Hub : Genes

DSE

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0690	0.0260	7.7e-04	0.019	0.033	0.030	NA	0.017	1.9e-03	6.5e-05	1.2e-04	NA	3.1e-03
2	GTEx	Adipose Subcutaneous	0.0800	0.0340	5.4e-03	0.024	NA	0.007	NA	0.028	4.3e-03	NA	8.5e-02	NA	2.2e-03
3	GTEx	Cells EBV-transformed lymphocytes	0.1290	0.0550	2.7e-03	0.086	NA	0.023	NA	0.033	9.6e-04	NA	5.8e-02	NA	3.0e-02
4	GTEx	Cells Transformed fibroblasts	0.0670	0.0310	6.2e-03	0.012	NA	0.012	NA	0.011	3.7e-02	NA	4.1e-02	NA	4.7e-02
5	GTEx	Testis	0.3620	0.0750	4.4e-11	0.406	NA	0.366	NA	0.394	2.3e-19	NA	3.8e-17	NA	1.1e-18
6	GTEx	Whole Blood	0.0890	0.0350	1.7e-03	0.053	NA	0.038	NA	0.038	1.2e-05	NA	2.0e-04	NA	1.8e-04
7	METSIM	Adipose	0.0656	0.0209	9.9e-07	0.018	0.051	0.048	0.053	0.038	8.1e-04	3.7e-08	1.0e-07	1.9e-08	2.0e-06
8	NTR	Blood	0.0351	0.0119	1.2e-06	0.016	0.024	0.024	0.025	0.023	5.6e-06	3.2e-08	2.9e-08	1.7e-08	4.9e-08
9	ROSMAP	Brain Pre-frontal Cortex	0.0578	0.0271	7.5e-03	0.042	0.004	0.012	0.018	0.034	3.4e-06	9.7e-02	9.8e-03	1.9e-03	3.3e-05
10	TCGA	Thyroid Carcinoma	0.0490	0.0240	3.1e-03	0.011	0.037	0.010	NA	0.013	2.9e-02	1.6e-04	3.4e-02	NA	1.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.8	1.2	3.9	-2.0	-0.3	-1.2	0.9	-0.5	0.1	-1.5	0.3	-0.3	-1.7
Bipolar Disorder or Schizophrenia	0.4	1.1	4.2	-2.1	0.6	-0.9	1.3	-0.9	0.7	-0.9	0.9	-0.4	-0.8
Depressed Affect (Nagel 2018)	0.8	1.6	5.2	1.1	-0.3	1.0	-1.5	0.5	-1.5	1.8	-0.6	-2.3	0.5
Depression (Nagel 2018)	0.4	0.6	2.1	-0.9	-0.6	-0.9	-0.6	-0.5	-1.5	-0.1	-0.7	0.0	-0.9
Intelligence (Savage-Jansen 2018)	0.5	1.7	6.3	-0.6	-0.9	-2.5	-0.7	-2.3	-0.6	-1.4	0.3	0.9	0.3
Neuroticism (Nagel 2018)	0.3	0.7	2.9	0.6	-0.2	0.3	-0.3	-0.6	-1.2	1.0	0.0	-1.7	0.9
Schizophrenia (2018)	0.3	0.5	1.1	-1.1	1.0	-0.1	0.9	-0.8	0.8	0.0	0.9	-0.3	0.3
Schizophrenia vs Biploar Disorder	0.7	0.9	1.9	0.7	1.4	-0.1	1.3	-0.3	0.8	0.9	1.1	-0.7	1.2
Worry (Nagel 2018)	0.6	1.4	3.8	0.8	-0.4	-0.9	1.4	-1.8	0.3	-0.5	1.4	-0.9	1.9
Alzheimer’s Disease (in mother)	0.9	1.1	2.5	-0.5	-0.7	0.9	-1.6	0.8	-1.4	-0.7	-1.5	-0.9	-0.9
Alzheimer’s Disease (in father)	1.6	1.7	3.3	0.2	-1.7	-1.7	-1.7	-0.8	-1.8	-0.7	-1.4	1.4	0.3
Alzheimer’s Disease (including proxy)	0.8	1.2	3.1	-0.5	-1.8	0.3	-1.7	-0.0	-1.7	-0.4	-1.5	0.3	-0.1
Crohns Disease (2017)	0.2	0.4	1.4	0.5	1.2	0.1	0.3	0.4	0.5	0.0	0.4	-0.7	0.9
Irritable Bowel Disease (IBD)	0.5	1.1	5.6	0.0	-0.9	0.1	-0.9	0.5	-0.0	-1.1	-1.3	-2.4	0.7
Ulcerative Colitis (UC)	1.5	2.8	9.3	0.2	-2.4	-0.1	-1.7	0.6	-0.6	-1.7	-2.3	-3.0	0.9
Major Depression (MDD)	0.6	0.8	2.1	0.4	-0.5	-1.2	-0.1	-1.2	-0.0	-0.0	0.8	-1.4	1.4
Reaction Time	0.1	0.2	1.0	-1.0	0.2	-0.9	0.3	0.2	-0.3	0.2	0.1	-0.6	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.4	-0.1	-1.8	-0.6	-1.3	-0.8	-0.6	0.3	-0.3	-0.2	0.6
Breast Cancer	0.3	0.8	3.3	0.1	-0.2	1.4	-0.2	1.0	0.2	-0.7	-0.9	0.6	-1.8
Ovarian Cancer	1.0	1.3	3.5	-0.4	1.2	-1.2	1.8	-0.4	1.2	0.8	1.9	0.1	1.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.8	1.2	2.6	0.2	-1.3	-0.3	1.3	-1.6	1.1	-1.1	1.0	1.4	0.9
Bipolar Disorder (2011)	0.7	0.7	1.9	-0.3	-0.9	-1.3	0.7	-1.4	0.3	-1.1	-0.1	0.8	-0.5
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	-0.7	0.1	-0.1	-0.0	-1.0	-0.3	-0.9	-0.5	1.1	-1.1
Coronary Artery Disease (CAD)	0.8	1.0	3.6	-0.5	-0.3	-1.9	0.4	-1.5	-0.1	-0.5	0.9	1.6	0.5
Crohns Disease (2012)	0.1	0.2	0.6	0.6	-0.0	-0.8	-0.1	-0.7	-0.2	-0.1	0.4	0.3	0.7
Mean Putamen Volume	1.4	1.6	4.9	-1.1	1.0	1.7	0.1	2.2	-0.2	1.7	0.0	0.4	-1.7
Fasting Glucose	0.7	0.8	5.7	0.9	-2.4	0.4	-0.5	0.2	-0.3	-0.3	-0.7	0.4	0.4
HbA1C	1.6	1.7	6.7	0.8	-0.8	-1.7	-1.4	-1.8	-0.8	-0.5	-0.1	2.6	-0.7
HDL Cholesterol	0.6	1.0	5.4	-1.1	-0.8	-0.8	0.9	-0.3	0.9	-2.3	0.1	-0.6	-0.4
LDL Cholesterol	2.8	4.5	19.3	0.3	-2.0	-4.4	1.8	-2.0	1.9	-2.7	1.2	0.5	1.3
Lupus	0.7	1.1	3.9	0.2	0.3	1.1	-0.8	0.8	-1.0	0.9	-2.0	0.9	-1.2
Neuroticism (2016)	0.7	1.0	3.0	0.9	-0.9	-1.0	0.9	-0.7	0.3	-0.2	0.9	-1.4	1.7
