Hub : Traits :

Loneliness, isolation

51 significantly associated models · 15 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48702606 50085153 1 1 2.7e-07 3.2e-05 0.290 94 GPX1
2 8 21720054 22214508 1 1 5.6e-08 1.7e-06 0.799 100 NUDT18
3 9 95518076 96910958 1 1 2.0e-08 1.1e-08 0.053 88 FAM120AOS
4 11 46622392 48559571 9 1 5.6e-11 3.2e-11 0.002 78 PSMC3
5 17 65938655 66402256 1 1 1.7e-07 8.1e-07 0.026 80 LOC651250
6 20 46840115 48410403 2 1 1.8e-08 1.1e-06 0.316 96 CSE1L

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 2.13 1 0 0.0 0.00 1.00000 PSMC3
Depressed Affect (Nagel 2018) 13.28 4 3 6.7 1.00 0.00181 FAM120AOS GPX1 NUDT18 PSMC3
Depression (Nagel 2018) 7.97 3 1 2.2 0.00 1.00000 CSE1L FAM120AOS NUDT18
Intelligence (Savage-Jansen 2018) 10.41 3 2 4.4 0.00 1.00000 CSE1L FAM120AOS GPX1
Neuroticism (Nagel 2018) 8.37 4 1 2.2 1.00 0.00099 FAM120AOS GPX1 NUDT18 PSMC3
Schizophrenia (2018) 2.98 1 0 0.0 0.00 1.00000 FAM120AOS
Schizophrenia vs Biploar Disorder 4.66 1 0 0.0 0.00 1.00000 CSE1L
Worry (Nagel 2018) 3.98 1 0 0.0 0.00 1.00000 PSMC3
Alzheimer’s Disease (including proxy) 2.29 1 0 0.0 0.00 1.00000 PSMC3
Crohns Disease (2017) 3.11 1 1 2.2 0.00 1.00000 GPX1
Irritable Bowel Disease (IBD) 4.36 1 1 2.2 0.00 1.00000 GPX1
Ulcerative Colitis (UC) 3.98 1 1 2.2 0.00 1.00000 GPX1
Major Depression (MDD) 10.50 2 0 0.0 0.00 1.00000 FAM120AOS GPX1
Reaction Time 1.79 1 0 0.0 0.00 1.00000 CSE1L
Verbal and Numeric Reasoning (VNR) 9.90 3 3 6.7 0.00 1.00000 CSE1L FAM120AOS GPX1
Prostate Cancer 3.42 1 0 0.0 0.00 1.00000 GPX1
Age at First Birth 5.71 1 1 2.2 0.00 1.00000 GPX1
Neuroticism (2016) 5.42 2 0 0.0 0.00 1.00000 GPX1 PSMC3
Ulcerative Colitis 6.14 1 1 2.2 0.00 1.00000 GPX1
Blood Eosinophil Count 1.90 2 1 2.2 0.00 1.00000 GPX1 LOC651250
Blood Platelet Count 0.63 1 0 0.0 0.00 1.00000 FAM120AOS
Blood Red Count 1.09 2 1 2.2 0.00 1.00000 CSE1L PSMC3
Blood White Count 3.42 2 1 2.2 0.00 1.00000 GPX1 PSMC3
Heel T-Score 1.94 2 1 2.2 0.00 1.00000 FAM120AOS PSMC3
BMI 3.59 3 1 2.2 0.00 1.00000 GPX1 LOC651250 PSMC3
Height 3.54 4 4 8.9 0.31 0.69089 CSE1L GPX1 LOC651250 PSMC3
Waist Hip Ratio (WHR) 1.51 1 1 2.2 0.00 1.00000 GPX1
Systolic Blood Pressure 3.77 2 1 2.2 0.00 1.00000 GPX1 PSMC3
Smoking Status 3.51 2 1 2.2 0.00 1.00000 GPX1 PSMC3
Allergy or Eczema 1.56 1 0 0.0 0.00 1.00000 CSE1L
Cardiovascular Disease 2.92 3 1 2.2 0.00 1.00000 GPX1 NUDT18 PSMC3
Hypothyroidism (self reported) 2.10 1 0 0.0 0.00 1.00000 PSMC3
Type 2 Diabetes (T2D) (2018) 1.45 1 0 0.0 0.00 1.00000 LOC651250
Lung FEV1/FVC ratio 2.30 2 1 2.2 0.00 1.00000 FAM120AOS LOC651250
Lung FVC 1.80 2 0 0.0 0.00 1.00000 GPX1 LOC651250
