Hub : Genes

KL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1170	0.0340	5.3e-06	0.032	0.059	0.075	0.071	0.074	8.0e-05	9.8e-08	2.2e-09	5.8e-09	2.4e-09
2	GTEx	Pituitary	0.5950	0.1060	1.4e-04	0.056	NA	0.075	NA	0.059	1.6e-02	NA	6.1e-03	NA	1.4e-02
3	GTEx	Whole Blood	0.1210	0.0430	5.8e-04	-0.001	NA	-0.003	NA	-0.002	3.7e-01	NA	7.1e-01	NA	4.9e-01
4	YFS	Blood	0.0538	0.0148	2.0e-10	0.009	0.039	0.036	0.039	0.031	3.9e-04	7.6e-13	6.1e-12	8.4e-13	1.4e-10
5	TCGA	Brain Lower Grade Glioma	0.0802	0.0489	9.7e-03	0.004	0.025	0.009	NA	0.005	1.0e-01	6.8e-04	2.6e-02	NA	7.3e-02
6	TCGA	Pheochromocytoma and Paraganglioma	0.1950	0.1000	4.5e-03	0.118	0.042	0.091	NA	0.087	2.0e-05	8.7e-03	1.8e-04	NA	2.4e-04
7	TCGA	Prostate Adenocarcinoma	0.0852	0.0353	4.0e-04	0.038	0.032	0.029	NA	0.038	6.4e-05	2.4e-04	4.4e-04	NA	7.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.7	2.8	-0.6	-1.7	-0.9	0.6	0.1	-0.3	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.6	1.4	-0.8	-1.2	-0.4	0.6	-1.2	0.5	0.2
Depressed Affect (Nagel 2018)	0.8	1.6	5.5	1.8	0.3	1.2	2.3	0.1	0.1	-1.2
Depression (Nagel 2018)	1.6	2.4	6.1	1.7	-0.1	1.9	2.5	0.8	1.7	-0.5
Intelligence (Savage-Jansen 2018)	1.0	3.2	9.1	-3.0	-2.1	1.1	2.0	-0.1	-0.7	-1.8
Neuroticism (Nagel 2018)	0.6	1.4	5.1	2.1	0.2	0.6	2.3	0.3	0.4	0.0
Schizophrenia (2018)	0.2	0.4	1.6	-0.5	0.2	0.2	0.3	-1.3	0.8	0.6
Schizophrenia vs Biploar Disorder	0.6	0.8	2.3	1.0	1.5	1.1	1.1	-0.2	-0.2	-0.0
Worry (Nagel 2018)	0.5	1.1	5.6	2.4	-0.2	-0.7	0.8	0.6	0.0	0.6
Alzheimer’s Disease (in mother)	0.7	0.9	2.6	-1.1	-0.3	-0.2	-0.6	-1.6	1.3	0.2
Alzheimer’s Disease (in father)	0.9	1.0	6.4	0.3	0.7	0.0	0.3	-0.2	2.5	0.3
Alzheimer’s Disease (including proxy)	0.4	0.6	3.3	-0.1	-0.0	-0.4	0.3	-0.8	1.8	-0.1
Crohns Disease (2017)	0.3	0.7	3.7	0.3	0.1	0.2	-0.8	0.3	1.9	0.6
Irritable Bowel Disease (IBD)	0.5	1.1	5.6	0.3	-0.5	1.1	-0.3	0.6	2.4	0.4
Ulcerative Colitis (UC)	0.4	0.7	1.8	0.0	-0.7	1.4	0.3	0.9	1.3	0.2
Major Depression (MDD)	0.7	0.8	3.4	-0.8	-0.1	0.1	-0.1	0.2	-1.3	-1.8
Reaction Time	0.3	0.6	1.3	0.5	0.6	-1.1	-1.1	0.9	-0.0	0.6
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.6	-1.9	-2.1	0.7	1.6	-0.9	-0.1	-1.6
Breast Cancer	0.5	1.1	2.9	0.1	-1.7	0.2	-1.0	-0.7	-1.4	1.2
Ovarian Cancer	1.1	1.5	8.0	0.4	-0.4	1.1	0.7	0.5	-0.5	-2.8
Prostate Cancer	0.8	1.2	5.5	-0.0	-2.3	1.3	-0.7	0.8	0.0	-0.1
Age at First Birth	0.2	0.4	1.1	0.5	1.0	0.0	1.1	0.1	0.3	0.1
Bipolar Disorder (2011)	0.3	0.3	0.9	0.0	1.0	-0.6	-0.1	0.8	0.0	-0.2
Body Mass Index (BMI) (2010)	1.7	2.4	7.9	-1.5	0.2	2.8	2.3	-0.7	-0.4	-0.2
Coronary Artery Disease (CAD)	1.1	1.3	3.1	-1.3	-1.4	1.0	0.8	0.5	0.9	-1.7
Crohns Disease (2012)	0.6	1.0	2.3	0.6	-0.8	-0.0	-0.7	1.5	1.5	0.9
Mean Putamen Volume	0.7	0.8	2.9	-1.7	-0.4	1.3	0.1	0.4	-0.7	-0.3
Fasting Glucose	2.5	2.9	13.0	1.8	1.1	0.4	-0.2	3.6	1.3	-1.2
HbA1C	1.2	1.4	3.7	1.1	-1.9	-0.3	0.4	1.8	0.6	-1.0
HDL Cholesterol	0.2	0.3	1.5	1.2	-0.4	0.3	0.3	0.4	0.1	-0.6
LDL Cholesterol	0.9	1.4	3.4	-1.8	0.4	-0.2	0.9	-1.9	1.1	-1.0
Lupus	0.4	0.5	2.6	0.1	0.3	0.3	0.6	-0.2	-0.7	1.6
Neuroticism (2016)	0.5	0.7	2.3	0.3	1.5	-0.0	1.0	-0.9	0.5	-0.4
Primary Biliary Cirrhosis	1.0	1.4	5.2	-0.4	0.0	2.3	2.1	0.3	-0.2	-0.0
Rheumatoid Arthritis	0.8	1.1	2.8	0.1	1.7	-1.4	-1.6	0.5	0.5	0.2
