Hub : Genes

PPFIA3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pituitary 0.485 0.110 3.2e-05 0.346 NA 0.372 NA 0.368 1.6e-09 NA 2.7e-10 NA 3.5e-10
2 GTEx Spleen 0.249 0.083 3.8e-03 0.231 NA 0.171 NA 0.212 1.3e-06 NA 3.7e-05 NA 3.9e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.0 0.1 0.1 0.1 -0.3
Bipolar Disorder or Schizophrenia 0.6 1.5 1.7 -1.3 1.1
Depressed Affect (Nagel 2018) 5.6 11.7 13.1 3.2 -3.6
Depression (Nagel 2018) 1.8 2.7 3.1 1.8 -1.6
Intelligence (Savage-Jansen 2018) 0.0 0.2 0.3 0.2 0.5
Neuroticism (Nagel 2018) 3.2 7.6 9.1 2.5 -3.0
Schizophrenia (2018) 1.4 2.9 3.0 -1.7 1.7
Schizophrenia vs Biploar Disorder 0.5 0.6 1.2 0.0 1.1
Worry (Nagel 2018) 1.8 3.7 5.1 1.5 -2.3
Alzheimer’s Disease (in mother) 0.4 0.4 0.7 0.4 -0.8
Alzheimer’s Disease (in father) 0.1 0.1 0.1 -0.4 -0.3
Alzheimer’s Disease (including proxy) 1.1 1.6 2.8 0.7 -1.7
Crohns Disease (2017) 1.4 3.1 4.5 2.1 -1.3
Irritable Bowel Disease (IBD) 1.1 2.6 3.6 1.9 -1.3
Ulcerative Colitis (UC) 0.8 1.5 1.9 1.4 -1.1
Major Depression (MDD) 0.1 0.1 0.2 -0.0 -0.5
Reaction Time 5.8 11.1 12.0 3.2 -3.5
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.8 0.3 0.9
Breast Cancer 0.6 1.5 2.9 0.4 -1.7
Ovarian Cancer 0.4 0.5 0.7 0.8 -0.5
Prostate Cancer 0.2 0.2 0.4 0.3 0.6
Age at First Birth 1.7 2.4 3.3 1.8 -1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.2 2.2 0.5 -1.5
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.1 1.7 2.2 1.5 -1.1
Mean Putamen Volume 1.9 2.2 2.8 -1.7 1.2
Fasting Glucose 0.3 0.3 0.6 -0.1 -0.8
HbA1C 0.2 0.3 0.4 0.6 0.4
HDL Cholesterol 0.2 0.3 0.7 -0.0 0.8
LDL Cholesterol 0.3 0.5 1.0 -0.3 1.0
Lupus 1.4 2.1 2.1 1.4 -1.5
Neuroticism (2016) 0.7 1.0 1.9 1.4 -0.4
Primary Biliary Cirrhosis 0.5 0.7 1.1 -0.6 1.1
Rheumatoid Arthritis 0.1 0.2 0.3 0.5 -0.0
Schizophrenia (2014) 1.8 4.0 4.1 -2.0 2.0
Triglycerides 0.8 1.4 1.9 1.4 -0.9
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 1.2 1.8 2.2 1.5 -1.2
Blood Eosinophil Count 0.1 0.6 1.2 1.1 0.3
Blood Platelet Count 0.3 3.0 5.3 2.3 -0.8
Blood Red Count 0.2 1.9 3.3 0.7 -1.8
Blood White Count 0.0 0.2 0.2 -0.3 0.5
Heel T-Score 0.4 2.9 5.3 -2.3 0.6
BMI 5.2 30.1 43.4 4.1 -6.6
Height 0.6 11.5 18.2 4.3 -2.2
Waist Hip Ratio (WHR) 0.1 0.2 0.3 -0.4 0.5
Systolic Blood Pressure 1.0 5.1 10.2 0.1 -3.2
Smoking Status 0.4 1.0 1.2 -1.1 0.9
Allergy or Eczema 1.9 4.9 4.9 2.2 -2.2
Cardiovascular Disease 1.4 4.6 5.8 2.4 -1.8
Hypothyroidism (self reported) 0.3 0.8 0.9 0.7 -1.0
Respiratory disease 0.0 0.1 0.1 0.4 -0.3
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 -0.6 0.4
Lung FEV1/FVC ratio 0.3 1.6 3.0 -0.3 -1.7
Lung FVC 1.2 5.9 9.2 3.0 -1.6
Neuroticism 4.8 11.6 11.6 3.4 -3.4
Chronotype (morning person) 3.5 8.0 8.7 2.9 -2.7
Hair Pigment 0.1 2.1 2.6 -1.2 -1.6
Tanning 0.0 0.4 0.4 -0.7 0.6
Hand grip strength (left) 0.3 0.8 0.9 1.0 -0.9
Number of treatments/medications taken 3.0 5.4 7.2 2.7 -1.9