Neuroticism 9.14 4 2 4.4 1.00 0.00033 FAM120AOS GPX1 NUDT18 PSMC3
Chronotype (morning person) 2.14 2 0 0.0 0.00 1.00000 FAM120AOS GPX1
Tanning 0.32 1 0 0.0 0.00 1.00000 PSMC3
Hand grip strength (left) 2.16 1 0 0.0 0.00 1.00000 LOC651250
Number of treatments/medications taken 4.18 1 0 0.0 0.00 1.00000 GPX1
Frequency of depressed mood in last 2 weeks 9.94 4 0 0.0 -0.58 0.42491 CSE1L FAM120AOS NUDT18 PSMC3
Hearing difficulty/problems: Yes 3.71 1 0 0.0 0.00 1.00000 FAM120AOS
Ever used hormone-replacement therapy (HRT) 4.49 2 0 0.0 0.00 1.00000 LOC651250 PSMC3
Systolic blood pressure, automated reading 2.83 1 1 2.2 0.00 1.00000 GPX1
Medication for hormone replacement therapy 4.01 1 0 0.0 0.00 1.00000 LOC651250
Medication: Co-codamol 3.86 2 0 0.0 0.00 1.00000 FAM120AOS GPX1
Pack years adult smoking proportion 5.66 2 0 0.0 0.00 1.00000 GPX1 NUDT18
Impedance of leg (right) 1.20 1 1 2.2 0.00 1.00000 GPX1
Leg fat-free mass (left) 1.31 2 0 0.0 0.00 1.00000 CSE1L GPX1
Trunk fat percentage 3.58 3 1 2.2 0.00 1.00000 GPX1 LOC651250 NUDT18
Hand grip strength (right) 3.14 2 0 0.0 0.00 1.00000 CSE1L LOC651250
Townsend deprivation index at recruitment 5.50 1 0 0.0 0.00 1.00000 PSMC3
Current tobacco smoking 2.98 2 0 0.0 0.00 1.00000 GPX1 PSMC3
Fed-up feelings 8.56 3 1 2.2 0.00 1.00000 FAM120AOS GPX1 PSMC3
Frequency of unenthusiasm / disinterest in last 2 weeks 6.96 2 0 0.0 0.00 1.00000 FAM120AOS GPX1
Taking other prescription medications 5.74 2 0 0.0 0.00 1.00000 GPX1 LOC651250
Age when periods started (menarche) 3.29 1 1 2.2 0.00 1.00000 GPX1
Heel bone mineral density (BMD) T-score, automated (left) 1.11 1 0 0.0 0.00 1.00000 FAM120AOS
Qualifications: CSEs or equivalent 2.00 1 0 0.0 0.00 1.00000 GPX1
High blood pressure 1.94 1 0 0.0 0.00 1.00000 PSMC3
Stomach or abdominal pain in last month 3.89 2 0 0.0 0.00 1.00000 NUDT18 PSMC3
Sitting height 3.55 2 2 4.4 0.00 1.00000 CSE1L PSMC3
High blood pressure (mother) 2.55 1 0 0.0 0.00 1.00000 PSMC3
Body mass index (BMI) 4.75 3 1 2.2 0.00 1.00000 GPX1 LOC651250 PSMC3
Impedance of leg (left) 1.20 1 0 0.0 0.00 1.00000 GPX1
Leg predicted mass (left) 1.26 2 0 0.0 0.00 1.00000 CSE1L GPX1
Trunk fat mass 2.90 3 1 2.2 0.00 1.00000 GPX1 LOC651250 NUDT18
Waist circumference 2.48 2 0 0.0 0.00 1.00000 GPX1 LOC651250
Nervous feelings 2.21 1 0 0.0 0.00 1.00000 PSMC3
Frequency of tenseness / restlessness in last 2 weeks 6.00 2 0 0.0 0.00 1.00000 GPX1 PSMC3
Forced vital capacity (FVC) 3.61 3 2 4.4 0.00 1.00000 CSE1L GPX1 PSMC3
Heel bone mineral density (BMD) T-score, automated (right) 1.42 1 0 0.0 0.00 1.00000 FAM120AOS
Qualifications: None of the above 7.29 3 1 2.2 0.00 1.00000 CSE1L FAM120AOS GPX1