Primary Biliary Cirrhosis	0.9	1.3	4.7	0.1	0.8	1.3	1.5	2.2	1.1	0.8	1.0	-0.7	0.0
Rheumatoid Arthritis	0.9	1.3	2.6	1.5	-0.0	0.4	1.6	0.6	1.2	1.5	1.4	-0.1	1.2
Schizophrenia (2014)	0.2	0.3	1.2	-0.7	1.1	0.0	0.7	-0.9	0.4	-0.2	0.3	0.3	-0.2
Triglycerides	2.5	4.1	11.9	-0.1	-0.0	-3.3	1.8	-3.4	1.4	-1.9	2.5	1.0	1.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.9	1.7	-0.1	1.3	-0.8	0.5	-0.5	-0.2	-0.6	-0.8	-0.2
Ulcerative Colitis	2.1	3.0	12.2	-0.7	-2.4	0.9	-2.1	0.6	-0.5	-0.2	-2.4	-3.5	0.4
Blood Eosinophil Count	0.5	3.6	14.8	-1.1	0.5	-1.9	2.5	-0.8	2.1	2.0	3.8	0.7	0.4
Blood Platelet Count	0.1	1.5	3.4	0.1	-1.4	1.7	-1.3	1.9	0.8	0.3	-1.4	-0.7	-1.4
Blood Red Count	0.2	2.1	5.8	2.0	-0.8	1.1	-1.8	0.3	-1.6	2.4	-0.5	1.0	1.6
Blood White Count	0.5	3.5	11.7	1.0	-0.3	-2.6	1.2	-2.4	1.2	0.5	2.5	0.3	3.4
Heel T-Score	0.2	1.5	3.9	0.0	0.3	0.0	-1.2	-0.1	-2.0	-1.6	-1.4	1.4	-1.7
BMI	0.1	0.7	3.4	-0.6	-1.4	-0.6	1.9	-0.3	0.2	-0.3	0.6	0.5	-0.3
Height	3.7	72.0	166.4	1.2	-2.4	12.6	-12.9	6.8	-10.2	3.2	-11.6	-0.8	-9.6
Waist Hip Ratio (WHR)	0.2	1.1	4.6	0.8	-0.7	0.3	2.1	0.9	1.3	0.1	1.0	-1.1	0.4
Systolic Blood Pressure	0.2	1.1	3.3	1.8	0.9	-0.7	-1.0	-0.4	0.4	-0.7	0.8	1.2	1.4
Smoking Status	0.2	0.5	1.9	0.7	-1.4	-0.0	-0.6	-1.1	-0.5	0.1	0.6	0.8	-0.1
Allergy or Eczema	1.1	2.9	7.6	-1.8	-1.1	-2.5	1.3	-2.6	0.2	-2.8	1.2	0.2	-0.3
Cardiovascular Disease	1.7	5.6	21.4	0.5	0.4	-4.6	1.2	-4.1	-0.2	-2.4	2.6	1.4	1.0
Hypothyroidism (self reported)	0.6	1.5	6.2	-0.2	-2.5	0.5	-1.9	-0.2	-1.6	-0.1	-1.4	-0.2	-0.1
Respiratory disease	1.7	3.8	12.4	-0.6	-0.3	-2.6	2.0	-3.5	1.5	-1.0	2.4	1.5	1.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.7	0.0	0.9	-0.4	-0.4	0.2	-0.3	-1.3	0.1	0.8	-0.8
Lung FEV1/FVC ratio	1.1	5.7	17.1	3.3	-1.1	4.1	-0.7	4.1	-0.7	3.1	-0.6	0.3	0.3
Lung FVC	0.8	3.9	9.5	0.4	-1.9	0.1	-2.9	-1.5	-3.0	-3.1	-2.3	-0.3	-1.0
Neuroticism	0.3	0.7	1.8	1.1	-0.2	0.7	-0.2	-1.1	-1.0	1.0	0.4	-1.3	0.5
Chronotype (morning person)	0.6	1.3	4.0	2.0	-0.2	0.3	1.2	0.9	1.3	0.1	0.5	-1.0	2.0
Hair Pigment	0.1	1.6	6.9	0.6	1.2	0.8	1.3	0.6	1.4	2.6	1.3	0.7	0.7
Tanning	0.0	0.5	2.3	-0.1	0.4	-0.3	0.6	-0.5	0.2	-1.0	0.0	1.5	-1.0
Hand grip strength (left)	1.0	2.7	7.2	2.1	-1.1	2.7	-1.3	2.4	0.4	-0.2	-2.0	-1.0	1.4
Number of treatments/medications taken	1.2	2.2	8.6	0.1	-0.6	-1.9	1.4	-2.9	-0.5	-1.0	2.4	0.8	-0.2
Average weekly spirits intake	1.7	2.1	5.8	1.7	0.5	0.3	1.9	-0.6	0.9	2.1	1.6	-0.3	2.4
Sensitivity / hurt feelings	0.5	0.8	2.1	-0.0	0.6	0.6	-0.9	-0.9	-1.3	1.4	-0.3	-0.5	-1.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	-0.6	-1.3	-1.4	0.1	-0.6	-0.6	-0.7	-0.4	-1.4	-0.2
Hearing difficulty/problems: Yes	0.3	0.5	1.4	-1.1	-0.2	-1.0	0.2	-1.2	0.1	-0.3	0.0	-0.5	-0.7
Relative age of first facial hair	0.2	0.4	1.3	-0.4	-0.0	0.7	-0.7	0.6	-1.1	1.0	-0.4	0.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	5.9	-1.1	-0.9	-0.7	1.0	-0.4	-0.1	-2.4	-0.4	0.3	-1.3
Ever used hormone-replacement therapy (HRT)	1.6	2.0	5.4	-1.3	0.9	-1.7	1.7	-2.0	1.5	0.0	2.3	-0.3	0.3
Ever had hysterectomy (womb removed)	1.4	1.6	4.6	2.1	-0.2	0.9	1.4	0.0	0.7	1.6	1.6	-0.9	1.4
Systolic blood pressure, automated reading	0.3	0.9	4.9	2.2	-0.1	0.6	-0.7	0.0	0.5	0.7	0.6	0.6	1.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	1.2	0.1	-1.4	1.3	-0.6	1.3	-0.1	1.0	1.2	1.3
Angina	0.7	0.9	3.3	0.1	-1.1	-0.6	-0.4	-1.8	-1.4	-0.4	0.4	1.2	-0.1
Medication for hormone replacement therapy	1.3	1.4	4.5	0.5	1.1	-0.2	2.1	1.4	1.7	0.4	1.3	-0.8	0.9
Vitamin and mineral supplements	2.2	3.0	7.6	-1.1	-2.3	-0.6	-1.6	-1.6	-1.9	-1.0	-2.2	-2.8	-0.6
Supplements: Zinc	1.5	1.6	6.2	0.4	2.0	-0.7	1.6	0.7	1.2	0.6	0.6	2.5	0.2
Medication: Co-codamol	1.1	1.3	4.2	0.0	1.1	0.5	-2.0	-0.4	-2.0	-0.6	-1.6	-0.2	-0.7
Medication: Metformin	0.5	0.8	1.8	0.4	-0.5	-0.5	-1.3	-0.3	-1.3	-0.6	-0.8	1.4	-0.7
Diabetes (father)	0.7	0.9	2.3	0.1	1.0	1.3	-0.3	1.5	0.3	-0.2	-1.3	0.4	-1.3
Diabetes (mother)	0.3	0.4	1.3	0.2	-0.4	-0.4	0.0	-0.8	-0.2	-0.6	1.1	0.6	0.9
