Best TWAS P=4.15e-09 · Best GWAS P=5.86e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells EBV-transformed lymphocytes | CTC-228N24.3 | 0.24 | -0.01 | enet | 26 | 0.04 | 2.2e-02 | 3.8 | -5.4 | 8.6e-08 | -0.57 | 0.04 | 0.58 | TRUE |
2 | GTEx | Esophagus Mucosa | CTC-228N24.3 | 0.18 | 0.14 | enet | 11 | 0.14 | 9.8e-10 | 5.4 | -5.2 | 2.4e-07 | -0.93 | 0.01 | 0.99 | FALSE |
3 | GTEx | Lung | CTC-228N24.3 | 0.18 | 0.14 | enet | 16 | 0.14 | 3.2e-11 | 5.4 | -5.4 | 7.9e-08 | -0.95 | 0.01 | 0.99 | TRUE |
4 | GTEx | Pancreas | CTC-228N24.3 | 0.14 | 0.19 | lasso | 2 | 0.17 | 1.1e-07 | 5.4 | -5.4 | 5.9e-08 | -1.00 | 0.01 | 0.99 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | CTC-228N24.3 | 0.29 | 0.21 | lasso | 7 | 0.22 | 1.7e-12 | 5.4 | -5.3 | 1.1e-07 | -0.97 | 0.01 | 0.99 | TRUE |
6 | GTEx | Stomach | SLC12A2 | 0.23 | 0.17 | enet | 19 | 0.17 | 1.6e-08 | 5.2 | -5.5 | 4.9e-08 | -0.45 | 0.03 | 0.97 | TRUE |
7 | GTEx | Stomach | CTC-228N24.3 | 0.17 | 0.04 | lasso | 6 | 0.08 | 1.5e-04 | 4.3 | -5.7 | 9.5e-09 | -0.81 | 0.03 | 0.92 | FALSE |
8 | METSIM | Adipose | CTC-228N24.3 | 0.17 | 0.19 | lasso | 6 | 0.18 | 1.9e-26 | 5.4 | -5.3 | 1.2e-07 | -1.00 | 0.01 | 0.99 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | CTC-228N24.3 | 0.15 | 0.09 | lasso | 3 | 0.12 | 8.0e-15 | 5.4 | -5.7 | 9.9e-09 | -0.88 | 0.00 | 0.99 | TRUE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ33630 | 0.05 | 0.04 | enet | 14 | 0.03 | 2.1e-07 | 5.4 | -5.9 | 4.1e-09 | -0.88 | 0.00 | 1.00 | TRUE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | FLJ33630 | 0.38 | 0.20 | lasso | 5 | 0.17 | 6.5e-06 | 5.4 | -5.3 | 9.1e-08 | -0.99 | 0.00 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FLJ33630 | 0.10 | 0.07 | lasso | 3 | 0.08 | 7.0e-09 | 4.8 | -5.2 | 2.0e-07 | -0.95 | 0.00 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FLJ33630 | 0.19 | 0.16 | enet | 4 | 0.16 | 1.2e-17 | 5.4 | -5.3 | 1.5e-07 | -1.00 | 0.00 | 1.00 | FALSE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | FBN2 | 0.11 | 0.12 | blup | 159 | 0.14 | 2.2e-16 | -4.9 | -5.7 | 1.2e-08 | -0.16 | 0.05 | 0.95 | TRUE |
15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FBN2 | 0.03 | 0.02 | lasso | 2 | 0.02 | 4.5e-03 | -5.2 | -5.3 | 1.3e-07 | -0.17 | 0.03 | 0.91 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FLJ33630 | 0.09 | 0.08 | lasso | 4 | 0.09 | 4.9e-10 | 5.4 | -5.3 | 1.0e-07 | -1.00 | 0.00 | 1.00 | FALSE |
17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FLJ33630 | 0.08 | 0.03 | lasso | 2 | 0.04 | 5.7e-03 | 4.8 | -5.7 | 1.2e-08 | -0.90 | 0.01 | 0.87 | FALSE |
18 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FBN2 | 0.09 | 0.04 | blup | 159 | 0.06 | 4.6e-05 | -4.6 | -5.3 | 1.1e-07 | -0.25 | 0.07 | 0.90 | TRUE |
19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FLJ33630 | 0.26 | 0.14 | lasso | 3 | 0.13 | 2.2e-05 | 5.4 | -5.5 | 3.7e-08 | -0.99 | 0.00 | 0.99 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | FLJ33630 | 0.10 | 0.10 | lasso | 2 | 0.09 | 5.3e-09 | 5.4 | -5.5 | 3.8e-08 | -1.00 | 0.00 | 1.00 | FALSE |