Average weekly spirits intake 1.1 1.3 2.4 0.5 -1.5
Sensitivity / hurt feelings 3.1 5.2 7.3 2.7 -1.8
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.0 -0.1 -0.0
Hearing difficulty/problems: Yes 0.6 0.9 1.4 0.7 -1.2
Relative age of first facial hair 2.3 4.6 8.9 3.0 -0.6
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 2.4 1.6 -0.8
Ever used hormone-replacement therapy (HRT) 2.1 2.7 3.5 1.3 -1.9
Ever had hysterectomy (womb removed) 1.6 1.9 2.0 1.4 -1.3
Systolic blood pressure, automated reading 1.6 4.6 9.2 -0.0 -3.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.3 -0.4
Angina 1.0 1.3 2.0 1.4 -0.7
Medication for hormone replacement therapy 0.3 0.3 0.3 -0.6 0.6
Vitamin and mineral supplements 0.3 0.4 0.8 -0.9 0.3
Supplements: Zinc 0.2 0.2 0.3 -0.5 0.4
Medication: Co-codamol 2.1 2.5 3.3 1.3 -1.8
Medication: Metformin 0.5 0.7 1.5 -1.2 -0.1
Diabetes (father) 1.0 1.2 1.3 -1.2 1.1
Diabetes (mother) 0.2 0.3 0.5 -0.7 0.4
Severe depression (siblings) 0.2 0.3 0.5 0.0 -0.7
Pack years adult smoking proportion 2.2 3.4 5.9 0.9 -2.4
Impedance of leg (right) 2.3 11.1 15.0 -2.7 3.9
Leg fat-free mass (left) 3.2 16.9 19.1 3.8 -4.4
Trunk fat percentage 3.2 12.6 15.3 3.2 -3.9
Hand grip strength (right) 0.3 0.7 0.8 0.7 -0.9
Townsend deprivation index at recruitment 0.1 0.1 0.2 -0.4 0.4
Current tobacco smoking 0.9 1.5 1.7 -1.3 1.2
Average weekly fortified wine intake 0.4 0.5 0.6 -0.6 -0.8
Maternal smoking around birth 6.9 10.0 11.8 2.9 -3.4
Fed-up feelings 2.0 3.7 6.1 1.1 -2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 1.7 0.6 -1.3
Relative age voice broke 2.8 4.2 6.2 2.5 -1.5
Taking other prescription medications 1.6 2.4 2.8 1.7 -1.4
Age when periods started (menarche) 0.4 1.0 2.0 -0.1 1.4
Bilateral oophorectomy (both ovaries removed) 2.2 2.6 3.5 1.3 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.6 0.0 -1.6
Tinnitus: Yes, but not now, but have in the past 1.7 1.9 3.0 0.8 -1.7
Qualifications: CSEs or equivalent 0.6 0.8 1.0 -0.8 1.0
Serious illness, injury or assault to yourself 0.0 0.0 0.0 0.2 -0.1
High blood pressure 2.8 7.8 10.3 2.3 -3.2
Hayfever, allergic rhinitis or eczema 1.2 2.5 3.4 1.8 -1.3
Multivitamins +/- minerals 0.5 0.7 1.1 -1.0 0.5
Stomach or abdominal pain in last month 1.2 1.5 2.4 1.6 -0.8
Supplements: Glucosamine 0.0 0.0 0.0 -0.2 -0.2
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.1 -0.3 0.0
Medication: Atenolol 4.4 5.5 6.9 2.6 -2.0
Medication: Levothyroxine sodium 2.6 4.4 5.9 2.4 -1.7
Sitting height 0.6 4.0 6.4 2.5 -1.3
Chronic bronchitis/emphysema (father) 0.9 1.0 1.4 1.2 -0.8
High blood pressure (mother) 1.4 2.0 4.0 0.1 -2.0
Body mass index (BMI) 5.1 21.7 30.5 3.6 -5.5
Impedance of leg (left) 1.9 9.3 12.7 -2.4 3.6
Leg predicted mass (left) 3.3 17.3 19.5 3.9 -4.4
Trunk fat mass 4.2 18.1 21.7 3.8 -4.7
Waist circumference 3.5 13.0 16.5 3.1 -4.1
Number of incorrect matches in round 0.4 0.6 1.2 -1.1 0.3
Past tobacco smoking 0.0 0.0 0.1 -0.2 -0.2