Severe depression (siblings)	0.3	0.3	0.8	0.8	-0.4	-0.2	0.9	0.0	0.1	-0.7	0.3	-0.7	0.4
Pack years adult smoking proportion	0.5	0.8	3.7	-0.0	-1.9	1.6	-0.3	1.0	-0.5	0.2	-0.8	0.1	-0.2
Impedance of leg (right)	0.7	3.4	11.5	2.3	0.7	3.4	-1.4	2.8	-0.1	2.1	-0.8	0.5	-1.2
Leg fat-free mass (left)	0.9	4.7	11.7	-0.3	-1.6	2.1	-3.1	1.0	-3.2	-0.5	-3.4	-0.8	-2.5
Trunk fat percentage	1.3	5.0	15.9	1.0	-1.8	4.0	-1.7	2.1	-2.2	2.7	-2.4	-0.3	-2.3
Hand grip strength (right)	0.8	2.1	6.6	0.7	-0.9	2.6	-2.1	1.9	-0.7	0.1	-2.0	-0.8	0.2
Townsend deprivation index at recruitment	0.5	0.7	2.0	0.6	-0.9	0.6	-1.4	-0.4	-1.3	-0.1	-0.7	-1.1	0.4
Current tobacco smoking	0.4	0.7	2.7	0.3	-1.7	0.6	-0.3	1.0	0.3	0.9	0.3	-1.3	0.0
Average weekly fortified wine intake	0.5	0.6	2.1	-1.4	0.7	-0.2	1.2	-0.3	0.9	-0.2	0.6	0.4	-0.7
Maternal smoking around birth	1.9	2.7	6.9	2.6	-0.7	2.1	-1.1	2.6	-0.9	0.2	-2.1	-1.1	-1.0
Fed-up feelings	0.7	1.3	2.4	0.7	-1.4	1.1	-1.4	0.9	-1.3	0.9	-1.1	-1.5	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.9	-0.3	0.3	-0.7	-0.1	0.5	-0.5	-0.1	0.0	-1.4	-0.1
Relative age voice broke	0.9	1.4	5.0	-0.6	-0.6	-1.5	-0.2	-2.2	-1.0	-1.5	0.2	1.5	-0.5
Taking other prescription medications	1.1	1.8	4.8	0.0	-1.9	-1.6	-0.7	-1.6	-1.6	-2.2	0.1	-1.0	-0.7
Age when periods started (menarche)	0.4	0.9	2.5	0.4	-1.1	1.6	0.8	0.6	1.3	0.4	-0.1	1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.0	0.1	-0.3	0.9	0.9	-0.2	-0.2	0.4	0.7	-1.4	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	3.9	-1.3	-0.6	-0.8	-0.5	-0.6	-0.7	-2.0	-0.7	-1.1	-0.5
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.4	-1.0	-1.8	1.3	-1.0	-0.4	0.0	-1.3	-1.8	-0.3	-1.2
Qualifications: CSEs or equivalent	0.3	0.4	1.8	1.4	-0.8	-0.0	0.1	-0.0	-0.3	0.1	0.4	1.1	0.7
Serious illness, injury or assault to yourself	2.1	2.5	8.4	-0.7	-2.1	-0.7	2.4	-1.9	1.3	-2.9	0.5	0.6	-0.1
High blood pressure	1.0	2.7	10.0	0.7	0.3	-2.7	0.7	-3.2	0.3	-0.7	2.2	0.2	1.6
Hayfever, allergic rhinitis or eczema	1.2	2.6	8.3	-1.1	0.0	-2.2	0.9	-2.9	-0.1	-2.6	1.4	1.4	-0.5
Multivitamins +/- minerals	2.1	2.7	8.1	0.6	1.9	-0.8	1.7	-0.1	1.9	0.1	2.9	2.3	1.4
Stomach or abdominal pain in last month	1.5	1.9	6.7	-0.2	-2.6	2.1	0.6	1.3	1.0	0.5	-1.0	-1.9	-0.4
Supplements: Glucosamine	1.2	1.6	6.0	-2.5	1.1	-1.3	0.2	-1.3	0.6	-1.6	0.7	0.7	-1.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	5.8	-2.4	-0.0	0.4	-1.2	-0.4	-1.4	-0.5	-0.7	-0.5	-1.9
Medication: Atenolol	0.5	0.6	2.4	0.3	-0.7	0.5	-0.3	-0.7	-1.3	0.8	-0.0	1.6	-0.2
Medication: Levothyroxine sodium	0.5	0.8	4.5	-1.4	-2.1	0.3	-0.3	-0.5	0.3	-0.8	-0.3	-0.6	0.1
Sitting height	5.8	41.0	110.2	2.9	-0.8	8.3	-10.5	5.5	-8.1	1.9	-9.2	0.4	-6.1
Chronic bronchitis/emphysema (father)	1.2	1.4	7.1	-1.3	0.6	1.1	-0.1	1.2	-0.2	0.9	0.8	-2.7	-1.0
High blood pressure (mother)	0.3	0.5	1.9	-0.7	1.1	-0.3	-0.3	-0.0	0.2	-1.4	0.1	-0.4	-0.9
Body mass index (BMI)	0.2	0.8	3.0	-0.4	-1.7	-0.5	1.4	-0.6	0.3	-0.4	0.5	-1.3	0.2
Impedance of leg (left)	0.8	3.7	12.4	2.5	0.5	3.5	-0.9	3.1	0.2	2.6	-0.6	0.5	-1.0
Leg predicted mass (left)	0.9	4.7	12.0	-0.2	-1.6	2.1	-3.1	1.0	-3.2	-0.6	-3.5	-0.8	-2.5
Trunk fat mass	1.5	6.4	17.5	1.0	-1.9	4.2	-2.6	2.2	-2.9	2.0	-3.0	-0.6	-3.0
Waist circumference	0.3	1.1	4.9	-0.2	-2.2	0.9	-0.2	0.2	-1.0	0.0	-0.9	-1.3	-1.2
Number of incorrect matches in round	0.4	0.7	1.5	-0.9	1.2	1.1	0.8	0.6	1.1	0.2	0.2	-0.8	-0.9
Past tobacco smoking	0.6	1.1	3.5	-0.8	1.1	0.5	0.5	1.9	1.0	1.6	0.1	-1.4	0.3
Alcohol usually taken with meals	1.5	2.3	6.5	-1.0	1.7	-0.7	2.5	-0.4	2.4	-0.6	2.0	-0.4	1.6
Nervous feelings	2.1	4.0	9.6	-0.6	-0.3	-2.2	3.1	-2.1	1.7	-1.3	2.5	-1.6	2.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.9	-0.1	-0.1	-0.9	0.7	-1.4	0.2	-0.6	0.6	-0.3	-0.1
Hearing difficulty/problems with background noise	0.9	1.4	3.9	-2.0	-1.8	-1.3	0.1	-1.7	0.3	-0.9	-0.3	-1.0	-0.7
Hair/balding pattern: Pattern 2	0.4	0.6	2.0	0.2	0.8	-0.8	0.8	-0.7	0.1	-0.2	1.1	-0.2	1.4
Had menopause	0.4	0.5	1.5	-1.0	0.2	0.1	-0.9	-0.2	-1.2	0.2	-0.2	-0.7	-1.0