Schizophrenia (2014)	0.1	0.3	0.8	0.4	-0.1	0.6	0.9	-0.6	0.4	0.3
Triglycerides	0.6	0.9	3.4	-1.8	-0.9	0.3	0.9	-1.1	-0.3	-0.3
Type 2 Diabetes (T2D) (2012)	2.3	2.7	6.7	1.1	-0.1	2.6	1.6	2.2	-0.8	-1.7
Ulcerative Colitis	0.7	1.0	3.6	0.1	-1.2	0.8	0.2	0.9	1.9	-0.1
Blood Eosinophil Count	0.1	0.8	2.0	1.4	-0.6	-0.7	-1.0	-0.2	0.2	-1.4
Blood Platelet Count	1.3	15.3	54.4	1.9	0.3	-7.4	-5.2	-1.6	0.9	-4.3
Blood Red Count	0.7	6.3	24.6	-0.6	0.8	-2.6	-2.8	0.4	-2.0	5.0
Blood White Count	0.3	2.2	6.4	-1.3	1.0	-0.8	-0.6	-2.5	-2.1	-1.1
Heel T-Score	0.5	4.0	16.6	-1.5	0.3	2.8	0.9	-0.1	0.2	4.1
BMI	1.8	10.4	52.5	-1.0	0.8	7.2	3.8	1.9	-0.8	0.3
Height	0.5	10.4	34.5	-0.8	-1.7	-5.9	-2.2	-1.1	-0.6	-5.3
Waist Hip Ratio (WHR)	0.5	2.2	8.1	0.1	1.1	-2.0	-2.8	0.1	0.2	-1.4
Systolic Blood Pressure	0.6	3.1	15.4	-0.3	-0.2	-0.1	-3.9	-0.5	1.2	-2.2
Smoking Status	0.6	1.4	4.2	-1.0	0.2	1.1	1.4	-2.1	-0.1	-1.2
Allergy or Eczema	0.5	1.3	5.0	-0.1	-0.7	-0.1	0.9	-1.1	2.2	1.3
Cardiovascular Disease	0.3	0.8	2.1	-1.4	-0.4	0.1	-1.2	0.4	0.8	1.3
Hypothyroidism (self reported)	2.0	4.6	16.8	-0.7	0.5	4.1	3.0	-0.4	-1.2	-2.0
Respiratory disease	0.1	0.2	0.4	-0.5	0.0	0.6	0.4	0.2	0.0	-0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	-0.1	0.7	0.3	1.2	0.9	-0.2	-0.2
Lung FEV1/FVC ratio	0.7	3.5	12.7	1.6	1.4	0.4	-0.3	2.6	0.2	3.6
Lung FVC	0.1	0.5	1.2	-0.7	-0.9	-0.4	0.5	-0.9	1.1	-0.3
Neuroticism	0.5	1.3	4.9	1.1	0.1	-0.1	2.2	-0.2	-0.1	-1.7
Chronotype (morning person)	0.8	1.8	3.4	-1.7	-1.7	-1.9	-1.3	-0.7	0.9	-0.5
Hair Pigment	0.1	2.9	12.5	-1.9	-1.4	-0.4	0.4	-0.1	-3.5	-1.3
Tanning	0.2	2.4	10.6	0.8	-0.3	-3.3	-1.7	0.5	-1.3	0.6
Hand grip strength (left)	1.3	3.5	15.1	-1.1	0.8	3.9	2.3	0.4	-1.0	-0.9
Number of treatments/medications taken	0.3	0.6	1.8	0.9	-1.3	0.3	1.1	0.1	0.3	0.2
Average weekly spirits intake	0.1	0.2	0.7	-0.4	0.2	0.9	0.2	0.3	-0.2	0.2
Sensitivity / hurt feelings	0.6	1.1	3.7	1.9	0.4	0.8	0.6	1.1	-1.1	0.4
Frequency of depressed mood in last 2 weeks	2.6	3.6	9.6	1.5	-0.7	2.4	3.1	0.2	2.2	-1.6
Hearing difficulty/problems: Yes	1.1	1.6	5.3	2.3	0.4	1.0	1.2	1.0	1.3	-1.0
Relative age of first facial hair	0.6	1.2	3.5	-1.9	-0.6	0.2	0.6	-0.2	-1.5	1.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	4.9	0.5	-0.4	0.4	0.9	0.3	2.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.3	-0.3	0.2	1.1	-0.7	-0.1	0.3	0.2
Ever had hysterectomy (womb removed)	0.4	0.4	1.4	-0.9	-0.2	0.3	0.2	0.7	-0.5	1.2
Systolic blood pressure, automated reading	0.6	1.8	5.2	-0.3	-0.7	2.3	-1.2	-0.1	0.4	-2.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.5	-1.6	-0.2	0.9	1.3	0.5	-0.0	-0.4
Angina	0.4	0.6	1.7	0.8	0.2	0.6	-0.4	0.4	1.3	1.0
Medication for hormone replacement therapy	0.4	0.5	1.9	0.2	-0.6	0.6	-1.4	-0.6	0.6	0.1
Vitamin and mineral supplements	0.8	1.0	4.3	0.5	2.1	0.6	-1.0	1.2	0.1	0.1
Supplements: Zinc	0.7	0.8	2.0	-1.3	0.2	-1.4	0.6	-0.0	-1.2	0.5
Medication: Co-codamol	0.7	0.8	3.3	-0.1	-0.4	1.8	1.0	-0.5	0.9	-0.5
Medication: Metformin	0.4	0.6	2.0	0.5	-0.1	-0.8	0.3	1.4	-0.5	0.8
Diabetes (father)	0.5	0.7	3.5	1.0	0.1	-0.1	1.9	0.3	-0.4	-0.1
Diabetes (mother)	0.5	0.6	1.8	-0.9	1.4	-0.7	-0.1	-0.5	-1.0	0.1
Severe depression (siblings)	0.7	0.8	2.0	-0.8	0.7	0.2	-0.5	-1.4	-1.3	0.7
Pack years adult smoking proportion	0.5	0.7	2.2	0.1	0.0	0.8	1.5	-0.6	1.3	0.0
