TWAS
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About
Usage
Models
Genes
Traits
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Traits
:
Forced vital capacity (FVC), Best measure
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chr4:57,080,198-58,531,645
Best TWAS P=1.8e-08 · Best GWAS P=1.46e-08 conditioned to 1
57M
57.2M
57.4M
57.6M
57.8M
58M
58.2M
58.4M
58.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
C4orf14
0.03
0.04
lasso
3
0.04
1.9e-05
-5.7
-5.6
1.8e-08
0.99
0.00
0.99
TRUE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
REST
0.04
0.01
lasso
5
0.02
7.8e-04
-4.6
-5.6
2.3e-08
0.77
0.11
0.47
FALSE
1
GTEx
Artery Aorta
NOA1
0.17
0.06
lasso
4
0.06
3.5e-04
5.0
-5.5
4.4e-08
0.90
0.01
0.98
FALSE
2
GTEx
Muscle Skeletal
REST
0.05
0.01
enet
9
0.02
3.9e-03
-3.9
-5.2
2.4e-07
0.85
0.02
0.96
FALSE