Best TWAS P=7.49e-10 · Best GWAS P=5.72e-10 conditioned to 0.0458
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | RP11-400F19.6 | 0.07 | 0.01 | lasso | 5 | 0.01 | 3.0e-02 | 5.7 | -5.8 | 9.2e-09 | 0.12 | 0.04 | 0.94 | FALSE |
2 | GTEx | Esophagus Mucosa | TUBG2 | 0.09 | 0.09 | lasso | 4 | 0.11 | 5.5e-08 | -4.3 | -5.5 | 4.9e-08 | 0.12 | 0.18 | 0.82 | FALSE |
3 | GTEx | Esophagus Muscularis | NAGLU | 0.29 | 0.09 | lasso | 5 | 0.07 | 6.2e-05 | 5.2 | -5.6 | 2.6e-08 | 0.16 | 0.31 | 0.58 | FALSE |
4 | GTEx | Esophagus Muscularis | RP11-400F19.8 | 0.17 | 0.05 | lasso | 4 | 0.02 | 3.9e-02 | 5.2 | -6.2 | 7.5e-10 | 0.24 | 0.06 | 0.18 | TRUE |
5 | GTEx | Pancreas | CNTNAP1 | 0.13 | 0.09 | lasso | 7 | 0.09 | 9.1e-05 | 5.1 | 5.6 | 2.4e-08 | -0.19 | 0.29 | 0.29 | FALSE |
6 | GTEx | Pancreas | FAM134C | 0.08 | 0.04 | enet | 9 | 0.03 | 2.0e-02 | 4.7 | 5.4 | 7.9e-08 | -0.17 | 0.19 | 0.26 | FALSE |
7 | GTEx | Pancreas | CTD-3193K9.3 | 0.12 | 0.07 | lasso | 5 | 0.07 | 5.7e-04 | 5.1 | 5.6 | 2.3e-08 | -0.18 | 0.20 | 0.22 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | TUBG2 | 0.15 | 0.13 | lasso | 5 | 0.12 | 4.0e-07 | 5.7 | -5.7 | 1.2e-08 | 0.10 | 0.03 | 0.97 | FALSE |
9 | GTEx | Stomach | HSD17B1P1 | 0.10 | 0.04 | lasso | 3 | 0.04 | 6.9e-03 | 4.6 | -5.2 | 1.6e-07 | 0.19 | 0.12 | 0.15 | FALSE |
10 | GTEx | Thyroid | HSD17B1P1 | 0.04 | 0.00 | enet | 9 | 0.00 | 2.2e-01 | -4.3 | -5.5 | 3.7e-08 | 0.25 | 0.13 | 0.44 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HSD17B1 | 0.30 | 0.05 | enet | 14 | 0.06 | 2.8e-07 | -4.3 | -5.4 | 6.1e-08 | 0.15 | 0.38 | 0.58 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | RND2 | 0.08 | 0.00 | enet | 16 | 0.02 | 3.5e-03 | -4.4 | 5.3 | 1.4e-07 | -0.61 | 0.00 | 0.07 | TRUE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | TUBG2 | 0.07 | 0.01 | enet | 7 | 0.02 | 2.2e-03 | 4.5 | -5.2 | 2.6e-07 | 0.11 | 0.00 | 0.22 | FALSE |
14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMC3IP | 0.02 | 0.02 | blup | 33 | 0.02 | 9.8e-04 | -4.3 | -5.3 | 9.9e-08 | 0.15 | 0.04 | 0.75 | FALSE |