TWAS hub - PPFIA3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pituitary	0.485	0.110	3.2e-05	0.346	NA	0.372	NA	0.368	1.6e-09	NA	2.7e-10	NA	3.5e-10
2	GTEx	Spleen	0.249	0.083	3.8e-03	0.231	NA	0.171	NA	0.212	1.3e-06	NA	3.7e-05	NA	3.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Irritability	8.1	13.7	20.3	2.7	-4.5
Mean time to correctly identify matches	7.7	14.7	16.4	4.1	-3.6
Medication: Blood pressure	7.1	12.6	13.3	3.5	-3.6
Maternal smoking around birth	6.9	10.0	11.8	2.9	-3.4
Qualifications: NVQ or HND or HNC or equivalent	6.8	8.2	8.6	-2.9	2.8
Wears glasses or contact lenses	6.2	7.1	7.7	2.6	-2.8
Reaction Time	5.8	11.1	12.0	3.2	-3.5
Arm fat-free mass (left)	5.8	29.5	32.3	5.2	-5.7
Depressed Affect (Nagel 2018)	5.6	11.7	13.1	3.2	-3.6
Leg fat mass (right)	5.5	21.5	28.1	3.9	-5.3
Leg fat mass (left)	5.5	21.6	28.3	3.9	-5.3
Arm fat mass (right)	5.4	22.1	28.5	4.0	-5.3
Arm predicted mass (left)	5.3	26.9	30.7	4.8	-5.5
BMI	5.2	30.1	43.4	4.1	-6.6
Mouth/teeth dental problems: Dentures	5.2	8.8	9.4	3.1	-2.9
Body mass index (BMI)	5.1	21.7	30.5	3.6	-5.5
Whole body fat mass	5.1	21.2	26.2	4.0	-5.1
Arm predicted mass (right)	5.1	26.0	28.2	4.9	-5.3
Weight	5.0	24.5	28.7	4.5	-5.4
Arm fat mass (left)	4.9	20.1	25.8	3.8	-5.1
Neuroticism	4.8	11.6	11.6	3.4	-3.4
Hearing difficulty/problems with background noise	4.7	7.5	8.5	2.9	-2.5
Medication: Atenolol	4.4	5.5	6.9	2.6	-2.0
Impedance of arm (left)	4.4	20.2	29.4	-3.3	5.4
Arm fat-free mass (right)	4.4	22.3	25.0	4.4	-5.0
Trunk fat mass	4.2	18.1	21.7	3.8	-4.7
Medication: Aspirin	4.2	5.5	6.4	2.5	-2.1
Leg fat percentage (left)	4.1	14.9	20.0	3.1	-4.5
Illnesses of father: None of the above (group 1)	4.0	4.9	5.5	-2.1	2.3
Mother’s age at death	4.0	5.0	6.9	-1.8	2.6
Impedance of whole body	4.0	20.2	28.3	-3.5	5.3
Hearing aid user	3.9	4.4	5.4	1.8	-2.3
Basal metabolic rate	3.9	21.9	24.1	4.4	-4.9
Leg fat percentage (right)	3.8	13.8	18.8	3.0	-4.3
Impedance of arm (right)	3.7	17.2	25.5	-3.0	5.0
Medication for cholesterol, blood pressure or diabetes	3.7	6.2	7.2	-2.7	2.3
Whole body water mass	3.7	21.3	22.7	4.5	-4.8
Body fat percentage	3.6	14.1	17.7	3.2	-4.2
Chronotype (morning person)	3.5	8.0	8.7	2.9	-2.7
Waist circumference	3.5	13.0	16.5	3.1	-4.1
Hip circumference	3.5	15.2	18.7	3.4	-4.3
Medication: Amlodipine	3.4	4.7	6.4	1.7	-2.5
Whole body fat-free mass	3.4	19.5	20.9	4.2	-4.6
Medication: Aspirin	3.4	4.5	5.6	2.4	-1.8
Leg predicted mass (left)	3.3	17.3	19.5	3.9	-4.4
Mouth/teeth dental problems	3.3	5.1	5.4	-2.2	2.3
Arm fat percentage (right)	3.3	13.2	17.6	3.0	-4.2
Number of full brothers	3.3	4.2	5.3	-2.3	1.8
Leg fat-free mass (right)	3.3	17.5	19.1	4.0	-4.4
Tinnitus: Yes, now most or all of the time	3.3	3.8	6.9	-0.9	2.6
Vascular/heart problems diagnosed by doctor	3.3	9.0	10.9	-2.7	3.3
Pack years of smoking	3.3	4.8	7.9	1.3	-2.8
Neuroticism (Nagel 2018)	3.2	7.6	9.1	2.5	-3.0
Leg fat-free mass (left)	3.2	16.9	19.1	3.8	-4.4
