Best TWAS P=6.81e-11 · Best GWAS P=2.99e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Testis | PDE4C | 0.39 | 0.44 | lasso | 2 | 0.43 | 5.8e-21 | -5.2 | -5.2 | 2.1e-07 | -0.39 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Testis | AC068499.10 | 0.38 | 0.41 | lasso | 3 | 0.40 | 6.8e-19 | -5.2 | -5.3 | 1.3e-07 | -0.41 | 0.99 | 0.01 | FALSE |
| 3 | YFS | Blood | MAST3 | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-12 | 6.1 | -6.0 | 2.4e-09 | -0.56 | 0.37 | 0.63 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAST3 | 0.04 | 0.02 | blup | 65 | 0.01 | 7.3e-02 | 6.1 | -5.5 | 5.2e-08 | -0.53 | 0.01 | 0.17 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAST3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.5e-02 | 6.5 | -6.5 | 6.8e-11 | -0.95 | 0.01 | 0.93 | TRUE |
| 6 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL12RB1 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.6e-03 | 1.2 | -5.8 | 7.2e-09 | -0.62 | 0.02 | 0.54 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | MAST3 | 0.04 | 0.02 | lasso | 2 | 0.00 | 3.4e-01 | 6.5 | -6.5 | 7.1e-11 | -0.95 | 0.02 | 0.86 | FALSE |