Impedance of leg (right)	0.4	2.2	5.8	-0.5	-0.8	-2.4	-2.0	-0.8	-0.3	-1.9
Leg fat-free mass (left)	0.4	2.2	5.2	0.1	0.4	2.3	1.9	1.7	-1.4	-1.3
Trunk fat percentage	1.0	4.1	21.2	-1.0	0.5	4.6	2.3	0.8	0.0	-0.6
Hand grip strength (right)	1.3	3.5	13.2	-1.4	0.5	3.6	2.4	-0.4	-1.1	-1.5
Townsend deprivation index at recruitment	0.9	1.3	3.2	1.4	0.3	-0.2	-0.4	1.7	1.0	-1.8
Current tobacco smoking	1.3	2.2	7.9	-1.4	-0.2	-1.1	0.3	-1.0	-1.7	-2.8
Average weekly fortified wine intake	0.7	0.9	2.5	1.6	1.0	0.4	1.0	0.2	-0.0	-1.2
Maternal smoking around birth	0.3	0.4	1.4	0.2	1.2	0.8	-0.2	0.1	0.5	0.5
Fed-up feelings	0.8	1.4	4.7	0.7	0.2	-0.3	2.0	-0.1	-0.7	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.5	1.9	0.2	1.0	1.7	1.0	1.2	-0.5
Relative age voice broke	1.2	1.8	5.4	0.2	0.1	-2.2	-0.8	-0.6	-1.3	2.3
Taking other prescription medications	0.2	0.4	1.1	-0.0	-0.5	1.0	0.4	0.0	1.1	0.1
Age when periods started (menarche)	1.2	3.0	11.6	0.0	1.0	-2.7	-3.4	-0.7	0.6	-0.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.9	-0.8	-2.0	1.0	-0.4	0.6	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.6	-0.3	-0.1	0.5	-0.8	-0.8	0.3	1.2
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	5.6	-2.4	-0.9	1.2	0.2	-1.3	0.1	-0.0
Qualifications: CSEs or equivalent	1.3	1.7	3.7	1.2	-0.1	-0.4	-1.6	-1.1	1.7	-1.9
Serious illness, injury or assault to yourself	1.6	1.9	3.9	1.1	1.5	1.9	2.0	1.3	0.3	0.9
High blood pressure	0.5	1.3	3.0	-1.2	-0.4	0.4	-1.3	-0.7	1.5	1.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.1	-1.0	-0.6	0.2	0.9	-1.2	2.5	0.6
Multivitamins +/- minerals	0.7	0.9	1.8	-0.1	-0.8	-1.3	1.2	-1.4	-0.8	-0.2
Stomach or abdominal pain in last month	0.8	1.0	3.4	0.4	1.1	1.2	1.8	0.3	0.9	-0.2
Supplements: Glucosamine	0.3	0.4	0.8	-0.6	0.3	-0.6	-0.5	-0.7	0.9	-0.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.4	-1.6	-1.3	1.6	-0.4	-0.1	0.5	-0.9
Medication: Atenolol	0.5	0.6	1.2	1.1	-0.9	0.7	-0.7	0.9	0.2	0.5
Medication: Levothyroxine sodium	1.7	2.8	10.2	0.3	0.9	3.2	2.4	-0.1	-0.6	-1.7
Sitting height	0.4	2.9	11.6	-1.4	-0.5	-1.6	0.7	0.2	-1.9	-3.4
Chronic bronchitis/emphysema (father)	1.6	1.9	3.6	1.2	0.5	1.5	1.9	1.1	-1.8	-1.2
High blood pressure (mother)	0.1	0.2	0.4	-0.4	0.7	0.5	0.6	0.4	-0.0	0.3
Body mass index (BMI)	1.7	7.2	34.3	-0.7	0.8	5.9	3.4	1.8	-0.1	-0.1
Impedance of leg (left)	0.4	1.9	3.5	-0.8	-1.0	-1.9	-1.9	-1.3	0.0	-1.7
Leg predicted mass (left)	0.4	2.3	5.5	0.1	0.4	2.4	1.9	1.7	-1.5	-1.2
Trunk fat mass	1.0	4.1	20.5	-0.8	0.5	4.5	2.3	1.0	-0.2	-1.1
Waist circumference	1.1	3.9	16.3	-0.2	0.7	4.0	2.2	1.6	-0.5	-1.7
Number of incorrect matches in round	0.5	0.9	2.7	1.0	-0.0	-1.7	-0.4	-0.2	-0.6	1.3
Past tobacco smoking	0.8	1.4	2.4	0.5	1.2	-1.4	-1.5	1.4	-1.3	-0.3
Alcohol usually taken with meals	0.6	0.9	3.1	0.2	-1.2	-0.3	-0.8	1.8	-0.4	0.8
Nervous feelings	0.6	1.1	5.7	2.4	-0.5	-0.6	-0.1	1.0	-0.4	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	6.5	2.5	0.7	-0.5	0.9	0.3	1.4	-0.2
Hearing difficulty/problems with background noise	2.2	3.5	7.8	1.7	0.2	2.2	2.8	0.9	2.4	-1.5
Hair/balding pattern: Pattern 2	1.7	2.1	7.3	-0.3	-0.3	1.4	2.7	-0.1	2.1	-0.9
Had menopause	0.5	0.6	1.7	-0.5	-0.4	1.2	1.3	0.5	-0.8	-0.2
Had other major operations	1.4	1.7	6.3	-0.5	0.7	2.5	1.1	0.8	1.3	1.1