Trunk fat percentage	3.2	12.6	15.3	3.2	-3.9
Medication: Ramipril	3.2	4.1	4.2	2.0	-2.0
Trunk fat-free mass	3.2	18.1	18.5	4.2	-4.3
Trunk predicted mass	3.2	18.2	18.7	4.2	-4.3
Sensitivity / hurt feelings	3.1	5.2	7.3	2.7	-1.8
Arm fat percentage (left)	3.1	12.5	16.7	2.9	-4.1
Leg predicted mass (right)	3.1	16.6	18.1	3.9	-4.3
Number of treatments/medications taken	3.0	5.4	7.2	2.7	-1.9
Qualifications: None of the above	3.0	6.4	9.0	3.0	-1.9
Qualifications: nursing, teaching	3.0	4.7	6.9	-2.6	1.6
Overall health rating	2.9	6.1	6.8	2.3	-2.6
Hypertension (Self-reported)	2.9	8.1	10.4	2.4	-3.2
Relative age voice broke	2.8	4.2	6.2	2.5	-1.5
High blood pressure	2.8	7.8	10.3	2.3	-3.2
Chest pain or discomfort	2.7	3.9	4.4	2.1	-1.8
Pain type(s) experienced in last month: Hip pain	2.7	3.4	5.2	1.2	-2.3
Medication: Levothyroxine sodium	2.6	4.4	5.9	2.4	-1.7
Medication for pain relief, constipation, heartburn	2.6	4.5	7.4	-2.7	1.2
Illnesses of siblings: Diabetes	2.6	3.2	4.2	-1.5	2.1
Eye problems/disorders: Glaucoma	2.6	3.0	4.5	-2.1	1.3
Medication: Simvastatin	2.5	3.6	7.1	2.7	-0.3
Long-standing illness, disability or infirmity	2.5	3.8	4.3	2.1	-1.8
Neuroticism score	2.4	4.9	6.5	1.8	-2.5
Shortness of breath walking on level ground	2.4	2.9	4.2	1.2	-2.0
Pulse rate, automated reading	2.4	7.6	8.1	2.8	-2.7
Relative age of first facial hair	2.3	4.6	8.9	3.0	-0.6
Impedance of leg (right)	2.3	11.1	15.0	-2.7	3.9
Illnesses of mother	2.3	2.9	5.0	-0.9	2.2
Length of working week for main job	2.3	2.6	3.2	1.8	-1.4
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	5.4	-2.3	1.4
Pack years adult smoking proportion	2.2	3.4	5.9	0.9	-2.4
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	3.5	1.3	-1.9
Commuting to job workplace: Car/motor vehicle	2.2	2.5	2.9	-1.4	1.7
Ever used hormone-replacement therapy (HRT)	2.1	2.7	3.5	1.3	-1.9
Medication: Co-codamol	2.1	2.5	3.3	1.3	-1.8
Headache pain in last month	2.1	3.6	6.2	2.5	-1.0
Mood swings	2.1	3.9	5.1	1.6	-2.3
Fed-up feelings	2.0	3.7	6.1	1.1	-2.5
Mean Putamen Volume	1.9	2.2	2.8	-1.7	1.2
Allergy or Eczema	1.9	4.9	4.9	2.2	-2.2
Impedance of leg (left)	1.9	9.3	12.7	-2.4	3.6
Pulse rate	1.9	3.1	3.5	1.9	-1.7
Depression (Nagel 2018)	1.8	2.7	3.1	1.8	-1.6
Worry (Nagel 2018)	1.8	3.7	5.1	1.5	-2.3
Schizophrenia (2014)	1.8	4.0	4.1	-2.0	2.0
Pain experienced in last month	1.8	3.0	4.3	-2.1	1.3
Age at First Birth	1.7	2.4	3.3	1.8	-1.2
Tinnitus: Yes, but not now, but have in the past	1.7	1.9	3.0	0.8	-1.7
Allergy	1.7	3.8	5.2	-2.3	1.6
Medication: Cholesterol lowering	1.7	2.7	3.8	2.0	-1.2
Leg pain on walking	1.7	2.1	3.5	0.9	-1.9
Alcohol drinker status: Never	1.7	2.1	2.6	1.3	-1.6
Alcohol drinker status: Previous	1.7	1.9	2.4	-1.6	1.2
Ever had hysterectomy (womb removed)	1.6	1.9	2.0	1.4	-1.3
Systolic blood pressure, automated reading	1.6	4.6	9.2	-0.0	-3.0
Taking other prescription medications	1.6	2.4	2.8	1.7	-1.4
Noisy workplace	1.6	2.0	2.8	1.1	-1.7
