[Hub]/) : Traits : Forced vital capacity (FVC), Best measure : ← →

chr6:108,994,161-110,844,259

Best TWAS P=1.41e-11 · Best GWAS P=1.06e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Artery Tibial	RP11-425D10.10	0.10	0.10	lasso	4	0.10	3.9e-08	-6.6	-6.8	1.4e-11	0.97	0.02	0.98	TRUE
57	The Cancer Genome Atlas	Esophageal Carcinoma	SMPD2	0.12	0.09	blup	41	0.07	2.6e-03	-6.8	-6.7	2.3e-11	0.99	0.01	0.90	FALSE
6	GTEx	Artery Tibial	MICAL1	0.08	0.02	lasso	3	0.01	6.5e-02	-6.6	-6.7	2.8e-11	0.98	0.02	0.95	FALSE
24	GTEx	Esophagus Mucosa	SMPD2	0.17	0.20	lasso	10	0.22	2.2e-14	-6.7	-6.7	2.8e-11	0.98	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PPIL6	0.07	0.03	blup	53	0.02	5.8e-02	-5.7	6.7	2.8e-11	-0.94	0.02	0.57	FALSE
23	GTEx	Colon Transverse	RP11-425D10.10	0.12	0.13	enet	21	0.14	2.2e-07	-6.7	-6.6	5.2e-11	0.97	0.03	0.97	FALSE
17	GTEx	Breast Mammary Tissue (Female)	RP11-425D10.10	0.14	0.04	lasso	10	0.02	6.5e-02	-6.8	-6.6	5.4e-11	0.98	0.03	0.53	FALSE
52	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SMPD2	0.04	0.04	blup	43	0.05	3.9e-05	-6.7	-6.4	1.2e-10	0.97	0.01	0.98	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZBTB24	0.04	0.05	lasso	4	0.04	7.8e-06	-6.6	6.4	1.2e-10	-0.97	0.01	0.99	FALSE
81	The Cancer Genome Atlas	Stomach Adenocarcinoma	SMPD2	0.07	0.07	blup	44	0.08	3.4e-06	-6.6	-6.4	1.6e-10	0.96	0.02	0.98	FALSE
15	GTEx	Breast Mammary Tissue (Male)	AK9	0.10	0.03	lasso	3	-0.01	5.4e-01	-5.9	6.3	2.3e-10	-0.97	0.03	0.56	FALSE
32	GTEx	Ovary	RP11-425D10.10	0.15	0.10	lasso	5	0.02	9.0e-02	-5.9	-6.3	3.6e-10	0.99	0.03	0.88	FALSE
44	GTEx	Vagina	RP11-425D10.10	0.42	0.22	lasso	19	0.17	9.0e-05	-5.9	-6.2	4.3e-10	0.98	0.03	0.94	FALSE
42	GTEx	Testis	SMPD2	0.28	0.18	lasso	7	0.17	7.6e-08	-5.7	-6.2	5.1e-10	0.88	0.09	0.91	FALSE
48	METSIM	Adipose	SMPD2	0.06	0.08	enet	14	0.08	2.0e-12	-5.7	-6.2	5.1e-10	0.89	0.32	0.68	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	SMPD2	0.27	0.15	lasso	10	0.17	1.6e-09	-5.9	-6.2	5.3e-10	0.94	0.11	0.89	FALSE
5	GTEx	Artery Aorta	SMPD2	0.10	0.04	enet	11	0.03	1.5e-02	-5.9	-6.2	5.4e-10	0.92	0.03	0.96	FALSE
20	GTEx	Colon Sigmoid	FIG4	0.17	0.11	lasso	9	0.03	3.7e-02	-6.7	6.2	5.6e-10	-0.92	0.02	0.90	FALSE
39	GTEx	Small Intestine Terminal Ileum	RP11-425D10.10	0.16	0.07	lasso	9	0.06	1.5e-02	-6.7	-6.2	5.6e-10	0.93	0.03	0.70	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SMPD2	0.07	0.08	blup	45	0.07	2.3e-04	-5.7	-6.2	5.8e-10	0.92	0.04	0.91	FALSE
