Hub : Genes

ARHGAP27

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.056 0.022 4.5e-04 0.041 0.024 0.034 0.031 0.034 8.9e-06 0.00053 4.5e-05 9.8e-05 4.6e-05
2 GTEx Brain Nucleus accumbens basal ganglia 0.263 0.103 1.2e-03 0.157 NA 0.077 NA 0.123 5.5e-05 NA 4.2e-03 NA 3.5e-04
3 GTEx Cells EBV-transformed lymphocytes 0.227 0.066 3.5e-05 0.221 NA 0.192 NA 0.204 8.7e-08 NA 7.1e-07 NA 3.0e-07
4 GTEx Esophagus Mucosa 0.074 0.029 1.5e-03 0.091 NA 0.055 NA 0.072 1.1e-06 NA 1.5e-04 NA 1.5e-05
5 GTEx Skin Not Sun Exposed Suprapubic 0.245 0.057 6.1e-09 0.268 NA 0.267 NA 0.273 5.3e-15 NA 6.1e-15 NA 2.9e-15
6 GTEx Skin Sun Exposed Lower leg 0.200 0.046 8.6e-12 0.215 NA 0.208 NA 0.210 1.2e-17 NA 4.2e-17 NA 3.1e-17
7 GTEx Testis 0.264 0.076 3.0e-06 0.098 NA 0.088 NA 0.110 3.9e-05 NA 1.0e-04 NA 1.5e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.6 1.0 1.5 0.2 1.2 -1.2 -1.1 1.2 1.1 -0.4
Bipolar Disorder or Schizophrenia 0.7 1.6 2.7 -1.6 -0.9 1.4 1.6 -0.8 -1.0 1.2
Depressed Affect (Nagel 2018) 32.6 68.6 89.9 6.8 9.2 -9.5 -9.4 7.8 8.4 -6.3
Depression (Nagel 2018) 9.0 13.6 17.8 3.2 4.2 -4.1 -4.1 3.6 3.9 -2.3
Intelligence (Savage-Jansen 2018) 7.3 22.5 24.8 -3.6 -4.9 4.9 4.9 -4.8 -5.0 5.0
Neuroticism (Nagel 2018) 39.9 93.9 124.3 8.1 10.5 -11.1 -10.9 9.3 9.9 -7.4
Schizophrenia (2018) 2.8 5.8 8.5 -2.5 -2.1 2.8 2.9 -2.1 -2.2 2.0
Schizophrenia vs Biploar Disorder 8.2 10.8 15.3 -3.0 -3.3 3.9 3.8 -2.9 -3.1 2.8
Worry (Nagel 2018) 21.0 44.2 57.8 5.0 7.4 -7.6 -7.4 6.5 6.9 -5.3
Alzheimer’s Disease (in mother) 0.2 0.2 1.0 0.1 0.1 -0.1 0.1 0.4 0.3 -1.0
Alzheimer’s Disease (in father) 1.3 1.5 2.9 -1.2 -0.9 1.1 1.0 -1.1 -1.3 1.7
Alzheimer’s Disease (including proxy) 0.5 0.7 3.0 -1.0 -0.6 0.6 1.7 -0.3 -0.6 0.2
Crohns Disease (2017) 3.3 7.2 8.9 -2.1 -2.6 2.8 2.8 -2.7 -2.6 3.0
Irritable Bowel Disease (IBD) 2.6 6.2 7.5 -1.8 -2.5 2.7 2.7 -2.5 -2.5 2.6
Ulcerative Colitis (UC) 1.5 2.8 3.5 -1.2 -1.7 1.8 1.9 -1.7 -1.7 1.4
Major Depression (MDD) 1.7 2.1 6.5 0.4 0.8 -0.5 -0.4 1.9 1.7 -2.5
Reaction Time 0.2 0.3 0.8 -0.4 0.3 -0.9 -0.8 -0.2 0.0 0.6
Verbal and Numeric Reasoning (VNR) 8.2 19.8 24.3 -3.8 -4.3 4.7 4.5 -4.3 -4.5 4.9
Breast Cancer 13.4 32.3 40.4 5.2 6.2 -6.3 -6.4 5.5 5.7 -4.4
Ovarian Cancer 37.3 49.3 54.0 -7.1 -7.2 7.1 7.1 -7.2 -7.3 6.1
Prostate Cancer 1.9 2.7 3.7 -1.7 -1.8 1.9 1.9 -1.4 -1.6 0.9
Age at First Birth 5.2 7.6 9.7 -1.8 -3.0 2.5 2.4 -3.1 -3.1 3.1
Bipolar Disorder (2011) 2.0 1.9 3.1 0.5 1.8 -1.5 -1.4 1.6 1.6 -0.9
Body Mass Index (BMI) (2010) 0.4 0.5 1.0 0.4 0.5 -0.8 -0.8 0.6 0.5 -1.0
Coronary Artery Disease (CAD) 4.7 5.6 6.7 2.5 2.6 -2.3 -2.3 2.5 2.5 -1.9
Crohns Disease (2012) 4.5 7.2 12.7 -2.1 -2.6 3.5 3.6 -2.0 -2.3 2.2
Mean Putamen Volume 10.1 11.5 14.1 2.9 3.5 -3.8 -3.6 3.1 3.3 -3.5
Fasting Glucose 1.8 2.1 2.9 -0.5 -1.4 1.5 1.7 -1.6 -1.7 1.5
HbA1C 0.7 0.8 1.6 0.7 1.1 -1.2 -1.1 0.5 0.6 -0.7
HDL Cholesterol 0.9 1.5 4.1 1.0 0.8 -0.6 -0.6 1.5 1.3 -2.0
LDL Cholesterol 3.0 4.7 6.7 2.6 2.2 -2.6 -2.5 1.9 2.1 -0.8
Lupus 7.3 11.1 15.2 -2.7 -3.3 3.4 3.5 -3.9 -3.8 2.5
Neuroticism (2016) 21.1 30.4 37.6 4.2 5.6 -5.8 -5.9 6.0 6.1 -4.7
Primary Biliary Cirrhosis 12.2 17.4 20.8 -3.5 -4.6 4.5 4.5 -4.1 -4.2 3.5
Rheumatoid Arthritis 1.1 1.5 2.5 1.0 1.2 -1.0 -1.1 1.6 1.5 -1.1
Schizophrenia (2014) 3.4 7.5 12.4 -2.4 -2.5 3.4 3.5 -2.2 -2.5 2.4