Had other major operations	2.6	3.2	11.7	-1.1	-0.7	0.8	-2.5	-0.1	-2.2	-1.5	-2.2	-0.0	-3.4
Forced vital capacity (FVC)	2.4	9.3	30.0	0.8	-0.7	3.4	-5.5	1.2	-4.6	-0.4	-4.7	-0.2	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.0	-0.4	-0.5	0.1	-0.6	0.1	-0.7	-0.8	-0.7	-1.0	-0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.0	0.2	0.5	-0.8	0.9	0.5	0.4	0.3	1.2	-1.4	1.3
Qualifications: None of the above	0.8	1.7	3.9	1.4	-1.0	2.0	-1.8	0.0	-1.6	0.8	-1.0	-1.4	0.5
Financial difficulties in last 2 years	0.6	0.8	2.9	-0.9	-0.7	-0.4	-1.1	0.0	-1.2	-0.8	-0.5	0.1	-1.7
Mouth/teeth dental problems	1.8	2.8	6.7	1.2	0.3	-2.5	2.1	-0.8	2.0	-1.8	0.9	-0.6	2.6
Heart attack	0.7	0.9	2.7	1.5	-0.3	0.4	-0.8	0.0	-1.6	0.0	-0.1	1.6	-0.4
Allergy	0.7	1.6	5.6	0.2	0.6	1.5	-0.9	2.4	0.4	2.0	-1.1	-1.1	0.4
Pain all over the body in last month	0.6	0.7	2.6	-0.9	1.4	-0.3	-0.7	-0.3	-1.6	-0.2	-0.3	-0.4	-0.7
Diabetes (self-reported)	0.2	0.3	1.0	-0.0	1.0	-0.5	-0.4	0.1	-0.4	-0.5	0.3	0.9	-0.5
Hayfever/allergic rhinitis (self-reported)	1.9	2.6	7.5	-0.8	-0.4	-1.9	-0.6	-2.7	-1.4	-2.7	-0.0	2.1	-0.2
Medication: Ramipril	0.5	0.7	1.5	-0.6	0.4	0.3	-1.2	1.1	-0.8	-0.1	-1.1	-0.5	-1.2
Medication: Simvastatin	1.6	2.4	6.8	-0.1	-0.6	-2.5	0.9	-2.6	1.0	-1.2	2.1	0.7	1.3
Fluid intelligence score	0.2	0.5	2.4	0.2	-0.3	-1.1	-0.1	-0.8	0.4	0.3	0.5	-0.3	1.5
Illnesses of siblings	0.8	1.1	3.8	-0.6	-1.9	0.6	-0.4	0.7	-0.8	-0.7	-1.8	0.8	-1.0
Neuroticism score	0.4	0.9	4.3	0.4	-0.5	0.2	-0.5	-1.5	-1.0	0.2	0.2	-2.1	0.6
Weight	1.1	5.6	10.5	0.2	-2.1	3.2	-2.7	2.1	-2.9	0.6	-3.2	-1.5	-3.0
Impedance of arm (right)	1.7	8.0	18.8	1.1	1.0	4.3	-3.8	2.7	-2.5	3.4	-3.0	2.0	-2.5
Arm fat percentage (right)	0.2	0.8	2.5	0.3	-1.6	1.2	-0.2	0.3	-1.0	1.0	-0.9	-0.2	-0.9
Trunk fat-free mass	1.2	6.7	16.6	-0.1	-1.6	2.0	-4.1	1.0	-3.7	-1.8	-3.8	-1.2	-3.1
Hip circumference	0.8	3.3	8.1	-1.0	-1.9	1.1	-2.4	-0.1	-2.9	0.2	-2.3	-0.9	-2.6
Time employed in main current job	1.3	1.5	4.2	-0.1	0.4	2.1	-1.1	1.3	-1.4	1.3	-1.5	0.1	-1.1
Alcohol intake versus 10 years previously	1.5	2.3	6.0	-0.3	1.2	1.7	-1.2	2.5	-1.0	1.1	-0.8	-2.4	-1.6
Father’s age at death	0.5	0.7	2.5	-1.0	0.2	-1.1	0.6	-1.6	0.9	-0.6	0.1	-0.1	0.9
Worrier / anxious feelings	0.3	0.6	2.8	0.3	0.3	-0.5	0.5	-0.7	0.0	0.8	0.6	-1.7	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.6	0.4	-0.4	-0.2	0.8	-0.3	0.3	1.9	1.3	-0.7	1.2
Falls in the last year	0.3	0.3	1.4	0.1	0.5	0.1	0.8	0.4	0.2	0.6	0.7	-1.2	-0.4
Hair/balding pattern: Pattern 3	0.3	0.5	1.9	-0.5	0.2	-0.3	0.3	-0.0	1.4	-1.0	0.1	-0.1	-1.2
Number of live births	1.1	1.5	3.5	0.3	-0.8	1.4	-1.4	1.0	-1.6	1.0	-1.2	-1.9	-0.8
Forced expiratory volume in 1-second (FEV1)	2.3	7.7	23.3	1.8	-0.4	3.6	-4.8	1.7	-4.1	0.1	-4.0	-0.4	-1.4
Pulse rate	0.7	1.2	4.9	-0.4	2.2	-1.1	0.6	-1.0	1.2	-1.2	1.2	0.5	0.5
Happiness	0.7	0.9	1.8	1.0	-0.5	0.9	-0.4	1.3	0.2	1.3	-0.5	-1.2	1.3
Noisy workplace	1.0	1.2	3.9	2.0	-1.3	1.2	0.6	1.3	0.5	1.1	0.6	-0.1	1.2
Qualifications: A levels/AS levels or equivalent	0.8	1.7	6.2	-2.2	0.5	-1.4	0.3	-1.5	0.0	-2.5	-0.3	1.0	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	1.3	-0.4	-0.9	-0.8	-1.1	-1.1	-1.1	-0.9	-1.1	0.8	-0.8
Mouth/teeth dental problems: Dentures	1.2	2.0	10.9	-0.1	-1.1	3.3	-0.7	1.4	-0.6	1.5	-0.4	0.4	-1.6
Asthma	0.7	1.3	3.9	-0.0	-0.4	-1.8	0.9	-2.0	0.3	-0.9	1.5	1.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	3.2	-1.2	1.8	-0.7	1.5	0.3	1.6	-0.7	1.4	0.3	-0.9
Medication: Cholesterol lowering	2.1	3.3	10.9	-0.4	-1.1	-3.3	-0.0	-3.1	-0.9	-2.2	1.4	1.6	0.7
Depression (self-reported)	2.6	3.1	7.5	-1.3	-1.2	-2.7	1.3	-1.8	0.9	-1.5	2.0	-2.0	2.0
Medication: Lansoprazole	0.3	0.4	1.9	0.2	-0.5	-0.1	0.3	-0.8	-0.1	0.5	1.4	0.6	0.3
Prospective memory result	0.2	0.2	0.9	0.5	-0.5	-0.0	0.1	-0.4	-0.5	0.2	0.3	-0.5	1.0
Lung cancer (father)	0.4	0.5	3.9	2.0	-0.2	0.1	0.4	0.8	0.3	0.4	0.3	-0.1	0.2
