[Hub]/) : Traits : Body mass index (BMI) :

chr17:45,271,680-47,718,188

Best TWAS P=2.48e-12 · Best GWAS P=6.73e-14 conditioned to 0.00288

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ATP5G1 0.07 0.05 lasso 3 0.06 4.7e-08 -5.8 6.5 7.4e-11 -0.56 0.93 0.06 FALSE
2 CommonMind Brain Pre-frontal Cortex CDK5RAP3 0.15 0.12 bslmm 392 0.14 3.6e-16 5.6 -5.1 3.0e-07 0.08 0.74 0.26 FALSE
3 CommonMind Brain Pre-frontal Cortex SNF8 0.08 0.07 lasso 5 0.08 9.3e-10 -5.6 6.8 8.3e-12 -0.74 0.09 0.91 TRUE
4 GTEx Artery Aorta SNF8 0.12 0.12 lasso 6 0.10 2.3e-06 -5.4 5.6 2.2e-08 -0.58 0.71 0.19 FALSE
5 GTEx Artery Aorta AC091133.1 0.10 0.07 lasso 5 0.07 1.2e-04 -5.4 5.9 3.9e-09 -0.59 0.35 0.38 FALSE
6 GTEx Brain Cerebellum ATP5G1 0.22 0.26 lasso 3 0.24 8.2e-08 -5.4 5.3 1.1e-07 -0.55 0.82 0.10 FALSE
7 GTEx Brain Cortex ATP5G1 0.16 0.15 lasso 2 0.14 1.3e-04 -5.4 5.5 5.1e-08 -0.55 0.15 0.22 FALSE
8 GTEx Brain Nucleus accumbens basal ganglia CDK5RAP3 0.21 0.04 lasso 4 0.02 7.2e-02 5.9 -5.3 9.5e-08 0.08 0.08 0.37 FALSE
9 GTEx Cells Transformed fibroblasts SNF8 0.12 0.10 lasso 3 0.12 5.1e-09 -5.4 5.9 3.3e-09 -0.59 0.98 0.02 FALSE
10 GTEx Cells Transformed fibroblasts AC091133.1 0.14 0.07 enet 22 0.09 1.9e-07 -5.4 5.4 6.8e-08 -0.56 0.86 0.10 FALSE
11 GTEx Esophagus Mucosa NFE2L1 0.07 0.02 lasso 4 0.01 8.6e-02 -5.3 -5.2 1.9e-07 0.07 0.32 0.03 FALSE
12 GTEx Esophagus Muscularis COPZ2 0.14 0.04 lasso 5 0.06 1.3e-04 2.9 5.7 1.3e-08 -0.04 0.18 0.04 FALSE
13 GTEx Esophagus Muscularis ATP5G1 0.09 0.06 lasso 5 0.05 4.5e-04 -5.4 5.5 4.8e-08 -0.56 0.17 0.49 FALSE
14 GTEx Esophagus Muscularis SNF8 0.08 0.03 lasso 3 0.01 5.7e-02 -6.1 5.8 4.8e-09 -0.63 0.03 0.72 FALSE
15 GTEx Heart Atrial Appendage CDK5RAP3 0.13 0.00 enet 18 0.04 5.1e-03 1.9 -5.4 5.7e-08 0.07 0.09 0.05 FALSE
16 GTEx Heart Atrial Appendage ATP5G1 0.22 0.10 enet 6 0.13 1.3e-06 -5.4 5.5 3.2e-08 -0.57 0.94 0.02 FALSE
17 GTEx Heart Left Ventricle ATP5G1 0.24 0.22 lasso 4 0.22 9.3e-12 -6.0 6.7 1.6e-11 -0.57 0.98 0.02 FALSE
18 GTEx Muscle Skeletal UBE2Z 0.06 0.02 lasso 8 0.03 9.8e-04 -6.0 6.2 7.9e-10 -0.64 0.31 0.61 FALSE
19 GTEx Muscle Skeletal AC003665.1 0.05 0.03 enet 8 0.03 1.4e-03 4.6 5.4 5.7e-08 -0.10 0.12 0.72 FALSE
20 GTEx Nerve Tibial UBE2Z 0.12 0.04 enet 16 0.05 1.5e-04 -5.4 5.2 2.0e-07 -0.52 0.88 0.02 FALSE