Forced vital capacity (FVC)	0.4	1.5	3.2	-1.7	0.2	-1.6	-1.4	0.1	-0.4	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.1	-0.8	-0.1	0.1	-1.4	-1.1	0.5	0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.7	0.7	-0.2	0.0	0.3	0.3	1.0	-1.3
Qualifications: None of the above	1.6	3.4	5.8	1.4	1.8	2.0	2.2	2.4	-1.5	-1.2
Financial difficulties in last 2 years	1.0	1.4	2.8	-0.2	1.4	0.5	1.4	0.4	1.7	-1.6
Mouth/teeth dental problems	0.1	0.2	0.8	-0.5	-0.2	-0.2	0.2	0.3	-0.4	0.9
Heart attack	1.1	1.4	5.2	-0.7	0.7	-0.7	-1.2	-1.3	-0.3	2.3
Allergy	1.0	2.4	6.0	1.1	-0.0	-0.9	-2.2	2.0	-2.5	0.2
Pain all over the body in last month	0.9	0.9	2.3	1.0	1.4	0.5	0.8	0.3	0.5	1.5
Diabetes (self-reported)	0.2	0.2	0.8	0.3	0.3	0.2	0.9	0.6	0.5	0.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.2	-0.0	-0.8	-1.5	0.1	-0.6	0.8	-0.5
Medication: Ramipril	0.6	0.8	3.4	0.3	0.7	0.8	-0.6	1.8	-0.6	0.2
Medication: Simvastatin	0.4	0.6	2.7	-1.6	-0.9	0.5	-0.3	-0.1	0.7	0.4
Fluid intelligence score	0.9	1.9	5.5	-2.3	-1.9	-0.1	0.7	0.0	0.0	-1.9
Illnesses of siblings	0.9	1.3	3.1	0.6	-1.7	0.8	1.8	0.4	1.0	0.8
Neuroticism score	0.6	1.2	2.8	1.7	0.1	-1.0	1.5	0.7	-0.3	-1.3
Weight	0.9	4.3	17.6	-0.7	0.6	4.2	2.5	1.4	-0.7	-1.6
Impedance of arm (right)	0.4	2.0	6.8	-0.4	0.0	-2.6	-2.0	-1.3	1.0	-0.3
Arm fat percentage (right)	1.6	6.1	30.4	-0.7	0.7	5.5	3.1	1.1	1.0	-0.3
Trunk fat-free mass	0.3	1.5	5.2	0.3	-0.7	0.9	1.4	1.0	-1.0	-2.3
Hip circumference	1.3	5.8	22.4	-0.9	-0.1	4.7	3.2	1.3	-0.8	-2.1
Time employed in main current job	0.6	0.7	2.0	0.4	-0.6	1.3	0.3	0.8	-1.4	-0.4
Alcohol intake versus 10 years previously	0.6	1.0	3.3	-0.8	1.0	1.8	1.1	-0.1	0.2	0.8
Father’s age at death	0.3	0.4	2.0	0.2	0.3	-0.4	0.1	-1.4	0.1	-0.5
Worrier / anxious feelings	0.4	0.7	1.9	1.3	-0.5	-1.4	1.0	0.5	-0.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.0	8.9	1.3	0.6	1.6	3.0	-0.1	0.3	-0.9
Falls in the last year	0.4	0.5	1.6	1.3	0.8	-0.1	-1.0	0.2	-0.4	0.6
Hair/balding pattern: Pattern 3	0.9	1.4	4.6	1.4	-0.7	-1.2	-0.8	-0.4	-0.5	2.1
Number of live births	1.1	1.5	4.0	0.4	-0.1	1.6	1.6	0.6	2.0	0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.5	-0.6	1.0	-1.1	-1.4	1.6	0.0	-0.7
Pulse rate	0.4	0.7	3.1	-1.1	0.3	-1.8	0.2	-0.2	-0.9	0.2
Happiness	1.1	1.4	2.8	0.0	-1.2	-1.4	-0.2	-1.7	0.9	-1.5
Noisy workplace	0.4	0.4	0.8	0.6	-0.6	0.6	0.9	-0.0	0.6	-0.8
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.4	-1.8	-0.9	-0.2	-0.3	-2.1	1.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	10.0	0.1	0.6	0.8	0.2	1.0	3.2	-2.6
Mouth/teeth dental problems: Dentures	0.6	1.1	2.9	-1.1	-0.2	0.8	0.6	-1.7	-0.2	-1.4
Asthma	0.6	1.1	2.6	-1.0	0.3	0.5	1.4	-1.1	0.6	-1.6
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	7.6	-1.6	-0.8	-2.8	-0.7	-1.8	-0.5	1.7
Medication: Cholesterol lowering	0.3	0.5	1.2	-0.1	0.1	0.7	-1.1	1.1	-0.6	0.7
Depression (self-reported)	0.8	1.0	3.1	0.7	-1.8	-1.0	0.2	0.6	-0.6	-1.2
Medication: Lansoprazole	0.3	0.3	0.6	-0.5	0.2	0.8	-0.6	-0.6	0.7	-0.4
Prospective memory result	0.7	0.8	2.7	0.0	0.8	0.6	0.8	-1.2	0.1	1.6
Lung cancer (father)	0.6	0.7	2.5	-0.4	1.0	0.4	-1.0	-0.3	-0.3	1.6
Illnesses of mother	0.6	0.8	3.5	1.9	-0.7	-1.1	-0.3	0.0	0.1	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.5	-0.3	1.2	-1.9	-0.9	1.2	-0.0	-0.8