Illnesses of mother	0.5	0.6	3.2	-0.7	-0.4	-0.2	-0.3	-0.6	-0.7	1.1	-0.2	1.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	3.6	11.4	28.9	2.1	-1.1	4.6	-5.4	2.5	-4.8	0.2	-4.9	-1.0	-2.0
Pulse wave Arterial Stiffness index	1.9	2.2	7.4	2.7	0.2	1.5	-0.6	2.4	0.5	1.5	0.4	-1.7	0.9
Impedance of arm (left)	1.8	8.2	22.3	1.3	1.0	4.7	-3.4	2.7	-2.5	3.9	-2.9	1.9	-2.2
Arm fat mass (right)	0.5	2.1	4.1	-0.2	-2.0	1.9	-1.4	0.5	-1.9	0.5	-1.8	-0.5	-2.0
Trunk predicted mass	1.1	6.5	16.0	-0.1	-1.5	2.0	-4.0	0.9	-3.6	-1.8	-3.8	-1.1	-3.1
Standing height	3.6	36.1	85.2	1.1	-1.2	8.3	-9.2	5.4	-7.3	1.8	-8.2	-0.3	-7.2
Length of working week for main job	0.7	0.8	2.5	1.6	-0.2	0.7	1.2	0.4	1.4	0.1	0.9	-0.1	0.7
Exposure to tobacco smoke at home	1.4	1.6	7.4	0.2	-1.1	-1.2	-0.6	-2.7	-1.4	-0.5	0.6	1.6	-0.1
Breastfed as a baby	1.1	1.3	2.9	-1.5	1.7	-1.0	1.5	-0.9	1.3	0.2	1.5	-0.6	0.2
Tense / ‘highly strung’	0.4	0.7	2.6	0.5	-0.7	-0.8	0.9	-0.8	0.9	-0.5	0.6	-0.5	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.5	0.5	-0.1	-0.9	0.6	0.1	-0.2	-0.5	0.4	-1.9	0.3
Hair/balding pattern: Pattern 4	1.1	2.6	8.4	-0.8	1.1	-2.9	2.1	-1.4	1.1	-1.0	2.1	0.6	1.5
Birth weight of first child	1.1	2.0	5.2	1.2	-2.2	-0.0	1.4	0.2	2.3	-1.5	0.2	-0.5	2.0
Peak expiratory flow (PEF)	0.9	2.1	6.1	0.1	-1.6	-1.8	-0.8	-2.4	-1.0	-2.5	-0.1	-0.2	1.3
Pulse wave reflection index	1.4	1.7	5.7	2.4	1.0	0.9	0.1	1.8	0.9	1.5	1.0	-1.4	0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	1.2	0.2	0.4	-0.9	1.4	-1.0	1.0	-0.4	0.2	-0.0
Loud music exposure frequency	0.3	0.3	1.3	-1.1	-0.4	0.1	0.1	0.4	0.8	-0.2	0.4	-0.7	0.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	6.1	-0.3	0.3	-1.4	0.9	-0.3	0.9	-2.5	-0.6	0.0	0.2
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	5.3	-1.1	-0.0	0.1	-1.6	-0.6	-2.3	0.7	-1.0	1.1	-2.0
Blood clot in the leg (DVT)	0.8	1.1	3.2	0.9	0.3	1.8	1.5	1.3	0.9	1.1	0.7	-0.3	-0.1
Medication: Paracetamol	0.5	0.8	4.8	1.1	-2.2	0.3	1.0	0.1	0.2	-0.1	0.3	0.7	0.3
Headache pain in last month	0.8	1.3	3.4	-0.4	0.2	-1.8	1.6	-1.6	0.2	-1.1	1.3	-0.6	0.8
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	7.8	-0.0	0.6	2.2	-0.8	2.8	0.2	1.3	-1.9	-1.6	-1.0
Glaucoma (self-reported)	1.0	1.2	4.2	-0.1	-0.2	-0.8	0.7	-1.5	1.1	0.5	2.0	0.3	1.5
Gout (self-reported)	3.0	4.1	12.7	-1.9	-2.2	-3.0	0.7	-2.8	0.9	-3.6	1.0	0.7	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.7	-1.0	-1.6	0.4	-1.0	-0.3	-0.4	-0.5	-1.0	-0.3	-0.4
Medication: Amlodipine	1.7	2.3	7.5	-1.4	0.1	-2.3	-0.8	-2.7	-1.1	-2.4	0.2	0.8	-0.5
Medication: Ventolin 100micrograms inhaler	3.1	4.0	13.2	-1.1	-0.0	-3.6	1.7	-3.2	0.7	-0.7	2.7	1.0	1.8
Birth weight	0.7	1.6	4.9	0.2	-1.1	1.6	-1.1	2.2	-0.6	0.1	-1.7	-1.7	-0.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.0	1.0	-0.1	-1.0	0.8	0.6	0.2	0.1	0.2	-0.8	0.5
High blood pressure (siblings)	0.2	0.3	0.8	0.9	-0.1	-0.3	-0.4	-0.3	-0.1	-0.7	0.2	-0.9	0.9
Forced vital capacity (FVC), Best measure	3.5	12.9	36.8	1.1	-1.4	4.2	-6.1	1.7	-5.3	-0.4	-5.6	-0.9	-2.8
Body fat percentage	0.7	2.8	9.7	1.2	-1.8	3.1	-0.6	1.7	-1.1	2.1	-1.5	-0.5	-1.6
Leg fat percentage (right)	0.3	1.2	2.6	1.5	-1.6	1.6	0.9	0.9	0.5	1.1	0.2	-1.0	-0.3
Arm fat-free mass (right)	0.6	3.3	6.7	0.1	-1.7	1.8	-2.5	0.8	-2.5	-1.2	-2.6	-1.1	-2.2
Exposure to tobacco smoke outside home	0.5	0.6	3.0	-1.0	1.0	0.8	-0.6	-0.4	-0.3	-0.1	-0.2	-1.7	-0.4
Comparative body size at age 10	1.0	2.8	8.8	-0.9	0.3	-2.2	3.0	-1.8	1.9	-1.0	1.6	1.3	0.8
Number of full brothers	0.3	0.4	1.1	1.0	-1.1	-0.7	-0.3	-0.2	-0.2	-0.8	0.3	0.7	0.7
Worry too long after embarrassment	0.4	0.8	2.3	0.2	-0.5	1.2	-0.3	-0.6	-0.6	1.5	-0.1	-1.5	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.7	-0.9	-0.7	-1.6	0.4	-1.9	0.2	-1.5	0.7	-0.4	-0.4
Wheeze or whistling in the chest in last year	0.5	0.9	3.1	-1.0	0.2	-0.7	0.8	-1.6	0.1	0.1	1.8	-0.6	1.1
Number of children fathered	0.9	1.0	3.0	-0.7	-0.6	1.1	-0.7	0.3	-1.3	-1.2	-0.8	-0.4	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	3.2	-0.4	0.8	0.4	1.3	1.0	0.5	-0.8	0.2	0.9	-1.8
