Hub : Genes

PDE4A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cortex 0.569 0.10 6.9e-05 0.001 NA 0.096 NA 0.047 0.300 NA 0.0013 NA 0.019
2 GTEx Testis 0.204 0.08 9.3e-03 0.023 NA 0.041 NA 0.009 0.033 NA 0.0064 NA 0.120

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.5 0.8 0.5 0.9
Bipolar Disorder or Schizophrenia 0.1 0.2 0.2 -0.5 0.3
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 0.6 -0.2
Depression (Nagel 2018) 0.2 0.3 0.5 -0.7 -0.3
Intelligence (Savage-Jansen 2018) 1.0 3.0 4.3 2.1 -1.3
Neuroticism (Nagel 2018) 1.0 2.3 4.3 0.5 -2.1
Schizophrenia (2018) 0.2 0.5 0.7 -0.8 -0.5
Schizophrenia vs Biploar Disorder 1.4 1.8 2.4 -1.6 -1.1
Worry (Nagel 2018) 1.3 2.8 5.4 -0.4 -2.3
Alzheimer’s Disease (in mother) 0.6 0.7 0.9 -0.9 -0.7
Alzheimer’s Disease (in father) 1.0 1.1 1.8 1.4 0.6
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 -0.5 -0.1
Crohns Disease (2017) 8.6 19.0 37.7 -0.5 6.1
Irritable Bowel Disease (IBD) 9.3 22.1 42.4 -1.3 6.5
Ulcerative Colitis (UC) 4.9 9.1 16.9 -1.2 4.1
Major Depression (MDD) 0.6 0.7 1.5 1.2 0.0
Reaction Time 0.8 1.6 2.5 0.8 -1.6
Verbal and Numeric Reasoning (VNR) 0.4 1.0 1.4 1.2 -0.7
Breast Cancer 1.0 2.5 5.0 -0.0 -2.2
Ovarian Cancer 1.0 1.3 1.5 -1.0 -1.2
Prostate Cancer 0.1 0.1 0.2 0.0 0.4
Age at First Birth 2.0 2.9 4.3 -2.1 1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 1.4 -0.8 1.2
Coronary Artery Disease (CAD) 2.6 3.1 6.2 -2.5 0.0
Crohns Disease (2012) 11.3 18.2 35.5 -0.9 6.0
Mean Putamen Volume 0.6 0.6 0.7 -0.8 0.8
Fasting Glucose 1.0 1.2 2.4 1.6 -0.1
HbA1C 0.8 0.8 1.7 1.3 -0.1
HDL Cholesterol 0.3 0.4 0.5 0.6 0.7
LDL Cholesterol 4.7 7.4 14.0 -3.7 -0.9
Lupus 3.5 5.4 8.7 -1.4 -2.9
Neuroticism (2016) 0.5 0.7 1.5 -0.1 -1.2
Primary Biliary Cirrhosis 5.6 8.1 10.0 -2.5 -3.2
Rheumatoid Arthritis 6.9 9.4 11.7 -3.4 -2.7
Schizophrenia (2014) 0.3 0.6 0.6 -0.7 -0.8
Triglycerides 0.7 1.2 2.0 0.7 -1.4
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.2 -0.4 0.5
Ulcerative Colitis 3.0 4.4 7.2 -1.2 2.7
Blood Eosinophil Count 0.6 4.6 4.8 2.1 2.2
Blood Platelet Count 1.0 11.7 20.2 -4.5 1.8
Blood Red Count 0.5 5.0 8.9 1.0 3.0
Blood White Count 2.8 20.7 26.8 3.8 5.2
Heel T-Score 0.1 0.6 1.0 -0.4 -1.0
BMI 1.3 7.8 15.5 -0.1 3.9
Height 2.0 38.6 45.0 -5.7 6.7
Waist Hip Ratio (WHR) 1.7 7.6 9.5 3.1 -2.4
Systolic Blood Pressure 0.5 2.7 5.1 2.3 -0.6
Smoking Status 0.1 0.2 0.2 0.4 -0.4
Allergy or Eczema 2.8 7.4 14.8 0.0 -3.8
Cardiovascular Disease 0.4 1.4 2.2 -1.5 0.8
Hypothyroidism (self reported) 0.2 0.4 0.6 -0.5 -0.8
Respiratory disease 0.4 0.9 1.8 -1.3 0.3
Type 2 Diabetes (T2D) (2018) 3.5 6.6 13.2 0.0 3.6
Lung FEV1/FVC ratio 1.3 6.7 11.8 -1.2 3.4
Lung FVC 0.0 0.2 0.3 0.1 -0.5
Neuroticism 0.8 2.0 3.9 -0.3 -2.0
Chronotype (morning person) 0.1 0.2 0.2 0.4 0.4
Hair Pigment 0.1 3.8 4.7 2.2 -1.7
Tanning 0.1 0.9 1.8 1.3 -0.3
Hand grip strength (left) 0.9 2.4 4.7 -0.3 2.2
Number of treatments/medications taken 0.0 0.0 0.0 -0.2 -0.1
