TWAS hub - PDE4A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.569	0.10	6.9e-05	0.001	NA	0.096	NA	0.047	0.300	NA	0.0013	NA	0.019
2	GTEx	Testis	0.204	0.08	9.3e-03	0.023	NA	0.041	NA	0.009	0.033	NA	0.0064	NA	0.120

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Crohns Disease (2012)	11.3	18.2	35.5	-0.9	6.0
Irritable Bowel Disease (IBD)	9.3	22.1	42.4	-1.3	6.5
Crohns Disease (2017)	8.6	19.0	37.7	-0.5	6.1
Rheumatoid Arthritis	6.9	9.4	11.7	-3.4	-2.7
Primary Biliary Cirrhosis	5.6	8.1	10.0	-2.5	-3.2
Other serious medical condition/disability diagnosed by doctor	5.1	6.6	12.2	-3.5	1.0
Forced expiratory volume in 1-second (FEV1), predicted	5.1	10.6	17.7	-1.8	4.2
Ulcerative Colitis (UC)	4.9	9.1	16.9	-1.2	4.1
LDL Cholesterol	4.7	7.4	14.0	-3.7	-0.9
Arm predicted mass (left)	4.5	22.7	40.7	-2.2	6.4
Whole body fat-free mass	4.2	24.0	41.0	-2.6	6.4
Basal metabolic rate	4.2	23.0	39.7	-2.5	6.3
Arm fat-free mass (left)	4.2	21.1	37.5	-2.2	6.1
Leg predicted mass (right)	4.1	21.6	36.0	-2.7	6.0
Medication: Co-codamol	4.0	4.6	8.8	0.7	3.0
Leg fat-free mass (left)	4.0	21.4	37.3	-2.3	6.1
Leg predicted mass (left)	4.0	21.1	36.7	-2.4	6.1
Qualifications: NVQ or HND or HNC or equivalent	4.0	4.9	8.4	1.1	2.9
Leg fat-free mass (right)	4.0	21.3	35.5	-2.6	6.0
Whole body water mass	4.0	22.8	38.8	-2.6	6.2
Hayfever/allergic rhinitis (self-reported)	3.9	5.1	9.7	-0.7	-3.1
Trunk fat-free mass	3.9	22.2	37.8	-2.6	6.2
Trunk predicted mass	3.9	22.4	38.4	-2.5	6.2
Arm predicted mass (right)	3.9	20.1	35.8	-2.1	6.0
Arm fat-free mass (right)	3.8	19.2	34.5	-2.0	5.9
Hayfever, allergic rhinitis or eczema	3.7	8.1	15.1	-1.1	-3.9
Health satisfaction	3.7	4.8	9.0	0.8	3.0
Lupus	3.5	5.4	8.7	-1.4	-2.9
Type 2 Diabetes (T2D) (2018)	3.5	6.6	13.2	0.0	3.6
Had menopause	3.3	4.1	8.1	0.5	-2.8
Hip circumference	3.3	14.2	21.2	-2.7	4.6
Weight	3.2	15.5	28.2	-1.7	5.3
Leg pain on walking	3.2	4.1	7.6	0.7	2.8
Average weekly beer plus cider intake	3.2	4.7	8.9	3.0	0.7
Ulcerative Colitis	3.0	4.4	7.2	-1.2	2.7
Blood White Count	2.8	20.7	26.8	3.8	5.2
Allergy or Eczema	2.8	7.4	14.8	0.0	-3.8
Hair/balding pattern: Pattern 3	2.8	4.2	7.8	-0.8	-2.8
Illnesses of father: High blood pressure	2.8	3.5	6.8	-2.6	0.4
Coronary Artery Disease (CAD)	2.6	3.1	6.2	-2.5	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.0	4.5	1.3	-2.1
Diabetes diagnosed by doctor	2.6	4.3	8.6	-0.3	2.9
Guilty feelings	2.6	3.9	7.1	0.9	-2.7
Supplements: Glucosamine	2.5	3.2	4.5	1.4	-2.1
Diabetes (self-reported)	2.5	3.8	7.7	-0.1	2.8
Worrier / anxious feelings	2.5	4.7	8.8	-0.7	-3.0
Stomach or abdominal pain in last month	2.2	2.8	4.8	0.9	2.2
Financial situation satisfaction	2.2	2.7	5.3	0.1	2.3
Ever used hormone-replacement therapy (HRT)	2.1	2.6	5.2	-0.3	-2.3
Lung cancer (father)	2.1	2.4	4.3	2.1	-0.7
Shortness of breath walking on level ground	2.1	2.5	4.2	0.9	2.0
Arm fat mass (left)	2.1	8.6	16.5	-0.8	4.1
Age at First Birth	2.0	2.9	4.3	-2.1	1.2
