Hub : Traits :

Loneliness, isolation

51 significantly associated models · 15 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	48702606	50085153	1	1	2.7e-07	3.2e-05	0.290	94	GPX1
2	8	21720054	22214508	1	1	5.6e-08	1.7e-06	0.799	100	NUDT18
3	9	95518076	96910958	1	1	2.0e-08	1.1e-08	0.053	88	FAM120AOS
4	11	46622392	48559571	9	1	5.6e-11	3.2e-11	0.002	78	PSMC3
5	17	65938655	66402256	1	1	1.7e-07	8.1e-07	0.026	80	LOC651250
6	20	46840115	48410403	2	1	1.8e-08	1.1e-06	0.316	96	CSE1L

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	2.13	1	0	0.0	0.00	1.00000	PSMC3
Depressed Affect (Nagel 2018)	13.28	4	3	6.7	1.00	0.00181	FAM120AOS GPX1 NUDT18 PSMC3
Depression (Nagel 2018)	7.97	3	1	2.2	0.00	1.00000	CSE1L FAM120AOS NUDT18
Intelligence (Savage-Jansen 2018)	10.41	3	2	4.4	0.00	1.00000	CSE1L FAM120AOS GPX1
Neuroticism (Nagel 2018)	8.37	4	1	2.2	1.00	0.00099	FAM120AOS GPX1 NUDT18 PSMC3
Schizophrenia (2018)	2.98	1	0	0.0	0.00	1.00000	FAM120AOS
Schizophrenia vs Biploar Disorder	4.66	1	0	0.0	0.00	1.00000	CSE1L
Worry (Nagel 2018)	3.98	1	0	0.0	0.00	1.00000	PSMC3
Alzheimer’s Disease (including proxy)	2.29	1	0	0.0	0.00	1.00000	PSMC3
Crohns Disease (2017)	3.11	1	1	2.2	0.00	1.00000	GPX1
Irritable Bowel Disease (IBD)	4.36	1	1	2.2	0.00	1.00000	GPX1
Ulcerative Colitis (UC)	3.98	1	1	2.2	0.00	1.00000	GPX1
Major Depression (MDD)	10.50	2	0	0.0	0.00	1.00000	FAM120AOS GPX1
Reaction Time	1.79	1	0	0.0	0.00	1.00000	CSE1L
Verbal and Numeric Reasoning (VNR)	9.90	3	3	6.7	0.00	1.00000	CSE1L FAM120AOS GPX1
Prostate Cancer	3.42	1	0	0.0	0.00	1.00000	GPX1
Age at First Birth	5.71	1	1	2.2	0.00	1.00000	GPX1
Neuroticism (2016)	5.42	2	0	0.0	0.00	1.00000	GPX1 PSMC3
Ulcerative Colitis	6.14	1	1	2.2	0.00	1.00000	GPX1
Blood Eosinophil Count	1.90	2	1	2.2	0.00	1.00000	GPX1 LOC651250
Blood Platelet Count	0.63	1	0	0.0	0.00	1.00000	FAM120AOS
Blood Red Count	1.09	2	1	2.2	0.00	1.00000	CSE1L PSMC3
Blood White Count	3.42	2	1	2.2	0.00	1.00000	GPX1 PSMC3
Heel T-Score	1.94	2	1	2.2	0.00	1.00000	FAM120AOS PSMC3
BMI	3.59	3	1	2.2	0.00	1.00000	GPX1 LOC651250 PSMC3
Height	3.54	4	4	8.9	0.31	0.69089	CSE1L GPX1 LOC651250 PSMC3
Waist Hip Ratio (WHR)	1.51	1	1	2.2	0.00	1.00000	GPX1
Systolic Blood Pressure	3.77	2	1	2.2	0.00	1.00000	GPX1 PSMC3
Smoking Status	3.51	2	1	2.2	0.00	1.00000	GPX1 PSMC3
Allergy or Eczema	1.56	1	0	0.0	0.00	1.00000	CSE1L
Cardiovascular Disease	2.92	3	1	2.2	0.00	1.00000	GPX1 NUDT18 PSMC3
Hypothyroidism (self reported)	2.10	1	0	0.0	0.00	1.00000	PSMC3
Type 2 Diabetes (T2D) (2018)	1.45	1	0	0.0	0.00	1.00000	LOC651250
Lung FEV1/FVC ratio	2.30	2	1	2.2	0.00	1.00000	FAM120AOS LOC651250
Lung FVC	1.80	2	0	0.0	0.00	1.00000	GPX1 LOC651250