Alcohol usually taken with meals 0.2 0.3 0.4 0.6 0.5
Nervous feelings 0.1 0.2 0.3 0.5 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.6 -0.3 -0.7
Hearing difficulty/problems with background noise 4.7 7.5 8.5 2.9 -2.5
Hair/balding pattern: Pattern 2 0.4 0.5 0.9 0.9 0.4
Had menopause 1.2 1.5 1.8 1.3 -1.1
Had other major operations 0.3 0.3 0.5 0.7 0.4
Forced vital capacity (FVC) 0.4 1.4 2.8 1.7 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.5 -0.2 -1.6
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.3 1.1 -0.8
Qualifications: None of the above 3.0 6.4 9.0 3.0 -1.9
Financial difficulties in last 2 years 0.1 0.2 0.3 0.1 -0.6
Mouth/teeth dental problems 3.3 5.1 5.4 -2.2 2.3
Heart attack 1.1 1.4 1.8 1.3 -1.0
Allergy 1.7 3.8 5.2 -2.3 1.6
Pain all over the body in last month 0.1 0.1 0.2 -0.4 0.1
Diabetes (self-reported) 0.7 1.1 2.1 -1.4 0.2
Hayfever/allergic rhinitis (self-reported) 1.2 1.5 1.8 -1.1 1.3
Medication: Ramipril 3.2 4.1 4.2 2.0 -2.0
Medication: Simvastatin 2.5 3.6 7.1 2.7 -0.3
Fluid intelligence score 0.2 0.4 0.8 0.3 0.9
Illnesses of siblings 0.2 0.2 0.3 0.6 -0.3
Neuroticism score 2.4 4.9 6.5 1.8 -2.5
Weight 5.0 24.5 28.7 4.5 -5.4
Impedance of arm (right) 3.7 17.2 25.5 -3.0 5.0
Arm fat percentage (right) 3.3 13.2 17.6 3.0 -4.2
Trunk fat-free mass 3.2 18.1 18.5 4.2 -4.3
Hip circumference 3.5 15.2 18.7 3.4 -4.3
Time employed in main current job 0.0 0.0 0.0 0.1 0.2
Alcohol intake versus 10 years previously 0.1 0.1 0.2 0.4 0.1
Father’s age at death 0.2 0.2 0.4 -0.6 0.3
Worrier / anxious feelings 1.2 2.4 3.3 1.2 -1.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.6 -0.4 -0.7
Falls in the last year 0.1 0.2 0.3 -0.1 -0.6
Hair/balding pattern: Pattern 3 1.3 1.9 3.2 -1.8 0.7
Number of live births 0.3 0.4 0.7 -0.2 0.8
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.3 1.1 -0.3
Pulse rate 1.9 3.1 3.5 1.9 -1.7
Happiness 0.3 0.4 0.7 -0.3 0.9
Noisy workplace 1.6 2.0 2.8 1.1 -1.7
Qualifications: A levels/AS levels or equivalent 1.3 3.0 5.1 -2.3 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.6 0.1 0.8
Mouth/teeth dental problems: Dentures 5.2 8.8 9.4 3.1 -2.9
Asthma 0.2 0.5 0.8 0.9 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 1.6 0.9 -1.2
Medication: Cholesterol lowering 1.7 2.7 3.8 2.0 -1.2
Depression (self-reported) 0.1 0.1 0.2 0.4 0.3
Medication: Lansoprazole 1.0 1.1 1.1 1.1 -1.1
Prospective memory result 0.2 0.2 0.3 0.5 -0.4
Lung cancer (father) 0.2 0.3 0.6 0.8 0.0
Illnesses of mother 2.3 2.9 5.0 -0.9 2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 1.5 1.2 -0.3
Pulse wave Arterial Stiffness index 1.3 1.5 2.5 0.6 -1.6
Impedance of arm (left) 4.4 20.2 29.4 -3.3 5.4
Arm fat mass (right) 5.4 22.1 28.5 4.0 -5.3
Trunk predicted mass 3.2 18.2 18.7 4.2 -4.3
Standing height 0.3 3.4 6.7 2.6 -0.3
Length of working week for main job 2.3 2.6 3.2 1.8 -1.4
Exposure to tobacco smoke at home 0.1 0.1 0.1 0.2 -0.3
