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chr11:26,818,083-29,054,545

Best TWAS P=7.54e-28 · Best GWAS P=3.45e-37 conditioned to 0.000859

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	LIN7C	0.08	0.06	lasso	1	0.04	4.1e-04	10.71	10.7	8.8e-27	0.63	0.74	0.14	FALSE
2	GTEx	Brain Putamen basal ganglia	BDNF-AS	0.22	0.17	lasso	4	0.13	5.5e-04	-6.13	7.5	4.4e-14	0.33	0.23	0.05	TRUE
3	GTEx	Cells Transformed fibroblasts	LIN7C	0.26	0.22	lasso	6	0.25	1.4e-18	10.71	9.1	6.8e-20	0.62	1.00	0.00	FALSE
4	GTEx	Esophagus Muscularis	LIN7C	0.14	0.08	enet	11	0.07	5.4e-05	4.18	7.9	2.6e-15	0.60	0.69	0.16	FALSE
5	GTEx	Liver	METTL15	0.18	0.05	lasso	3	0.09	1.9e-03	-0.16	-8.2	3.2e-16	-0.68	0.02	0.83	FALSE
6	GTEx	Nerve Tibial	LIN7C	0.18	0.08	enet	27	0.12	4.2e-09	10.71	6.9	4.5e-12	0.56	0.61	0.36	FALSE
7	GTEx	Thyroid	LIN7C	0.08	0.04	lasso	4	0.04	6.0e-04	10.71	10.5	7.7e-26	0.69	0.54	0.34	FALSE
8	NTR	Blood	LIN7C	0.01	0.00	lasso	3	0.01	2.2e-03	11.20	-10.9	7.5e-28	-0.72	0.10	0.80	TRUE
9	ROSMAP	Brain Pre-frontal Cortex	METTL15	0.04	0.03	blup	364	0.03	4.6e-05	-3.31	-5.8	7.9e-09	-0.19	0.72	0.01	TRUE
10	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LIN7C	0.04	0.01	lasso	3	0.02	1.0e-02	-2.21	6.6	3.7e-11	0.46	0.02	0.84	FALSE
11	The Cancer Genome Atlas	Colon Adenocarcinoma	LIN7C	0.10	0.03	blup	32	0.08	2.8e-05	11.03	8.4	2.8e-17	0.57	0.01	0.95	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIN7C	0.05	0.02	lasso	3	0.03	2.9e-04	11.05	10.1	5.3e-24	0.63	0.01	0.98	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	LIN7C	0.09	0.12	lasso	2	0.12	2.6e-13	4.27	6.6	5.4e-11	0.52	0.94	0.06	FALSE
14	The Cancer Genome Atlas	Lung Adenocarcinoma	LIN7C	0.02	0.02	enet	3	0.02	5.6e-03	2.23	5.5	3.7e-08	0.52	0.02	0.63	TRUE
15	The Cancer Genome Atlas	Testicular Germ Cell Tumors	BDNFOS	0.19	0.10	blup	85	0.15	5.2e-06	-0.33	-5.2	2.6e-07	-0.59	0.19	0.43	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	LIN7C	0.09	0.10	enet	7	0.09	8.1e-09	4.27	5.9	3.0e-09	0.48	0.86	0.14	TRUE