Triglycerides 1.1 1.8 3.8 -0.7 -1.3 1.1 1.0 -1.5 -1.5 2.0
Type 2 Diabetes (T2D) (2012) 1.9 2.2 3.4 -1.1 -1.7 1.2 1.0 -1.8 -1.6 1.9
Ulcerative Colitis 0.6 0.9 2.0 -1.4 -0.9 1.2 1.3 -0.6 -0.7 0.2
Blood Eosinophil Count 14.0 107.6 141.6 -8.2 -10.7 11.9 11.8 -9.4 -10.2 9.8
Blood Platelet Count 2.5 28.7 38.8 4.6 5.0 -5.1 -4.9 5.7 5.8 -6.2
Blood Red Count 40.9 395.3 475.2 17.7 21.1 -21.7 -21.8 19.4 20.1 -16.8
Blood White Count 5.0 37.1 52.9 5.7 5.7 -5.4 -5.3 7.3 6.9 -6.1
Heel T-Score 13.1 104.3 116.6 -10.1 -10.2 10.8 10.5 -10.5 -10.6 8.6
BMI 0.8 4.4 7.6 1.2 1.5 -2.2 -2.4 2.1 2.2 -2.8
Height 4.8 92.6 116.6 -10.0 -10.8 10.5 10.5 -9.0 -9.6 6.3
Waist Hip Ratio (WHR) 17.2 77.2 91.4 7.5 9.5 -9.5 -9.6 8.6 8.9 -7.7
Systolic Blood Pressure 7.2 36.1 43.2 -4.9 -6.5 6.6 6.3 -6.2 -6.1 5.2
Smoking Status 4.7 11.3 13.8 -3.0 -3.7 3.5 3.5 -3.3 -3.4 3.0
Allergy or Eczema 0.3 0.8 1.5 -0.8 -1.1 1.1 1.2 -0.6 -0.5 0.4
Cardiovascular Disease 0.5 1.6 2.2 -1.1 -1.5 1.5 1.4 -1.2 -1.2 0.9
Hypothyroidism (self reported) 2.5 5.8 7.5 2.3 2.5 -2.6 -2.5 2.7 2.7 -1.0
Respiratory disease 0.1 0.2 0.5 -0.7 -0.0 0.5 0.5 -0.3 -0.0 0.6
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.0 -0.1 1.3 -1.4 -1.4 1.2 1.3 -0.6
Lung FEV1/FVC ratio 3.3 16.7 22.9 -4.3 -4.6 4.8 4.8 -3.1 -3.6 3.0
Lung FVC 39.4 200.3 240.2 -12.3 -14.7 15.5 15.4 -14.2 -14.8 11.7
Neuroticism 38.7 93.4 118.8 7.6 10.6 -10.9 -10.6 9.6 10.1 -7.7
Chronotype (morning person) 1.6 3.7 9.5 1.0 1.8 -1.7 -1.6 1.9 1.8 -3.1
Hair Pigment 0.6 16.1 21.3 -3.3 -4.4 4.5 4.6 -3.6 -3.9 3.5
Tanning 1.0 12.7 15.8 -3.2 -3.7 3.7 3.5 -3.9 -4.0 2.8
Hand grip strength (left) 16.5 43.6 50.1 -6.7 -6.9 7.1 7.0 -6.7 -7.0 4.4
Number of treatments/medications taken 1.5 2.8 3.9 1.0 2.0 -1.8 -1.8 1.6 1.9 -1.3
Average weekly spirits intake 0.3 0.4 0.5 0.7 0.6 -0.5 -0.6 0.7 0.7 -0.5
Sensitivity / hurt feelings 45.2 77.5 93.8 7.9 9.3 -9.7 -9.5 8.7 9.0 -7.1
Frequency of depressed mood in last 2 weeks 9.0 12.6 16.8 3.3 3.9 -4.1 -4.0 3.5 3.8 -1.7
Hearing difficulty/problems: Yes 6.0 9.2 11.0 2.7 3.1 -3.3 -3.3 2.9 3.1 -2.8
Relative age of first facial hair 47.9 98.6 123.2 9.2 10.7 -11.0 -11.1 9.6 9.9 -7.4
Other serious medical condition/disability diagnosed by doctor 3.8 4.9 7.0 2.2 2.2 -2.1 -2.0 2.5 2.7 -1.7
Ever used hormone-replacement therapy (HRT) 1.1 1.5 2.3 0.8 1.1 -1.3 -1.2 1.3 1.5 -1.0
Ever had hysterectomy (womb removed) 0.9 1.1 2.1 1.5 0.9 -1.1 -1.1 0.9 1.0 -0.6
Systolic blood pressure, automated reading 8.5 24.7 34.3 -3.7 -5.9 5.8 5.7 -4.7 -4.8 3.6
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.5 -0.4 0.2 0.3 0.2 0.0 -0.3
Angina 0.0 0.0 0.1 0.2 0.3 0.0 -0.1 0.1 0.1 0.1
Medication for hormone replacement therapy 2.7 3.1 4.0 -1.5 -1.8 2.0 2.0 -1.7 -1.8 1.4
Vitamin and mineral supplements 9.2 12.5 16.9 -3.2 -3.7 4.1 4.0 -3.1 -3.6 2.8
Supplements: Zinc 3.5 3.8 6.4 1.4 2.2 -2.5 -2.5 1.6 1.9 -0.9
Medication: Co-codamol 0.2 0.2 0.4 -0.5 0.3 -0.5 -0.5 0.4 0.6 -0.3
Medication: Metformin 0.4 0.5 1.0 -0.2 0.7 -0.8 -0.8 1.0 0.8 -0.3
Diabetes (father) 1.1 1.4 2.5 1.4 1.0 -1.6 -1.6 0.9 0.9 -0.3
Diabetes (mother) 0.3 0.4 1.4 -0.2 -0.5 -0.1 -0.1 -1.2 -0.9 0.3
Severe depression (siblings) 2.2 2.5 4.2 2.0 1.9 -1.5 -1.5 1.5 1.6 -0.1
Pack years adult smoking proportion 1.5 2.2 3.0 1.7 1.4 -1.5 -1.5 1.4 1.6 -1.4