Age at first live birth	0.7	1.2	4.4	-0.9	-0.3	0.2	-1.1	-1.6	-0.4	-0.8	-1.4	2.1	-0.3
Pulse wave peak to peak time	1.9	2.2	7.9	-2.8	-0.5	-0.8	-0.4	-1.8	-1.3	-1.3	-1.3	1.6	-1.6
Health satisfaction	0.3	0.4	1.4	-0.5	-0.2	0.0	-0.1	-0.3	-0.6	-0.7	0.1	-1.0	-1.2
Shortness of breath walking on level ground	0.5	0.6	1.6	-0.3	-0.4	-1.1	0.5	-1.3	0.3	-0.0	1.2	0.2	1.1
Qualifications: College or University degree	0.5	1.6	3.6	-1.0	1.0	-1.8	1.3	-1.0	1.5	-1.5	0.7	1.9	0.2
Eye problems/disorders: None of the above	1.2	1.4	4.0	0.1	-1.0	1.1	-1.7	1.5	-1.4	0.5	-2.0	-0.5	-0.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.4	-0.9	-1.8	0.2	-1.2	-1.1	-0.8	-1.0	-0.9	1.2	-1.2
Emphysema/chronic bronchitis	1.6	1.7	4.5	-1.0	0.5	-2.1	1.5	-2.1	0.8	-1.4	1.1	0.9	0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.8	-0.6	0.9	0.5	-1.0	0.4	-0.5	0.3	-1.3	0.0	-0.5
Neck or shoulder pain in last month	1.6	2.3	4.9	-2.1	0.2	-2.2	2.1	-0.4	1.8	-1.9	1.1	-0.9	-0.2
Medication: Blood pressure	0.5	1.0	2.7	0.6	-0.7	-1.0	0.4	-1.4	-0.1	-0.2	1.7	1.4	0.7
Angina (self-reported)	0.7	0.9	3.8	0.1	-1.2	-0.7	-0.1	-1.9	-1.1	-0.6	0.4	1.3	0.0
Migraine (self-reported)	0.7	0.9	4.4	0.5	2.1	0.6	0.1	0.2	-0.2	1.3	0.8	1.0	-0.8
Medication: Ibuprofen	1.5	1.9	3.7	-1.4	1.7	-0.8	1.9	0.2	1.9	-0.9	1.7	0.6	-1.3
Medication: Allopurinol	2.7	3.6	9.3	-1.2	-1.3	-3.1	1.3	-2.7	0.9	-2.8	1.9	0.5	1.3
Medication: Omeprazole	1.4	1.7	10.3	0.6	-3.2	0.1	0.0	0.4	-0.3	-0.6	-0.7	-1.9	1.3
Medication: Seretide 50 evohaler	0.8	0.9	2.3	0.4	0.9	0.0	-1.0	-1.2	-1.3	0.6	-0.1	1.0	-1.5
Mean time to correctly identify matches	0.2	0.3	1.5	-1.2	0.2	0.1	-0.3	-0.3	-0.7	0.5	-0.2	0.3	-0.8
Heart disease (mother)	0.3	0.4	2.0	1.4	0.9	-0.0	0.2	-0.8	-0.1	0.1	0.4	0.6	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.8	-0.3	0.5	0.4	-0.5	0.9	-0.5	-0.6	-0.9	-1.7	-0.8
Whole body fat mass	0.9	3.9	10.6	0.8	-2.2	3.3	-1.7	1.5	-2.1	1.2	-2.4	-0.6	-2.4
Leg fat mass (right)	0.4	1.5	4.8	0.9	-2.2	2.0	-0.3	0.9	-0.8	0.7	-1.1	-0.8	-1.2
Arm predicted mass (right)	0.7	3.6	7.2	0.2	-1.8	1.9	-2.7	0.8	-2.6	-1.0	-2.6	-1.2	-2.2
Pulse rate, automated reading	0.5	1.6	5.5	0.7	1.5	-0.4	1.2	0.4	2.3	0.3	1.2	-0.1	2.1
Alcohol intake frequency.	0.6	1.3	5.9	0.4	1.5	0.2	1.0	0.9	0.5	2.4	1.2	-1.0	0.0
Comparative height size at age 10	2.7	14.7	37.6	-0.6	-0.9	4.5	-6.1	3.2	-4.6	0.3	-5.3	0.4	-5.3
Number of full sisters	1.1	1.4	4.6	0.0	1.8	-2.1	-0.2	-1.5	0.1	-1.6	1.0	-0.3	0.3
Suffer from ‘nerves’	0.9	1.4	3.2	0.9	-0.4	-0.8	1.8	-1.6	0.4	-0.6	1.8	-0.2	1.8
Overall health rating	1.0	2.1	5.1	-1.4	-2.2	-2.2	0.6	-1.6	0.4	-2.0	0.2	-1.1	-0.5
Chest pain or discomfort	0.9	1.3	4.1	-0.7	0.9	-2.0	0.8	-1.6	0.2	-1.3	1.4	-0.9	0.1
Had major operations	4.5	5.2	11.9	-3.5	-1.8	-0.0	-2.8	-1.3	-3.0	-1.1	-2.6	0.5	-3.3
Age at last live birth	0.7	1.0	3.2	-1.4	-1.6	0.6	-1.1	-0.1	-0.6	-0.0	-1.8	-0.3	-0.0
Family relationship satisfaction	0.4	0.4	1.3	-0.6	0.4	-0.2	0.3	-0.7	0.9	0.1	1.0	1.2	0.3
Leg pain on walking	2.1	2.7	8.5	-1.4	-0.7	-2.9	1.4	-2.6	0.5	-1.6	1.8	1.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	8.2	2.9	-1.6	0.4	-0.5	1.2	-0.2	0.1	-1.0	-1.0	1.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.0	-0.8	-0.4	0.7	-0.4	1.4	-0.0	0.7	-0.5	-0.7	-0.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	7.0	0.3	2.6	-0.6	-0.5	-0.1	-0.2	1.0	0.4	0.5	0.7
Medication: Aspirin	0.4	0.6	2.5	-0.3	-0.2	-0.5	-0.5	-1.6	-1.2	-0.6	0.6	0.2	-0.7
Supplements: Vitamin C	2.0	2.3	9.7	1.3	1.6	2.2	-0.4	3.1	0.4	1.6	-0.5	0.9	-0.6
Knee pain experienced in last month	1.2	1.8	8.2	-2.8	-0.7	0.1	-0.6	0.2	-0.3	-0.9	-0.6	-0.6	-2.9
Hypertension (Self-reported)	0.8	2.3	7.8	1.0	0.4	-2.4	0.8	-2.8	0.3	-0.7	2.1	0.2	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	4.1	-0.3	-2.0	1.4	-0.2	0.3	-0.1	1.1	-0.2	0.4	0.1
Illnesses of father: Heart disease	0.9	1.2	4.2	-0.4	0.6	-2.0	-0.9	-2.0	-0.9	0.2	0.6	0.0	1.2