Average weekly spirits intake 0.5 0.6 1.3 -1.1 0.0
Sensitivity / hurt feelings 0.9 1.5 3.0 0.3 -1.7
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.2 -0.4 -0.5
Hearing difficulty/problems: Yes 1.3 2.0 4.1 0.1 2.0
Relative age of first facial hair 0.2 0.3 0.6 0.8 0.3
Other serious medical condition/disability diagnosed by doctor 5.1 6.6 12.2 -3.5 1.0
Ever used hormone-replacement therapy (HRT) 2.1 2.6 5.2 -0.3 -2.3
Ever had hysterectomy (womb removed) 1.1 1.2 2.3 1.5 -0.4
Systolic blood pressure, automated reading 0.5 1.5 3.0 1.7 0.1
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 2.4 -1.6 1.1
Angina 0.1 0.2 0.3 0.2 0.6
Medication for hormone replacement therapy 0.8 0.8 1.1 0.8 -1.0
Vitamin and mineral supplements 0.0 0.0 0.0 0.0 0.2
Supplements: Zinc 0.6 0.7 0.7 -0.8 0.8
Medication: Co-codamol 4.0 4.6 8.8 0.7 3.0
Medication: Metformin 0.4 0.6 0.6 0.7 0.7
Diabetes (father) 0.4 0.5 0.7 -0.5 -0.8
Diabetes (mother) 0.3 0.4 0.4 -0.7 0.6
Severe depression (siblings) 0.1 0.2 0.3 0.5 0.2
Pack years adult smoking proportion 0.9 1.4 2.4 1.6 -0.6
Impedance of leg (right) 0.7 3.5 5.2 1.4 -2.3
Leg fat-free mass (left) 4.0 21.4 37.3 -2.3 6.1
Trunk fat percentage 0.7 3.0 6.0 -0.1 2.4
Hand grip strength (right) 1.8 4.8 9.7 0.1 3.1
Townsend deprivation index at recruitment 1.9 2.7 5.5 2.3 0.0
Current tobacco smoking 1.5 2.5 4.6 2.1 -0.7
Average weekly fortified wine intake 1.5 1.7 2.3 -1.1 -1.5
Maternal smoking around birth 0.9 1.2 2.5 1.6 -0.1
Fed-up feelings 0.3 0.6 1.0 1.0 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.0 0.1 -0.2
Relative age voice broke 0.1 0.1 0.2 -0.0 -0.4
Taking other prescription medications 0.1 0.2 0.4 -0.6 -0.1
Age when periods started (menarche) 0.3 0.8 1.2 1.1 0.6
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.5 0.7 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 6.6 0.4 -2.6
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 2.4 -1.6 1.2
Qualifications: CSEs or equivalent 1.2 1.5 3.1 -0.1 1.8
Serious illness, injury or assault to yourself 0.2 0.2 0.2 0.5 0.5
High blood pressure 0.3 0.9 1.7 -0.5 1.3
Hayfever, allergic rhinitis or eczema 3.7 8.1 15.1 -1.1 -3.9
Multivitamins +/- minerals 0.0 0.0 0.0 -0.2 -0.1
Stomach or abdominal pain in last month 2.2 2.8 4.8 0.9 2.2
Supplements: Glucosamine 2.5 3.2 4.5 1.4 -2.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 0.9 0.4 1.0
Medication: Atenolol 0.7 0.9 1.7 -1.3 0.1
Medication: Levothyroxine sodium 0.2 0.3 0.6 -0.8 0.2
Sitting height 1.6 11.4 14.8 -2.8 3.8
Chronic bronchitis/emphysema (father) 0.5 0.6 0.7 0.6 -0.9
High blood pressure (mother) 0.4 0.6 0.8 0.9 0.6
Body mass index (BMI) 1.3 5.7 11.4 -0.3 3.4
Impedance of leg (left) 0.9 4.1 6.6 1.3 -2.6
Leg predicted mass (left) 4.0 21.1 36.7 -2.4 6.1
Trunk fat mass 1.8 7.6 14.5 -0.8 3.8
Waist circumference 1.2 4.4 8.9 -0.1 3.0
Number of incorrect matches in round 0.1 0.2 0.3 0.5 0.5