Impedance of leg (right) 3.4 16.2 21.1 -3.3 -3.8 4.5 4.6 -3.7 -3.7 4.4
Leg fat-free mass (left) 0.2 0.8 3.8 -1.1 -1.0 0.1 -0.0 -0.1 -0.2 -1.9
Trunk fat percentage 5.5 22.1 30.2 -4.6 -5.5 5.5 5.4 -4.2 -4.4 2.8
Hand grip strength (right) 12.9 35.1 40.2 -6.3 -6.2 6.3 6.3 -5.9 -6.2 3.8
Townsend deprivation index at recruitment 0.3 0.4 1.2 0.4 0.4 -0.5 -0.4 1.1 1.0 -0.2
Current tobacco smoking 0.9 1.4 2.1 -1.2 -1.3 1.3 1.4 -0.9 -1.0 1.1
Average weekly fortified wine intake 3.7 4.4 5.1 -1.8 -2.0 2.3 2.2 -2.1 -2.1 2.1
Maternal smoking around birth 0.1 0.1 0.5 -0.1 0.0 0.1 0.0 0.4 0.4 -0.7
Fed-up feelings 18.9 34.3 44.1 5.8 6.4 -6.6 -6.6 5.3 5.7 -4.1
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 6.1 2.5 2.0 -2.0 -2.0 1.9 2.0 -1.5
Relative age voice broke 30.5 46.6 55.5 5.4 7.1 -7.4 -7.4 6.9 7.2 -6.0
Taking other prescription medications 0.7 1.0 1.4 0.8 1.2 -1.1 -1.1 1.0 1.2 -0.8
Age when periods started (menarche) 5.6 13.5 16.7 3.9 3.8 -4.1 -4.1 3.5 3.7 -2.3
Bilateral oophorectomy (both ovaries removed) 2.1 2.5 3.8 1.8 1.2 -1.5 -1.4 1.4 1.5 -2.0
Heel bone mineral density (BMD) T-score, automated (left) 7.4 16.7 18.5 -4.3 -4.0 3.9 3.8 -4.2 -4.3 4.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 -0.4 -0.4 0.4 0.3 -0.8 -0.8 0.9
Qualifications: CSEs or equivalent 6.2 8.2 11.2 1.8 3.1 -3.4 -3.3 2.9 2.9 -2.5
Serious illness, injury or assault to yourself 1.0 1.2 1.5 1.2 1.0 -1.1 -1.1 1.2 1.1 -0.8
High blood pressure 4.4 12.3 15.4 -3.1 -3.9 3.8 3.8 -3.4 -3.5 2.8
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.5 -0.2 -0.3 0.3 0.4 0.3 0.4 -0.7
Multivitamins +/- minerals 4.8 6.1 8.8 2.3 2.3 -3.0 -2.8 2.0 2.4 -2.3
Stomach or abdominal pain in last month 1.4 1.7 2.6 0.9 1.6 -1.5 -1.6 1.2 1.3 -0.7
Supplements: Glucosamine 0.2 0.2 0.5 0.7 0.1 -0.6 -0.6 0.0 0.2 -0.4
Diverticular disease/diverticulitis (self-reported) 3.6 4.3 6.9 -2.0 -2.3 2.6 2.6 -1.7 -1.8 0.7
Medication: Atenolol 0.9 1.2 2.8 -1.7 -0.9 1.1 1.1 -0.7 -0.8 0.9
Medication: Levothyroxine sodium 3.7 6.3 7.8 2.7 2.6 -2.8 -2.8 2.5 2.6 -1.2
Sitting height 14.6 103.9 130.0 -9.3 -11.4 11.3 11.2 -9.9 -10.5 7.0
Chronic bronchitis/emphysema (father) 0.2 0.2 0.8 -0.9 -0.6 0.3 0.3 -0.3 -0.3 0.4
High blood pressure (mother) 2.7 3.8 5.6 -1.6 -2.3 2.2 2.4 -1.6 -1.8 1.7
Body mass index (BMI) 0.5 2.1 6.0 0.7 0.6 -1.2 -1.2 1.6 1.5 -2.4
Impedance of leg (left) 3.9 18.7 25.1 -3.4 -4.1 4.9 5.0 -3.9 -4.1 4.7
Leg predicted mass (left) 0.2 0.9 3.9 -1.1 -1.0 0.1 0.1 -0.1 -0.2 -2.0
Trunk fat mass 3.4 14.8 22.2 -4.0 -4.7 4.4 4.3 -3.4 -3.6 1.7
Waist circumference 1.6 5.7 11.6 1.0 1.7 -2.3 -2.3 2.6 2.6 -3.4
Number of incorrect matches in round 5.3 8.8 13.0 2.5 2.7 -2.5 -2.4 3.4 3.4 -3.6
Past tobacco smoking 7.6 14.0 15.4 3.8 3.6 -3.6 -3.6 3.8 3.9 -3.8
Alcohol usually taken with meals 1.0 1.7 2.3 -1.0 -1.5 1.4 1.4 -1.3 -1.4 0.9
Nervous feelings 16.6 31.0 42.9 3.9 6.2 -6.6 -6.4 5.3 5.7 -4.4
Frequency of tenseness / restlessness in last 2 weeks 23.4 36.4 47.9 5.5 6.4 -6.9 -6.8 5.6 6.1 -4.6
Hearing difficulty/problems with background noise 11.6 18.6 21.7 3.4 4.3 -4.7 -4.5 4.4 4.4 -4.3
Hair/balding pattern: Pattern 2 14.8 18.8 24.3 4.0 4.6 -4.9 -4.8 4.2 4.4 -3.3
Had menopause 0.1 0.1 0.5 0.7 -0.1 0.3 0.2 -0.0 -0.1 0.3
Had other major operations 0.2 0.2 0.9 -0.0 -0.0 -0.3 -0.1 0.5 0.6 -0.9