Pulse wave Arterial Stiffness index	0.7	0.8	1.8	0.0	-0.4	-1.3	-1.0	-1.0	1.0	-0.6
Impedance of arm (left)	0.4	2.1	6.8	-0.5	0.2	-2.6	-2.4	-1.2	0.4	0.1
Arm fat mass (right)	1.3	5.4	25.4	-0.7	0.6	5.0	3.0	1.4	0.1	-1.0
Trunk predicted mass	0.3	1.6	5.4	0.2	-0.7	1.0	1.4	1.1	-1.1	-2.3
Standing height	0.4	3.9	12.9	-0.2	-0.9	-2.9	-1.5	-0.7	-1.5	-3.6
Length of working week for main job	1.5	1.7	5.7	1.0	0.1	-0.3	-1.4	1.7	-2.4	0.6
Exposure to tobacco smoke at home	0.9	1.0	4.9	-0.5	-0.3	-1.2	0.1	-0.1	-0.6	-2.2
Breastfed as a baby	0.4	0.5	2.7	0.5	-1.6	-0.2	-0.7	-0.0	0.6	0.1
Tense / ‘highly strung’	0.3	0.5	1.0	0.6	-0.5	-1.0	1.0	0.5	-0.8	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.2	-1.8	-1.4	1.3	1.8	0.4	0.9	-1.2
Hair/balding pattern: Pattern 4	1.0	2.3	4.9	1.4	1.9	2.2	2.0	0.4	-0.8	1.0
Birth weight of first child	0.5	0.9	3.8	1.9	0.4	0.1	-0.9	-0.2	0.6	0.9
Peak expiratory flow (PEF)	0.2	0.5	1.1	0.3	0.8	-0.7	0.5	0.7	0.7	-1.0
Pulse wave reflection index	0.5	0.6	1.5	1.2	0.8	0.3	-0.5	0.7	1.0	-0.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	-0.7	-0.3	1.3	1.2	0.6	-0.2	-0.8
Loud music exposure frequency	0.6	0.7	1.8	-1.2	0.9	-0.3	0.8	-0.4	0.1	-1.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	3.5	-1.2	0.6	-1.7	-0.0	-1.9	0.4	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.5	0.5	-0.1	-0.2	0.7	-0.1	0.2	0.4
Blood clot in the leg (DVT)	1.2	1.5	6.5	0.2	0.7	2.5	1.9	0.0	-0.0	0.4
Medication: Paracetamol	0.7	1.2	6.1	-0.3	-2.5	0.4	0.2	-1.2	-0.8	0.2
Headache pain in last month	0.4	0.8	2.2	-0.7	0.1	0.9	1.5	-1.0	0.7	-0.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.8	-0.7	-0.0	-0.9	1.7	-1.1	0.1	-1.5
Glaucoma (self-reported)	0.8	0.9	4.6	-0.1	-0.5	-2.2	-0.7	0.6	-0.9	-0.0
Gout (self-reported)	1.7	2.3	3.9	-2.0	-1.7	1.8	1.4	-0.7	-0.5	-1.9
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	12.5	-0.4	0.8	3.5	2.0	-0.3	-1.2	-1.4
Medication: Amlodipine	1.2	1.6	4.0	-1.7	-0.8	2.0	0.4	1.0	-1.6	-0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.5	1.2	0.4	-1.0	0.1	0.5	0.3	-1.0
Birth weight	0.4	0.9	3.0	0.8	-0.5	1.7	-0.3	1.2	-0.2	-0.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	0.6	0.0	0.7	1.0	-0.6	0.5	0.5
High blood pressure (siblings)	0.6	0.9	3.3	0.1	1.8	0.1	-1.2	-0.9	0.4	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.2	5.1	-0.8	0.7	-2.2	-0.7	-0.1	-0.4	-1.3
Body fat percentage	1.4	5.4	27.6	-1.0	0.5	5.3	2.7	1.1	0.1	-0.6
Leg fat percentage (right)	1.4	5.0	26.2	-0.6	0.0	5.1	2.6	1.3	-0.1	-0.6
Arm fat-free mass (right)	0.4	2.3	4.1	-0.0	-0.5	1.9	1.7	1.5	-1.8	-2.0
Exposure to tobacco smoke outside home	0.9	1.3	2.9	-0.9	0.4	-0.7	1.6	-0.6	-1.2	-1.7
Comparative body size at age 10	0.6	1.7	5.5	-0.4	1.1	2.4	1.9	0.5	-1.0	0.4
Number of full brothers	0.9	1.1	2.6	-1.3	0.5	1.4	0.9	0.8	-0.1	-1.6
Worry too long after embarrassment	0.5	0.9	4.4	0.2	0.9	-2.1	-0.4	0.4	-0.7	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	7.2	-0.4	-0.6	0.3	1.8	-0.1	0.6	-2.7
Wheeze or whistling in the chest in last year	0.7	1.2	3.3	0.9	1.8	1.2	1.5	-0.5	0.8	-0.2
Number of children fathered	1.3	1.5	2.8	-1.7	-1.3	1.6	1.4	-1.0	-0.5	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.7	-0.2	-1.2	-0.1	-0.2	0.1	0.2	1.9
Age at first live birth	0.3	0.6	3.7	0.4	1.9	-0.3	0.1	0.1	0.2	-0.5