21 GTEx Ovary ATP5G1 0.15 0.08 enet 13 0.09 2.8e-03 -5.2 5.9 2.8e-09 -0.62 0.06 0.74 FALSE
22 GTEx Pancreas CDK5RAP3 0.11 -0.01 lasso 4 0.02 5.1e-02 4.6 -5.8 6.1e-09 0.06 0.09 0.18 FALSE
23 GTEx Pancreas RP11-6N17.9 0.15 0.04 lasso 5 0.04 9.3e-03 -3.0 -6.2 5.4e-10 0.08 0.13 0.17 FALSE
24 GTEx Skin Not Sun Exposed Suprapubic UBE2Z 0.11 0.07 lasso 6 0.04 1.8e-03 -6.1 6.2 6.7e-10 -0.61 0.10 0.12 FALSE
25 GTEx Skin Sun Exposed Lower leg UBE2Z 0.14 0.11 lasso 9 0.14 6.3e-12 -5.4 6.0 1.9e-09 -0.59 0.99 0.01 FALSE
26 GTEx Stomach RP11-6N17.9 0.13 0.02 lasso 6 0.04 8.0e-03 5.1 -6.3 3.4e-10 0.05 0.12 0.69 FALSE
27 GTEx Testis SNF8 0.23 0.11 lasso 5 0.08 1.6e-04 -5.4 5.5 4.3e-08 -0.56 0.67 0.10 FALSE
28 GTEx Testis RP11-6N17.4 0.14 0.02 lasso 10 0.02 4.8e-02 5.9 5.8 5.7e-09 -0.06 0.17 0.67 FALSE
29 GTEx Thyroid SNF8 0.11 0.08 lasso 3 0.07 2.5e-06 -5.5 5.8 5.8e-09 -0.56 0.89 0.08 FALSE
30 GTEx Thyroid RP11-6N17.10 0.19 0.12 lasso 5 0.13 3.0e-10 -3.3 -5.6 2.3e-08 0.12 1.00 0.00 FALSE
31 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CBX1 0.03 0.01 lasso 3 0.01 8.7e-03 5.9 -5.4 8.2e-08 0.08 0.01 0.82 FALSE
32 The Cancer Genome Atlas Brain Lower Grade Glioma CALCOCO2 0.03 0.00 blup 50 0.01 1.9e-02 4.5 6.0 1.8e-09 -0.54 0.02 0.82 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma SNF8 0.11 0.12 lasso 4 0.12 1.4e-13 -5.6 5.7 1.3e-08 -0.60 0.35 0.65 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma TTLL6 0.03 0.00 blup 59 0.02 2.7e-03 -4.6 -5.5 3.4e-08 0.51 0.02 0.81 FALSE
35 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SNX11 0.06 0.06 lasso 3 0.05 2.8e-06 -5.3 5.3 1.2e-07 -0.06 0.35 0.62 FALSE
36 The Cancer Genome Atlas Prostate Adenocarcinoma CBX1 0.03 0.04 lasso 4 0.04 3.7e-05 6.0 -5.9 4.2e-09 0.07 0.01 0.99 FALSE
37 The Cancer Genome Atlas Prostate Adenocarcinoma CDK5RAP3 0.06 0.00 blup 62 0.03 1.0e-03 -5.5 -7.0 2.5e-12 0.06 0.01 0.80 TRUE
38 The Cancer Genome Atlas Prostate Adenocarcinoma SNF8 0.05 0.06 blup 47 0.06 1.0e-06 -6.1 5.5 3.7e-08 -0.62 0.08 0.92 FALSE
39 The Cancer Genome Atlas Thyroid Carcinoma CALCOCO2 0.07 0.05 enet 9 0.06 1.3e-06 -6.1 5.7 1.5e-08 -0.42 0.01 0.99 FALSE
40 The Cancer Genome Atlas Thyroid Carcinoma SNF8 0.16 0.18 lasso 7 0.18 5.9e-17 -5.4 5.5 4.5e-08 -0.58 0.36 0.64 FALSE
41 The Cancer Genome Atlas Thyroid Carcinoma UBE2Z 0.13 0.09 lasso 4 0.12 2.7e-11 -5.4 5.8 8.5e-09 -0.58 0.14 0.86 FALSE