Height	2.0	38.6	45.0	-5.7	6.7
Medication: Lansoprazole	2.0	2.3	3.4	-1.8	1.1
Arm fat mass (right)	2.0	8.1	15.2	-1.0	3.9
Illnesses of siblings: Diabetes	2.0	2.5	5.0	-2.2	0.1
Medication: Gliclazide	2.0	2.3	3.4	-1.1	1.9
Alcohol drinker status: Never	2.0	2.4	4.5	0.6	2.1
Townsend deprivation index at recruitment	1.9	2.7	5.5	2.3	0.0
Hearing difficulty/problems with background noise	1.9	3.1	5.5	0.9	2.3
Whole body fat mass	1.9	8.1	15.8	-0.6	4.0
Overall health rating	1.9	4.1	7.7	0.8	2.8
Supplements: Fish oil (including cod liver oil)	1.9	2.4	4.6	-0.5	-2.1
Ever depressed for a whole week	1.9	2.4	2.5	-1.5	-1.6
Hand grip strength (right)	1.8	4.8	9.7	0.1	3.1
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	2.4	-1.6	1.2
Trunk fat mass	1.8	7.6	14.5	-0.8	3.8
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	3.2	1.8	1.6
Standing height	1.8	17.7	25.8	-3.1	5.1
Heart disease (mother)	1.8	2.2	2.8	-1.7	-1.3
Leg fat mass (right)	1.8	7.0	13.8	-0.4	3.7
Pulse rate, automated reading	1.8	5.8	10.8	-0.9	3.3
Waist Hip Ratio (WHR)	1.7	7.6	9.5	3.1	-2.4
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	2.4	-1.6	1.1
Sitting height	1.6	11.4	14.8	-2.8	3.8
Allergy	1.6	3.7	7.1	0.6	2.7
Fluid intelligence score	1.6	3.3	4.4	2.1	-1.4
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.8	0.0	2.0
Qualifications: College or University degree	1.6	4.9	9.7	0.2	-3.1
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	5.0	0.3	2.2
Hearing aid user	1.6	1.8	3.3	-0.6	1.8
Tinnitus: Yes, now most or all of the time	1.6	1.8	3.7	-0.0	1.9
Leg fat mass (left)	1.6	6.4	12.7	-0.4	3.6
Current tobacco smoking	1.5	2.5	4.6	2.1	-0.7
Average weekly fortified wine intake	1.5	1.7	2.3	-1.1	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	6.6	0.4	-2.6
Happiness	1.5	1.9	1.9	-1.4	1.3
Schizophrenia vs Biploar Disorder	1.4	1.8	2.4	-1.6	-1.1
Illnesses of siblings	1.4	2.0	2.7	1.1	1.6
Illnesses of mother	1.4	1.7	2.7	0.8	1.6
Back pain experienced in last month	1.4	2.1	3.0	1.7	1.1
Worry (Nagel 2018)	1.3	2.8	5.4	-0.4	-2.3
BMI	1.3	7.8	15.5	-0.1	3.9
Lung FEV1/FVC ratio	1.3	6.7	11.8	-1.2	3.4
Hearing difficulty/problems: Yes	1.3	2.0	4.1	0.1	2.0
Body mass index (BMI)	1.3	5.7	11.4	-0.3	3.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	5.0	1.1	-2.2
Medication: Ramipril	1.3	1.6	2.0	-1.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	2.4	0.9	1.6
Peak expiratory flow (PEF)	1.3	2.9	3.6	-1.9	1.5
High blood pressure (siblings)	1.3	1.9	3.8	-0.2	-1.9
Smoking status: Current	1.3	2.0	3.9	2.0	-0.4
Alcohol drinker status: Previous	1.3	1.5	2.7	-1.6	0.6
Qualifications: CSEs or equivalent	1.2	1.5	3.1	-0.1	1.8
Waist circumference	1.2	4.4	8.9	-0.1	3.0
Mouth/teeth dental problems: Dentures	1.2	2.0	3.6	1.9	-0.7
Exposure to tobacco smoke at home	1.2	1.4	2.1	1.5	0.8
Age started oral contraceptive pill	1.2	1.5	3.0	0.1	-1.7
Pack years of smoking	1.2	1.8	3.1	1.8	-0.7
Ever had hysterectomy (womb removed)	1.1	1.2	2.3	1.5	-0.4