Breastfed as a baby 0.7 0.8 1.0 -1.0 0.8
Tense / ‘highly strung’ 1.2 1.9 2.9 1.0 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.5 -0.5 0.7
Hair/balding pattern: Pattern 4 0.0 0.0 0.0 0.1 -0.1
Birth weight of first child 0.2 0.4 0.7 0.2 -0.8
Peak expiratory flow (PEF) 0.2 0.4 0.9 0.9 0.0
Pulse wave reflection index 0.7 0.9 1.1 -0.8 1.1
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.5 -0.5 -0.7
Loud music exposure frequency 0.1 0.2 0.3 0.5 0.2
Qualifications: O levels/GCSEs or equivalent 2.3 3.6 5.4 -2.3 1.4
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 2.0 -1.3 1.4
Blood clot in the leg (DVT) 0.8 1.1 1.8 0.6 1.3
Medication: Paracetamol 0.8 1.3 2.5 1.6 -0.1
Headache pain in last month 2.1 3.6 6.2 2.5 -1.0
Medication for cholesterol, blood pressure or diabetes 3.7 6.2 7.2 -2.7 2.3
Glaucoma (self-reported) 1.1 1.3 2.3 -1.5 0.6
Gout (self-reported) 0.2 0.3 0.4 -0.4 -0.6
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 1.9 1.2 -1.4
Medication: Amlodipine 3.4 4.7 6.4 1.7 -2.5
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.6 1.3 0.1
Birth weight 0.1 0.1 0.2 0.4 0.2
Chronic bronchitis/emphysema (mother) 1.1 1.2 2.0 0.7 -1.4
High blood pressure (siblings) 0.1 0.1 0.3 -0.5 0.1
Forced vital capacity (FVC), Best measure 0.3 1.0 1.9 1.4 0.2
Body fat percentage 3.6 14.1 17.7 3.2 -4.2
Leg fat percentage (right) 3.8 13.8 18.8 3.0 -4.3
Arm fat-free mass (right) 4.4 22.3 25.0 4.4 -5.0
Exposure to tobacco smoke outside home 0.3 0.4 0.6 -0.7 0.5
Comparative body size at age 10 1.3 3.6 6.9 0.6 -2.6
Number of full brothers 3.3 4.2 5.3 -2.3 1.8
Worry too long after embarrassment 0.1 0.2 0.2 -0.4 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 0.8 0.8 -0.9
Wheeze or whistling in the chest in last year 0.3 0.4 0.5 -0.6 0.7
Number of children fathered 0.2 0.2 0.4 0.3 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.9 1.0 0.2
Age at first live birth 0.1 0.1 0.1 0.3 -0.4
Pulse wave peak to peak time 1.0 1.2 2.2 -0.5 1.5
Health satisfaction 0.7 0.9 1.5 1.2 -0.7
Shortness of breath walking on level ground 2.4 2.9 4.2 1.2 -2.0
Qualifications: College or University degree 0.0 0.1 0.1 -0.2 0.3
Eye problems/disorders: None of the above 0.2 0.3 0.5 0.7 0.1
Mouth/teeth dental problems: Loose teeth 1.1 1.3 1.4 1.0 -1.2
Emphysema/chronic bronchitis 0.5 0.6 1.1 0.0 -1.1
Medication for pain relief, constipation, heartburn 2.6 4.5 7.4 -2.7 1.2
Neck or shoulder pain in last month 0.8 1.2 2.3 1.5 -0.2
Medication: Blood pressure 7.1 12.6 13.3 3.5 -3.6
Angina (self-reported) 0.9 1.1 1.8 1.3 -0.7
Migraine (self-reported) 0.2 0.3 0.4 0.4 -0.7
Medication: Ibuprofen 0.5 0.6 1.0 0.4 -1.0
Medication: Allopurinol 0.7 1.0 1.6 -1.2 0.6
Medication: Omeprazole 0.0 0.0 0.0 0.2 -0.2
Medication: Seretide 50 evohaler 0.4 0.4 0.7 -0.4 0.9
Mean time to correctly identify matches 7.7 14.7 16.4 4.1 -3.6