Financial difficulties in last 2 years 6.75 3 0 0.0 0.00 1.00000 CSE1L FAM120AOS GPX1
Pain all over the body in last month 3.48 1 0 0.0 0.00 1.00000 GPX1
Medication: Ramipril 2.25 1 0 0.0 0.00 1.00000 PSMC3
Fluid intelligence score 5.01 3 0 0.0 0.00 1.00000 CSE1L GPX1 PSMC3
Neuroticism score 8.43 3 2 4.4 0.00 1.00000 FAM120AOS GPX1 PSMC3
Weight 2.36 2 1 2.2 0.00 1.00000 GPX1 LOC651250
Impedance of arm (right) 3.53 2 1 2.2 0.00 1.00000 FAM120AOS GPX1
Arm fat percentage (right) 4.52 5 1 2.2 0.50 0.38793 CSE1L GPX1 LOC651250 NUDT18 PSMC3
Trunk fat-free mass 2.16 3 1 2.2 0.00 1.00000 CSE1L GPX1 PSMC3
Hip circumference 2.65 3 1 2.2 0.00 1.00000 GPX1 LOC651250 NUDT18
Alcohol intake versus 10 years previously 2.15 1 0 0.0 0.00 1.00000 GPX1
Father's age at death 3.82 1 0 0.0 0.00 1.00000 GPX1
Frequency of tiredness / lethargy in last 2 weeks 8.82 3 0 0.0 0.00 1.00000 CSE1L GPX1 PSMC3
Falls in the last year 2.56 1 0 0.0 0.00 1.00000 PSMC3
Forced expiratory volume in 1-second (FEV1) 2.88 2 1 2.2 0.00 1.00000 CSE1L GPX1
Noisy workplace 3.66 2 0 0.0 0.00 1.00000 FAM120AOS GPX1
Qualifications: A levels/AS levels or equivalent 7.92 3 1 2.2 0.00 1.00000 CSE1L FAM120AOS GPX1
Mouth/teeth dental problems: Dentures 2.31 1 0 0.0 0.00 1.00000 GPX1
Lung cancer (father) 4.00 1 0 0.0 0.00 1.00000 GPX1
Illnesses of mother 2.41 1 0 0.0 0.00 1.00000 PSMC3
Forced expiratory volume in 1-second (FEV1), Best measure 3.00 2 1 2.2 0.00 1.00000 CSE1L GPX1
Impedance of arm (left) 3.70 2 1 2.2 0.00 1.00000 FAM120AOS GPX1
Arm fat mass (right) 3.51 3 1 2.2 0.00 1.00000 GPX1 LOC651250 NUDT18
Trunk predicted mass 2.10 3 1 2.2 0.00 1.00000 CSE1L GPX1 PSMC3
Standing height 3.74 3 3 6.7 0.00 1.00000 CSE1L GPX1 PSMC3
Exposure to tobacco smoke at home 2.90 1 0 0.0 0.00 1.00000 GPX1
Seen doctor (GP) for nerves, anxiety, tension or depression 4.66 2 0 0.0 0.00 1.00000 GPX1 PSMC3
Ever highly irritable/argumentative for 2 days 4.13 1 0 0.0 0.00 1.00000 GPX1
Qualifications: O levels/GCSEs or equivalent 6.29 2 1 2.2 0.00 1.00000 CSE1L GPX1
Medication: Paracetamol 4.74 1 1 2.2 0.00 1.00000 GPX1
Headache pain in last month 2.63 1 0 0.0 0.00 1.00000 NUDT18
Forced vital capacity (FVC), Best measure 3.98 3 2 4.4 0.00 1.00000 CSE1L GPX1 PSMC3
Body fat percentage 4.32 3 2 4.4 0.00 1.00000 GPX1 LOC651250 NUDT18
Leg fat percentage (right) 6.05 5 1 2.2 0.76 0.13970 CSE1L FAM120AOS GPX1 LOC651250 NUDT18
Arm fat-free mass (right) 2.28 3 0 0.0 0.00 1.00000 CSE1L GPX1 PSMC3
Comparative body size at age 10 3.14 1 1 2.2 0.00 1.00000 FAM120AOS
Number of full brothers 3.29 1 0 0.0 0.00 1.00000 GPX1