Forced vital capacity (FVC) 32.4 124.8 146.4 -9.8 -11.8 12.1 11.9 -11.4 -11.8 8.9
Heel bone mineral density (BMD) T-score, automated (right) 7.2 16.6 20.1 -4.5 -4.2 4.0 3.9 -4.0 -4.2 3.8
Ever unenthusiastic/disinterested for a whole week 13.6 16.7 22.8 3.1 4.8 -4.5 -4.4 4.2 4.3 -2.9
Qualifications: None of the above 2.9 6.2 8.5 1.8 2.5 -2.4 -2.4 2.5 2.7 -2.9
Financial difficulties in last 2 years 6.7 9.0 12.3 2.3 3.0 -3.1 -2.9 3.1 3.0 -3.5
Mouth/teeth dental problems 9.0 13.9 20.9 -2.0 -3.3 3.9 3.8 -3.9 -4.0 4.6
Heart attack 0.1 0.1 0.3 0.0 0.4 -0.4 -0.5 0.1 0.1 0.6
Allergy 0.2 0.4 1.0 -0.3 -0.6 0.2 0.2 -0.8 -1.0 1.0
Pain all over the body in last month 1.0 1.1 1.8 0.6 0.8 -1.0 -0.9 1.3 1.4 -1.1
Diabetes (self-reported) 0.1 0.2 0.7 -0.1 0.3 -0.2 -0.2 0.8 0.6 -0.5
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.5 0.6 0.0 -0.3 -0.2 0.4 0.5 -0.7
Medication: Ramipril 0.6 0.7 1.1 -0.5 -0.9 0.7 0.6 -1.0 -1.0 1.0
Medication: Simvastatin 0.1 0.1 0.2 -0.4 -0.1 0.4 0.3 0.5 0.2 0.3
Fluid intelligence score 8.0 16.6 21.6 -3.5 -4.0 4.0 4.0 -4.1 -4.2 4.6
Illnesses of siblings 0.3 0.4 0.8 0.8 0.5 -0.9 -0.9 0.3 0.3 0.4
Neuroticism score 33.0 68.8 86.7 6.4 9.3 -9.3 -9.1 8.3 8.6 -6.5
Weight 0.4 1.9 4.3 -1.7 -2.1 1.3 1.3 -0.8 -0.9 -1.0
Impedance of arm (right) 8.7 40.6 47.8 -5.1 -6.1 6.9 6.9 -6.4 -6.5 6.5
Arm fat percentage (right) 0.4 1.7 3.0 -1.6 -1.7 1.5 1.5 -0.9 -1.0 -0.1
Trunk fat-free mass 0.4 2.3 9.2 0.1 0.4 -1.4 -1.4 1.3 1.1 -3.0
Hip circumference 1.2 5.1 9.9 -2.7 -3.1 2.4 2.4 -1.8 -1.9 0.4
Time employed in main current job 8.6 10.0 14.8 -2.5 -3.4 3.8 3.8 -2.7 -3.0 2.5
Alcohol intake versus 10 years previously 0.2 0.3 0.9 -0.7 0.9 -0.5 -0.5 0.1 0.2 -0.0
Father’s age at death 1.4 1.9 2.7 -0.4 -1.5 1.5 1.5 -1.3 -1.4 1.6
Worrier / anxious feelings 12.5 23.6 31.9 3.8 5.6 -5.6 -5.5 4.7 5.0 -3.3
Frequency of tiredness / lethargy in last 2 weeks 3.8 6.1 8.7 2.2 2.8 -3.0 -2.9 2.3 2.6 -1.3
Falls in the last year 5.3 7.1 8.6 2.6 2.6 -2.9 -2.9 2.6 2.7 -2.2
Hair/balding pattern: Pattern 3 47.5 70.7 83.2 -8.7 -8.9 9.1 9.1 -8.0 -8.2 6.6
Number of live births 12.3 17.4 21.9 3.4 4.7 -4.3 -4.3 4.2 4.3 -3.8
Forced expiratory volume in 1-second (FEV1) 34.7 117.1 136.9 -9.6 -11.5 11.7 11.5 -11.0 -11.4 8.7
Pulse rate 0.4 0.6 1.2 0.3 -0.6 1.1 1.0 -0.8 -0.8 0.6
Happiness 3.0 3.7 4.3 1.8 2.1 -1.9 -1.9 2.0 2.1 -1.6
Noisy workplace 9.9 12.2 13.4 2.9 3.7 -3.6 -3.7 3.4 3.6 -3.5
Qualifications: A levels/AS levels or equivalent 7.2 15.9 20.3 -2.6 -4.3 4.4 4.5 -3.8 -4.1 3.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 2.0 -0.3 0.1 0.1 0.1 -0.3 -0.3 1.4
Mouth/teeth dental problems: Dentures 0.4 0.6 1.9 -0.9 -0.1 0.1 0.3 0.9 0.7 -1.4
Asthma 0.5 0.9 1.6 -0.1 -0.5 1.3 1.1 -1.1 -0.9 1.2
Medication: Ibuprofen (e.g. Nurofen) 15.8 20.0 24.7 3.4 4.5 -4.4 -4.3 5.0 5.0 -4.5
Medication: Cholesterol lowering 0.2 0.3 0.8 0.1 0.9 -0.4 -0.4 0.7 0.5 0.3
Depression (self-reported) 3.5 4.2 7.1 0.7 2.2 -2.2 -2.1 2.7 2.6 -1.1
Medication: Lansoprazole 5.4 6.1 7.3 -2.3 -2.6 2.7 2.6 -2.5 -2.5 2.0
Prospective memory result 3.2 3.9 7.4 1.7 1.5 -1.9 -1.8 2.0 2.1 -2.7
Lung cancer (father) 0.1 0.2 0.3 -0.2 -0.4 0.5 0.6 -0.0 0.0 -0.6
Illnesses of mother 0.0 0.0 0.1 -0.4 0.0 0.2 0.2 -0.1 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 32.3 103.1 121.0 -9.2 -10.6 11.0 10.8 -10.2 -10.7 8.2