Miserableness	1.6	2.8	3.3	1.5	-1.8
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	2.0	-1.3	1.4
Schizophrenia (2018)	1.4	2.9	3.0	-1.7	1.7
Crohns Disease (2017)	1.4	3.1	4.5	2.1	-1.3
Lupus	1.4	2.1	2.1	1.4	-1.5
Cardiovascular Disease	1.4	4.6	5.8	2.4	-1.8
High blood pressure (mother)	1.4	2.0	4.0	0.1	-2.0
Medication: Bendroflumethiazide	1.4	2.2	2.2	1.5	-1.5
Hair/balding pattern: Pattern 3	1.3	1.9	3.2	-1.8	0.7
Qualifications: A levels/AS levels or equivalent	1.3	3.0	5.1	-2.3	0.9
Pulse wave Arterial Stiffness index	1.3	1.5	2.5	0.6	-1.6
Comparative body size at age 10	1.3	3.6	6.9	0.6	-2.6
Illnesses of father: Heart disease	1.3	1.8	2.0	1.4	-1.2
Ever had bowel cancer screening	1.3	1.5	3.0	1.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	4.2	2.1	-1.2
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.2	1.5	-1.1
Ulcerative Colitis	1.2	1.8	2.2	1.5	-1.2
Lung FVC	1.2	5.9	9.2	3.0	-1.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.4	1.6	-0.8
Hayfever, allergic rhinitis or eczema	1.2	2.5	3.4	1.8	-1.3
Stomach or abdominal pain in last month	1.2	1.5	2.4	1.6	-0.8
Had menopause	1.2	1.5	1.8	1.3	-1.1
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	1.8	-1.1	1.3
Worrier / anxious feelings	1.2	2.4	3.3	1.2	-1.8
Tense / ‘highly strung’	1.2	1.9	2.9	1.0	-1.7
Smoking status: Current	1.2	1.9	2.0	-1.3	1.4
Alzheimer’s Disease (including proxy)	1.1	1.6	2.8	0.7	-1.7
Irritable Bowel Disease (IBD)	1.1	2.6	3.6	1.9	-1.3
Crohns Disease (2012)	1.1	1.7	2.2	1.5	-1.1
Average weekly spirits intake	1.1	1.3	2.4	0.5	-1.5
Heart attack	1.1	1.4	1.8	1.3	-1.0
Glaucoma (self-reported)	1.1	1.3	2.3	-1.5	0.6
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.0	0.7	-1.4
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.4	1.0	-1.2
Medication: Paracetamol	1.1	1.8	3.4	1.9	-0.3
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.4	0.3	-1.6
Systolic Blood Pressure	1.0	5.1	10.2	0.1	-3.2
Angina	1.0	1.3	2.0	1.4	-0.7
Diabetes (father)	1.0	1.2	1.3	-1.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	1.6	0.9	-1.2
Medication: Lansoprazole	1.0	1.1	1.1	1.1	-1.1
Pulse wave peak to peak time	1.0	1.2	2.2	-0.5	1.5
Age started oral contraceptive pill	1.0	1.3	1.7	1.3	-0.9
Cholesterol lowering medication	1.0	1.5	2.9	1.7	0.2
Body Mass Index (BMI) (2010)	0.9	1.2	2.2	0.5	-1.5
Current tobacco smoking	0.9	1.5	1.7	-1.3	1.2
Chronic bronchitis/emphysema (father)	0.9	1.0	1.4	1.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	1.9	1.2	-1.4
Angina (self-reported)	0.9	1.1	1.8	1.3	-0.7
Osteoporosis (self-reported)	0.9	1.1	1.8	1.3	-0.5
Number of self-reported non-cancer illnesses	0.9	1.6	1.7	1.3	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.2	0.3	1.5
Ulcerative Colitis (UC)	0.8	1.5	1.9	1.4	-1.1
Triglycerides	0.8	1.4	1.9	1.4	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.7	0.6	-1.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.3	1.1	-0.8