Illnesses of siblings: Diabetes	1.2	1.5	4.5	1.2	1.1	-0.6	0.9	-0.8	1.2	1.1	1.8	0.2	2.1
Smoking status: Previous	1.4	2.1	7.5	0.6	-0.3	-1.0	-0.3	-2.7	-1.4	-2.2	0.0	2.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.9	14.0	0.8	0.2	3.0	-3.2	2.3	-2.3	0.2	-3.7	-0.2	-2.0
Whole body fat-free mass	1.0	5.5	12.6	-0.2	-1.7	1.9	-3.5	0.8	-3.4	-1.3	-3.5	-1.1	-2.8
Leg fat-free mass (right)	0.9	4.7	12.3	-0.3	-1.8	2.0	-3.0	1.1	-3.1	-0.4	-3.5	-1.0	-2.5
Arm fat percentage (left)	0.2	0.8	2.2	0.4	-1.4	1.5	0.1	0.5	-0.8	1.2	-0.7	-0.3	-0.8
Average weekly red wine intake	2.7	4.0	12.8	-2.2	1.9	-3.6	0.9	-2.3	0.6	-2.4	1.5	2.0	-0.7
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.5	-0.0	0.2	1.6	-1.2	1.4	-1.2	1.0	-1.2	-0.7	-1.2
Mood swings	0.5	0.9	3.9	1.2	-0.2	0.7	-1.0	0.4	-0.7	1.0	-0.7	-2.0	0.6
Loneliness, isolation	0.8	1.2	7.2	0.7	0.1	-0.5	1.0	-0.0	0.3	0.4	0.8	-2.7	1.3
Long-standing illness, disability or infirmity	0.8	1.2	4.8	0.4	-0.5	-1.8	0.9	-2.2	-0.3	-1.1	0.6	1.2	0.1
Ever had bowel cancer screening	0.5	0.6	2.8	0.8	-0.7	-0.1	0.9	-0.3	-0.0	-0.2	0.1	-1.7	1.1
Diabetes diagnosed by doctor	0.4	0.6	2.2	0.2	1.1	-0.3	-0.8	0.4	-0.7	-0.8	0.2	1.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.4	-0.6	-1.4	1.1	-2.3	1.4	-1.4	-0.2	-1.6	-1.5	-0.7
Friendships satisfaction	0.3	0.4	1.8	-0.4	-0.1	-0.4	-0.2	0.3	0.3	-1.3	-0.0	-1.1	-0.5
Qualifications: nursing, teaching	1.6	2.5	4.9	-2.0	1.3	-1.3	1.4	-1.7	0.7	-2.0	1.3	2.2	-1.5
Commuting to job workplace: Walk	0.8	0.9	3.6	-0.1	0.9	-1.5	0.4	-1.9	0.0	-1.0	-0.0	0.9	0.4
Eye problems/disorders: Cataract	0.3	0.3	1.5	0.2	-0.2	0.3	0.2	-0.3	-0.1	-1.1	-0.6	-0.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.1	0.7	0.1	1.3	-0.5	1.5	0.3	0.3	-0.5	-0.1	-0.2
Medication for cholesterol	0.9	1.4	3.4	-0.3	-1.6	1.8	-1.6	0.8	-0.2	-0.2	-1.8	0.9	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.2	-0.0	-1.8	-0.8	1.3	-1.6	1.0	-0.1	1.8	-0.3	1.0
Back pain experienced in last month	0.2	0.4	1.1	-0.5	-0.5	-0.2	1.1	0.2	0.4	-0.1	0.5	-1.0	-0.7
Mineral and other dietary supplements	0.9	1.2	2.7	1.4	-1.6	1.1	-0.2	1.1	-0.4	0.8	-0.8	-1.3	1.2
Breast cancer (self-reported)	0.9	1.1	6.2	0.0	-1.4	-0.4	0.8	0.3	0.6	-1.0	-0.2	-2.5	0.6
Asthma (self-reported)	0.7	1.4	4.8	-0.2	-0.3	-1.7	1.0	-2.2	0.3	-0.9	1.5	1.2	0.8
Osteoporosis (self-reported)	0.6	0.8	3.2	0.5	-1.8	1.4	-0.5	0.4	-0.2	0.8	-0.4	0.3	-1.1
Osteoarthritis (self-reported)	0.8	1.1	2.7	-1.6	-0.8	-1.0	-0.2	-0.3	-0.6	-1.1	-0.1	-1.6	-1.5
Medication: Aspirin	0.7	0.9	3.9	-0.7	-0.3	-1.1	0.0	-2.0	-0.9	-1.1	0.9	0.5	-0.6
Medication: Gliclazide	0.9	1.0	2.3	0.1	-1.2	0.5	-0.5	0.0	-1.1	-1.2	-1.5	1.3	-1.3
Illnesses of father: None of the above (group 1)	0.5	0.7	1.6	0.8	-0.3	1.0	0.8	1.3	0.3	-0.9	-1.0	0.1	-0.9
Smoking status: Current	0.5	0.8	2.0	0.3	-1.4	0.8	-0.3	1.1	0.5	1.1	0.4	-1.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.5	20.3	3.0	0.3	1.7	-3.4	1.0	-4.5	0.4	-3.1	-0.1	-0.5
Whole body water mass	1.0	5.5	12.7	-0.2	-1.9	1.9	-3.6	0.8	-3.4	-1.4	-3.5	-1.0	-2.7
Leg predicted mass (right)	0.9	4.8	12.3	-0.3	-1.7	2.2	-3.0	1.2	-3.1	-0.3	-3.5	-1.0	-2.5
Arm fat mass (left)	0.5	1.9	3.7	0.0	-1.9	1.9	-1.2	0.5	-1.7	0.5	-1.8	-0.6	-1.8
Number of self-reported non-cancer illnesses	1.5	2.6	9.4	-1.3	-0.6	-2.0	-0.1	-3.1	-1.0	-2.7	0.9	0.3	-1.3
Average weekly champagne plus white wine intake	0.5	0.8	2.3	0.3	1.5	1.2	0.8	1.3	0.7	0.7	-0.2	-0.4	0.4
Miserableness	1.2	2.0	8.1	-0.9	-1.2	-0.4	-2.2	-1.1	-1.6	-0.4	-0.9	-2.8	0.3
Guilty feelings	0.8	1.2	3.9	-0.8	-1.0	0.0	-0.7	-0.6	-1.5	-1.4	-1.1	-0.5	-2.0
Wears glasses or contact lenses	1.6	1.8	3.5	1.6	-1.9	1.4	-1.6	-0.3	-1.8	1.6	-1.3	0.1	0.2
Ever taken oral contraceptive pill	0.8	0.9	1.7	-0.7	0.8	-1.2	1.0	-0.9	1.3	-0.7	0.6	1.3	0.3
Hearing aid user	0.5	0.6	2.1	1.1	-0.8	0.3	0.1	-0.4	0.5	0.8	0.4	-0.8	1.4
Mother’s age at death	1.6	2.0	10.0	-0.9	3.2	-0.2	1.1	-0.4	0.7	0.6	2.7	0.2	0.4
