[Hub]/) : Traits : Body mass index (BMI) :

chr14:102,544,860-105,007,585

Best TWAS P=7.26e-13 · Best GWAS P=3.08e-16 conditioned to 9.28e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous MARK3 0.12 0.05 lasso 3 0.06 2.5e-05 -6.125 -5.3 9.6e-08 0.03 0.69 0.21 FALSE
2 GTEx Adipose Subcutaneous KLC1 0.05 0.03 lasso 3 0.03 1.8e-03 4.383 6.3 3.4e-10 -0.02 0.07 0.77 FALSE
3 GTEx Adipose Subcutaneous APOPT1 0.06 0.02 lasso 5 0.02 8.2e-03 5.282 -5.6 1.9e-08 0.03 0.22 0.48 FALSE
4 GTEx Adipose Visceral Omentum KLC1 0.06 0.02 lasso 2 0.00 2.2e-01 -6.166 6.4 1.3e-10 0.00 0.05 0.70 FALSE
5 GTEx Adrenal Gland KLC1 0.15 0.03 lasso 3 0.06 4.6e-03 5.260 6.5 6.7e-11 -0.03 0.09 0.45 FALSE
6 GTEx Artery Aorta KLC1 0.10 0.14 lasso 3 0.14 6.1e-08 -6.109 6.6 5.2e-11 0.00 0.04 0.96 FALSE
7 GTEx Artery Coronary APOPT1 0.19 0.02 lasso 5 0.05 1.2e-02 3.387 -5.6 2.0e-08 0.07 0.04 0.61 FALSE
8 GTEx Artery Tibial ZFYVE21 0.11 0.09 lasso 1 0.08 8.0e-07 -6.118 6.1 9.5e-10 0.00 0.03 0.97 FALSE
9 GTEx Artery Tibial KLC1 0.11 0.08 lasso 3 0.08 1.1e-06 -6.166 6.2 7.7e-10 -0.01 0.03 0.96 FALSE
10 GTEx Artery Tibial TRMT61A 0.07 0.07 lasso 3 0.06 2.4e-05 -6.144 -6.1 1.4e-09 0.03 0.04 0.95 FALSE
11 GTEx Brain Frontal Cortex BA9 APOPT1 0.17 0.07 lasso 3 0.08 4.6e-03 4.926 -6.1 9.8e-10 0.02 0.05 0.72 FALSE
12 GTEx Breast Mammary Tissue MARK3 0.12 0.11 lasso 2 0.08 3.9e-05 -6.063 -6.1 1.3e-09 0.02 0.54 0.16 FALSE
13 GTEx Breast Mammary Tissue KLC1 0.12 0.02 enet 26 0.07 2.9e-04 4.314 6.3 3.0e-10 0.00 0.58 0.35 FALSE
14 GTEx Breast Mammary Tissue (Male) MARK3 0.08 0.00 enet 9 -0.01 7.2e-01 -6.070 -5.7 1.2e-08 0.04 0.04 0.10 FALSE
15 GTEx Cells EBV-transformed lymphocytes PPP1R13B 0.15 0.08 lasso 4 0.07 2.2e-03 4.254 -5.1 2.7e-07 -0.04 0.41 0.06 FALSE
16 GTEx Cells Transformed fibroblasts ZFYVE21 0.10 0.03 lasso 4 0.11 1.1e-08 -5.085 5.4 8.6e-08 -0.03 0.08 0.86 FALSE
17 GTEx Cells Transformed fibroblasts KLC1 0.16 0.11 enet 17 0.10 3.1e-08 5.282 5.6 2.3e-08 -0.03 0.73 0.26 FALSE
18 GTEx Cells Transformed fibroblasts APOPT1 0.14 0.12 lasso 3 0.10 6.4e-08 -6.142 -6.5 9.4e-11 0.00 0.04 0.96 FALSE
19 GTEx Colon Transverse KLC1 0.16 0.01 lasso 7 0.00 1.9e-01 4.433 5.5 4.8e-08 -0.02 0.09 0.42 FALSE
20 GTEx Esophagus Mucosa XRCC3 0.12 0.15 lasso 2 0.13 4.4e-09 5.260 5.3 1.3e-07 -0.02 0.86 0.14 FALSE
21 GTEx Esophagus Muscularis ZFYVE21 0.11 0.06 lasso 5 0.05 5.7e-04 -6.050 5.6 1.8e-08 -0.04 0.02 0.96 FALSE
22 GTEx Esophagus Muscularis KLC1 0.07 0.01 enet 10 0.02 2.6e-02 -6.167 6.0 1.8e-09 -0.04 0.05 0.76 FALSE