36	GTEx	Skin Sun Exposed Lower leg	SMPD2	0.19	0.19	lasso	12	0.24	1.6e-19	-5.5	-6.2	6.1e-10	0.96	0.46	0.54	FALSE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SMPD2	0.04	0.06	blup	45	0.06	8.9e-08	-6.5	-6.1	8.8e-10	0.91	0.04	0.96	FALSE
46	GTEx	Whole Blood	RP11-425D10.10	0.04	0.03	enet	16	0.03	6.2e-04	-5.4	-6.1	9.8e-10	0.96	0.04	0.95	FALSE
82	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SMPD2	0.23	0.13	lasso	5	0.17	1.4e-06	-5.9	-6.1	1.1e-09	0.91	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMPD2	0.05	0.07	lasso	4	0.06	9.6e-08	-5.3	-6.0	1.7e-09	0.85	0.07	0.93	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	RP11-425D10.10	0.20	0.27	lasso	5	0.27	5.5e-15	-5.9	-6.0	1.9e-09	0.98	0.36	0.64	FALSE
11	GTEx	Breast Mammary Tissue	SMPD2	0.14	0.09	lasso	5	0.05	2.2e-03	-5.7	-6.0	2.2e-09	0.87	0.13	0.75	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AKD1	0.07	0.06	blup	116	0.06	4.2e-07	-6.7	6.0	2.4e-09	-0.93	0.02	0.98	FALSE
27	GTEx	Esophagus Muscularis	CD164	0.04	0.02	enet	6	0.01	1.0e-01	-5.7	-6.0	2.7e-09	0.95	0.05	0.80	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMPD2	0.04	0.07	lasso	4	0.07	8.8e-14	-5.7	-6.0	2.7e-09	0.86	0.10	0.90	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKD1	0.11	0.08	lasso	5	0.10	5.8e-11	-6.6	6.0	2.7e-09	-0.91	0.02	0.98	FALSE
50	YFS	Blood	SMPD2	0.06	0.08	lasso	7	0.08	2.5e-24	-5.7	-5.9	2.8e-09	0.86	0.16	0.84	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	AKD1	0.05	0.03	blup	122	0.04	1.3e-05	-5.8	5.9	3.4e-09	-0.93	0.02	0.98	FALSE
13	GTEx	Breast Mammary Tissue	RP11-425D10.10	0.12	0.12	lasso	1	0.08	5.1e-05	-5.9	-5.9	3.5e-09	0.97	0.04	0.95	FALSE
16	GTEx	Breast Mammary Tissue (Female)	AK9	0.12	0.15	lasso	1	0.12	1.9e-04	-5.9	5.9	3.5e-09	-0.97	0.06	0.62	FALSE
76	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMPD2	0.10	0.04	lasso	2	0.07	1.2e-03	-5.3	-5.9	3.9e-09	0.73	0.02	0.52	FALSE
26	GTEx	Esophagus Mucosa	RP11-425D10.10	0.09	0.13	lasso	5	0.12	1.1e-08	-5.9	-5.9	4.0e-09	0.97	0.16	0.84	FALSE
38	GTEx	Skin Sun Exposed Lower leg	RP11-425D10.10	0.19	0.23	enet	18	0.23	3.4e-19	-5.9	-5.9	4.4e-09	0.95	0.75	0.25	FALSE
47	METSIM	Adipose	AK9	0.05	0.03	lasso	6	0.02	1.0e-04	-5.9	5.9	4.4e-09	-0.95	0.03	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-425D10.10	0.16	0.10	lasso	6	0.06	7.2e-04	-5.9	-5.8	5.1e-09	0.95	0.07	0.88	FALSE
22	GTEx	Colon Transverse	SMPD2	0.19	0.25	lasso	5	0.24	1.1e-11	-5.7	-5.8	6.0e-09	0.85	0.24	0.76	FALSE
7	GTEx	Artery Tibial	AK9	0.13	0.12	enet	18	0.13	3.5e-10	-5.9	5.8	7.2e-09	-0.95	0.29	0.71	FALSE
