Best TWAS P=3.39e-11 · Best GWAS P=5.31e-12 conditioned to 0.133
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | MTIF3 | 0.12 | 0.03 | lasso | 5 | 0.03 | 1.2e-03 | -5.2 | -5.7 | 1.6e-08 | 0.74 | 0.28 | 0.56 | FALSE |
| 2 | GTEx | Nerve Tibial | AL137059.1 | 0.10 | 0.02 | lasso | 3 | 0.03 | 2.9e-03 | 5.3 | -6.6 | 3.4e-11 | 0.71 | 0.02 | 0.94 | TRUE |
| 3 | GTEx | Testis | MTIF3 | 0.45 | 0.28 | lasso | 11 | 0.25 | 1.8e-11 | 5.3 | -6.0 | 2.5e-09 | 0.49 | 0.95 | 0.05 | FALSE |
| 4 | YFS | Blood | GTF3A | 0.17 | 0.15 | lasso | 5 | 0.19 | 1.1e-58 | 4.0 | -5.6 | 1.6e-08 | 0.44 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GTF3A | 0.03 | 0.00 | enet | 8 | 0.01 | 2.3e-02 | 1.9 | 6.2 | 5.2e-10 | -0.63 | 0.01 | 0.84 | TRUE |