23 GTEx Lung MARK3 0.06 0.02 lasso 3 0.01 6.6e-02 -6.063 -6.2 4.5e-10 0.02 0.35 0.24 FALSE
24 GTEx Lung CKB 0.07 0.01 lasso 2 0.01 3.4e-02 -6.166 -6.7 2.0e-11 0.01 0.04 0.90 FALSE
25 GTEx Muscle Skeletal ZFYVE21 0.10 0.05 lasso 2 0.03 3.3e-04 -6.142 6.2 6.8e-10 -0.02 0.04 0.94 FALSE
26 GTEx Muscle Skeletal KLC1 0.11 0.07 lasso 7 0.08 3.3e-08 -6.109 6.4 1.8e-10 -0.02 0.04 0.96 FALSE
27 GTEx Muscle Skeletal APOPT1 0.14 0.21 enet 10 0.22 6.7e-21 -6.050 6.7 2.3e-11 -0.02 0.01 0.99 FALSE
28 GTEx Nerve Tibial XRCC3 0.08 0.06 lasso 3 0.05 3.5e-04 5.282 5.2 2.3e-07 -0.05 0.79 0.16 FALSE
29 GTEx Pituitary MARK3 0.21 0.27 enet 8 0.25 4.9e-07 -6.070 -6.4 1.6e-10 0.02 0.50 0.18 FALSE
30 GTEx Pituitary RP11-73M18.8 0.23 0.17 lasso 2 0.13 3.6e-04 5.282 5.2 2.3e-07 -0.04 0.14 0.10 FALSE
31 GTEx Prostate MARK3 0.18 0.22 enet 11 0.20 8.0e-06 -6.069 -6.2 5.7e-10 0.03 0.43 0.15 FALSE
32 GTEx Prostate RP11-73M18.8 0.15 0.29 lasso 1 0.25 5.2e-07 5.260 5.3 1.4e-07 -0.02 0.38 0.14 FALSE
33 GTEx Skin Not Sun Exposed Suprapubic MARK3 0.16 0.10 lasso 3 0.10 6.7e-06 -6.154 -5.7 1.4e-08 0.01 0.71 0.26 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic XRCC3 0.14 0.03 lasso 14 0.03 1.3e-02 5.260 5.4 7.0e-08 -0.02 0.39 0.52 FALSE
35 GTEx Skin Sun Exposed Lower leg MARK3 0.10 0.09 enet 13 0.08 7.5e-07 -6.125 -6.5 7.2e-11 0.02 0.78 0.22 FALSE
36 GTEx Skin Sun Exposed Lower leg KLC1 0.06 0.09 enet 19 0.08 2.2e-07 5.282 5.7 1.4e-08 -0.02 0.18 0.82 FALSE
37 GTEx Spleen KLC1 0.15 0.05 lasso 3 0.03 6.4e-02 4.926 5.8 6.8e-09 -0.03 0.08 0.24 FALSE
38 GTEx Stomach MARK3 0.10 0.09 lasso 2 0.04 4.5e-03 -6.070 -6.1 9.2e-10 0.02 0.30 0.12 FALSE
39 GTEx Stomach TRMT61A 0.12 0.11 lasso 5 0.08 1.2e-04 -6.070 -6.1 1.2e-09 0.02 0.05 0.91 FALSE
40 GTEx Testis ZFYVE21 0.11 0.14 lasso 2 0.11 1.4e-05 -6.142 6.1 8.0e-10 0.00 0.04 0.94 FALSE
41 GTEx Testis KLC1 0.17 0.17 lasso 2 0.15 4.4e-07 5.260 5.2 2.5e-07 -0.02 0.78 0.12 FALSE
42 GTEx Thyroid MARK3 0.38 0.48 lasso 4 0.48 2.8e-41 -6.070 -6.1 1.2e-09 0.02 0.81 0.19 FALSE
43 GTEx Thyroid TRAF3 0.10 0.00 enet 20 0.05 1.4e-04 -0.021 6.1 1.0e-09 0.59 0.02 0.87 FALSE
44 GTEx Whole Blood KLC1 0.16 0.13 lasso 3 0.11 3.6e-10 5.260 5.1 2.8e-07 -0.03 0.85 0.15 FALSE
45 METSIM Adipose MARK3 0.03 0.02 lasso 6 0.03 6.3e-05 4.652 -5.9 4.1e-09 0.04 0.96 0.00 FALSE
46 METSIM Adipose TRAF3 0.04 0.02 enet 7 0.04 4.5e-06 6.818 6.9 6.6e-12 0.79 0.04 0.95 TRUE
47 NTR Blood BAG5 0.02 0.00 lasso 5 0.01 6.3e-03 -6.050 6.0 1.7e-09 -0.03 0.01 0.98 FALSE