Pulse wave peak to peak time	0.5	0.6	1.4	-0.1	0.2	1.0	1.0	0.8	-1.2	0.3
Health satisfaction	0.5	0.7	1.8	-0.7	0.8	-0.2	1.0	-1.3	0.4	-1.0
Shortness of breath walking on level ground	1.0	1.2	5.3	0.5	0.3	2.3	1.2	0.2	0.3	1.1
Qualifications: College or University degree	0.3	1.0	3.2	-0.5	-1.1	-1.8	-0.0	-1.2	-0.0	0.8
Eye problems/disorders: None of the above	1.2	1.3	3.5	-0.7	1.0	-0.1	0.7	-1.9	-1.2	-1.6
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.3	-1.0	0.0	0.9	1.8	-1.1	0.1	-0.6
Emphysema/chronic bronchitis	0.7	0.8	2.5	-0.5	0.2	-0.9	0.1	-1.6	1.2	0.5
Medication for pain relief, constipation, heartburn	0.3	0.6	2.4	0.5	0.8	0.7	-0.4	0.3	0.2	-1.6
Neck or shoulder pain in last month	0.3	0.4	0.8	0.7	-0.5	-0.7	-0.6	-0.6	0.9	-0.2
Medication: Blood pressure	0.7	1.3	3.0	1.0	1.0	0.9	-1.7	1.0	0.0	1.5
Angina (self-reported)	0.4	0.6	1.5	0.9	0.4	0.5	-0.4	0.4	1.2	1.0
Migraine (self-reported)	0.4	0.6	2.0	-1.0	-0.2	-0.2	-0.2	-0.3	1.4	-0.7
Medication: Ibuprofen	2.2	2.7	6.9	-1.6	-1.1	-2.6	-0.2	-2.1	-0.5	1.9
Medication: Allopurinol	1.1	1.5	6.5	0.4	0.2	2.6	1.6	0.7	-0.4	-0.7
Medication: Omeprazole	1.2	1.4	4.5	0.6	0.5	0.7	2.1	0.6	0.4	1.9
Medication: Seretide 50 evohaler	1.2	1.4	3.2	1.6	0.4	1.2	-0.6	1.8	0.8	1.1
Mean time to correctly identify matches	0.3	0.6	2.4	0.5	1.6	-1.0	-0.6	0.1	0.1	0.6
Heart disease (mother)	0.4	0.5	2.3	-0.4	0.5	1.5	0.2	-0.1	0.9	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	0.8	-0.9	-0.9	0.6	0.7	0.3	-0.7	-0.9
Whole body fat mass	1.4	5.9	28.3	-0.8	0.5	5.3	3.0	1.4	-0.3	-1.2
Leg fat mass (right)	1.3	5.0	25.0	-0.8	0.4	5.0	2.6	1.4	-0.3	-1.0
Arm predicted mass (right)	0.4	2.2	3.8	-0.6	-0.7	1.8	1.9	1.0	-1.8	-1.9
Pulse rate, automated reading	0.6	2.0	9.2	0.7	0.1	-3.0	-1.6	1.1	-0.4	0.8
Alcohol intake frequency.	0.5	1.1	2.9	-1.1	-1.7	0.4	0.8	-0.7	0.3	-1.4
Comparative height size at age 10	0.2	1.3	3.0	1.2	-0.3	-1.6	-1.3	0.0	-0.3	-1.7
Number of full sisters	0.6	0.7	2.2	-1.0	1.5	-0.9	-0.1	-0.7	-0.3	0.4
Suffer from ‘nerves’	1.0	1.6	7.7	2.8	0.3	-1.0	0.0	1.3	-0.5	0.5
Overall health rating	1.0	2.1	5.7	0.5	0.8	2.4	2.3	0.1	1.7	-0.6
Chest pain or discomfort	0.7	1.0	3.4	-1.4	-0.3	1.8	1.3	0.3	-0.2	0.3
Had major operations	0.4	0.4	1.9	0.2	0.5	-0.2	-0.5	0.4	1.4	0.7
Age at last live birth	0.4	0.6	1.8	0.6	1.1	0.4	0.2	-0.6	1.3	-0.1
Family relationship satisfaction	0.6	0.7	2.1	-0.1	-0.2	-0.3	0.9	-1.5	-1.2	-0.6
Leg pain on walking	1.1	1.4	3.3	1.6	1.8	0.3	1.1	1.6	0.4	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	7.4	-2.2	-1.0	1.2	-0.4	-0.9	-0.3	-2.7
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.8	1.0	-0.6	2.0	1.1	-1.5	0.5	0.1
Illness, injury, bereavement, stress in last 2 years	2.1	2.5	6.2	-0.6	-2.5	-1.6	-2.2	-0.7	-1.8	0.0
Medication: Aspirin	0.7	1.0	2.6	-0.8	-0.5	1.6	1.6	0.5	0.3	0.6
Supplements: Vitamin C	0.8	1.0	1.7	-0.3	-1.3	-0.8	-1.2	0.1	1.3	1.2
Knee pain experienced in last month	1.1	1.8	4.0	1.4	1.4	1.5	0.2	1.3	2.0	0.2
Hypertension (Self-reported)	0.4	1.2	3.0	-0.9	-0.0	0.7	-0.9	-0.4	1.7	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	3.6	-1.0	-0.5	1.1	-0.3	-1.3	1.9	1.0
Illnesses of father: Heart disease	0.5	0.7	1.5	-0.9	1.1	1.2	0.2	-0.7	0.4	0.8
Illnesses of siblings: Diabetes	1.0	1.2	2.6	0.0	0.7	-0.8	-1.6	1.6	-1.3	-0.9