Wheeze or whistling in the chest in last year 3.57 1 0 0.0 0.00 1.00000 GPX1
Age at first live birth 5.54 1 1 2.2 0.00 1.00000 GPX1
Health satisfaction 6.18 2 0 0.0 0.00 1.00000 GPX1 PSMC3
Qualifications: College or University degree 8.62 3 1 2.2 0.00 1.00000 CSE1L FAM120AOS GPX1
Medication for pain relief, constipation, heartburn 4.70 1 0 0.0 0.00 1.00000 GPX1
Neck or shoulder pain in last month 5.50 1 0 0.0 0.00 1.00000 GPX1
Medication: Seretide 50 evohaler 3.40 1 0 0.0 0.00 1.00000 GPX1
Mean time to correctly identify matches 2.19 1 0 0.0 0.00 1.00000 CSE1L
Whole body fat mass 3.50 3 2 4.4 0.00 1.00000 GPX1 LOC651250 NUDT18
Leg fat mass (right) 4.25 2 1 2.2 0.00 1.00000 GPX1 LOC651250
Arm predicted mass (right) 2.39 3 0 0.0 0.00 1.00000 CSE1L GPX1 PSMC3
Pulse rate, automated reading 0.69 1 0 0.0 0.00 1.00000 GPX1
Comparative height size at age 10 3.10 3 2 4.4 0.00 1.00000 CSE1L GPX1 PSMC3
Suffer from 'nerves' 4.61 1 1 2.2 0.00 1.00000 PSMC3
Overall health rating 8.85 3 1 2.2 0.00 1.00000 FAM120AOS GPX1 NUDT18
Chest pain or discomfort 4.22 2 0 0.0 0.00 1.00000 GPX1 PSMC3
Had major operations 2.74 1 0 0.0 0.00 1.00000 GPX1
Age at last live birth 4.81 1 1 2.2 0.00 1.00000 GPX1
Illness, injury, bereavement, stress in last 2 years 3.34 1 0 0.0 0.00 1.00000 PSMC3
Knee pain experienced in last month 2.79 1 0 0.0 0.00 1.00000 GPX1
Hypertension (Self-reported) 1.96 1 0 0.0 0.00 1.00000 PSMC3
Whole body fat-free mass 1.82 3 0 0.0 0.00 1.00000 CSE1L GPX1 PSMC3
Leg fat-free mass (right) 1.32 2 0 0.0 0.00 1.00000 CSE1L GPX1
Arm fat percentage (left) 4.36 4 1 2.2 0.58 0.41716 GPX1 LOC651250 NUDT18 PSMC3
Mood swings 9.32 3 2 4.4 0.00 1.00000 FAM120AOS GPX1 PSMC3
Long-standing illness, disability or infirmity 3.85 1 0 0.0 0.00 1.00000 FAM120AOS
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.18 1 0 0.0 0.00 1.00000 GPX1
Smoking status: Current 3.34 2 0 0.0 0.00 1.00000 GPX1 PSMC3
Whole body water mass 1.84 3 0 0.0 0.00 1.00000 CSE1L GPX1 PSMC3
Leg predicted mass (right) 1.31 2 0 0.0 0.00 1.00000 CSE1L GPX1
Arm fat mass (left) 3.43 3 1 2.2 0.00 1.00000 GPX1 LOC651250 NUDT18
Miserableness 10.70 3 1 2.2 0.00 1.00000 CSE1L GPX1 PSMC3
Guilty feelings 4.56 2 0 0.0 0.00 1.00000 FAM120AOS GPX1
Financial situation satisfaction 7.41 1 1 2.2 0.00 1.00000 GPX1
Medication: Blood pressure 1.52 1 0 0.0 0.00 1.00000 NUDT18
Pain type(s) experienced in last month: Hip pain 2.97 1 0 0.0 0.00 1.00000 FAM120AOS
Medication: Paracetamol 4.39 1 0 0.0 0.00 1.00000 GPX1
Basal metabolic rate 1.84 3 0 0.0 0.00 1.00000 CSE1L GPX1 PSMC3
Leg fat percentage (left) 6.05 4 1 2.2 0.74 0.26230 CSE1L GPX1 LOC651250 NUDT18
Arm fat-free mass (left) 2.51 3 1 2.2 0.00 1.00000 CSE1L GPX1 PSMC3
