[Hub]/) : Traits : Guilty feelings : ← →

chr17:42,774,693-43,913,030

Best TWAS P=9.32e-09 · Best GWAS P=1.84e-07 conditioned to 0.0838

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CRHR1	0.31	0.52	lasso	11	0.52	9.4e-49	5.0	5.1	2.8e-07	0.66	0.01	0.98	FALSE
2	GTEx	Adipose Subcutaneous	LRRC37A4P	0.32	0.48	enet	15	0.48	1.5e-44	5.1	-5.3	1.2e-07	-0.71	0.01	0.98	FALSE
3	GTEx	Artery Aorta	LRRC37A4P	0.43	0.50	lasso	8	0.51	7.2e-32	5.1	-5.2	2.0e-07	-0.64	0.01	0.98	FALSE
4	GTEx	Artery Aorta	RP11-669E14.6	0.05	0.06	enet	12	0.05	1.0e-03	5.1	-5.2	2.6e-07	-0.68	0.01	0.96	FALSE
5	GTEx	Artery Coronary	CRHR1-IT1	0.51	0.65	lasso	10	0.67	9.9e-30	5.1	5.2	2.2e-07	0.67	0.01	0.98	FALSE
6	GTEx	Artery Coronary	LRRC37A4P	0.46	0.25	enet	37	0.33	5.3e-12	5.1	-5.6	2.8e-08	-0.80	0.02	0.98	FALSE
7	GTEx	Artery Tibial	LRRC37A4P	0.31	0.37	lasso	10	0.36	8.9e-30	5.1	-5.2	2.0e-07	-0.68	0.01	0.98	FALSE
8	GTEx	Brain Cerebellum	PLEKHM1	0.41	0.44	enet	19	0.45	6.8e-15	5.0	-5.7	9.3e-09	-0.69	0.01	0.98	TRUE
9	GTEx	Brain Frontal Cortex BA9	LRRC37A4P	0.48	0.52	lasso	12	0.50	3.4e-15	5.1	-5.1	2.7e-07	-0.64	0.01	0.98	FALSE
10	GTEx	Brain Hypothalamus	CRHR1-IT1	0.12	0.03	lasso	9	-0.01	4.7e-01	5.1	5.2	2.1e-07	0.64	0.01	0.76	FALSE
11	GTEx	Brain Putamen basal ganglia	CRHR1-IT1	0.14	0.22	enet	11	0.21	1.2e-05	5.1	5.3	1.4e-07	0.63	0.01	0.93	FALSE
12	GTEx	Breast Mammary Tissue (Male)	CRHR1-IT1	0.35	0.41	lasso	11	0.41	1.5e-10	5.0	5.2	2.6e-07	0.64	0.01	0.98	FALSE
13	GTEx	Breast Mammary Tissue (Male)	RP11-669E14.6	0.05	0.02	enet	12	0.00	3.9e-01	5.1	-5.2	2.4e-07	-0.76	0.00	0.26	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	ARHGAP27	0.23	0.22	lasso	7	0.20	3.0e-07	5.1	-5.2	1.8e-07	-0.65	0.02	0.98	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	CRHR1-IT1	0.18	0.22	lasso	4	0.22	1.0e-07	5.1	5.2	1.9e-07	0.64	0.01	0.98	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	LRRC37A4P	0.52	0.64	lasso	4	0.62	2.0e-25	5.1	-5.1	2.6e-07	-0.64	0.01	0.98	FALSE
17	GTEx	Cells Transformed fibroblasts	CRHR1	0.37	0.63	enet	25	0.63	6.5e-61	5.0	5.1	2.8e-07	0.68	0.01	0.98	FALSE
18	GTEx	Cells Transformed fibroblasts	CRHR1-IT1	0.49	0.71	enet	23	0.71	2.3e-75	5.0	5.1	2.8e-07	0.67	0.01	0.98	FALSE
19	GTEx	Colon Sigmoid	CRHR1	0.32	0.49	lasso	13	0.46	3.0e-18	5.1	5.2	2.6e-07	0.64	0.01	0.98	FALSE