Neuroticism	9.14	4	2	4.4	1.00	0.00033	FAM120AOS GPX1 NUDT18 PSMC3
Chronotype (morning person)	2.14	2	0	0.0	0.00	1.00000	FAM120AOS GPX1
Tanning	0.32	1	0	0.0	0.00	1.00000	PSMC3
Hand grip strength (left)	2.16	1	0	0.0	0.00	1.00000	LOC651250
Number of treatments/medications taken	4.18	1	0	0.0	0.00	1.00000	GPX1
Frequency of depressed mood in last 2 weeks	9.94	4	0	0.0	-0.58	0.42491	CSE1L FAM120AOS NUDT18 PSMC3
Hearing difficulty/problems: Yes	3.71	1	0	0.0	0.00	1.00000	FAM120AOS
Ever used hormone-replacement therapy (HRT)	4.49	2	0	0.0	0.00	1.00000	LOC651250 PSMC3
Systolic blood pressure, automated reading	2.83	1	1	2.2	0.00	1.00000	GPX1
Medication for hormone replacement therapy	4.01	1	0	0.0	0.00	1.00000	LOC651250
Medication: Co-codamol	3.86	2	0	0.0	0.00	1.00000	FAM120AOS GPX1
Pack years adult smoking proportion	5.66	2	0	0.0	0.00	1.00000	GPX1 NUDT18
Impedance of leg (right)	1.20	1	1	2.2	0.00	1.00000	GPX1
Leg fat-free mass (left)	1.31	2	0	0.0	0.00	1.00000	CSE1L GPX1
Trunk fat percentage	3.58	3	1	2.2	0.00	1.00000	GPX1 LOC651250 NUDT18
Hand grip strength (right)	3.14	2	0	0.0	0.00	1.00000	CSE1L LOC651250
Townsend deprivation index at recruitment	5.50	1	0	0.0	0.00	1.00000	PSMC3
Current tobacco smoking	2.98	2	0	0.0	0.00	1.00000	GPX1 PSMC3
Fed-up feelings	8.56	3	1	2.2	0.00	1.00000	FAM120AOS GPX1 PSMC3
Frequency of unenthusiasm / disinterest in last 2 weeks	6.96	2	0	0.0	0.00	1.00000	FAM120AOS GPX1
Taking other prescription medications	5.74	2	0	0.0	0.00	1.00000	GPX1 LOC651250
Age when periods started (menarche)	3.29	1	1	2.2	0.00	1.00000	GPX1
Heel bone mineral density (BMD) T-score, automated (left)	1.11	1	0	0.0	0.00	1.00000	FAM120AOS
Qualifications: CSEs or equivalent	2.00	1	0	0.0	0.00	1.00000	GPX1
High blood pressure	1.94	1	0	0.0	0.00	1.00000	PSMC3
Stomach or abdominal pain in last month	3.89	2	0	0.0	0.00	1.00000	NUDT18 PSMC3
Sitting height	3.55	2	2	4.4	0.00	1.00000	CSE1L PSMC3
High blood pressure (mother)	2.55	1	0	0.0	0.00	1.00000	PSMC3
Body mass index (BMI)	4.75	3	1	2.2	0.00	1.00000	GPX1 LOC651250 PSMC3
Impedance of leg (left)	1.20	1	0	0.0	0.00	1.00000	GPX1
Leg predicted mass (left)	1.26	2	0	0.0	0.00	1.00000	CSE1L GPX1
Trunk fat mass	2.90	3	1	2.2	0.00	1.00000	GPX1 LOC651250 NUDT18
Waist circumference	2.48	2	0	0.0	0.00	1.00000	GPX1 LOC651250
Nervous feelings	2.21	1	0	0.0	0.00	1.00000	PSMC3
Frequency of tenseness / restlessness in last 2 weeks	6.00	2	0	0.0	0.00	1.00000	GPX1 PSMC3
Forced vital capacity (FVC)	3.61	3	2	4.4	0.00	1.00000	CSE1L GPX1 PSMC3
Heel bone mineral density (BMD) T-score, automated (right)	1.42	1	0	0.0	0.00	1.00000	FAM120AOS
