Best TWAS P=3.81e-10 · Best GWAS P=1.24e-10 conditioned to 0.077
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GSDMC | 0.03 | 0.01 | blup | 57 | 0.02 | 1.4e-02 | -6.2 | -5.8 | 6.4e-09 | 0.94 | 0.01 | 0.88 | FALSE |
2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GSDMC | 0.05 | 0.06 | lasso | 7 | 0.05 | 1.5e-10 | -6.2 | -6.0 | 1.6e-09 | 0.90 | 0.01 | 0.99 | FALSE |
3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GSDMC | 0.21 | 0.14 | blup | 57 | 0.15 | 1.2e-07 | -6.4 | -5.4 | 5.1e-08 | 0.83 | 0.00 | 1.00 | FALSE |
4 | The Cancer Genome Atlas | Colon Adenocarcinoma | GSDMC | 0.13 | 0.08 | lasso | 7 | 0.09 | 5.0e-06 | -5.6 | -5.2 | 1.9e-07 | 0.88 | 0.01 | 0.98 | FALSE |
5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GSDMC | 0.25 | 0.30 | lasso | 5 | 0.32 | 4.6e-36 | -6.2 | -6.0 | 1.9e-09 | 0.95 | 0.02 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GSDMC | 0.16 | 0.14 | blup | 57 | 0.15 | 6.3e-17 | -5.5 | -5.4 | 7.6e-08 | 0.85 | 0.14 | 0.86 | FALSE |
7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GSDMC | 0.03 | 0.02 | blup | 57 | 0.02 | 1.4e-03 | -6.2 | -6.3 | 3.8e-10 | 0.91 | 0.01 | 0.92 | TRUE |
8 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | GSDMC | 0.21 | 0.05 | blup | 57 | 0.06 | 1.2e-02 | -6.4 | -5.3 | 9.3e-08 | 0.86 | 0.01 | 0.82 | FALSE |