Best TWAS P=2.97e-11 · Best GWAS P=1.19e-11 conditioned to 0.773
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | SLC44A2 | 0.19 | 0.18 | lasso | 5 | 0.19 | 5.1e-18 | 5.8 | 6.2 | 4.0e-10 | 0.76 | 0.69 | 0.31 | FALSE |
| 2 | GTEx | Testis | PDE4A | 0.20 | 0.02 | enet | 39 | 0.04 | 6.4e-03 | 4.6 | 5.3 | 1.1e-07 | 0.08 | 0.06 | 0.05 | TRUE |
| 3 | GTEx | Whole Blood | CTD-2369P2.8 | 0.12 | 0.11 | lasso | 3 | 0.10 | 9.2e-10 | 4.8 | 5.2 | 1.5e-07 | 0.04 | 1.00 | 0.00 | TRUE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC147727 | 0.07 | 0.02 | lasso | 2 | 0.02 | 5.4e-03 | 6.4 | -6.7 | 3.0e-11 | -0.93 | 0.03 | 0.52 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC44A2 | 0.32 | 0.22 | enet | 14 | 0.25 | 3.8e-24 | 6.8 | 5.6 | 2.5e-08 | 0.93 | 0.01 | 0.99 | FALSE |