Pulse wave Arterial Stiffness index 0.3 0.3 0.6 0.4 -0.7 0.8 0.8 -0.1 -0.4 0.4
Impedance of arm (left) 10.4 48.3 58.0 -5.6 -6.7 7.6 7.6 -6.9 -7.0 7.0
Arm fat mass (right) 0.3 1.3 3.1 -1.4 -1.8 1.3 1.2 -0.5 -0.7 -0.8
Trunk predicted mass 0.4 2.2 9.0 0.0 0.4 -1.3 -1.3 1.2 1.1 -3.0
Standing height 3.4 33.3 44.4 -5.7 -6.7 6.3 6.3 -5.6 -5.9 3.4
Length of working week for main job 1.3 1.4 2.3 -1.5 -1.5 1.1 1.3 -1.0 -1.2 0.2
Exposure to tobacco smoke at home 0.7 0.8 4.9 -0.0 0.4 -0.3 -0.4 -0.6 -0.4 2.2
Breastfed as a baby 0.2 0.2 0.5 0.5 -0.3 0.3 0.1 -0.6 -0.6 0.7
Tense / ‘highly strung’ 6.8 11.2 14.0 3.0 3.6 -3.7 -3.5 3.4 3.6 -2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.7 0.2 1.3 -1.1 -1.2 0.5 0.6 0.5
Hair/balding pattern: Pattern 4 80.8 195.8 243.4 -12.3 -14.6 15.6 15.6 -13.7 -14.2 11.4
Birth weight of first child 2.3 4.2 6.2 -2.1 -2.5 1.9 1.9 -2.1 -2.2 1.5
Peak expiratory flow (PEF) 20.7 48.0 56.4 -5.1 -7.3 7.5 7.2 -7.1 -7.4 6.5
Pulse wave reflection index 2.1 2.5 4.2 1.2 1.3 -1.4 -1.2 2.1 1.8 -1.9
Ever highly irritable/argumentative for 2 days 5.9 7.1 8.7 2.3 2.7 -3.0 -2.9 2.6 2.8 -2.3
Loud music exposure frequency 1.0 1.1 2.2 -1.0 -0.7 0.9 0.8 -1.2 -1.2 1.5
Qualifications: O levels/GCSEs or equivalent 4.5 7.2 8.6 -1.3 -2.8 2.8 2.9 -2.8 -2.9 2.9
Mouth/teeth dental problems: Bleeding gums 3.0 3.8 5.8 2.0 1.7 -2.3 -2.4 1.5 1.7 -2.0
Blood clot in the leg (DVT) 0.9 1.1 2.0 0.8 0.9 -1.0 -1.0 1.2 1.4 -1.0
Medication: Paracetamol 28.1 46.6 59.4 5.2 7.5 -7.6 -7.7 6.4 7.0 -6.0
Headache pain in last month 33.4 57.4 68.2 6.5 7.8 -8.3 -8.1 7.5 7.9 -6.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.8 1.7 0.3 -0.8 -0.9 0.0 0.3 -0.7
Glaucoma (self-reported) 6.0 7.0 9.4 2.5 3.1 -2.8 -2.8 2.6 2.7 -2.1
Gout (self-reported) 5.8 8.0 9.3 -3.0 -2.8 2.6 2.6 -3.0 -3.0 2.8
Hypothyroidism/myxoedema (self-reported) 4.0 7.8 11.4 2.3 2.7 -2.9 -2.8 3.3 3.4 -1.8
Medication: Amlodipine 4.1 5.8 8.7 -3.0 -2.6 2.5 2.5 -2.3 -2.3 1.6
Medication: Ventolin 100micrograms inhaler 2.4 3.0 5.9 0.1 -1.4 1.7 1.6 -2.1 -1.9 2.4
Birth weight 0.1 0.2 1.1 1.0 0.3 -0.1 -0.1 0.2 0.1 0.2
Chronic bronchitis/emphysema (mother) 5.2 6.1 9.8 1.1 2.2 -2.4 -2.4 3.1 3.1 -2.4
High blood pressure (siblings) 4.8 7.0 11.8 -2.1 -2.9 3.4 3.4 -2.4 -2.5 1.2
Forced vital capacity (FVC), Best measure 31.8 116.2 136.9 -9.8 -11.3 11.7 11.5 -10.9 -11.3 8.6
Body fat percentage 2.4 9.5 14.4 -3.3 -3.8 3.7 3.6 -2.5 -2.6 1.2
Leg fat percentage (right) 0.3 1.0 2.2 -1.2 -1.5 1.1 1.1 -0.3 -0.4 -0.6
Arm fat-free mass (right) 0.3 1.4 7.2 -0.4 -0.3 -0.5 -0.5 1.0 0.8 -2.7
Exposure to tobacco smoke outside home 7.5 9.9 13.7 2.5 3.7 -3.6 -3.7 2.9 3.2 -2.0
Comparative body size at age 10 1.2 3.2 7.1 1.0 2.0 -2.6 -2.7 1.0 1.4 -0.7
Number of full brothers 9.2 11.6 13.5 3.1 3.4 -3.5 -3.4 3.7 3.5 -3.2
Worry too long after embarrassment 12.3 20.7 23.8 4.9 4.6 -4.8 -4.7 4.5 4.6 -3.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.9 0.0 0.7 -0.7 -0.6 0.7 0.9 0.3
Wheeze or whistling in the chest in last year 2.9 5.2 7.0 1.9 2.4 -2.6 -2.6 2.1 2.4 -1.7
Number of children fathered 1.6 1.8 2.7 1.7 1.3 -1.2 -1.2 1.4 1.3 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.2 0.7 1.0 -1.1 -1.0 1.1 1.0 -0.6
