[Hub]/) : Traits : Body mass index (BMI) : ← →

chr17:45,271,680-47,718,188

Best TWAS P=2.48e-12 · Best GWAS P=6.73e-14 conditioned to 0.00288

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK5RAP3	0.06	0.00	blup	62	0.03	1.0e-03	-5.5	-7.0	2.5e-12	0.06	0.01	0.80	TRUE
3	CommonMind	Brain Pre-frontal Cortex	SNF8	0.08	0.07	lasso	5	0.08	9.3e-10	-5.6	6.8	8.3e-12	-0.74	0.09	0.91	TRUE
17	GTEx	Heart Left Ventricle	ATP5G1	0.24	0.22	lasso	4	0.22	9.3e-12	-6.0	6.7	1.6e-11	-0.57	0.98	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATP5G1	0.07	0.05	lasso	3	0.06	4.7e-08	-5.8	6.5	7.4e-11	-0.56	0.93	0.06	FALSE
26	GTEx	Stomach	RP11-6N17.9	0.13	0.02	lasso	6	0.04	8.0e-03	5.1	-6.3	3.4e-10	0.05	0.12	0.69	FALSE
23	GTEx	Pancreas	RP11-6N17.9	0.15	0.04	lasso	5	0.04	9.3e-03	-3.0	-6.2	5.4e-10	0.08	0.13	0.17	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	UBE2Z	0.11	0.07	lasso	6	0.04	1.8e-03	-6.1	6.2	6.7e-10	-0.61	0.10	0.12	FALSE
18	GTEx	Muscle Skeletal	UBE2Z	0.06	0.02	lasso	8	0.03	9.8e-04	-6.0	6.2	7.9e-10	-0.64	0.31	0.61	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	CALCOCO2	0.03	0.00	blup	50	0.01	1.9e-02	4.5	6.0	1.8e-09	-0.54	0.02	0.82	FALSE
25	GTEx	Skin Sun Exposed Lower leg	UBE2Z	0.14	0.11	lasso	9	0.14	6.3e-12	-5.4	6.0	1.9e-09	-0.59	0.99	0.01	FALSE
21	GTEx	Ovary	ATP5G1	0.15	0.08	enet	13	0.09	2.8e-03	-5.2	5.9	2.8e-09	-0.62	0.06	0.74	FALSE
9	GTEx	Cells Transformed fibroblasts	SNF8	0.12	0.10	lasso	3	0.12	5.1e-09	-5.4	5.9	3.3e-09	-0.59	0.98	0.02	FALSE
5	GTEx	Artery Aorta	AC091133.1	0.10	0.07	lasso	5	0.07	1.2e-04	-5.4	5.9	3.9e-09	-0.59	0.35	0.38	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	CBX1	0.03	0.04	lasso	4	0.04	3.7e-05	6.0	-5.9	4.2e-09	0.07	0.01	0.99	FALSE
14	GTEx	Esophagus Muscularis	SNF8	0.08	0.03	lasso	3	0.01	5.7e-02	-6.1	5.8	4.8e-09	-0.63	0.03	0.72	FALSE
28	GTEx	Testis	RP11-6N17.4	0.14	0.02	lasso	10	0.02	4.8e-02	5.9	5.8	5.7e-09	-0.06	0.17	0.67	FALSE
29	GTEx	Thyroid	SNF8	0.11	0.08	lasso	3	0.07	2.5e-06	-5.5	5.8	5.8e-09	-0.56	0.89	0.08	FALSE
22	GTEx	Pancreas	CDK5RAP3	0.11	-0.01	lasso	4	0.02	5.1e-02	4.6	-5.8	6.1e-09	0.06	0.09	0.18	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	UBE2Z	0.13	0.09	lasso	4	0.12	2.7e-11	-5.4	5.8	8.5e-09	-0.58	0.14	0.86	FALSE
