[Hub]/) : Traits : Loneliness, isolation : ← →

chr11:46,622,392-48,559,571

Best TWAS P=5.55e-11 · Best GWAS P=3.25e-11 conditioned to 0.00197

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	-4.2	-5.3	1.0e-07	0.90	0.05	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	3.3	-5.4	7.2e-08	0.74	0.03	0.78	FALSE
3	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	-4.2	5.1	3.0e-07	-0.90	0.44	0.56	FALSE
4	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-6.5	-6.4	2.0e-10	0.97	0.01	0.97	FALSE
5	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	4.1	5.4	5.3e-08	-0.77	0.03	0.41	FALSE
6	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	-5.9	5.9	3.3e-09	-0.88	0.04	0.87	FALSE
7	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	-6.0	-6.0	1.6e-09	0.86	0.03	0.55	FALSE
8	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	4.1	-5.1	2.7e-07	0.84	0.31	0.69	FALSE
9	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	-6.4	5.4	6.7e-08	-0.83	0.02	0.98	FALSE
10	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-4.2	5.4	5.4e-08	-0.93	0.03	0.91	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	2.7	-5.4	8.5e-08	0.56	0.14	0.52	FALSE
12	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	-6.4	-6.5	9.7e-11	0.89	0.02	0.96	FALSE
13	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	-4.2	5.3	1.0e-07	-0.90	0.05	0.95	FALSE
14	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-5.9	6.0	2.6e-09	-0.92	0.03	0.97	FALSE
15	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	-6.1	-5.3	9.9e-08	0.92	0.02	0.97	FALSE
16	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	3.6	-5.5	4.0e-08	0.69	0.04	0.94	FALSE
17	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-4.2	5.4	7.9e-08	-0.90	0.06	0.94	FALSE
18	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-6.5	6.0	2.2e-09	-0.94	0.02	0.98	FALSE
19	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	-5.9	-5.9	2.8e-09	0.88	0.06	0.94	FALSE
20	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-6.4	6.4	1.4e-10	-0.99	0.02	0.97	FALSE
21	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-6.5	6.4	1.6e-10	-0.96	0.01	0.99	FALSE
22	METSIM	Adipose	PSMC3	0.06	0.03	enet	28	0.04	2.3e-06	-4.3	-5.4	5.6e-08	0.82	0.05	0.95	FALSE
23	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-6.4	6.4	1.7e-10	-0.96	0.02	0.98	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-6.5	-6.2	4.4e-10	0.96	0.02	0.98	FALSE
25	YFS	Blood	SPI1	0.65	0.18	enet	75	0.27	1.6e-87	-5.8	5.6	1.8e-08	-0.69	0.28	0.72	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-6.4	6.0	2.4e-09	-0.96	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	-5.9	5.8	5.6e-09	-0.79	0.01	0.97	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP160	0.03	0.01	blup	44	0.01	1.9e-03	-6.1	-5.5	3.4e-08	0.85	0.01	0.61	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	4.2	-5.6	1.9e-08	0.63	0.02	0.80	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-6.5	6.5	1.1e-10	-0.97	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	-6.5	-5.9	4.7e-09	0.82	0.00	0.99	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-6.6	-5.7	9.9e-09	0.91	0.01	0.97	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMC3	0.05	0.01	lasso	3	0.02	9.4e-04	4.2	-6.6	5.6e-11	0.66	0.01	0.68	TRUE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-6.5	5.8	8.1e-09	-0.95	0.00	1.00	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMC3	0.05	0.04	lasso	3	0.05	3.8e-06	-4.3	-5.4	8.3e-08	0.79	0.01	0.98	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-6.4	6.4	1.8e-10	-0.96	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	-6.0	-6.0	1.9e-09	0.87	0.01	0.98	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-6.5	-6.5	9.6e-11	0.97	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-6.5	6.5	9.6e-11	-0.97	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	-6.0	-5.1	2.8e-07	0.85	0.01	0.98	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-6.1	-5.9	3.3e-09	0.95	0.01	0.90	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-6.4	6.0	2.0e-09	-0.96	0.00	0.93	FALSE