Past tobacco smoking 0.3 0.6 0.7 -0.7 -0.8
Alcohol usually taken with meals 0.0 0.0 0.1 -0.2 -0.0
Nervous feelings 0.5 1.0 2.0 -0.1 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.4 0.1 1.2
Hearing difficulty/problems with background noise 1.9 3.1 5.5 0.9 2.3
Hair/balding pattern: Pattern 2 0.6 0.8 1.5 0.3 -1.2
Had menopause 3.3 4.1 8.1 0.5 -2.8
Had other major operations 0.3 0.3 0.4 0.6 0.5
Forced vital capacity (FVC) 0.6 2.4 3.5 -1.1 1.9
Heel bone mineral density (BMD) T-score, automated (right) 1.3 3.1 5.0 1.1 -2.2
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.5 0.7 0.3
Qualifications: None of the above 0.2 0.5 0.8 0.9 -0.3
Financial difficulties in last 2 years 0.3 0.4 0.6 -0.6 0.7
Mouth/teeth dental problems 0.5 0.7 1.4 -1.2 -0.1
Heart attack 0.1 0.1 0.2 0.5 0.0
Allergy 1.6 3.7 7.1 0.6 2.7
Pain all over the body in last month 0.6 0.7 0.8 0.7 0.9
Diabetes (self-reported) 2.5 3.8 7.7 -0.1 2.8
Hayfever/allergic rhinitis (self-reported) 3.9 5.1 9.7 -0.7 -3.1
Medication: Ramipril 1.3 1.6 2.0 -1.4 -1.1
Medication: Simvastatin 0.0 0.0 0.0 -0.0 -0.1
Fluid intelligence score 1.6 3.3 4.4 2.1 -1.4
Illnesses of siblings 1.4 2.0 2.7 1.1 1.6
Neuroticism score 0.3 0.6 1.2 0.0 -1.1
Weight 3.2 15.5 28.2 -1.7 5.3
Impedance of arm (right) 1.1 5.0 10.0 0.1 -3.2
Arm fat percentage (right) 0.8 3.2 6.2 -0.4 2.5
Trunk fat-free mass 3.9 22.2 37.8 -2.6 6.2
Hip circumference 3.3 14.2 21.2 -2.7 4.6
Time employed in main current job 0.4 0.4 0.6 -0.5 -0.8
Alcohol intake versus 10 years previously 0.0 0.0 0.0 0.2 0.1
Father’s age at death 0.8 1.0 1.2 -1.1 -0.9
Worrier / anxious feelings 2.5 4.7 8.8 -0.7 -3.0
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 3.2 1.8 1.6
Falls in the last year 0.4 0.5 0.9 0.9 -0.4
Hair/balding pattern: Pattern 3 2.8 4.2 7.8 -0.8 -2.8
Number of live births 0.2 0.2 0.4 -0.6 -0.4
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 5.2 -1.2 2.3
Pulse rate 0.4 0.7 1.4 -0.1 1.2
Happiness 1.5 1.9 1.9 -1.4 1.3
Noisy workplace 0.3 0.4 0.7 -0.3 0.9
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.1 0.1 -0.3
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 1.7 -1.3 0.9
Mouth/teeth dental problems: Dentures 1.2 2.0 3.6 1.9 -0.7
Asthma 0.5 1.1 1.4 -1.2 0.8
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 2.4 0.9 1.6
Medication: Cholesterol lowering 0.2 0.3 0.4 -0.7 0.3
Depression (self-reported) 0.2 0.2 0.4 0.6 -0.3
Medication: Lansoprazole 2.0 2.3 3.4 -1.8 1.1
Prospective memory result 0.6 0.8 1.1 -0.7 -1.1
Lung cancer (father) 2.1 2.4 4.3 2.1 -0.7
Illnesses of mother 1.4 1.7 2.7 0.8 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 4.4 -1.3 2.1
Pulse wave Arterial Stiffness index 0.2 0.2 0.3 0.1 0.6
Impedance of arm (left) 1.0 4.8 9.5 0.2 -3.1
Arm fat mass (right) 2.0 8.1 15.2 -1.0 3.9
Trunk predicted mass 3.9 22.4 38.4 -2.5 6.2
Standing height 1.8 17.7 25.8 -3.1 5.1
Length of working week for main job 0.2 0.2 0.4 0.2 0.6