12	GTEx	Esophagus Muscularis	COPZ2	0.14	0.04	lasso	5	0.06	1.3e-04	2.9	5.7	1.3e-08	-0.04	0.18	0.04	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNF8	0.11	0.12	lasso	4	0.12	1.4e-13	-5.6	5.7	1.3e-08	-0.60	0.35	0.65	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	CALCOCO2	0.07	0.05	enet	9	0.06	1.3e-06	-6.1	5.7	1.5e-08	-0.42	0.01	0.99	FALSE
4	GTEx	Artery Aorta	SNF8	0.12	0.12	lasso	6	0.10	2.3e-06	-5.4	5.6	2.2e-08	-0.58	0.71	0.19	FALSE
30	GTEx	Thyroid	RP11-6N17.10	0.19	0.12	lasso	5	0.13	3.0e-10	-3.3	-5.6	2.3e-08	0.12	1.00	0.00	FALSE
16	GTEx	Heart Atrial Appendage	ATP5G1	0.22	0.10	enet	6	0.13	1.3e-06	-5.4	5.5	3.2e-08	-0.57	0.94	0.02	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTLL6	0.03	0.00	blup	59	0.02	2.7e-03	-4.6	-5.5	3.4e-08	0.51	0.02	0.81	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNF8	0.05	0.06	blup	47	0.06	1.0e-06	-6.1	5.5	3.7e-08	-0.62	0.08	0.92	FALSE
27	GTEx	Testis	SNF8	0.23	0.11	lasso	5	0.08	1.6e-04	-5.4	5.5	4.3e-08	-0.56	0.67	0.10	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	SNF8	0.16	0.18	lasso	7	0.18	5.9e-17	-5.4	5.5	4.5e-08	-0.58	0.36	0.64	FALSE
13	GTEx	Esophagus Muscularis	ATP5G1	0.09	0.06	lasso	5	0.05	4.5e-04	-5.4	5.5	4.8e-08	-0.56	0.17	0.49	FALSE
7	GTEx	Brain Cortex	ATP5G1	0.16	0.15	lasso	2	0.14	1.3e-04	-5.4	5.5	5.1e-08	-0.55	0.15	0.22	FALSE
15	GTEx	Heart Atrial Appendage	CDK5RAP3	0.13	0.00	enet	18	0.04	5.1e-03	1.9	-5.4	5.7e-08	0.07	0.09	0.05	FALSE
19	GTEx	Muscle Skeletal	AC003665.1	0.05	0.03	enet	8	0.03	1.4e-03	4.6	5.4	5.7e-08	-0.10	0.12	0.72	FALSE
10	GTEx	Cells Transformed fibroblasts	AC091133.1	0.14	0.07	enet	22	0.09	1.9e-07	-5.4	5.4	6.8e-08	-0.56	0.86	0.10	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CBX1	0.03	0.01	lasso	3	0.01	8.7e-03	5.9	-5.4	8.2e-08	0.08	0.01	0.82	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	CDK5RAP3	0.21	0.04	lasso	4	0.02	7.2e-02	5.9	-5.3	9.5e-08	0.08	0.08	0.37	FALSE
6	GTEx	Brain Cerebellum	ATP5G1	0.22	0.26	lasso	3	0.24	8.2e-08	-5.4	5.3	1.1e-07	-0.55	0.82	0.10	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNX11	0.06	0.06	lasso	3	0.05	2.8e-06	-5.3	5.3	1.2e-07	-0.06	0.35	0.62	FALSE
11	GTEx	Esophagus Mucosa	NFE2L1	0.07	0.02	lasso	4	0.01	8.6e-02	-5.3	-5.2	1.9e-07	0.07	0.32	0.03	FALSE
20	GTEx	Nerve Tibial	UBE2Z	0.12	0.04	enet	16	0.05	1.5e-04	-5.4	5.2	2.0e-07	-0.52	0.88	0.02	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CDK5RAP3	0.15	0.12	bslmm	392	0.14	3.6e-16	5.6	-5.1	3.0e-07	0.08	0.74	0.26	FALSE