Qualifications: None of the above	7.29	3	1	2.2	0.00	1.00000	CSE1L FAM120AOS GPX1
Financial difficulties in last 2 years	6.75	3	0	0.0	0.00	1.00000	CSE1L FAM120AOS GPX1
Pain all over the body in last month	3.48	1	0	0.0	0.00	1.00000	GPX1
Medication: Ramipril	2.25	1	0	0.0	0.00	1.00000	PSMC3
Fluid intelligence score	5.01	3	0	0.0	0.00	1.00000	CSE1L GPX1 PSMC3
Neuroticism score	8.43	3	2	4.4	0.00	1.00000	FAM120AOS GPX1 PSMC3
Weight	2.36	2	1	2.2	0.00	1.00000	GPX1 LOC651250
Impedance of arm (right)	3.53	2	1	2.2	0.00	1.00000	FAM120AOS GPX1
Arm fat percentage (right)	4.52	5	1	2.2	0.50	0.38793	CSE1L GPX1 LOC651250 NUDT18 PSMC3
Trunk fat-free mass	2.16	3	1	2.2	0.00	1.00000	CSE1L GPX1 PSMC3
Hip circumference	2.65	3	1	2.2	0.00	1.00000	GPX1 LOC651250 NUDT18
Alcohol intake versus 10 years previously	2.15	1	0	0.0	0.00	1.00000	GPX1
Father's age at death	3.82	1	0	0.0	0.00	1.00000	GPX1
Frequency of tiredness / lethargy in last 2 weeks	8.82	3	0	0.0	0.00	1.00000	CSE1L GPX1 PSMC3
Falls in the last year	2.56	1	0	0.0	0.00	1.00000	PSMC3
Forced expiratory volume in 1-second (FEV1)	2.88	2	1	2.2	0.00	1.00000	CSE1L GPX1
Noisy workplace	3.66	2	0	0.0	0.00	1.00000	FAM120AOS GPX1
Qualifications: A levels/AS levels or equivalent	7.92	3	1	2.2	0.00	1.00000	CSE1L FAM120AOS GPX1
Mouth/teeth dental problems: Dentures	2.31	1	0	0.0	0.00	1.00000	GPX1
Lung cancer (father)	4.00	1	0	0.0	0.00	1.00000	GPX1
Illnesses of mother	2.41	1	0	0.0	0.00	1.00000	PSMC3
Forced expiratory volume in 1-second (FEV1), Best measure	3.00	2	1	2.2	0.00	1.00000	CSE1L GPX1
Impedance of arm (left)	3.70	2	1	2.2	0.00	1.00000	FAM120AOS GPX1
Arm fat mass (right)	3.51	3	1	2.2	0.00	1.00000	GPX1 LOC651250 NUDT18
Trunk predicted mass	2.10	3	1	2.2	0.00	1.00000	CSE1L GPX1 PSMC3
Standing height	3.74	3	3	6.7	0.00	1.00000	CSE1L GPX1 PSMC3
Exposure to tobacco smoke at home	2.90	1	0	0.0	0.00	1.00000	GPX1
Seen doctor (GP) for nerves, anxiety, tension or depression	4.66	2	0	0.0	0.00	1.00000	GPX1 PSMC3
Ever highly irritable/argumentative for 2 days	4.13	1	0	0.0	0.00	1.00000	GPX1
Qualifications: O levels/GCSEs or equivalent	6.29	2	1	2.2	0.00	1.00000	CSE1L GPX1
Medication: Paracetamol	4.74	1	1	2.2	0.00	1.00000	GPX1
Headache pain in last month	2.63	1	0	0.0	0.00	1.00000	NUDT18
Forced vital capacity (FVC), Best measure	3.98	3	2	4.4	0.00	1.00000	CSE1L GPX1 PSMC3
Body fat percentage	4.32	3	2	4.4	0.00	1.00000	GPX1 LOC651250 NUDT18
Leg fat percentage (right)	6.05	5	1	2.2	0.76	0.13970	CSE1L FAM120AOS GPX1 LOC651250 NUDT18
Arm fat-free mass (right)	2.28	3	0	0.0	0.00	1.00000	CSE1L GPX1 PSMC3
Comparative body size at age 10	3.14	1	1	2.2	0.00	1.00000	FAM120AOS