Impedance of arm (right)	1.1	5.0	10.0	0.1	-3.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	1.7	-1.3	0.9
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.3	1.5	-0.5
Neck or shoulder pain in last month	1.1	1.6	2.2	1.0	1.5
Medication: Seretide 50 evohaler	1.1	1.2	2.4	-0.2	1.6
Comparative height size at age 10	1.1	5.8	7.8	-2.8	2.0
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.4	-0.1	-1.6
Intelligence (Savage-Jansen 2018)	1.0	3.0	4.3	2.1	-1.3
Neuroticism (Nagel 2018)	1.0	2.3	4.3	0.5	-2.1
Alzheimer’s Disease (in father)	1.0	1.1	1.8	1.4	0.6
Breast Cancer	1.0	2.5	5.0	-0.0	-2.2
Ovarian Cancer	1.0	1.3	1.5	-1.0	-1.2
Fasting Glucose	1.0	1.2	2.4	1.6	-0.1
Blood Platelet Count	1.0	11.7	20.2	-4.5	1.8
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	5.2	-1.2	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	4.4	-1.3	2.1
Impedance of arm (left)	1.0	4.8	9.5	0.2	-3.1
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.4	-1.5	-1.2
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.3	-1.1	-1.0
Comparative body size at age 10	1.0	2.6	4.6	-2.1	-0.8
Long-standing illness, disability or infirmity	1.0	1.5	3.0	-1.7	0.3
Unable to work because of sickness or disability	1.0	1.2	2.5	1.6	-0.1
Impedance of whole body	1.0	5.1	9.5	0.9	-3.1
Hand grip strength (left)	0.9	2.4	4.7	-0.3	2.2
Sensitivity / hurt feelings	0.9	1.5	3.0	0.3	-1.7
Pack years adult smoking proportion	0.9	1.4	2.4	1.6	-0.6
Maternal smoking around birth	0.9	1.2	2.5	1.6	-0.1
Impedance of leg (left)	0.9	4.1	6.6	1.3	-2.6
Birth weight of first child	0.9	1.5	2.7	-0.6	1.6
Exposure to tobacco smoke outside home	0.9	1.2	1.3	1.1	1.1
Knee pain experienced in last month	0.9	1.4	2.7	-1.6	0.4
Breast cancer (self-reported)	0.9	1.0	1.9	-0.4	1.4
Osteoporosis (self-reported)	0.9	1.1	2.2	-0.1	-1.5
Risk taking	0.9	1.4	2.7	1.6	-0.2
Basal cell carcinoma (self-reported)	0.9	1.0	1.4	1.2	-0.8
Reaction Time	0.8	1.6	2.5	0.8	-1.6
HbA1C	0.8	0.8	1.7	1.3	-0.1
Neuroticism	0.8	2.0	3.9	-0.3	-2.0
Medication for hormone replacement therapy	0.8	0.8	1.1	0.8	-1.0
Arm fat percentage (right)	0.8	3.2	6.2	-0.4	2.5
Father’s age at death	0.8	1.0	1.2	-1.1	-0.9
Forced vital capacity (FVC), Best measure	0.8	2.8	4.0	-1.2	2.0
Number of children fathered	0.8	0.9	1.8	0.3	-1.3
Emphysema/chronic bronchitis	0.8	0.9	0.9	0.9	-1.0
Medication: Allopurinol	0.8	1.1	2.2	-1.5	-0.1
Number of full sisters	0.8	1.0	1.7	-0.5	1.3
Illnesses of father: None of the above (group 1)	0.8	1.0	1.0	1.0	1.0
Ever taken oral contraceptive pill	0.8	0.9	1.0	-0.8	1.0
Mother’s age at death	0.8	1.0	1.9	-0.1	-1.4
Body Mass Index (BMI) (2010)	0.7	1.0	1.4	-0.8	1.2
Triglycerides	0.7	1.2	2.0	0.7	-1.4
Impedance of leg (right)	0.7	3.5	5.2	1.4	-2.3
Trunk fat percentage	0.7	3.0	6.0	-0.1	2.4
Medication: Atenolol	0.7	0.9	1.7	-1.3	0.1
Body fat percentage	0.7	2.6	5.2	0.2	2.3
Leg fat percentage (right)	0.7	2.5	4.7	0.6	2.2