Blood clot in the leg (DVT)	0.8	1.1	1.8	0.6	1.3
Medication: Paracetamol	0.8	1.3	2.5	1.6	-0.1
Neck or shoulder pain in last month	0.8	1.2	2.3	1.5	-0.2
Number of full sisters	0.8	1.0	1.8	-0.4	1.4
Knee pain experienced in last month	0.8	1.3	2.0	0.8	-1.4
Back pain experienced in last month	0.8	1.2	1.5	0.9	-1.2
Unable to work because of sickness or disability	0.8	1.0	1.9	-1.4	0.4
Neuroticism (2016)	0.7	1.0	1.9	1.4	-0.4
Diabetes (self-reported)	0.7	1.1	2.1	-1.4	0.2
Breastfed as a baby	0.7	0.8	1.0	-1.0	0.8
Pulse wave reflection index	0.7	0.9	1.1	-0.8	1.1
Health satisfaction	0.7	0.9	1.5	1.2	-0.7
Medication: Allopurinol	0.7	1.0	1.6	-1.2	0.6
Bipolar Disorder or Schizophrenia	0.6	1.5	1.7	-1.3	1.1
Breast Cancer	0.6	1.5	2.9	0.4	-1.7
Height	0.6	11.5	18.2	4.3	-2.2
Hearing difficulty/problems: Yes	0.6	0.9	1.4	0.7	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.6	0.0	-1.6
Qualifications: CSEs or equivalent	0.6	0.8	1.0	-0.8	1.0
Sitting height	0.6	4.0	6.4	2.5	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.5	-0.2	-1.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.6	1.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	0.8	0.8	-0.9
Heart disease (mother)	0.6	0.8	0.8	0.9	-0.9
Financial situation satisfaction	0.6	0.7	1.4	-0.2	1.2
Medication: Blood pressure	0.6	1.1	1.8	0.6	-1.4
Illnesses of father: High blood pressure	0.6	0.8	1.0	-1.0	-0.7
Number of operations (self-reported)	0.6	0.9	1.3	1.1	-0.7
Average weekly beer plus cider intake	0.6	0.9	1.6	-0.4	1.3
Schizophrenia vs Biploar Disorder	0.5	0.6	1.2	0.0	1.1
Primary Biliary Cirrhosis	0.5	0.7	1.1	-0.6	1.1
Medication: Metformin	0.5	0.7	1.5	-1.2	-0.1
Multivitamins +/- minerals	0.5	0.7	1.1	-1.0	0.5
Emphysema/chronic bronchitis	0.5	0.6	1.1	0.0	-1.1
Medication: Ibuprofen	0.5	0.6	1.0	0.4	-1.0
Had major operations	0.5	0.6	0.6	-0.7	0.8
Loneliness, isolation	0.5	0.7	1.1	1.1	-0.5
Medication: Gliclazide	0.5	0.5	1.0	-1.0	0.1
Alzheimer’s Disease (in mother)	0.4	0.4	0.7	0.4	-0.8
Ovarian Cancer	0.4	0.5	0.7	0.8	-0.5
Heel T-Score	0.4	2.9	5.3	-2.3	0.6
Smoking Status	0.4	1.0	1.2	-1.1	0.9
Average weekly fortified wine intake	0.4	0.5	0.6	-0.6	-0.8
Age when periods started (menarche)	0.4	1.0	2.0	-0.1	1.4
Number of incorrect matches in round	0.4	0.6	1.2	-1.1	0.3
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	0.9	0.4
Forced vital capacity (FVC)	0.4	1.4	2.8	1.7	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	1.0	0.2
Medication: Seretide 50 evohaler	0.4	0.4	0.7	-0.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.3	-0.5	1.1
Average weekly red wine intake	0.4	0.6	1.3	-1.1	0.0
Osteoarthritis (self-reported)	0.4	0.5	0.6	0.6	-0.8
Medication: Lisinopril	0.4	0.5	0.9	-1.0	0.2
Fractured/broken bones in last 5 years	0.4	0.5	0.7	0.8	0.7
Myopia	0.4	0.6	1.1	-0.2	-1.1
Basal cell carcinoma (self-reported)	0.4	0.4	0.7	0.4	0.9
Fasting Glucose	0.3	0.3	0.6	-0.1	-0.8
LDL Cholesterol	0.3	0.5	1.0	-0.3	1.0