Exposure to tobacco smoke at home 1.2 1.4 2.1 1.5 0.8
Breastfed as a baby 0.2 0.2 0.4 0.2 0.6
Tense / ‘highly strung’ 0.3 0.5 0.7 0.8 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.1 -0.4
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 -0.0 0.4
Birth weight of first child 0.9 1.5 2.7 -0.6 1.6
Peak expiratory flow (PEF) 1.3 2.9 3.6 -1.9 1.5
Pulse wave reflection index 0.0 0.1 0.1 0.3 -0.1
Ever highly irritable/argumentative for 2 days 1.6 1.9 3.8 0.0 2.0
Loud music exposure frequency 0.5 0.5 0.9 -0.9 -0.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.2 0.5 0.7 -0.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.6 0.0 -0.8
Blood clot in the leg (DVT) 0.5 0.7 1.1 0.5 1.1
Medication: Paracetamol 0.5 0.8 1.2 0.6 1.1
Headache pain in last month 0.1 0.2 0.3 -0.6 0.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.3 0.5 -0.5
Glaucoma (self-reported) 0.1 0.1 0.3 -0.1 0.5
Gout (self-reported) 0.2 0.3 0.3 -0.6 0.6
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 2.4 -1.5 -1.2
Medication: Amlodipine 0.6 0.9 1.5 1.2 -0.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.9 0.1 1.0
Birth weight 0.4 0.8 1.4 0.5 1.2
Chronic bronchitis/emphysema (mother) 1.0 1.1 1.3 -1.1 -1.0
High blood pressure (siblings) 1.3 1.9 3.8 -0.2 -1.9
Forced vital capacity (FVC), Best measure 0.8 2.8 4.0 -1.2 2.0
Body fat percentage 0.7 2.6 5.2 0.2 2.3
Leg fat percentage (right) 0.7 2.5 4.7 0.6 2.2
Arm fat-free mass (right) 3.8 19.2 34.5 -2.0 5.9
Exposure to tobacco smoke outside home 0.9 1.2 1.3 1.1 1.1
Comparative body size at age 10 1.0 2.6 4.6 -2.1 -0.8
Number of full brothers 0.5 0.7 1.3 0.1 -1.1
Worry too long after embarrassment 0.3 0.4 0.8 -0.2 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.6 0.5 -0.7
Wheeze or whistling in the chest in last year 0.2 0.4 0.8 0.1 0.9
Number of children fathered 0.8 0.9 1.8 0.3 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.6 0.1 0.8
Age at first live birth 0.3 0.5 0.9 -0.2 0.9
Pulse wave peak to peak time 0.1 0.1 0.1 -0.4 -0.1
Health satisfaction 3.7 4.8 9.0 0.8 3.0
Shortness of breath walking on level ground 2.1 2.5 4.2 0.9 2.0
Qualifications: College or University degree 1.6 4.9 9.7 0.2 -3.1
Eye problems/disorders: None of the above 0.6 0.7 1.4 0.1 -1.2
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.3 1.5 -0.5
Emphysema/chronic bronchitis 0.8 0.9 0.9 0.9 -1.0
Medication for pain relief, constipation, heartburn 0.2 0.4 0.5 -0.7 -0.6
Neck or shoulder pain in last month 1.1 1.6 2.2 1.0 1.5
Medication: Blood pressure 0.2 0.4 0.7 0.3 0.8
Angina (self-reported) 0.2 0.2 0.4 0.2 0.6
Migraine (self-reported) 0.3 0.3 0.6 -0.3 0.8
Medication: Ibuprofen 0.3 0.4 0.5 0.5 0.7
Medication: Allopurinol 0.8 1.1 2.2 -1.5 -0.1
Medication: Omeprazole 0.5 0.6 0.8 0.9 0.6
Medication: Seretide 50 evohaler 1.1 1.2 2.4 -0.2 1.6
Mean time to correctly identify matches 0.7 1.4 2.2 0.8 -1.5
