Best TWAS P=2.72e-14 · Best GWAS P=4.85e-10 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ABHD12 | 0.10 | 0.17 | blup | 405 | 0.17 | 1.7e-20 | 4.9 | 6.2 | 7.4e-10 | -0.19 | 0.71 | 0.29 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | NINL | 0.19 | 0.17 | lasso | 20 | 0.23 | 1.2e-27 | 4.9 | 6.3 | 3.7e-10 | -0.16 | 0.62 | 0.38 | FALSE |
3 | GTEx | Adipose Visceral Omentum | ABHD12 | 0.06 | 0.00 | lasso | 8 | 0.00 | 4.6e-01 | 4.9 | 5.3 | 1.3e-07 | -0.14 | 0.22 | 0.11 | FALSE |
4 | GTEx | Artery Aorta | NINL | 0.17 | 0.18 | lasso | 6 | 0.19 | 1.5e-10 | 4.9 | 5.6 | 2.2e-08 | -0.15 | 0.64 | 0.36 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | ACSS1 | 0.31 | 0.24 | lasso | 3 | 0.16 | 7.1e-05 | -4.9 | -5.3 | 9.1e-08 | 0.23 | 0.18 | 0.12 | TRUE |
6 | GTEx | Breast Mammary Tissue | ABHD12 | 0.08 | 0.09 | lasso | 5 | 0.09 | 3.3e-05 | 4.9 | 5.3 | 1.3e-07 | -0.14 | 0.51 | 0.30 | FALSE |
7 | GTEx | Breast Mammary Tissue (Male) | CST7 | 0.15 | 0.00 | lasso | 4 | 0.03 | 7.0e-02 | -4.3 | -5.3 | 9.8e-08 | 0.62 | 0.06 | 0.07 | FALSE |
8 | GTEx | Breast Mammary Tissue (Male) | ABHD12 | 0.06 | 0.01 | lasso | 3 | 0.02 | 1.3e-01 | 4.6 | 5.5 | 4.4e-08 | -0.13 | 0.05 | 0.17 | FALSE |
9 | GTEx | Heart Left Ventricle | ABHD12 | 0.15 | 0.14 | lasso | 10 | 0.12 | 4.0e-07 | 5.0 | 5.3 | 9.1e-08 | -0.18 | 0.66 | 0.34 | FALSE |
10 | GTEx | Lung | ABHD12 | 0.06 | 0.00 | lasso | 6 | 0.00 | 2.7e-01 | 5.6 | 6.0 | 2.2e-09 | -0.12 | 0.07 | 0.79 | FALSE |
11 | GTEx | Pancreas | ENTPD6 | 0.11 | 0.05 | enet | 23 | 0.05 | 5.0e-03 | 5.6 | -5.7 | 1.2e-08 | 0.15 | 0.16 | 0.74 | FALSE |
12 | GTEx | Pituitary | ABHD12 | 0.27 | 0.31 | enet | 25 | 0.31 | 1.8e-08 | 4.8 | 5.6 | 1.9e-08 | -0.14 | 0.71 | 0.29 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | PYGB | 0.12 | 0.13 | enet | 13 | 0.14 | 4.2e-08 | 4.2 | -5.1 | 2.8e-07 | 0.28 | 0.61 | 0.22 | FALSE |
14 | GTEx | Skin Sun Exposed Lower leg | ABHD12 | 0.07 | 0.03 | lasso | 10 | 0.05 | 7.3e-05 | 4.7 | 5.6 | 1.6e-08 | -0.19 | 0.66 | 0.25 | FALSE |
15 | GTEx | Testis | ABHD12 | 0.21 | 0.18 | enet | 25 | 0.23 | 1.1e-10 | 4.9 | 5.3 | 9.3e-08 | -0.14 | 0.68 | 0.32 | FALSE |
16 | ROSMAP | Brain Pre-frontal Cortex | PYGB | 0.20 | 0.10 | bslmm | 414 | 0.11 | 3.2e-14 | 5.6 | -5.3 | 1.1e-07 | 0.07 | 0.08 | 0.92 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | ABHD12 | 0.26 | 0.35 | enet | 35 | 0.42 | 7.9e-58 | 4.7 | 5.4 | 6.2e-08 | -0.14 | 0.72 | 0.27 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | APMAP | 0.09 | 0.12 | lasso | 6 | 0.12 | 3.5e-15 | -5.1 | 5.3 | 1.3e-07 | -0.18 | 0.34 | 0.66 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | ENTPD6 | 0.32 | 0.10 | bslmm | 432 | 0.12 | 1.8e-15 | 5.6 | 7.6 | 2.7e-14 | -0.70 | 0.03 | 0.97 | TRUE |
20 | YFS | Blood | ABHD12 | 0.15 | 0.35 | bslmm | 390 | 0.34 | 2.2e-118 | 5.0 | 5.2 | 1.8e-07 | -0.16 | 0.65 | 0.35 | TRUE |
21 | YFS | Blood | NINL | 0.04 | 0.03 | lasso | 8 | 0.03 | 2.8e-10 | 5.4 | 5.2 | 1.9e-07 | -0.07 | 0.17 | 0.83 | FALSE |
22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PYGB | 0.08 | 0.02 | enet | 7 | 0.03 | 1.7e-07 | 5.3 | -5.4 | 7.8e-08 | 0.06 | 0.21 | 0.78 | TRUE |
23 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PYGB | 0.08 | 0.04 | blup | 74 | 0.06 | 1.0e-03 | 4.7 | -5.3 | 9.9e-08 | 0.14 | 0.20 | 0.27 | TRUE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ABHD12 | 0.03 | 0.01 | blup | 77 | 0.01 | 8.7e-03 | 4.0 | 5.1 | 3.0e-07 | -0.14 | 0.06 | 0.74 | FALSE |
25 | The Cancer Genome Atlas | Thyroid Carcinoma | PYGB | 0.10 | 0.08 | lasso | 7 | 0.07 | 1.4e-07 | 4.5 | -5.4 | 7.4e-08 | 0.10 | 0.32 | 0.68 | FALSE |