Heart disease (mother) 0.6 0.8 0.8 0.9 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.0 0.4
Whole body fat mass 5.1 21.2 26.2 4.0 -5.1
Leg fat mass (right) 5.5 21.5 28.1 3.9 -5.3
Arm predicted mass (right) 5.1 26.0 28.2 4.9 -5.3
Pulse rate, automated reading 2.4 7.6 8.1 2.8 -2.7
Alcohol intake frequency. 0.0 0.1 0.2 -0.1 -0.4
Comparative height size at age 10 0.3 1.9 3.2 1.8 -0.8
Number of full sisters 0.8 1.0 1.8 -0.4 1.4
Suffer from ‘nerves’ 0.1 0.2 0.2 -0.5 -0.5
Overall health rating 2.9 6.1 6.8 2.3 -2.6
Chest pain or discomfort 2.7 3.9 4.4 2.1 -1.8
Had major operations 0.5 0.6 0.6 -0.7 0.8
Age at last live birth 0.1 0.2 0.2 0.4 -0.3
Family relationship satisfaction 0.2 0.3 0.3 -0.4 0.6
Leg pain on walking 1.7 2.1 3.5 0.9 -1.9
Qualifications: NVQ or HND or HNC or equivalent 6.8 8.2 8.6 -2.9 2.8
Commuting to job workplace: Car/motor vehicle 2.2 2.5 2.9 -1.4 1.7
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.6 0.8 -0.3
Medication: Aspirin 4.2 5.5 6.4 2.5 -2.1
Supplements: Vitamin C 0.2 0.2 0.4 0.6 0.2
Knee pain experienced in last month 0.8 1.3 2.0 0.8 -1.4
Hypertension (Self-reported) 2.9 8.1 10.4 2.4 -3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.2 0.3
Illnesses of father: Heart disease 1.3 1.8 2.0 1.4 -1.2
Illnesses of siblings: Diabetes 2.6 3.2 4.2 -1.5 2.1
Smoking status: Previous 0.1 0.2 0.2 0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.3 -0.5 1.1
Whole body fat-free mass 3.4 19.5 20.9 4.2 -4.6
Leg fat-free mass (right) 3.3 17.5 19.1 4.0 -4.4
Arm fat percentage (left) 3.1 12.5 16.7 2.9 -4.1
Average weekly red wine intake 0.4 0.6 1.3 -1.1 0.0
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.8 -0.0 -0.9
Mood swings 2.1 3.9 5.1 1.6 -2.3
Loneliness, isolation 0.5 0.7 1.1 1.1 -0.5
Long-standing illness, disability or infirmity 2.5 3.8 4.3 2.1 -1.8
Ever had bowel cancer screening 1.3 1.5 3.0 1.7 -0.1
Diabetes diagnosed by doctor 0.2 0.4 0.8 -0.9 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.7 0.8 0.2
Friendships satisfaction 0.1 0.1 0.1 -0.4 -0.4
Qualifications: nursing, teaching 3.0 4.7 6.9 -2.6 1.6
Commuting to job workplace: Walk 0.3 0.3 0.7 -0.0 -0.8
Eye problems/disorders: Cataract 0.1 0.2 0.3 0.2 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 -0.1 -0.2
Medication for cholesterol 0.0 0.1 0.1 -0.3 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.2 0.3 0.5
Back pain experienced in last month 0.8 1.2 1.5 0.9 -1.2
Mineral and other dietary supplements 0.1 0.2 0.3 -0.5 0.3
Breast cancer (self-reported) 0.3 0.4 0.6 0.8 -0.3
Asthma (self-reported) 0.2 0.4 0.8 0.9 -0.2
Osteoporosis (self-reported) 0.9 1.1 1.8 1.3 -0.5
Osteoarthritis (self-reported) 0.4 0.5 0.6 0.6 -0.8
Medication: Aspirin 3.4 4.5 5.6 2.4 -1.8
Medication: Gliclazide 0.5 0.5 1.0 -1.0 0.1
Illnesses of father: None of the above (group 1) 4.0 4.9 5.5 -2.1 2.3
Smoking status: Current 1.2 1.9 2.0 -1.3 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.8 4.2 2.1 -1.2