Number of operations (self-reported) 4.97 2 0 0.0 0.00 1.00000 FAM120AOS GPX1
Average weekly beer plus cider intake 3.36 1 0 0.0 0.00 1.00000 GPX1
Irritability 5.22 1 0 0.0 0.00 1.00000 GPX1
Age started oral contraceptive pill 2.71 1 0 0.0 0.00 1.00000 GPX1
Diastolic blood pressure, automated reading 2.18 1 0 0.0 0.00 1.00000 GPX1
Ever depressed for a whole week 6.45 2 0 0.0 0.00 1.00000 CSE1L GPX1
Vascular/heart problems diagnosed by doctor 2.15 1 0 0.0 0.00 1.00000 PSMC3
Pain experienced in last month 5.51 1 1 2.2 0.00 1.00000 GPX1
Alcohol drinker status: Previous 3.07 1 0 0.0 0.00 1.00000 LOC651250
Pack years of smoking 5.22 2 0 0.0 0.00 1.00000 GPX1 NUDT18
Impedance of whole body 2.40 1 1 2.2 0.00 1.00000 GPX1
Leg fat mass (left) 4.44 2 1 2.2 0.00 1.00000 GPX1 LOC651250
Arm predicted mass (left) 2.52 3 1 2.2 0.00 1.00000 CSE1L GPX1 PSMC3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.5
GTEx Artery Tibial 1 0.027 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 2 0.193 1.5
GTEx Brain Frontal Cortex BA9 1 0.108 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 1 0.051 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 1 0.061 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.5
GTEx Cells Transformed fibroblasts 2 0.048 1.4
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 2 0.097 1.4
GTEx Esophagus Gastroesophageal Junction 1 0.069 1.5
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 1 0.031 1.4
GTEx Heart Atrial Appendage 2 0.127 1.4
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.5
GTEx Lung 1 0.035 1.4
GTEx Muscle Skeletal 1 0.035 1.4
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 1 0.090 1.5
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.5
GTEx Skin Sun Exposed Lower leg 1 0.027 1.5
GTEx Small Intestine Terminal Ileum 0 0.000 1.6
GTEx Spleen 1 0.071 1.5
GTEx Stomach 0 0.000 1.4
GTEx Testis 1 0.032 1.4
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 1 0.050 1.4
METSIM Adipose 2 0.043 1.3
NTR Blood 1 0.042 1.4
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.4
YFS Blood 2 0.043 1.3
CommonMind Brain Pre-frontal Cortex 2 0.037 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.121 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.097 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.6
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.4
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 4 0.147 1.5
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 3 0.073 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 2 0.181 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4