20	GTEx	Colon Transverse	CRHR1	0.29	0.29	lasso	4	0.30	1.8e-14	5.0	5.1	2.7e-07	0.64	0.01	0.98	FALSE
21	GTEx	Esophagus Mucosa	LRRC37A4P	0.36	0.26	lasso	8	0.27	4.0e-18	5.0	-5.2	2.6e-07	-0.63	0.01	0.98	FALSE
22	GTEx	Esophagus Muscularis	LRRC37A4P	0.47	0.52	lasso	6	0.54	8.7e-39	5.1	-5.4	5.4e-08	-0.76	0.01	0.98	FALSE
23	GTEx	Heart Left Ventricle	LRRC37A4P	0.31	0.43	lasso	9	0.42	2.0e-24	5.0	-5.2	1.7e-07	-0.67	0.01	0.98	FALSE
24	GTEx	Lung	LRRC37A4P	0.45	0.54	enet	25	0.54	1.0e-48	5.0	-5.2	2.1e-07	-0.67	0.01	0.98	FALSE
25	GTEx	Muscle Skeletal	MAPT	0.06	0.03	enet	9	0.06	8.7e-07	5.0	-5.2	1.6e-07	-0.76	0.02	0.98	FALSE
26	GTEx	Muscle Skeletal	CRHR1-IT1	0.18	0.34	lasso	3	0.33	2.9e-33	5.1	5.2	2.6e-07	0.65	0.01	0.98	FALSE
27	GTEx	Pancreas	LRRC37A4P	0.41	0.53	lasso	4	0.54	9.1e-27	5.1	-5.2	2.0e-07	-0.72	0.01	0.98	FALSE
28	GTEx	Pituitary	CRHR1-IT1	0.33	0.43	lasso	5	0.44	1.6e-12	5.0	5.2	2.0e-07	0.66	0.01	0.98	FALSE
29	GTEx	Prostate	LRRC37A4P	0.42	0.39	enet	32	0.38	1.2e-10	5.0	-5.3	1.3e-07	-0.77	0.01	0.98	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	LRRC37A4P	0.45	0.47	enet	34	0.50	6.3e-31	5.0	-5.2	2.2e-07	-0.64	0.01	0.98	FALSE
31	GTEx	Skin Sun Exposed Lower leg	CRHR1	0.31	0.42	lasso	10	0.42	8.9e-38	5.1	5.2	2.1e-07	0.67	0.01	0.98	FALSE
32	GTEx	Skin Sun Exposed Lower leg	CRHR1-IT1	0.40	0.64	lasso	7	0.64	5.9e-69	5.0	5.1	3.0e-07	0.65	0.01	0.98	FALSE
33	GTEx	Small Intestine Terminal Ileum	CRHR1-IT1	0.32	0.41	lasso	8	0.38	1.6e-09	5.1	5.3	1.1e-07	0.72	0.01	0.98	FALSE
34	GTEx	Spleen	CRHR1	0.29	0.36	enet	16	0.34	1.7e-09	5.1	5.4	5.1e-08	0.75	0.01	0.98	FALSE
35	GTEx	Stomach	LRRC37A4P	0.31	0.41	lasso	9	0.43	3.9e-22	5.1	-5.3	1.5e-07	-0.69	0.01	0.98	FALSE
36	GTEx	Testis	CRHR1	0.14	0.19	lasso	7	0.18	2.6e-08	5.1	5.3	1.3e-07	0.70	0.01	0.98	FALSE
37	GTEx	Testis	MAPT	0.32	0.54	enet	19	0.54	9.4e-28	5.1	5.2	1.8e-07	0.65	0.01	0.98	FALSE
38	GTEx	Testis	PLEKHM1	0.14	0.10	lasso	12	0.07	5.5e-04	5.1	-5.4	8.0e-08	-0.64	0.02	0.96	FALSE
39	GTEx	Thyroid	LRRC37A4P	0.56	0.56	enet	52	0.60	6.3e-57	5.1	-5.4	5.3e-08	-0.68	0.01	0.98	FALSE
40	GTEx	Uterus	MAPT	0.19	0.04	enet	16	0.08	1.1e-02	5.0	-5.3	9.0e-08	-0.84	0.01	0.76	FALSE
41	GTEx	Uterus	CRHR1-IT1	0.54	0.66	enet	19	0.69	4.4e-19	5.1	5.2	2.4e-07	0.75	0.01	0.98	FALSE
42	GTEx	Uterus	LRRC37A4P	0.43	0.47	lasso	12	0.46	9.5e-11	5.1	-5.1	3.1e-07	-0.64	0.01	0.98	FALSE