41	GTEx	Testis	ZBTB24	0.11	0.11	lasso	4	0.10	4.9e-05	-5.9	5.8	7.7e-09	-0.94	0.24	0.68	FALSE
43	GTEx	Thyroid	AK9	0.11	0.08	enet	22	0.13	1.9e-10	-6.7	5.8	8.6e-09	-0.92	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMPD2	0.09	0.09	blup	42	0.10	2.1e-11	-6.5	-5.8	8.9e-09	0.76	0.05	0.95	FALSE
45	GTEx	Whole Blood	SMPD2	0.15	0.16	lasso	8	0.15	1.0e-13	-5.7	-5.7	9.2e-09	0.88	0.91	0.09	FALSE
19	GTEx	Cells Transformed fibroblasts	SMPD2	0.20	0.13	lasso	9	0.15	3.1e-11	-5.7	-5.7	9.3e-09	0.90	0.93	0.07	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	SMPD2	0.06	0.09	enet	11	0.08	4.7e-10	-5.7	-5.7	1.1e-08	0.86	0.09	0.91	FALSE
10	GTEx	Brain Cerebellar Hemisphere	AK9	0.24	0.17	lasso	3	0.11	1.0e-03	-5.9	5.7	1.2e-08	-0.96	0.17	0.51	FALSE
33	GTEx	Pancreas	SMPD2	0.09	0.07	lasso	3	0.08	2.1e-04	-5.7	-5.7	1.3e-08	0.85	0.10	0.73	FALSE
30	GTEx	Lung	SMPD2	0.10	0.12	lasso	2	0.10	7.5e-08	-5.7	-5.7	1.5e-08	0.85	0.71	0.29	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SMPD2	0.12	0.15	enet	6	0.14	3.8e-08	-5.7	-5.7	1.5e-08	0.85	0.17	0.83	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SMPD2	0.08	0.07	lasso	3	0.05	3.3e-03	-5.7	-5.7	1.5e-08	0.85	0.04	0.82	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMPD2	0.08	0.13	lasso	3	0.13	2.4e-13	-5.7	-5.7	1.5e-08	0.85	0.72	0.28	FALSE
79	The Cancer Genome Atlas	Rectum Adenocarcinoma	SMPD2	0.13	0.08	lasso	2	0.06	1.5e-02	-5.7	-5.7	1.5e-08	0.85	0.01	0.38	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	SMPD2	0.18	0.08	enet	17	0.11	2.5e-04	-5.3	-5.6	1.8e-08	0.72	0.03	0.63	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	FIG4	0.05	0.02	blup	92	0.02	1.0e-03	-5.7	5.6	1.8e-08	-0.81	0.01	0.99	FALSE
9	GTEx	Brain Caudate basal ganglia	AK9	0.20	0.16	enet	16	0.17	1.1e-05	-5.5	5.6	1.9e-08	-0.91	0.16	0.77	FALSE
40	GTEx	Stomach	RP11-425D10.10	0.25	0.10	lasso	6	0.09	3.0e-05	-6.5	-5.6	1.9e-08	0.82	0.03	0.97	FALSE
21	GTEx	Colon Sigmoid	AK9	0.13	0.06	enet	32	0.13	3.1e-05	-6.7	5.6	2.2e-08	-0.82	0.04	0.91	FALSE
80	The Cancer Genome Atlas	Stomach Adenocarcinoma	AKD1	0.03	0.03	blup	121	0.02	6.3e-03	-6.6	5.6	2.2e-08	-0.92	0.02	0.83	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AKD1	0.08	0.06	blup	114	0.05	4.7e-05	-5.4	5.6	2.6e-08	-0.87	0.06	0.93	FALSE
3	GTEx	Adipose Visceral Omentum	AK9	0.10	0.02	enet	27	0.04	2.7e-03	-5.4	5.6	2.7e-08	-0.90	0.14	0.81	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	AKD1	0.24	0.18	enet	21	0.26	2.5e-25	-5.4	5.5	2.9e-08	-0.87	0.04	0.96	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	SMPD2	0.15	0.17	enet	14	0.18	9.4e-18	-5.7	-5.5	3.2e-08	0.73	0.22	0.78	FALSE