Heart disease (mother) 1.8 2.2 2.8 -1.7 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.6 3.0 4.5 1.3 -2.1
Whole body fat mass 1.9 8.1 15.8 -0.6 4.0
Leg fat mass (right) 1.8 7.0 13.8 -0.4 3.7
Arm predicted mass (right) 3.9 20.1 35.8 -2.1 6.0
Pulse rate, automated reading 1.8 5.8 10.8 -0.9 3.3
Alcohol intake frequency. 0.5 1.1 1.8 -0.7 1.3
Comparative height size at age 10 1.1 5.8 7.8 -2.8 2.0
Number of full sisters 0.8 1.0 1.7 -0.5 1.3
Suffer from ‘nerves’ 0.0 0.1 0.1 -0.3 -0.0
Overall health rating 1.9 4.1 7.7 0.8 2.8
Chest pain or discomfort 0.6 0.9 1.2 1.1 0.8
Had major operations 0.2 0.3 0.5 -0.1 -0.7
Age at last live birth 0.3 0.5 1.0 -0.0 1.0
Family relationship satisfaction 0.6 0.7 1.5 0.1 1.2
Leg pain on walking 3.2 4.1 7.6 0.7 2.8
Qualifications: NVQ or HND or HNC or equivalent 4.0 4.9 8.4 1.1 2.9
Commuting to job workplace: Car/motor vehicle 1.1 1.2 2.4 -0.1 -1.6
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.8 0.3 -0.9
Medication: Aspirin 0.0 0.0 0.1 0.2 0.2
Supplements: Vitamin C 0.7 0.9 1.6 1.3 0.4
Knee pain experienced in last month 0.9 1.4 2.7 -1.6 0.4
Hypertension (Self-reported) 0.3 0.9 1.3 -0.7 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 0.8 0.5 0.9
Illnesses of father: Heart disease 0.5 0.6 1.0 -1.0 -0.5
Illnesses of siblings: Diabetes 2.0 2.5 5.0 -2.2 0.1
Smoking status: Previous 0.2 0.3 0.5 0.1 0.7
Forced expiratory volume in 1-second (FEV1), predicted 5.1 10.6 17.7 -1.8 4.2
Whole body fat-free mass 4.2 24.0 41.0 -2.6 6.4
Leg fat-free mass (right) 4.0 21.3 35.5 -2.6 6.0
Arm fat percentage (left) 0.7 2.8 5.5 -0.3 2.4
Average weekly red wine intake 0.1 0.2 0.2 0.5 -0.4
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.4 -0.3 -1.2
Mood swings 0.3 0.5 0.8 0.9 -0.5
Loneliness, isolation 0.2 0.3 0.4 0.3 -0.7
Long-standing illness, disability or infirmity 1.0 1.5 3.0 -1.7 0.3
Ever had bowel cancer screening 0.7 0.8 1.4 0.5 -1.2
Diabetes diagnosed by doctor 2.6 4.3 8.6 -0.3 2.9
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.3 1.1 -0.1
Friendships satisfaction 0.2 0.3 0.4 0.4 0.7
Qualifications: nursing, teaching 0.1 0.2 0.4 0.1 -0.7
Commuting to job workplace: Walk 0.4 0.4 0.8 0.9 0.3
Eye problems/disorders: Cataract 0.0 0.0 0.0 -0.2 0.2
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 5.0 0.3 2.2
Medication for cholesterol 0.4 0.6 0.7 0.7 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.2 0.4 -1.1
Back pain experienced in last month 1.4 2.1 3.0 1.7 1.1
Mineral and other dietary supplements 0.7 0.9 1.8 -0.2 1.3
Breast cancer (self-reported) 0.9 1.0 1.9 -0.4 1.4
Asthma (self-reported) 0.4 0.8 1.3 -1.1 0.5
Osteoporosis (self-reported) 0.9 1.1 2.2 -0.1 -1.5
Osteoarthritis (self-reported) 0.2 0.2 0.3 -0.6 -0.2
Medication: Aspirin 0.0 0.0 0.1 0.1 -0.3
Medication: Gliclazide 2.0 2.3 3.4 -1.1 1.9
Illnesses of father: None of the above (group 1) 0.8 1.0 1.0 1.0 1.0
Smoking status: Current 1.3 2.0 3.9 2.0 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.8 -0.3 1.4