Mean time to correctly identify matches	0.7	1.4	2.2	0.8	-1.5
Supplements: Vitamin C	0.7	0.9	1.6	1.3	0.4
Arm fat percentage (left)	0.7	2.8	5.5	-0.3	2.4
Ever had bowel cancer screening	0.7	0.8	1.4	0.5	-1.2
Mineral and other dietary supplements	0.7	0.9	1.8	-0.2	1.3
High cholesterol (Self-reported)	0.7	1.3	2.5	-1.6	-0.0
Diastolic blood pressure, automated reading	0.7	2.2	3.9	0.8	2.0
Alzheimer’s Disease (in mother)	0.6	0.7	0.9	-0.9	-0.7
Major Depression (MDD)	0.6	0.7	1.5	1.2	0.0
Mean Putamen Volume	0.6	0.6	0.7	-0.8	0.8
Blood Eosinophil Count	0.6	4.6	4.8	2.1	2.2
Supplements: Zinc	0.6	0.7	0.7	-0.8	0.8
Hair/balding pattern: Pattern 2	0.6	0.8	1.5	0.3	-1.2
Forced vital capacity (FVC)	0.6	2.4	3.5	-1.1	1.9
Pain all over the body in last month	0.6	0.7	0.8	0.7	0.9
Prospective memory result	0.6	0.8	1.1	-0.7	-1.1
Medication: Amlodipine	0.6	0.9	1.5	1.2	-0.6
Eye problems/disorders: None of the above	0.6	0.7	1.4	0.1	-1.2
Chest pain or discomfort	0.6	0.9	1.2	1.1	0.8
Family relationship satisfaction	0.6	0.7	1.5	0.1	1.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.4	-0.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.3	1.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.2	0.4	-1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.4	-0.4	1.2
Leg fat percentage (left)	0.6	2.0	3.9	0.4	2.0
Commuting to job workplace: Cycle	0.6	0.7	0.9	0.7	-1.0
Neuroticism (2016)	0.5	0.7	1.5	-0.1	-1.2
Blood Red Count	0.5	5.0	8.9	1.0	3.0
Systolic Blood Pressure	0.5	2.7	5.1	2.3	-0.6
Average weekly spirits intake	0.5	0.6	1.3	-1.1	0.0
Systolic blood pressure, automated reading	0.5	1.5	3.0	1.7	0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	0.9	0.4	1.0
Chronic bronchitis/emphysema (father)	0.5	0.6	0.7	0.6	-0.9
Nervous feelings	0.5	1.0	2.0	-0.1	-1.4
Mouth/teeth dental problems	0.5	0.7	1.4	-1.2	-0.1
Asthma	0.5	1.1	1.4	-1.2	0.8
Loud music exposure frequency	0.5	0.5	0.9	-0.9	-0.4
Blood clot in the leg (DVT)	0.5	0.7	1.1	0.5	1.1
Medication: Paracetamol	0.5	0.8	1.2	0.6	1.1
Number of full brothers	0.5	0.7	1.3	0.1	-1.1
Medication: Omeprazole	0.5	0.6	0.8	0.9	0.6
Alcohol intake frequency.	0.5	1.1	1.8	-0.7	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.8	0.5	0.9
Illnesses of father: Heart disease	0.5	0.6	1.0	-1.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.8	-0.3	1.4
Medication: Blood pressure	0.5	0.9	1.8	-0.1	1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.0	0.5	1.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.4	1.2	-0.7
Cardiovascular Disease	0.4	1.4	2.2	-1.5	0.8
Respiratory disease	0.4	0.9	1.8	-1.3	0.3
Medication: Metformin	0.4	0.6	0.6	0.7	0.7
Diabetes (father)	0.4	0.5	0.7	-0.5	-0.8
High blood pressure (mother)	0.4	0.6	0.8	0.9	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.4	0.1	1.2
Time employed in main current job	0.4	0.4	0.6	-0.5	-0.8
Falls in the last year	0.4	0.5	0.9	0.9	-0.4