Smoking status: Previous	1.6	2.4	4.8	0.0	-1.4	1.9	1.2	-1.6	2.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	8.1	-0.5	0.2	-2.3	0.1	-0.8	0.2	-2.8
Whole body fat-free mass	0.3	1.9	3.7	0.1	-0.3	1.7	1.8	1.4	-1.2	-1.9
Leg fat-free mass (right)	0.4	2.0	5.4	-0.1	0.3	2.3	1.9	1.4	-1.4	-1.1
Arm fat percentage (left)	1.6	6.2	31.2	-0.8	0.7	5.6	3.1	1.2	0.5	-0.1
Average weekly red wine intake	0.3	0.5	1.5	-0.9	-0.3	-0.8	0.2	-0.6	-1.2	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	2.1	0.1	0.2	1.5	0.3	0.5	-0.1	-0.2
Mood swings	1.7	3.1	9.5	3.1	2.2	-0.5	0.4	1.7	0.5	-1.9
Loneliness, isolation	1.5	2.1	6.2	-0.2	0.6	0.7	2.2	-1.2	-1.3	-2.5
Long-standing illness, disability or infirmity	0.7	1.0	3.8	1.3	0.7	-0.2	0.6	0.8	2.0	-0.1
Ever had bowel cancer screening	1.0	1.2	2.8	0.4	-0.9	1.7	1.0	0.9	1.3	1.0
Diabetes diagnosed by doctor	0.2	0.4	1.3	-0.0	0.0	1.0	1.2	0.5	0.3	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	-1.1	-1.0	0.9	-0.0	0.3	-0.8	0.2
Friendships satisfaction	1.2	1.5	7.2	0.1	-0.0	-0.7	-0.2	-2.7	-1.6	0.1
Qualifications: nursing, teaching	1.5	2.4	6.7	1.9	-1.0	0.7	-1.1	0.7	1.7	2.6
Commuting to job workplace: Walk	1.0	1.1	3.7	-0.2	-1.2	-0.0	-0.3	-0.8	-1.9	-1.3
Eye problems/disorders: Cataract	1.4	1.6	5.1	-0.1	-1.2	2.3	1.2	1.7	0.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.5	1.6	-0.1	-0.7	-0.6	-0.1	0.9	-1.2
Medication for cholesterol	0.2	0.3	0.7	-0.4	0.8	-0.4	-0.1	0.2	-0.8	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.2	-0.5	1.5	-1.4	-1.0	1.1	0.7	-0.3
Back pain experienced in last month	0.4	0.6	1.3	1.1	0.2	-0.5	0.5	-0.4	0.9	1.1
Mineral and other dietary supplements	0.2	0.3	1.2	0.1	0.4	-0.3	-0.6	-0.5	-0.5	-1.1
Breast cancer (self-reported)	1.5	1.7	6.3	0.5	0.1	2.5	1.2	1.8	0.1	-1.0
Asthma (self-reported)	0.4	0.8	2.2	-0.8	0.1	0.2	1.2	-0.9	0.6	-1.5
Osteoporosis (self-reported)	0.7	0.9	3.2	1.8	0.8	-0.8	0.3	0.3	1.4	0.0
Osteoarthritis (self-reported)	1.9	2.4	9.8	3.1	0.1	-0.2	-0.1	0.8	2.4	-0.9
Medication: Aspirin	0.7	1.0	2.1	-0.9	-0.8	1.4	1.5	0.7	-0.6	0.4
Medication: Gliclazide	0.4	0.5	1.6	-0.0	-0.4	0.8	0.5	0.6	-0.6	-1.3
Illnesses of father: None of the above (group 1)	0.9	1.1	3.2	0.6	-1.5	-1.2	-1.8	-0.1	0.6	-0.6
Smoking status: Current	1.1	1.7	6.5	-1.2	0.0	-0.5	0.5	-0.5	-1.9	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.5	0.6	0.4	0.7	1.2	1.2	0.8	-0.4
Whole body water mass	0.3	2.0	3.6	0.2	-0.2	1.7	1.9	1.4	-1.3	-1.9
Leg predicted mass (right)	0.4	1.9	5.1	-0.1	0.2	2.3	1.9	1.4	-1.3	-1.1
Arm fat mass (left)	1.4	5.8	27.0	-0.7	0.8	5.2	3.1	1.6	-0.1	-0.9
Number of self-reported non-cancer illnesses	1.1	1.9	7.5	-1.1	-0.7	1.1	0.4	-1.6	2.7	-0.5
Average weekly champagne plus white wine intake	1.5	2.0	5.7	0.9	0.3	-2.4	-1.4	0.8	1.0	1.9
Miserableness	0.6	1.1	3.0	0.4	-0.2	-0.4	1.7	0.4	-1.1	-1.7
Guilty feelings	0.4	0.6	2.0	1.1	0.1	0.1	1.4	0.5	0.2	-0.8
Wears glasses or contact lenses	0.5	0.6	2.4	0.3	-1.0	0.4	-0.7	1.5	0.5	-0.1
Ever taken oral contraceptive pill	0.7	0.7	2.0	-1.2	0.4	-1.4	-0.5	-1.0	0.5	0.3
Hearing aid user	2.5	2.9	7.7	2.8	0.9	-0.1	1.4	2.3	1.9	0.8
Mother’s age at death	0.4	0.5	1.2	0.1	-0.2	-1.1	-1.1	-0.0	0.2	0.9
Financial situation satisfaction	0.7	0.8	1.6	-0.4	0.9	-0.9	0.8	-1.0	-1.3	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	-0.1	0.1	1.2	1.3	-0.7	0.8	-0.8
