWAS P=1.44e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Cells EBV-transformed lymphocytes | FAM136A | 0.31 | 0.12 | lasso | 7 | 0.16 | 5.6e-06 | 5.4 | 6.6 | 3.9e-11 | 0.03 | 0.02 | 0.98 | TRUE |
| 1 | GTEx | Artery Aorta | ZNF638 | 0.25 | 0.07 | enet | 20 | 0.10 | 5.2e-06 | 5.5 | 5.5 | 5.1e-08 | 0.97 | 0.01 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C2orf42 | 0.12 | 0.03 | enet | 17 | 0.05 | 1.0e-03 | -5.0 | 5.5 | 3.2e-08 | 0.01 | 0.00 | 0.84 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | SNRPG | 0.03 | 0.01 | blup | 225 | 0.02 | 2.7e-03 | 5.4 | 5.4 | 7.9e-08 | 0.02 | 0.02 | 0.92 | FALSE |
| 2 | GTEx | Artery Tibial | ZNF638 | 0.10 | 0.06 | enet | 13 | 0.07 | 2.4e-06 | 5.4 | 5.2 | 2.0e-07 | 0.86 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Colon Transverse | PCYOX1 | 0.13 | 0.01 | lasso | 3 | 0.00 | 2.7e-01 | -5.5 | -5.2 | 2.6e-07 | 0.00 | 0.02 | 0.92 | FALSE |