Whole body water mass 3.7 21.3 22.7 4.5 -4.8
Leg predicted mass (right) 3.1 16.6 18.1 3.9 -4.3
Arm fat mass (left) 4.9 20.1 25.8 3.8 -5.1
Number of self-reported non-cancer illnesses 0.9 1.6 1.7 1.3 -1.2
Average weekly champagne plus white wine intake 0.2 0.3 0.5 -0.2 -0.7
Miserableness 1.6 2.8 3.3 1.5 -1.8
Guilty feelings 0.1 0.2 0.4 -0.3 0.6
Wears glasses or contact lenses 6.2 7.1 7.7 2.6 -2.8
Ever taken oral contraceptive pill 0.0 0.0 0.0 -0.1 0.1
Hearing aid user 3.9 4.4 5.4 1.8 -2.3
Mother’s age at death 4.0 5.0 6.9 -1.8 2.6
Financial situation satisfaction 0.6 0.7 1.4 -0.2 1.2
Tinnitus: Yes, now most or all of the time 3.3 3.8 6.9 -0.9 2.6
Commuting to job workplace: Public transport 0.3 0.3 0.6 -0.8 -0.0
Eye problems/disorders: Glaucoma 2.6 3.0 4.5 -2.1 1.3
Medication: Blood pressure 0.6 1.1 1.8 0.6 -1.4
Pain type(s) experienced in last month: Hip pain 2.7 3.4 5.2 1.2 -2.3
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.3 0.5 -0.5
High cholesterol (Self-reported) 0.3 0.6 0.6 0.8 0.7
Medication: Bendroflumethiazide 1.4 2.2 2.2 1.5 -1.5
Medication: Paracetamol 1.1 1.8 3.4 1.9 -0.3
Medication: Lisinopril 0.4 0.5 0.9 -1.0 0.2
Medication: Atorvastatin 0.1 0.1 0.2 -0.2 -0.4
Illnesses of father: High blood pressure 0.6 0.8 1.0 -1.0 -0.7
Alcohol drinker status: Never 1.7 2.1 2.6 1.3 -1.6
Ever smoked 0.3 0.5 0.7 -0.5 0.8
Basal metabolic rate 3.9 21.9 24.1 4.4 -4.9
Leg fat percentage (left) 4.1 14.9 20.0 3.1 -4.5
Arm fat-free mass (left) 5.8 29.5 32.3 5.2 -5.7
Number of operations (self-reported) 0.6 0.9 1.3 1.1 -0.7
Average weekly beer plus cider intake 0.6 0.9 1.6 -0.4 1.3
Irritability 8.1 13.7 20.3 2.7 -4.5
Risk taking 0.2 0.2 0.5 0.7 -0.1
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.4 0.3 -1.6
Fractured/broken bones in last 5 years 0.4 0.5 0.7 0.8 0.7
Age started oral contraceptive pill 1.0 1.3 1.7 1.3 -0.9
Diastolic blood pressure, automated reading 0.2 0.7 1.3 -0.3 -1.1
Ever depressed for a whole week 0.1 0.1 0.2 0.5 -0.1
Unable to work because of sickness or disability 0.8 1.0 1.9 -1.4 0.4
Commuting to job workplace: Cycle 0.1 0.1 0.1 -0.4 0.2
Myopia 0.4 0.6 1.1 -0.2 -1.1
Vascular/heart problems diagnosed by doctor 3.3 9.0 10.9 -2.7 3.3
Cholesterol lowering medication 1.0 1.5 2.9 1.7 0.2
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.0 0.0 -0.0
Pain experienced in last month 1.8 3.0 4.3 -2.1 1.3
Supplements: Calcium 0.3 0.4 0.5 0.4 -0.7
Basal cell carcinoma (self-reported) 0.4 0.4 0.7 0.4 0.9
Heart attack/myocardial infarction (self-reported) 1.3 1.6 2.2 1.5 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 2.2 0.3 1.5
Heart disease (siblings) 0.0 0.0 0.0 0.2 0.2
Alcohol drinker status: Previous 1.7 1.9 2.4 -1.6 1.2
Pack years of smoking 3.3 4.8 7.9 1.3 -2.8
Impedance of whole body 4.0 20.2 28.3 -3.5 5.3
Leg fat mass (left) 5.5 21.6 28.3 3.9 -5.3
Arm predicted mass (left) 5.3 26.9 30.7 4.8 -5.5