14	GTEx	Breast Mammary Tissue (Male)	SMPD2	0.14	0.04	lasso	4	0.07	9.4e-03	4.0	-5.5	3.3e-08	0.81	0.10	0.38	FALSE
31	GTEx	Lung	RP11-425D10.10	0.10	0.08	enet	24	0.07	6.4e-06	-6.8	-5.5	3.6e-08	0.92	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKD1	0.11	0.06	lasso	3	0.06	2.7e-04	-5.4	5.5	4.0e-08	-0.91	0.04	0.96	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	SMPD2	0.17	0.14	lasso	4	0.14	2.3e-08	-5.3	-5.5	4.2e-08	0.80	0.29	0.71	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	AKD1	0.02	0.02	blup	122	0.03	1.0e-06	-5.4	5.5	4.5e-08	-0.89	0.04	0.96	FALSE
25	GTEx	Esophagus Mucosa	AK9	0.11	0.06	lasso	13	0.04	6.0e-04	-5.5	5.5	4.8e-08	-0.90	0.04	0.95	FALSE
12	GTEx	Breast Mammary Tissue	AK9	0.17	0.13	enet	19	0.13	4.0e-07	-5.9	5.4	5.6e-08	-0.91	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKD1	0.12	0.11	lasso	6	0.12	9.8e-14	-5.5	5.4	6.4e-08	-0.91	0.34	0.66	FALSE
28	GTEx	Heart Atrial Appendage	RP11-425D10.10	0.12	0.11	lasso	5	0.07	4.0e-04	-5.9	-5.4	7.0e-08	0.91	0.08	0.88	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	MICAL1	0.08	0.11	lasso	4	0.12	1.8e-13	-5.3	5.4	7.4e-08	-0.82	0.31	0.69	FALSE
78	The Cancer Genome Atlas	Rectum Adenocarcinoma	AKD1	0.26	0.12	blup	114	0.18	6.5e-05	3.5	5.3	8.6e-08	-0.82	0.12	0.62	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AKD1	0.06	0.07	lasso	4	0.05	2.8e-06	-5.7	5.3	8.7e-08	-0.88	0.28	0.72	FALSE
74	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AKD1	0.04	0.03	blup	114	0.03	4.7e-03	-5.5	5.3	9.0e-08	-0.89	0.07	0.51	FALSE
29	GTEx	Heart Left Ventricle	RP11-425D10.10	0.13	0.04	enet	34	0.03	9.2e-03	-5.9	-5.3	9.4e-08	0.73	0.02	0.94	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	CD164	0.03	0.01	blup	49	0.01	2.1e-02	-5.7	-5.3	9.5e-08	0.82	0.03	0.64	FALSE
37	GTEx	Skin Sun Exposed Lower leg	AK9	0.14	0.12	lasso	3	0.14	1.9e-11	-5.9	5.3	1.1e-07	-0.93	0.48	0.52	FALSE
2	GTEx	Adipose Subcutaneous	AK9	0.12	0.09	lasso	7	0.10	2.1e-08	-5.9	5.2	1.6e-07	-0.91	0.16	0.83	FALSE
1	GTEx	Adipose Subcutaneous	SMPD2	0.14	0.10	lasso	10	0.12	2.3e-10	-5.7	-5.2	1.7e-07	0.81	0.61	0.39	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	AK9	0.32	0.13	lasso	7	0.25	1.2e-08	-5.5	5.2	1.7e-07	-0.88	0.26	0.74	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	FIG4	0.14	0.13	lasso	6	0.14	3.8e-17	-3.6	5.2	2.0e-07	-0.76	0.86	0.14	FALSE