Number of full brothers	3.29	1	0	0.0	0.00	1.00000	GPX1
Wheeze or whistling in the chest in last year	3.57	1	0	0.0	0.00	1.00000	GPX1
Age at first live birth	5.54	1	1	2.2	0.00	1.00000	GPX1
Health satisfaction	6.18	2	0	0.0	0.00	1.00000	GPX1 PSMC3
Qualifications: College or University degree	8.62	3	1	2.2	0.00	1.00000	CSE1L FAM120AOS GPX1
Medication for pain relief, constipation, heartburn	4.70	1	0	0.0	0.00	1.00000	GPX1
Neck or shoulder pain in last month	5.50	1	0	0.0	0.00	1.00000	GPX1
Medication: Seretide 50 evohaler	3.40	1	0	0.0	0.00	1.00000	GPX1
Mean time to correctly identify matches	2.19	1	0	0.0	0.00	1.00000	CSE1L
Whole body fat mass	3.50	3	2	4.4	0.00	1.00000	GPX1 LOC651250 NUDT18
Leg fat mass (right)	4.25	2	1	2.2	0.00	1.00000	GPX1 LOC651250
Arm predicted mass (right)	2.39	3	0	0.0	0.00	1.00000	CSE1L GPX1 PSMC3
Pulse rate, automated reading	0.69	1	0	0.0	0.00	1.00000	GPX1
Comparative height size at age 10	3.10	3	2	4.4	0.00	1.00000	CSE1L GPX1 PSMC3
Suffer from 'nerves'	4.61	1	1	2.2	0.00	1.00000	PSMC3
Overall health rating	8.85	3	1	2.2	0.00	1.00000	FAM120AOS GPX1 NUDT18
Chest pain or discomfort	4.22	2	0	0.0	0.00	1.00000	GPX1 PSMC3
Had major operations	2.74	1	0	0.0	0.00	1.00000	GPX1
Age at last live birth	4.81	1	1	2.2	0.00	1.00000	GPX1
Illness, injury, bereavement, stress in last 2 years	3.34	1	0	0.0	0.00	1.00000	PSMC3
Knee pain experienced in last month	2.79	1	0	0.0	0.00	1.00000	GPX1
Hypertension (Self-reported)	1.96	1	0	0.0	0.00	1.00000	PSMC3
Whole body fat-free mass	1.82	3	0	0.0	0.00	1.00000	CSE1L GPX1 PSMC3
Leg fat-free mass (right)	1.32	2	0	0.0	0.00	1.00000	CSE1L GPX1
Arm fat percentage (left)	4.36	4	1	2.2	0.58	0.41716	GPX1 LOC651250 NUDT18 PSMC3
Mood swings	9.32	3	2	4.4	0.00	1.00000	FAM120AOS GPX1 PSMC3
Long-standing illness, disability or infirmity	3.85	1	0	0.0	0.00	1.00000	FAM120AOS
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.18	1	0	0.0	0.00	1.00000	GPX1
Smoking status: Current	3.34	2	0	0.0	0.00	1.00000	GPX1 PSMC3
Whole body water mass	1.84	3	0	0.0	0.00	1.00000	CSE1L GPX1 PSMC3
Leg predicted mass (right)	1.31	2	0	0.0	0.00	1.00000	CSE1L GPX1
Arm fat mass (left)	3.43	3	1	2.2	0.00	1.00000	GPX1 LOC651250 NUDT18
Miserableness	10.70	3	1	2.2	0.00	1.00000	CSE1L GPX1 PSMC3
Guilty feelings	4.56	2	0	0.0	0.00	1.00000	FAM120AOS GPX1
Financial situation satisfaction	7.41	1	1	2.2	0.00	1.00000	GPX1
Medication: Blood pressure	1.52	1	0	0.0	0.00	1.00000	NUDT18
Pain type(s) experienced in last month: Hip pain	2.97	1	0	0.0	0.00	1.00000	FAM120AOS
Medication: Paracetamol	4.39	1	0	0.0	0.00	1.00000	GPX1
Basal metabolic rate	1.84	3	0	0.0	0.00	1.00000	CSE1L GPX1 PSMC3
