TWAS
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Genes
Traits
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Traits
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Body mass index (BMI)
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chr19:48,931,222-50,349,958
Best TWAS P=3.32e-08 · Best GWAS P=5.07e-08 conditioned to 0.288
49M
49.2M
49.4M
49.6M
49.8M
50M
50.2M
50.4M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Spleen
PPFIA3
0.25
0.23
lasso
4
0.21
3.9e-06
5.0
-5.5
3.3e-08
-0.9
0.01
0.98
TRUE
2
The Cancer Genome Atlas
Colon Adenocarcinoma
SNRNP70
0.05
0.02
lasso
3
0.02
2.9e-02
4.8
-5.1
2.9e-07
-0.7
0.01
0.68
FALSE