Financial situation satisfaction	0.3	0.4	1.0	-0.2	-0.0	-0.6	-1.0	0.2	-0.9	-0.9	-0.6	0.3	-0.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.8	0.7	1.4	1.1	-0.6	0.8	-0.8	0.9	-0.8	1.0	-1.7
Commuting to job workplace: Public transport	0.4	0.4	1.3	-1.1	1.1	0.3	-0.6	-0.3	-0.5	-0.1	-0.2	-0.7	-0.6
Eye problems/disorders: Glaucoma	0.8	1.0	3.0	0.7	-0.0	-0.4	0.9	-0.9	1.2	0.4	1.7	-0.3	1.7
Medication: Blood pressure	0.7	1.3	7.4	-0.6	0.6	-1.3	-0.2	-2.7	-1.2	-0.4	0.5	0.5	-1.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.2	-0.8	0.3	-1.1	1.3	0.2	1.5	0.3	1.4	-1.5	-0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.9	0.2	1.4	0.2	0.1	-0.1	0.8	0.4	0.8	1.2	-0.7
High cholesterol (Self-reported)	1.9	3.4	10.4	-1.3	-1.1	-3.2	0.7	-2.9	0.1	-3.0	1.4	0.6	-0.7
Medication: Bendroflumethiazide	1.3	1.9	4.9	-0.0	1.4	-1.7	0.9	-2.2	0.4	0.3	2.2	1.8	0.4
Medication: Paracetamol	0.4	0.6	3.2	0.2	-1.8	-0.3	1.0	-0.6	-0.0	-0.4	0.1	1.2	-0.3
Medication: Lisinopril	0.8	1.0	3.1	0.4	0.8	-0.8	0.9	-1.7	0.3	-0.1	1.8	1.4	0.1
Medication: Atorvastatin	1.4	1.7	4.7	2.0	0.5	-1.8	0.2	-0.8	-1.2	-0.2	1.4	2.2	0.8
Illnesses of father: High blood pressure	0.2	0.2	0.8	0.8	0.1	-0.3	-0.9	-0.0	-0.2	0.8	-0.1	-0.5	0.3
Alcohol drinker status: Never	0.5	0.6	2.8	-0.8	-0.1	0.2	1.7	0.2	1.3	0.1	0.7	-0.7	-0.2
Ever smoked	0.3	0.5	1.2	0.3	-1.0	-0.7	0.3	-1.1	0.3	-0.9	0.7	0.7	0.4
Basal metabolic rate	1.0	5.6	12.7	0.0	-1.9	2.4	-3.4	1.3	-3.3	-0.8	-3.6	-1.3	-2.8
Leg fat percentage (left)	0.3	1.2	2.9	1.4	-1.4	1.7	1.0	1.1	0.5	1.2	0.2	-1.2	-0.5
Arm fat-free mass (left)	0.7	3.7	7.7	-0.1	-1.7	1.6	-2.8	0.8	-2.7	-1.3	-2.6	-1.2	-2.4
Number of operations (self-reported)	4.0	6.0	17.8	-2.0	-1.8	-0.5	-3.4	-1.4	-4.2	-1.4	-2.7	0.7	-3.5
Average weekly beer plus cider intake	0.8	1.2	7.1	0.9	-2.7	0.7	0.5	0.7	0.3	-0.1	-0.7	-1.2	0.9
Irritability	0.8	1.3	5.9	0.3	-0.5	2.4	-1.8	0.9	-0.6	0.5	-1.0	-0.6	-0.7
Risk taking	2.6	3.8	10.5	-3.0	-0.6	1.5	-2.5	0.3	-1.7	-0.8	-2.4	-0.5	-3.2
Ever had prostate specific antigen (PSA) test	1.1	1.2	4.3	-1.0	-1.0	1.1	-0.1	-0.6	0.4	-2.1	-0.8	0.3	-1.9
Fractured/broken bones in last 5 years	2.5	3.2	6.5	0.4	-2.6	2.3	-2.0	0.6	-1.8	-0.1	-2.4	0.1	-2.5
Age started oral contraceptive pill	2.8	3.6	12.6	-1.7	-1.1	-2.3	1.2	-3.5	1.1	-1.2	2.1	2.2	-0.2
Diastolic blood pressure, automated reading	2.2	6.9	19.2	1.9	1.2	-2.9	3.0	-1.5	3.5	-0.4	3.7	-0.1	4.4
Ever depressed for a whole week	0.3	0.4	2.1	0.4	-0.7	-0.1	0.1	-0.3	-0.4	-0.8	0.1	-1.5	0.8
Unable to work because of sickness or disability	0.8	1.1	3.7	0.2	-0.8	-0.8	1.9	0.3	1.6	0.1	1.0	-0.6	1.3
Commuting to job workplace: Cycle	1.0	1.3	7.6	0.1	2.8	0.3	-0.1	-0.5	-0.6	-1.5	0.7	0.3	-1.2
Myopia	2.5	3.6	7.3	2.7	-2.1	1.1	-2.0	0.7	-1.7	2.6	-0.8	2.5	1.6
Vascular/heart problems diagnosed by doctor	1.1	3.0	11.8	-1.1	0.2	2.6	-0.7	3.4	-0.2	0.7	-2.4	-0.2	-1.7
Cholesterol lowering medication	0.6	0.8	3.1	0.9	0.7	-1.0	1.0	-0.9	-0.0	0.7	1.8	0.5	0.5
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	7.1	1.1	-2.7	0.4	0.3	0.7	-0.2	0.4	-0.1	-1.2	1.8
Pain experienced in last month	1.6	2.7	9.5	3.1	-1.1	2.1	-1.1	0.9	-0.2	1.7	-0.4	1.1	2.2
Supplements: Calcium	0.3	0.3	1.0	-0.1	-0.2	0.1	0.2	1.0	-0.1	-0.5	-0.7	0.9	-0.9
Basal cell carcinoma (self-reported)	1.5	1.8	6.6	0.2	0.4	-0.9	0.9	-2.2	0.2	-1.1	1.7	2.6	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.1	1.8	-0.1	0.6	-0.3	0.2	-1.2	0.2	0.2	1.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.6	0.6	0.2	1.3	1.9	1.0	1.2	0.7	1.2	-0.3	0.0
Heart disease (siblings)	2.4	3.0	8.5	0.6	0.9	-2.2	1.4	-1.7	1.4	1.2	2.9	2.0	1.7
Alcohol drinker status: Previous	0.7	0.8	3.4	-0.1	0.9	-1.0	0.6	-1.0	0.3	0.7	1.1	1.8	0.5
Pack years of smoking	0.5	0.8	2.7	0.1	-1.6	1.6	-0.5	0.7	-0.8	0.3	-0.9	0.2	-0.1
Impedance of whole body	1.3	6.8	19.4	2.0	1.1	4.4	-2.5	3.3	-1.4	3.8	-1.9	1.7	-1.9
Leg fat mass (left)	0.4	1.7	5.0	0.9	-2.0	2.2	-0.4	1.1	-0.9	0.7	-1.2	-1.0	-1.4
Arm predicted mass (left)	0.8	4.2	8.8	0.1	-2.0	1.8	-3.0	1.0	-2.7	-1.2	-2.9	-0.9	-2.5