Best TWAS P=6.23e-15 · Best GWAS P=1.28e-10 conditioned to 0.787
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCNA2 | 0.03 | 0.01 | blup | 34 | 0.02 | 1.5e-03 | -6.3 | 7.8 | 6.2e-15 | -0.80 | 0.00 | 0.96 | TRUE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | EXOSC9 | 0.04 | 0.05 | lasso | 2 | 0.04 | 7.1e-05 | 6.2 | 6.9 | 5.4e-12 | -0.78 | 0.01 | 0.98 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | BBS7 | 0.19 | 0.21 | bslmm | 423 | 0.23 | 1.8e-27 | -6.3 | -6.9 | 5.6e-12 | 0.93 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EXOSC9 | 0.03 | 0.04 | enet | 9 | 0.04 | 2.8e-08 | 6.2 | 6.7 | 1.9e-11 | -0.70 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | BBS7 | 0.16 | 0.09 | lasso | 7 | 0.16 | 2.9e-12 | -6.4 | -6.6 | 3.8e-11 | 0.91 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Testis | EXOSC9 | 0.17 | 0.07 | lasso | 8 | 0.10 | 2.5e-05 | -4.7 | 6.3 | 2.4e-10 | -0.87 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | EXOSC9 | 0.29 | 0.17 | lasso | 7 | 0.16 | 6.6e-06 | 5.6 | 6.3 | 3.3e-10 | -0.68 | 0.13 | 0.85 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | BBS7 | 0.04 | 0.04 | lasso | 2 | 0.03 | 6.1e-04 | -6.3 | -6.2 | 4.3e-10 | 1.00 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EXOSC9 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.0e-03 | 5.4 | 6.1 | 1.3e-09 | -0.66 | 0.04 | 0.68 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | BBS7 | 0.05 | 0.00 | blup | 47 | 0.02 | 1.9e-02 | 6.3 | -6.0 | 1.7e-09 | 0.56 | 0.01 | 0.43 | FALSE |
| 5 | YFS | Blood | EXOSC9 | 0.06 | 0.09 | bslmm | 401 | 0.09 | 7.0e-28 | 5.4 | 6.0 | 1.8e-09 | -0.63 | 0.25 | 0.75 | FALSE |