Leg fat percentage (left)	6.05	4	1	2.2	0.74	0.26230	CSE1L GPX1 LOC651250 NUDT18
Arm fat-free mass (left)	2.51	3	1	2.2	0.00	1.00000	CSE1L GPX1 PSMC3
Number of operations (self-reported)	4.97	2	0	0.0	0.00	1.00000	FAM120AOS GPX1
Average weekly beer plus cider intake	3.36	1	0	0.0	0.00	1.00000	GPX1
Irritability	5.22	1	0	0.0	0.00	1.00000	GPX1
Age started oral contraceptive pill	2.71	1	0	0.0	0.00	1.00000	GPX1
Diastolic blood pressure, automated reading	2.18	1	0	0.0	0.00	1.00000	GPX1
Ever depressed for a whole week	6.45	2	0	0.0	0.00	1.00000	CSE1L GPX1
Vascular/heart problems diagnosed by doctor	2.15	1	0	0.0	0.00	1.00000	PSMC3
Pain experienced in last month	5.51	1	1	2.2	0.00	1.00000	GPX1
Alcohol drinker status: Previous	3.07	1	0	0.0	0.00	1.00000	LOC651250
Pack years of smoking	5.22	2	0	0.0	0.00	1.00000	GPX1 NUDT18
Impedance of whole body	2.40	1	1	2.2	0.00	1.00000	GPX1
Leg fat mass (left)	4.44	2	1	2.2	0.00	1.00000	GPX1 LOC651250
Arm predicted mass (left)	2.52	3	1	2.2	0.00	1.00000	CSE1L GPX1 PSMC3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	1	0.029	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.5
GTEx	Artery Tibial	1	0.027	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Cortex	2	0.193	1.5
GTEx	Brain Frontal Cortex BA9	1	0.108	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Breast Mammary Tissue	1	0.051	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.4
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.5
GTEx	Cells Transformed fibroblasts	2	0.048	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Colon Transverse	2	0.097	1.4
GTEx	Esophagus Gastroesophageal Junction	1	0.069	1.5
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Esophagus Muscularis	1	0.031	1.4
GTEx	Heart Atrial Appendage	2	0.127	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Liver	0	0.000	1.5
GTEx	Lung	1	0.035	1.4
GTEx	Muscle Skeletal	1	0.035	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	1	0.090	1.5
GTEx	Prostate	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.5
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.6
GTEx	Spleen	1	0.071	1.5
GTEx	Stomach	0	0.000	1.4
GTEx	Testis	1	0.032	1.4
GTEx	Thyroid	0	0.000	1.3
GTEx	Uterus	0	0.000	1.5
GTEx	Vagina	0	0.000	1.4
GTEx	Whole Blood	1	0.050	1.4
METSIM	Adipose	2	0.043	1.3
NTR	Blood	1	0.042	1.4
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.4
YFS	Blood	2	0.043	1.3
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	4	0.147	1.5
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	3	0.073	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	2	0.181	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4