Age at first live birth 5.7 10.1 11.8 -3.0 -3.2 3.4 3.3 -3.2 -3.4 2.8
Pulse wave peak to peak time 0.2 0.2 1.2 -1.1 -0.1 -0.1 -0.1 -0.6 -0.2 0.1
Health satisfaction 2.0 2.5 3.5 1.9 1.2 -1.3 -1.3 1.9 1.8 -1.7
Shortness of breath walking on level ground 3.2 3.8 4.7 1.9 1.9 -1.8 -1.7 2.1 2.2 -2.0
Qualifications: College or University degree 11.7 37.0 44.3 -4.9 -6.6 6.5 6.7 -6.0 -6.4 5.4
Eye problems/disorders: None of the above 2.8 3.2 5.5 -2.3 -1.6 1.9 1.9 -1.6 -1.9 1.0
Mouth/teeth dental problems: Loose teeth 0.2 0.3 1.1 -1.1 -0.6 0.1 0.1 0.1 0.2 -0.5
Emphysema/chronic bronchitis 8.1 9.1 12.2 1.7 3.5 -3.5 -3.5 2.9 3.3 -2.3
Medication for pain relief, constipation, heartburn 16.8 28.8 34.9 -4.4 -5.8 5.8 5.9 -5.0 -5.5 4.9
Neck or shoulder pain in last month 1.8 2.5 3.1 -1.7 -1.6 1.7 1.8 -1.4 -1.5 1.5
Medication: Blood pressure 1.3 2.3 5.6 -2.4 -1.5 1.6 1.6 -0.9 -1.1 1.0
Angina (self-reported) 0.0 0.0 0.1 0.4 0.2 -0.0 -0.2 0.0 0.0 0.1
Migraine (self-reported) 3.1 3.8 6.1 1.3 1.6 -1.7 -1.6 2.3 2.3 -2.5
Medication: Ibuprofen 13.3 15.9 21.0 3.1 4.0 -4.0 -3.9 4.5 4.6 -3.7
Medication: Allopurinol 3.5 4.6 5.4 -2.3 -2.2 1.9 1.9 -2.3 -2.2 2.1
Medication: Omeprazole 1.4 1.7 2.4 -1.1 -1.6 1.5 1.5 -1.2 -1.2 0.8
Medication: Seretide 50 evohaler 0.5 0.6 1.0 -0.2 -0.8 1.0 0.9 -0.8 -0.8 0.4
Mean time to correctly identify matches 0.4 0.7 2.1 -0.8 -0.4 0.2 0.2 -1.0 -0.9 1.4
Heart disease (mother) 3.7 4.6 6.0 1.9 2.1 -2.3 -2.4 2.3 2.4 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 6.6 7.8 11.0 1.9 2.6 -2.8 -2.7 3.1 3.0 -3.3
Whole body fat mass 1.5 6.2 10.7 -2.9 -3.3 2.9 2.8 -1.9 -2.1 0.3
Leg fat mass (right) 0.3 1.3 2.7 -1.5 -1.6 1.2 1.1 -0.4 -0.5 -1.0
Arm predicted mass (right) 0.4 1.8 8.1 -0.1 0.0 -0.9 -0.9 1.3 1.1 -2.8
Pulse rate, automated reading 1.1 3.5 6.0 -1.6 -2.5 2.1 2.2 -1.5 -1.6 1.3
Alcohol intake frequency. 13.1 30.4 39.8 3.8 5.8 -6.3 -6.3 5.2 5.7 -5.1
Comparative height size at age 10 5.5 30.2 38.6 -5.5 -6.2 5.7 5.7 -5.7 -5.7 3.5
Number of full sisters 1.9 2.3 4.4 1.1 1.6 -1.5 -1.4 1.4 1.5 -2.1
Suffer from ‘nerves’ 8.6 13.4 17.0 2.1 3.9 -4.1 -3.9 3.8 3.9 -3.5
Overall health rating 1.0 2.1 4.1 2.0 0.8 -1.3 -1.2 1.2 1.4 -1.9
Chest pain or discomfort 0.3 0.5 1.4 -1.2 -0.8 0.8 0.8 0.3 0.2 -0.1
Had major operations 0.7 0.8 1.4 1.1 0.4 -1.2 -1.1 0.8 0.9 -0.6
Age at last live birth 2.7 4.0 4.8 -2.2 -2.1 2.2 2.2 -1.9 -2.0 1.3
Family relationship satisfaction 2.6 3.2 4.7 1.7 1.3 -1.7 -1.5 2.1 2.2 -1.8
Leg pain on walking 10.2 12.7 14.2 3.7 3.0 -3.7 -3.7 3.5 3.6 -3.8
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.3 0.8 0.8 -1.5 -1.5 0.4 0.7 -0.2
Commuting to job workplace: Car/motor vehicle 3.3 3.8 5.9 1.6 2.0 -2.3 -2.2 1.2 1.5 -2.4
Illness, injury, bereavement, stress in last 2 years 4.0 4.8 6.1 -1.9 -2.1 2.5 2.3 -2.4 -2.3 1.9
Medication: Aspirin 0.8 1.1 2.2 1.5 1.1 -1.1 -1.2 0.7 0.7 -0.6
Supplements: Vitamin C 7.9 9.3 13.0 2.8 3.2 -3.6 -3.6 2.7 3.1 -2.0
Knee pain experienced in last month 0.9 1.5 2.8 0.5 1.0 -1.1 -1.0 1.4 1.4 -1.7
Hypertension (Self-reported) 4.1 11.3 14.4 -3.1 -3.8 3.6 3.6 -3.3 -3.3 2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 6.7 7.8 9.6 -2.4 -3.1 2.7 2.7 -2.9 -2.8 2.9
Illnesses of father: Heart disease 7.0 9.7 10.8 2.8 3.3 -3.1 -3.1 3.2 3.3 -2.9
Illnesses of siblings: Diabetes 0.2 0.2 0.5 -0.0 0.4 -0.6 -0.6 0.5 0.5 -0.7
