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chr1:752,566-3,191,909

Best TWAS P=5.66e-10 · Best GWAS P=1.12e-08 conditioned to 0.00832

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	METSIM	Adipose	TNFRSF14	0.07	0.05	blup	373	0.05	1.9e-07	4.9	6.2	5.7e-10	-0.01	0.02	0.97	TRUE
4	GTEx	Brain Cerebellar Hemisphere	RP5-890O3.9	0.24	0.02	lasso	9	0.02	1.3e-01	-5.4	6.2	7.5e-10	0.28	0.02	0.52	TRUE
2	GTEx	Adipose Visceral Omentum	RP1-283E3.4	0.26	0.05	enet	25	0.16	1.5e-08	-3.4	-5.9	4.7e-09	-0.27	0.13	0.19	TRUE
8	GTEx	Esophagus Muscularis	RP1-283E3.4	0.46	0.14	enet	23	0.24	1.6e-14	-3.4	-5.8	5.0e-09	-0.24	0.90	0.03	FALSE
12	GTEx	Muscle Skeletal	TMEM52	0.11	0.08	lasso	6	0.10	7.2e-10	-5.3	5.7	1.0e-08	0.26	0.04	0.96	FALSE
7	GTEx	Esophagus Mucosa	RP1-283E3.4	0.53	0.12	enet	20	0.22	4.1e-15	-3.4	-5.7	1.1e-08	-0.19	0.96	0.01	FALSE
19	GTEx	Thyroid	RP1-283E3.4	0.59	0.04	lasso	10	0.22	3.8e-17	-3.4	-5.6	2.3e-08	-0.07	0.71	0.03	FALSE
11	GTEx	Muscle Skeletal	NADK	0.06	0.00	enet	9	0.00	1.3e-01	-5.2	-5.6	2.5e-08	-0.23	0.04	0.86	FALSE
5	GTEx	Cells Transformed fibroblasts	RP1-283E3.4	0.59	0.13	lasso	8	0.29	3.0e-22	2.4	-5.5	3.0e-08	-0.10	0.97	0.00	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	C1orf222	0.11	0.14	enet	18	0.14	1.8e-17	-4.7	5.5	3.4e-08	0.22	0.17	0.82	FALSE
9	GTEx	Esophagus Muscularis	RP3-395M20.12	0.08	0.06	enet	6	0.06	2.3e-04	4.7	-5.5	5.0e-08	0.05	0.02	0.94	FALSE
17	GTEx	Skin Sun Exposed Lower leg	TMEM52	0.17	0.14	lasso	7	0.15	2.0e-12	5.2	5.4	5.6e-08	0.26	0.04	0.96	FALSE
10	GTEx	Lung	NADK	0.07	0.03	lasso	3	0.02	8.5e-03	5.1	-5.4	7.5e-08	-0.27	0.05	0.86	FALSE
18	GTEx	Spleen	TMEM52	0.47	0.21	lasso	5	0.22	2.3e-06	-4.3	-5.4	8.7e-08	-0.15	0.18	0.54	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	MMP23B	0.05	0.04	lasso	2	0.03	1.9e-04	-5.4	-5.3	9.2e-08	-0.24	0.03	0.96	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	TMEM52	0.19	0.18	lasso	4	0.14	2.6e-08	5.1	5.3	9.4e-08	0.25	0.05	0.95	FALSE
1	GTEx	Adipose Subcutaneous	RP1-283E3.4	0.65	0.14	lasso	9	0.33	5.1e-28	-3.4	-5.3	9.9e-08	-0.08	0.97	0.01	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	RP1-283E3.4	0.48	0.12	lasso	5	0.31	1.1e-17	-3.4	-5.3	1.0e-07	-0.09	0.44	0.11	FALSE
3	GTEx	Brain Cerebellar Hemisphere	NADK	0.18	0.11	lasso	7	0.09	3.1e-03	-5.2	-5.3	1.2e-07	-0.27	0.04	0.57	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM52	0.02	0.01	blup	37	0.02	6.6e-03	-5.2	5.3	1.3e-07	0.26	0.01	0.75	FALSE
6	GTEx	Esophagus Mucosa	TMEM52	0.17	0.18	lasso	2	0.20	2.9e-13	-5.4	5.3	1.4e-07	0.24	0.04	0.96	FALSE
14	GTEx	Pancreas	TNFRSF14	0.13	0.04	enet	8	0.04	1.0e-02	4.7	5.1	2.6e-07	-0.05	0.02	0.95	FALSE
13	GTEx	Muscle Skeletal	SLC35E2B	0.35	0.06	lasso	4	0.19	3.2e-18	-3.1	5.1	2.7e-07	0.14	0.94	0.02	FALSE