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chr1:10,391,536-12,013,869

Best TWAS P=1.05e-15 · Best GWAS P=2.98e-14 conditioned to 0.219

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EXOSC10	0.06	0.08	lasso	2	0.07	6.8e-09	7.5	7.5	4.5e-14	0.92	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTOR	0.13	0.15	lasso	4	0.15	5.6e-18	7.1	7.2	8.2e-13	0.87	0.20	0.80	FALSE
3	GTEx	Adipose Subcutaneous	MASP2	0.10	0.06	lasso	2	0.03	8.8e-04	6.0	6.0	1.8e-09	0.73	0.34	0.51	FALSE
4	GTEx	Adipose Subcutaneous	EXOSC10	0.17	0.00	lasso	3	0.00	1.8e-01	7.2	6.9	5.8e-12	0.88	0.04	0.29	FALSE
5	GTEx	Adipose Visceral Omentum	RP4-635E18.7	0.19	0.08	lasso	6	0.05	9.0e-04	7.5	6.9	4.0e-12	0.90	0.03	0.93	FALSE
6	GTEx	Brain Cerebellar Hemisphere	EXOSC10	0.23	0.10	lasso	3	0.12	6.4e-04	7.0	7.5	6.4e-14	0.97	0.02	0.88	FALSE
7	GTEx	Brain Cerebellum	EXOSC10	0.33	0.16	lasso	6	0.18	3.8e-06	7.3	7.6	3.3e-14	0.93	0.04	0.95	FALSE
8	GTEx	Brain Cerebellum	RP4-635E18.7	0.17	0.17	lasso	5	0.09	1.3e-03	7.3	7.4	1.2e-13	0.91	0.04	0.89	FALSE
9	GTEx	Brain Cortex	RP4-635E18.7	0.17	0.05	lasso	4	0.07	6.4e-03	7.1	7.2	6.0e-13	0.88	0.07	0.63	FALSE
10	GTEx	Lung	EXOSC10	0.11	0.07	lasso	4	0.05	1.2e-04	7.3	7.2	6.7e-13	0.89	0.06	0.93	FALSE
11	GTEx	Nerve Tibial	MASP2	0.14	0.07	lasso	5	0.09	1.2e-06	6.0	5.8	7.2e-09	0.68	0.57	0.28	FALSE
12	GTEx	Thyroid	RP4-635E18.7	0.07	0.02	lasso	2	0.01	5.5e-02	7.3	7.5	8.2e-14	0.86	0.05	0.74	FALSE
13	GTEx	Whole Blood	MTOR	0.16	0.06	enet	18	0.07	5.1e-07	7.2	6.2	6.1e-10	0.69	0.17	0.83	FALSE
14	METSIM	Adipose	EXOSC10	0.05	0.06	lasso	1	0.05	3.5e-08	5.9	5.9	4.0e-09	0.76	0.06	0.94	FALSE
15	METSIM	Adipose	MTOR	0.04	0.02	bslmm	434	0.02	1.5e-04	7.1	7.3	3.9e-13	0.84	0.10	0.89	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	EXOSC10	0.06	0.06	lasso	2	0.06	4.9e-08	7.5	7.5	8.0e-14	0.92	0.04	0.96	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	MTOR	0.07	0.05	bslmm	423	0.04	2.0e-06	7.1	8.0	1.0e-15	0.87	0.19	0.81	TRUE
18	ROSMAP	Brain Pre-frontal Cortex	RP4-635E18.7	0.23	0.09	enet	24	0.24	3.8e-30	5.2	5.7	1.4e-08	0.63	0.05	0.95	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MTOR	0.02	0.02	blup	54	0.02	5.4e-03	7.5	7.6	2.0e-14	0.97	0.02	0.88	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTOR	0.03	0.01	blup	54	0.02	5.9e-03	7.5	7.4	1.0e-13	0.93	0.03	0.70	FALSE
21	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MASP2	0.05	0.03	blup	30	0.04	6.0e-03	3.2	-6.4	1.2e-10	-0.80	0.02	0.59	FALSE