Best TWAS P=7.88e-12 · Best GWAS P=9.43e-12 conditioned to 0.0643
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | LINC00674 | 0.12 | 0.13 | enet | 6 | 0.14 | 9.9e-12 | 5.6 | 5.7 | 1.5e-08 | 0.79 | 0.90 | 0.10 | FALSE |
2 | GTEx | Adipose Subcutaneous | SH3GL1P3 | 0.08 | 0.06 | lasso | 5 | 0.04 | 2.5e-04 | 5.6 | 5.5 | 3.9e-08 | 0.80 | 0.06 | 0.91 | FALSE |
3 | GTEx | Brain Cerebellum | BPTF | 0.22 | -0.01 | lasso | 10 | -0.01 | 6.9e-01 | 6.1 | -6.2 | 6.6e-10 | -0.85 | 0.03 | 0.48 | FALSE |
4 | GTEx | Brain Cortex | C17orf58 | 0.34 | 0.09 | lasso | 6 | 0.13 | 2.4e-04 | 6.7 | 6.4 | 1.9e-10 | 0.95 | 0.03 | 0.95 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | LINC00674 | 0.30 | 0.31 | enet | 10 | 0.32 | 1.5e-24 | 5.6 | 6.2 | 5.3e-10 | 0.86 | 0.94 | 0.06 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | LRRC37A16P | 0.50 | 0.46 | lasso | 8 | 0.47 | 1.1e-38 | 5.6 | 5.8 | 7.1e-09 | 0.84 | 0.94 | 0.06 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | SH3GL1P3 | 0.26 | 0.31 | lasso | 7 | 0.31 | 1.5e-23 | 5.6 | 6.2 | 5.6e-10 | 0.90 | 0.93 | 0.07 | FALSE |
8 | GTEx | Colon Sigmoid | LINC00674 | 0.42 | 0.09 | lasso | 8 | 0.12 | 5.5e-05 | 6.1 | 5.7 | 1.5e-08 | 0.80 | 0.13 | 0.69 | FALSE |
9 | GTEx | Esophagus Muscularis | LINC00674 | 0.11 | 0.04 | lasso | 6 | 0.07 | 7.9e-05 | 3.9 | 5.8 | 4.8e-09 | 0.77 | 0.18 | 0.80 | FALSE |
10 | GTEx | Heart Atrial Appendage | LINC00674 | 0.14 | 0.08 | lasso | 17 | 0.09 | 1.1e-04 | 3.9 | 5.5 | 4.0e-08 | 0.73 | 0.05 | 0.87 | FALSE |
11 | GTEx | Lung | LINC00674 | 0.14 | 0.03 | enet | 22 | 0.08 | 2.1e-06 | 6.5 | 5.2 | 1.7e-07 | 0.80 | 0.12 | 0.88 | FALSE |
12 | GTEx | Nerve Tibial | LRRC37A16P | 0.09 | 0.08 | lasso | 4 | 0.06 | 2.7e-05 | 5.7 | 5.7 | 1.1e-08 | 0.84 | 0.11 | 0.77 | FALSE |
13 | YFS | Blood | KPNA2 | 0.01 | 0.01 | blup | 312 | 0.01 | 2.8e-04 | 6.1 | -6.8 | 7.9e-12 | -0.86 | 0.05 | 0.93 | TRUE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf58 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.8e-02 | 6.7 | 6.7 | 2.1e-11 | 1.00 | 0.00 | 0.76 | FALSE |