Blood Platelet Count	0.3	3.0	5.3	2.3	-0.8
Hypothyroidism (self reported)	0.3	0.8	0.9	0.7	-1.0
Lung FEV1/FVC ratio	0.3	1.6	3.0	-0.3	-1.7
Hand grip strength (left)	0.3	0.8	0.9	1.0	-0.9
Medication for hormone replacement therapy	0.3	0.3	0.3	-0.6	0.6
Vitamin and mineral supplements	0.3	0.4	0.8	-0.9	0.3
Hand grip strength (right)	0.3	0.7	0.8	0.7	-0.9
Had other major operations	0.3	0.3	0.5	0.7	0.4
Number of live births	0.3	0.4	0.7	-0.2	0.8
Happiness	0.3	0.4	0.7	-0.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	0.1	0.8
Standing height	0.3	3.4	6.7	2.6	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	-0.5	-0.7
Forced vital capacity (FVC), Best measure	0.3	1.0	1.9	1.4	0.2
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.7	0.5
Wheeze or whistling in the chest in last year	0.3	0.4	0.5	-0.6	0.7
Comparative height size at age 10	0.3	1.9	3.2	1.8	-0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	0.8	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	-0.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.7	0.8	0.2
Commuting to job workplace: Walk	0.3	0.3	0.7	-0.0	-0.8
Breast cancer (self-reported)	0.3	0.4	0.6	0.8	-0.3
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.8	-0.0
High cholesterol (Self-reported)	0.3	0.6	0.6	0.8	0.7
Ever smoked	0.3	0.5	0.7	-0.5	0.8
Supplements: Calcium	0.3	0.4	0.5	0.4	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.8	0.3	0.9
Prostate Cancer	0.2	0.2	0.4	0.3	0.6
HbA1C	0.2	0.3	0.4	0.6	0.4
HDL Cholesterol	0.2	0.3	0.7	-0.0	0.8
Blood Red Count	0.2	1.9	3.3	0.7	-1.8
Supplements: Zinc	0.2	0.2	0.3	-0.5	0.4
Diabetes (mother)	0.2	0.3	0.5	-0.7	0.4
Severe depression (siblings)	0.2	0.3	0.5	0.0	-0.7
Alcohol usually taken with meals	0.2	0.3	0.4	0.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	-0.3	-0.7
Fluid intelligence score	0.2	0.4	0.8	0.3	0.9
Illnesses of siblings	0.2	0.2	0.3	0.6	-0.3
Father’s age at death	0.2	0.2	0.4	-0.6	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.6	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.3	1.1	-0.3
Asthma	0.2	0.5	0.8	0.9	-0.3
Prospective memory result	0.2	0.2	0.3	0.5	-0.4
Lung cancer (father)	0.2	0.3	0.6	0.8	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.5	1.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.5	-0.5	0.7
Birth weight of first child	0.2	0.4	0.7	0.2	-0.8
Peak expiratory flow (PEF)	0.2	0.4	0.9	0.9	0.0
Gout (self-reported)	0.2	0.3	0.4	-0.4	-0.6
Number of children fathered	0.2	0.2	0.4	0.3	-0.6
Eye problems/disorders: None of the above	0.2	0.3	0.5	0.7	0.1
Migraine (self-reported)	0.2	0.3	0.4	0.4	-0.7
Family relationship satisfaction	0.2	0.3	0.3	-0.4	0.6
Supplements: Vitamin C	0.2	0.2	0.4	0.6	0.2
Diabetes diagnosed by doctor	0.2	0.4	0.8	-0.9	0.0
Asthma (self-reported)	0.2	0.4	0.8	0.9	-0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.5	-0.2	-0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.3	0.5	-0.5