48 YFS Blood KLC1 0.01 0.01 blup 389 0.01 1.0e-03 -6.026 6.0 1.9e-09 -0.03 0.03 0.93 FALSE
49 The Cancer Genome Atlas Breast Invasive Carcinoma C14orf153 0.05 0.02 lasso 4 0.02 8.0e-05 -6.050 -6.4 1.4e-10 0.03 0.00 0.99 FALSE
50 The Cancer Genome Atlas Colon Adenocarcinoma C14orf153 0.07 0.05 lasso 4 0.04 1.5e-03 -6.449 -6.0 1.5e-09 0.03 0.00 0.93 FALSE
51 The Cancer Genome Atlas Glioblastoma Multiforme C14orf153 0.14 0.01 blup 40 0.03 3.5e-02 -6.050 -6.8 1.2e-11 0.02 0.01 0.52 FALSE
52 The Cancer Genome Atlas Glioblastoma Multiforme MARK3 0.12 0.05 blup 64 0.07 3.3e-03 -6.154 -6.0 2.4e-09 0.01 0.01 0.62 FALSE
53 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MARK3 0.07 0.03 blup 64 0.06 5.5e-07 -4.471 -5.7 1.2e-08 0.03 0.04 0.96 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma XRCC3 0.03 0.04 enet 3 0.04 6.1e-05 5.260 5.3 1.4e-07 -0.02 0.41 0.47 FALSE
55 The Cancer Genome Atlas Brain Lower Grade Glioma C14orf153 0.04 0.01 blup 38 0.03 6.2e-04 4.383 -6.6 4.0e-11 0.03 0.02 0.77 FALSE
56 The Cancer Genome Atlas Lung Adenocarcinoma C14orf153 0.06 0.02 blup 38 0.04 2.4e-05 -6.050 -7.0 2.3e-12 0.03 0.03 0.88 FALSE
57 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C14orf153 0.05 0.05 blup 40 0.04 8.6e-06 -6.442 -5.8 5.7e-09 0.03 0.00 1.00 FALSE
58 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CKB 0.03 0.00 blup 34 0.02 1.4e-03 4.652 -6.7 2.2e-11 0.03 0.02 0.72 FALSE
59 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma BAG5 0.08 0.09 lasso 2 0.08 3.7e-04 -6.070 -6.1 1.1e-09 0.02 0.01 0.88 FALSE
60 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C14orf153 0.11 0.11 lasso 3 0.10 1.1e-04 -6.449 -6.7 2.2e-11 0.03 0.00 0.98 FALSE
61 The Cancer Genome Atlas Prostate Adenocarcinoma C14orf153 0.09 0.08 blup 38 0.09 6.2e-10 -6.449 -7.2 7.3e-13 0.04 0.00 1.00 TRUE
62 The Cancer Genome Atlas Prostate Adenocarcinoma CKB 0.07 0.09 blup 32 0.10 1.1e-10 4.926 -6.0 2.6e-09 0.02 0.95 0.05 FALSE
63 The Cancer Genome Atlas Prostate Adenocarcinoma MARK3 0.07 0.06 enet 7 0.08 1.0e-08 -4.419 -5.5 4.4e-08 0.03 0.04 0.96 FALSE
64 The Cancer Genome Atlas Stomach Adenocarcinoma C14orf153 0.20 0.05 lasso 2 0.04 8.8e-04 4.926 -5.4 8.1e-08 0.02 0.03 0.34 FALSE
65 The Cancer Genome Atlas Testicular Germ Cell Tumors C14orf153 0.20 0.07 blup 38 0.07 1.5e-03 2.883 -5.3 1.3e-07 0.00 0.01 0.60 FALSE
66 The Cancer Genome Atlas Thyroid Carcinoma KLC1 0.04 0.01 blup 82 0.03 5.4e-04 4.402 6.0 1.5e-09 -0.03 0.03 0.79 FALSE