Smoking status: Previous 7.4 11.0 12.6 -3.4 -3.3 3.3 3.3 -3.4 -3.5 2.9
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.1 4.2 -1.9 -1.8 1.6 1.6 -2.0 -2.0 1.5
Whole body fat-free mass 0.3 1.5 7.7 -0.4 -0.2 -0.8 -0.8 0.8 0.6 -2.8
Leg fat-free mass (right) 0.2 0.8 4.2 -0.9 -0.8 -0.0 -0.1 0.0 -0.1 -2.0
Arm fat percentage (left) 0.8 3.1 5.2 -2.0 -2.3 2.1 2.0 -1.3 -1.4 0.3
Average weekly red wine intake 3.6 5.3 8.3 -2.1 -2.9 2.6 2.7 -1.9 -2.1 1.5
Handedness (chirality/laterality): Left-handed 18.9 22.8 28.9 -3.4 -5.1 5.4 5.2 -4.8 -4.9 4.4
Mood swings 28.9 52.2 65.9 5.8 8.1 -7.9 -7.8 7.2 7.5 -6.0
Loneliness, isolation 10.6 14.6 18.3 2.3 4.1 -4.3 -4.2 3.8 4.0 -3.7
Long-standing illness, disability or infirmity 0.8 1.2 2.1 0.4 1.2 -1.1 -1.2 1.3 1.4 -0.6
Ever had bowel cancer screening 4.1 4.8 7.2 -2.0 -2.4 2.7 2.7 -1.9 -2.1 1.3
Diabetes diagnosed by doctor 0.1 0.2 0.6 -0.8 0.1 -0.1 -0.1 0.6 0.5 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 2.7 1.6 0.1 -0.4 -0.5 0.1 0.1 0.5
Friendships satisfaction 2.1 2.6 4.5 0.8 2.1 -1.8 -1.8 1.8 1.8 -0.5
Qualifications: nursing, teaching 3.2 4.9 7.1 -0.7 -2.6 2.7 2.6 -2.0 -2.2 2.1
Commuting to job workplace: Walk 0.2 0.3 1.3 0.4 -0.3 0.4 0.3 -0.1 -0.2 1.1
Eye problems/disorders: Cataract 1.7 2.0 2.8 1.4 1.3 -1.7 -1.6 1.4 1.7 -0.4
Mouth/teeth dental problems: Mouth ulcers 20.2 32.2 41.7 4.1 5.7 -6.5 -6.4 5.6 5.9 -5.2
Medication for cholesterol 6.5 9.9 13.0 2.1 3.4 -3.6 -3.5 3.3 3.4 -2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.3 -1.1 -0.4 0.3 0.4 -0.3 -0.1 0.6
Back pain experienced in last month 0.2 0.2 0.6 -0.8 -0.4 0.4 0.4 -0.4 -0.4 0.3
Mineral and other dietary supplements 0.8 1.0 1.9 -0.6 -1.3 1.3 1.4 -0.6 -0.9 0.6
Breast cancer (self-reported) 5.7 6.7 11.0 -1.4 -3.3 3.2 3.3 -2.2 -2.5 1.4
Asthma (self-reported) 0.4 0.8 1.6 0.1 -0.3 1.1 1.0 -1.0 -0.8 1.3
Osteoporosis (self-reported) 5.6 6.9 8.3 2.6 2.9 -2.9 -2.9 2.5 2.6 -1.9
Osteoarthritis (self-reported) 0.7 0.9 2.7 0.3 0.2 -0.4 -0.2 1.3 1.3 -1.6
Medication: Aspirin 0.6 0.8 1.3 1.1 0.9 -1.0 -1.0 0.6 0.6 -0.5
Medication: Gliclazide 1.6 1.8 2.8 0.6 1.4 -1.5 -1.5 1.2 1.3 -1.7
Illnesses of father: None of the above (group 1) 3.2 4.0 5.4 -1.2 -2.2 2.0 2.1 -2.3 -2.2 1.8
Smoking status: Current 1.1 1.8 2.5 -1.3 -1.4 1.4 1.6 -1.1 -1.1 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 29.5 62.3 71.8 -6.8 -8.1 8.4 8.2 -8.3 -8.5 6.8
Whole body water mass 0.3 1.6 8.0 -0.3 -0.1 -0.9 -0.9 0.9 0.8 -2.8
Leg predicted mass (right) 0.1 0.8 4.2 -0.8 -0.7 -0.1 -0.2 0.1 -0.0 -2.1
Arm fat mass (left) 0.3 1.3 2.9 -1.4 -1.7 1.3 1.2 -0.6 -0.7 -0.7
Number of self-reported non-cancer illnesses 0.6 1.0 2.2 0.9 1.0 -0.8 -0.7 1.3 1.5 -0.3
Average weekly champagne plus white wine intake 12.4 17.0 24.6 -5.0 -4.5 4.6 4.8 -3.1 -3.5 2.8
Miserableness 13.9 24.1 35.5 3.3 5.9 -6.0 -5.8 4.5 4.9 -3.0
Guilty feelings 12.4 18.6 27.2 3.4 4.6 -5.2 -5.1 4.2 4.6 -2.5
Wears glasses or contact lenses 0.3 0.3 0.5 0.0 0.7 -0.7 -0.7 0.6 0.6 -0.1
Ever taken oral contraceptive pill 4.8 5.4 7.3 1.6 2.3 -2.4 -2.4 2.7 2.7 -1.9
Hearing aid user 2.4 2.8 5.1 0.1 2.0 -2.3 -2.2 1.4 1.6 -0.8
Mother’s age at death 0.5 0.6 2.1 1.5 -0.3 0.8 0.8 0.5 0.2 -0.7
Financial situation satisfaction 0.2 0.2 0.6 0.8 0.2 -0.5 -0.6 -0.0 0.2 0.6