Risk taking	0.2	0.2	0.5	0.7	-0.1
Diastolic blood pressure, automated reading	0.2	0.7	1.3	-0.3	-1.1
Alzheimer’s Disease (in father)	0.1	0.1	0.1	-0.4	-0.3
Major Depression (MDD)	0.1	0.1	0.2	-0.0	-0.5
Rheumatoid Arthritis	0.1	0.2	0.3	0.5	-0.0
Blood Eosinophil Count	0.1	0.6	1.2	1.1	0.3
Waist Hip Ratio (WHR)	0.1	0.2	0.3	-0.4	0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.6	0.4
Hair Pigment	0.1	2.1	2.6	-1.2	-1.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.3	-0.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.4	0.4
Nervous feelings	0.1	0.2	0.3	0.5	-0.5
Financial difficulties in last 2 years	0.1	0.2	0.3	0.1	-0.6
Pain all over the body in last month	0.1	0.1	0.2	-0.4	0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.4	0.1
Falls in the last year	0.1	0.2	0.3	-0.1	-0.6
Depression (self-reported)	0.1	0.1	0.2	0.4	0.3
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.2	-0.3
Loud music exposure frequency	0.1	0.2	0.3	0.5	0.2
Birth weight	0.1	0.1	0.2	0.4	0.2
High blood pressure (siblings)	0.1	0.1	0.3	-0.5	0.1
Worry too long after embarrassment	0.1	0.2	0.2	-0.4	0.4
Age at first live birth	0.1	0.1	0.1	0.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.0	0.4
Suffer from ‘nerves’	0.1	0.2	0.2	-0.5	-0.5
Age at last live birth	0.1	0.2	0.2	0.4	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.2	0.3
Smoking status: Previous	0.1	0.2	0.2	0.4	-0.5
Friendships satisfaction	0.1	0.1	0.1	-0.4	-0.4
Eye problems/disorders: Cataract	0.1	0.2	0.3	0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.2	0.3	0.5
Mineral and other dietary supplements	0.1	0.2	0.3	-0.5	0.3
Guilty feelings	0.1	0.2	0.4	-0.3	0.6
Medication: Atorvastatin	0.1	0.1	0.2	-0.2	-0.4
Ever depressed for a whole week	0.1	0.1	0.2	0.5	-0.1
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.4	0.2
Bipolar Disorder (2018)	0.0	0.1	0.1	0.1	-0.3
Intelligence (Savage-Jansen 2018)	0.0	0.2	0.3	0.2	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.2	0.2	-0.3	0.5
Respiratory disease	0.0	0.1	0.1	0.4	-0.3
Tanning	0.0	0.4	0.4	-0.7	0.6
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.1	-0.0
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.2	-0.1
Supplements: Glucosamine	0.0	0.0	0.0	-0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	-0.3	0.0
Past tobacco smoking	0.0	0.0	0.1	-0.2	-0.2
Time employed in main current job	0.0	0.0	0.0	0.1	0.2
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	0.1	-0.1
Qualifications: College or University degree	0.0	0.1	0.1	-0.2	0.3
Medication: Omeprazole	0.0	0.0	0.0	0.2	-0.2
Alcohol intake frequency.	0.0	0.1	0.2	-0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.1	-0.2
Medication for cholesterol	0.0	0.1	0.1	-0.3	0.2
Ever taken oral contraceptive pill	0.0	0.0	0.0	-0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.0	-0.0
Heart disease (siblings)	0.0	0.0	0.0	0.2	0.2

Hub : Genes

PPFIA3

Models

Trait associations