Pulse rate	0.4	0.7	1.4	-0.1	1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	0.1	1.0
Birth weight	0.4	0.8	1.4	0.5	1.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.8	0.3	-0.9
Commuting to job workplace: Walk	0.4	0.4	0.8	0.9	0.3
Medication for cholesterol	0.4	0.6	0.7	0.7	-0.8
Asthma (self-reported)	0.4	0.8	1.3	-1.1	0.5
Wears glasses or contact lenses	0.4	0.4	0.6	0.8	-0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-1.0	0.1
Medication: Bendroflumethiazide	0.4	0.7	1.3	-1.2	-0.1
Ever smoked	0.4	0.6	0.8	0.9	0.7
Cholesterol lowering medication	0.4	0.6	1.1	-1.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.9	-0.0
Supplements: Calcium	0.4	0.4	0.8	-0.2	-0.9
Bipolar Disorder (2018)	0.3	0.5	0.8	0.5	0.9
HDL Cholesterol	0.3	0.4	0.5	0.6	0.7
Schizophrenia (2014)	0.3	0.6	0.6	-0.7	-0.8
Diabetes (mother)	0.3	0.4	0.4	-0.7	0.6
Fed-up feelings	0.3	0.6	1.0	1.0	0.3
Age when periods started (menarche)	0.3	0.8	1.2	1.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.5	0.7	0.6
High blood pressure	0.3	0.9	1.7	-0.5	1.3
Past tobacco smoking	0.3	0.6	0.7	-0.7	-0.8
Had other major operations	0.3	0.3	0.4	0.6	0.5
Financial difficulties in last 2 years	0.3	0.4	0.6	-0.6	0.7
Neuroticism score	0.3	0.6	1.2	0.0	-1.1
Noisy workplace	0.3	0.4	0.7	-0.3	0.9
Tense / ‘highly strung’	0.3	0.5	0.7	0.8	-0.6
Worry too long after embarrassment	0.3	0.4	0.8	-0.2	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.6	0.5	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.1	0.8
Age at first live birth	0.3	0.5	0.9	-0.2	0.9
Migraine (self-reported)	0.3	0.3	0.6	-0.3	0.8
Medication: Ibuprofen	0.3	0.4	0.5	0.5	0.7
Age at last live birth	0.3	0.5	1.0	-0.0	1.0
Hypertension (Self-reported)	0.3	0.9	1.3	-0.7	1.1
Mood swings	0.3	0.5	0.8	0.9	-0.5
Number of self-reported non-cancer illnesses	0.3	0.6	0.9	-0.9	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	0.5	0.6	0.7
Miserableness	0.3	0.5	0.7	0.5	-0.9
Medication: Lisinopril	0.3	0.4	0.7	-0.4	0.8
Medication: Atorvastatin	0.3	0.4	0.7	-0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.3	0.6	-1.1
Pain experienced in last month	0.3	0.4	0.5	-0.6	-0.7
Heart disease (siblings)	0.3	0.4	0.8	-0.1	0.9
Depression (Nagel 2018)	0.2	0.3	0.5	-0.7	-0.3
Schizophrenia (2018)	0.2	0.5	0.7	-0.8	-0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.2	-0.4	0.5
Hypothyroidism (self reported)	0.2	0.4	0.6	-0.5	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.2	-0.4	-0.5
Relative age of first facial hair	0.2	0.3	0.6	0.8	0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.2	0.5	0.5
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.8	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	0.7	0.3
Qualifications: None of the above	0.2	0.5	0.8	0.9	-0.3
Number of live births	0.2	0.2	0.4	-0.6	-0.4
Medication: Cholesterol lowering	0.2	0.3	0.4	-0.7	0.3
Depression (self-reported)	0.2	0.2	0.4	0.6	-0.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	0.1	0.6