Tinnitus: Yes, now most or all of the time 2.1 2.4 4.7 1.1 1.1 -1.4 -1.3 1.8 1.7 -2.2
Commuting to job workplace: Public transport 3.8 4.6 6.7 -0.8 -2.0 2.4 2.4 -1.9 -2.3 2.6
Eye problems/disorders: Glaucoma 7.3 8.6 10.4 3.0 3.2 -2.9 -2.9 2.9 3.0 -2.5
Medication: Blood pressure 11.4 21.7 25.4 -3.8 -5.0 5.0 4.9 -5.0 -5.0 3.7
Pain type(s) experienced in last month: Hip pain 4.1 5.2 5.8 2.2 2.2 -2.3 -2.2 2.4 2.4 -2.3
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.4 -0.4 0.1 -0.2 -0.4 -0.6 -0.3 0.5
High cholesterol (Self-reported) 0.8 1.5 2.2 -1.4 -0.9 1.4 1.3 -0.7 -1.0 1.5
Medication: Bendroflumethiazide 3.3 5.0 7.5 -1.3 -2.7 2.6 2.5 -2.1 -2.2 1.8
Medication: Paracetamol 28.2 43.6 56.3 5.2 7.2 -7.4 -7.5 6.2 6.8 -5.5
Medication: Lisinopril 3.5 4.5 7.2 -1.2 -2.5 1.8 1.8 -2.7 -2.4 2.0
Medication: Atorvastatin 0.1 0.2 0.5 -0.6 0.2 -0.1 -0.2 -0.4 -0.4 0.7
Illnesses of father: High blood pressure 1.4 1.7 2.3 -1.2 -1.4 1.5 1.5 -1.2 -1.2 1.1
Alcohol drinker status: Never 1.2 1.5 2.6 0.2 1.3 -1.3 -1.3 1.2 1.2 -1.6
Ever smoked 4.9 8.6 10.6 -3.0 -2.5 2.6 2.6 -3.2 -3.2 3.2
Basal metabolic rate 0.2 1.1 6.2 -0.7 -0.6 -0.4 -0.4 0.5 0.4 -2.5
Leg fat percentage (left) 0.4 1.3 2.9 -1.3 -1.7 1.4 1.4 -0.4 -0.5 -0.5
Arm fat-free mass (left) 0.4 1.9 9.4 -0.1 -0.1 -0.9 -0.9 1.2 1.0 -3.1
Number of operations (self-reported) 2.6 3.9 6.0 2.0 1.5 -2.4 -2.3 1.7 2.0 -1.6
Average weekly beer plus cider intake 3.9 5.7 7.5 -2.0 -2.6 2.2 2.1 -2.7 -2.5 2.4
Irritability 16.7 28.2 34.9 4.8 5.8 -5.9 -5.9 5.2 5.5 -3.9
Risk taking 1.1 1.6 2.3 1.3 1.4 -1.5 -1.5 1.0 1.2 -0.6
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 -0.2 0.3 0.4 0.4 0.7 0.5 -0.7
Fractured/broken bones in last 5 years 7.0 9.1 12.8 3.0 3.3 -3.6 -3.6 2.6 2.8 -1.9
Age started oral contraceptive pill 1.8 2.2 3.6 -0.5 -1.6 1.9 1.8 -1.4 -1.6 1.2
Diastolic blood pressure, automated reading 2.4 7.6 12.5 -2.1 -3.5 3.4 3.3 -2.4 -2.5 1.1
Ever depressed for a whole week 9.5 11.8 16.6 1.5 4.1 -3.9 -3.7 3.5 3.6 -3.1
Unable to work because of sickness or disability 0.2 0.3 0.5 -0.6 0.4 -0.6 -0.6 0.5 0.6 -0.7
Commuting to job workplace: Cycle 0.3 0.3 0.9 -0.1 -0.1 0.1 0.1 -0.9 -0.9 0.8
Myopia 10.1 14.6 16.6 -3.6 -3.8 3.7 3.7 -3.9 -4.1 3.9
Vascular/heart problems diagnosed by doctor 3.3 8.9 11.0 2.6 3.3 -3.2 -3.2 3.0 3.0 -2.5
Cholesterol lowering medication 1.0 1.5 2.6 -0.7 -1.2 1.5 1.3 -1.0 -1.1 1.6
Medication: Omeprazole (e.g. Zanprol) 2.7 3.3 4.2 -1.3 -2.0 2.1 2.0 -1.9 -1.9 1.2
Pain experienced in last month 9.5 15.8 17.9 -3.2 -4.0 4.2 4.2 -3.9 -4.2 4.1
Supplements: Calcium 1.0 1.1 2.0 1.4 0.9 -1.1 -1.2 1.0 1.1 -0.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.4 -0.1 0.2 -0.2 -0.2 0.5 0.6 0.2
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 -0.2 0.3 -0.4 -0.4 -0.1 -0.0 0.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.5 0.6 0.7 -0.8 -0.7 1.1 1.2 -1.0
Heart disease (siblings) 9.3 11.4 15.1 3.5 3.9 -3.4 -3.5 3.3 3.4 -2.3
Alcohol drinker status: Previous 0.2 0.3 0.9 -1.0 -0.7 0.4 0.5 0.0 0.1 -0.2
Pack years of smoking 1.7 2.5 3.5 1.9 1.4 -1.5 -1.4 1.6 1.7 -1.4
Impedance of whole body 8.7 44.1 55.7 -5.2 -6.5 7.4 7.5 -6.4 -6.5 6.8
Leg fat mass (left) 0.3 1.3 2.6 -1.5 -1.6 1.3 1.2 -0.4 -0.6 -1.0
Arm predicted mass (left) 0.3 1.4 8.2 -0.4 -0.4 -0.5 -0.5 0.8 0.6 -2.9