Whole body water mass 4.0 22.8 38.8 -2.6 6.2
Leg predicted mass (right) 4.1 21.6 36.0 -2.7 6.0
Arm fat mass (left) 2.1 8.6 16.5 -0.8 4.1
Number of self-reported non-cancer illnesses 0.3 0.6 0.9 -0.9 -0.5
Average weekly champagne plus white wine intake 0.3 0.4 0.5 0.6 0.7
Miserableness 0.3 0.5 0.7 0.5 -0.9
Guilty feelings 2.6 3.9 7.1 0.9 -2.7
Wears glasses or contact lenses 0.4 0.4 0.6 0.8 -0.5
Ever taken oral contraceptive pill 0.8 0.9 1.0 -0.8 1.0
Hearing aid user 1.6 1.8 3.3 -0.6 1.8
Mother’s age at death 0.8 1.0 1.9 -0.1 -1.4
Financial situation satisfaction 2.2 2.7 5.3 0.1 2.3
Tinnitus: Yes, now most or all of the time 1.6 1.8 3.7 -0.0 1.9
Commuting to job workplace: Public transport 0.2 0.3 0.4 0.4 -0.7
Eye problems/disorders: Glaucoma 0.4 0.5 1.0 -1.0 0.1
Medication: Blood pressure 0.5 0.9 1.8 -0.1 1.4
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.4 -0.4 1.2
Supplements: Fish oil (including cod liver oil) 1.9 2.4 4.6 -0.5 -2.1
High cholesterol (Self-reported) 0.7 1.3 2.5 -1.6 -0.0
Medication: Bendroflumethiazide 0.4 0.7 1.3 -1.2 -0.1
Medication: Paracetamol 0.2 0.4 0.7 0.3 0.8
Medication: Lisinopril 0.3 0.4 0.7 -0.4 0.8
Medication: Atorvastatin 0.3 0.4 0.7 -0.9 -0.1
Illnesses of father: High blood pressure 2.8 3.5 6.8 -2.6 0.4
Alcohol drinker status: Never 2.0 2.4 4.5 0.6 2.1
Ever smoked 0.4 0.6 0.8 0.9 0.7
Basal metabolic rate 4.2 23.0 39.7 -2.5 6.3
Leg fat percentage (left) 0.6 2.0 3.9 0.4 2.0
Arm fat-free mass (left) 4.2 21.1 37.5 -2.2 6.1
Number of operations (self-reported) 0.0 0.0 0.0 0.2 -0.1
Average weekly beer plus cider intake 3.2 4.7 8.9 3.0 0.7
Irritability 0.1 0.1 0.2 -0.4 0.0
Risk taking 0.9 1.4 2.7 1.6 -0.2
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 -0.3 0.3
Fractured/broken bones in last 5 years 0.2 0.3 0.4 0.6 0.5
Age started oral contraceptive pill 1.2 1.5 3.0 0.1 -1.7
Diastolic blood pressure, automated reading 0.7 2.2 3.9 0.8 2.0
Ever depressed for a whole week 1.9 2.4 2.5 -1.5 -1.6
Unable to work because of sickness or disability 1.0 1.2 2.5 1.6 -0.1
Commuting to job workplace: Cycle 0.6 0.7 0.9 0.7 -1.0
Myopia 0.0 0.1 0.1 0.4 -0.1
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.3 0.6 -1.1
Cholesterol lowering medication 0.4 0.6 1.1 -1.1 0.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.9 0.9 -0.0
Pain experienced in last month 0.3 0.4 0.5 -0.6 -0.7
Supplements: Calcium 0.4 0.4 0.8 -0.2 -0.9
Basal cell carcinoma (self-reported) 0.9 1.0 1.4 1.2 -0.8
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.3 0.6 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.0 0.5 1.0
Heart disease (siblings) 0.3 0.4 0.8 -0.1 0.9
Alcohol drinker status: Previous 1.3 1.5 2.7 -1.6 0.6
Pack years of smoking 1.2 1.8 3.1 1.8 -0.7
Impedance of whole body 1.0 5.1 9.5 0.9 -3.1
Leg fat mass (left) 1.6 6.4 12.7 -0.4 3.6
Arm predicted mass (left) 4.5 22.7 40.7 -2.2 6.4