Commuting to job workplace: Public transport	0.5	0.6	1.6	0.0	-0.8	-1.1	-0.5	-0.1	0.4	1.3
Eye problems/disorders: Glaucoma	1.7	2.0	9.2	0.5	-0.5	-3.0	-1.5	1.2	0.1	0.8
Medication: Blood pressure	0.4	0.7	2.3	-0.3	-1.0	0.8	0.5	-0.4	0.8	1.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	1.0	1.1	-0.5	-0.1	-0.0	0.8	-0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	-0.1	0.0	0.6	0.7	0.9	-0.2	1.2
High cholesterol (Self-reported)	0.2	0.3	1.1	-1.0	-0.5	-0.1	-0.5	-0.6	0.7	-0.1
Medication: Bendroflumethiazide	0.8	1.1	3.4	1.4	-0.0	-1.9	-1.0	-0.0	-0.0	1.2
Medication: Paracetamol	0.8	1.3	5.5	-0.6	-2.4	0.3	-0.1	-1.3	-0.8	0.6
Medication: Lisinopril	0.4	0.5	2.3	-0.2	-0.4	0.7	-0.2	0.8	1.5	-0.4
Medication: Atorvastatin	1.3	1.6	3.8	1.9	0.3	-0.7	-1.9	-0.1	-0.1	1.8
Illnesses of father: High blood pressure	0.7	0.8	3.1	-0.6	1.3	-0.0	-0.6	0.7	-0.2	1.8
Alcohol drinker status: Never	2.3	2.8	6.6	-0.4	-1.0	-2.6	-1.8	-1.3	1.2	2.3
Ever smoked	1.1	1.9	5.4	-1.8	-1.1	1.0	2.3	-1.4	0.2	-0.6
Basal metabolic rate	0.5	2.6	6.1	-0.1	-0.0	2.5	2.1	1.5	-1.1	-2.0
Leg fat percentage (left)	1.5	5.5	29.2	-0.8	-0.1	5.4	2.6	1.1	-0.0	-0.6
Arm fat-free mass (left)	0.5	2.5	4.9	-0.4	-0.3	2.1	2.1	1.4	-1.4	-2.2
Number of operations (self-reported)	0.8	1.1	2.8	-1.2	0.4	1.7	-0.3	0.8	1.7	0.2
Average weekly beer plus cider intake	0.6	0.8	2.4	-0.2	-0.0	1.1	1.2	-0.8	-0.4	-1.5
Irritability	0.8	1.4	4.4	-1.3	-1.1	-0.2	2.1	0.1	0.1	-1.4
Risk taking	1.0	1.4	4.5	-1.9	-0.0	0.7	1.1	-2.1	-0.5	-0.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.5	-0.2	0.2	0.3	0.4	0.3	1.1	1.2
Fractured/broken bones in last 5 years	0.3	0.4	1.4	0.4	0.4	0.3	0.9	-1.2	0.3	0.1
Age started oral contraceptive pill	0.9	1.1	2.8	1.5	1.7	0.3	0.9	0.6	0.4	1.1
Diastolic blood pressure, automated reading	0.5	1.5	5.6	-1.4	0.8	2.4	-0.3	0.6	-0.5	-1.4
Ever depressed for a whole week	0.9	1.1	4.6	0.2	0.0	1.2	1.2	2.1	0.0	0.1
Unable to work because of sickness or disability	1.4	1.8	4.4	-0.3	1.8	1.4	2.1	1.0	0.8	-1.2
Commuting to job workplace: Cycle	0.9	1.1	3.3	-0.1	-0.4	-0.9	-0.3	1.8	-1.8	-0.4
Myopia	0.3	0.4	1.6	-0.7	0.7	-0.4	-0.0	-0.5	-1.2	-0.2
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.4	0.8	0.4	-0.4	1.5	0.2	-1.2	-1.8
Cholesterol lowering medication	0.2	0.4	1.1	-0.2	-1.0	0.7	0.6	-0.2	0.6	0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.5	0.3	0.6	0.8	1.4	0.9	0.0	1.6
Pain experienced in last month	0.8	1.3	4.2	-1.7	-0.4	-1.0	-0.9	0.1	-2.1	-0.3
Supplements: Calcium	0.7	0.8	3.8	0.5	0.1	-0.6	-0.4	-0.2	0.9	1.9
Basal cell carcinoma (self-reported)	0.6	0.7	1.8	-1.1	1.4	1.1	-0.3	0.0	-0.5	0.3
Heart attack/myocardial infarction (self-reported)	1.1	1.5	4.9	-0.6	0.5	-0.7	-1.4	-1.4	-0.0	2.2
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	5.4	0.3	0.2	2.3	1.6	0.5	-0.5	0.4
Heart disease (siblings)	0.1	0.1	0.3	-0.4	0.3	0.5	0.2	-0.3	-0.1	-0.1
Alcohol drinker status: Previous	2.0	2.2	6.4	-0.4	-2.0	-1.5	0.2	-2.5	0.6	-1.5
Pack years of smoking	0.6	0.8	2.2	0.0	-0.2	1.1	1.2	-0.7	1.5	0.6
Impedance of whole body	0.4	2.2	6.0	-1.0	-0.3	-2.5	-2.3	-1.4	-0.0	-0.9
Leg fat mass (left)	1.3	5.1	25.9	-0.8	0.3	5.1	2.6	1.3	-0.3	-1.0
Arm predicted mass (left)	0.6	2.8	6.0	-0.2	-0.3	2.5	2.2	1.6	-1.0	-2.3