Length of working week for main job	0.2	0.2	0.4	0.2	0.6
Breastfed as a baby	0.2	0.2	0.4	0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.5	0.7	-0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.0	-0.8
Gout (self-reported)	0.2	0.3	0.3	-0.6	0.6
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.1	0.9
Medication for pain relief, constipation, heartburn	0.2	0.4	0.5	-0.7	-0.6
Medication: Blood pressure	0.2	0.4	0.7	0.3	0.8
Angina (self-reported)	0.2	0.2	0.4	0.2	0.6
Had major operations	0.2	0.3	0.5	-0.1	-0.7
Smoking status: Previous	0.2	0.3	0.5	0.1	0.7
Loneliness, isolation	0.2	0.3	0.4	0.3	-0.7
Friendships satisfaction	0.2	0.3	0.4	0.4	0.7
Osteoarthritis (self-reported)	0.2	0.2	0.3	-0.6	-0.2
Commuting to job workplace: Public transport	0.2	0.3	0.4	0.4	-0.7
Medication: Paracetamol	0.2	0.4	0.7	0.3	0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.4	0.6	0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.2	-0.5	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.6	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.5	-0.1
Prostate Cancer	0.1	0.1	0.2	0.0	0.4
Heel T-Score	0.1	0.6	1.0	-0.4	-1.0
Smoking Status	0.1	0.2	0.2	0.4	-0.4
Chronotype (morning person)	0.1	0.2	0.2	0.4	0.4
Hair Pigment	0.1	3.8	4.7	2.2	-1.7
Tanning	0.1	0.9	1.8	1.3	-0.3
Angina	0.1	0.2	0.3	0.2	0.6
Severe depression (siblings)	0.1	0.2	0.3	0.5	0.2
Relative age voice broke	0.1	0.1	0.2	-0.0	-0.4
Taking other prescription medications	0.1	0.2	0.4	-0.6	-0.1
Number of incorrect matches in round	0.1	0.2	0.3	0.5	0.5
Heart attack	0.1	0.1	0.2	0.5	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.1	-0.4
Headache pain in last month	0.1	0.2	0.3	-0.6	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	0.5	-0.5
Glaucoma (self-reported)	0.1	0.1	0.3	-0.1	0.5
Pulse wave peak to peak time	0.1	0.1	0.1	-0.4	-0.1
Average weekly red wine intake	0.1	0.2	0.2	0.5	-0.4
Qualifications: nursing, teaching	0.1	0.2	0.4	0.1	-0.7
Irritability	0.1	0.1	0.2	-0.4	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.6	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Lung FVC	0.0	0.2	0.3	0.1	-0.5
Number of treatments/medications taken	0.0	0.0	0.0	-0.2	-0.1
Vitamin and mineral supplements	0.0	0.0	0.0	0.0	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	0.1	-0.2
Multivitamins +/- minerals	0.0	0.0	0.0	-0.2	-0.1
Alcohol usually taken with meals	0.0	0.0	0.1	-0.2	-0.0
Medication: Simvastatin	0.0	0.0	0.0	-0.0	-0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	0.1	-0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.0	0.4
Pulse wave reflection index	0.0	0.1	0.1	0.3	-0.1
Suffer from ‘nerves’	0.0	0.1	0.1	-0.3	-0.0
Medication: Aspirin	0.0	0.0	0.1	0.2	0.2
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.2	0.2
Medication: Aspirin	0.0	0.0	0.1	0.1	-0.3
Number of operations (self-reported)	0.0	0.0	0.0	0.2	-0.1
Myopia	0.0	0.1	0.1	0.4	-0.1

Hub : Genes

PDE4A

Models

Trait associations