Best TWAS P=4e-09 · Best GWAS P=3.63e-08 conditioned to 0.629
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | SDHA | 0.10 | 0.09 | lasso | 5 | 0.07 | 1.9e-06 | 5.5 | 5.1 | 3.0e-07 | 0.97 | 0.01 | 0.99 | FALSE |
2 | GTEx | Artery Aorta | PDCD6 | 0.26 | 0.17 | lasso | 4 | 0.14 | 2.8e-08 | 5.5 | -5.3 | 1.0e-07 | -0.98 | 0.01 | 0.99 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | SDHA | 0.23 | 0.18 | lasso | 2 | 0.17 | 1.6e-12 | 5.5 | 5.5 | 3.9e-08 | 0.99 | 0.01 | 0.99 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | CTD-2083E4.5 | 0.09 | 0.07 | lasso | 3 | 0.05 | 1.2e-04 | 5.5 | -5.3 | 1.1e-07 | -1.00 | 0.01 | 0.98 | FALSE |
5 | GTEx | Nerve Tibial | CCDC127 | 0.05 | 0.01 | lasso | 4 | 0.02 | 2.2e-02 | 4.3 | 5.2 | 1.8e-07 | 0.86 | 0.04 | 0.82 | FALSE |
6 | GTEx | Thyroid | CTD-2083E4.5 | 0.07 | 0.06 | lasso | 2 | 0.04 | 3.6e-04 | 5.5 | -5.6 | 1.8e-08 | -0.99 | 0.01 | 0.98 | FALSE |
7 | GTEx | Whole Blood | SDHA | 0.05 | 0.01 | lasso | 5 | 0.01 | 3.4e-02 | 4.3 | -5.2 | 1.5e-07 | -0.90 | 0.02 | 0.92 | FALSE |
8 | YFS | Blood | PDCD6 | 0.03 | 0.03 | bslmm | 276 | 0.03 | 1.6e-09 | 5.5 | 5.9 | 4.0e-09 | 0.90 | 0.01 | 0.98 | TRUE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PDCD6 | 0.03 | 0.02 | blup | 49 | 0.02 | 2.9e-03 | 5.3 | 5.6 | 2.6e-08 | 0.95 | 0.02 | 0.96 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SDHA | 0.04 | 0.03 | blup | 62 | 0.05 | 3.3e-06 | 5.5 | 5.3 | 1.0e-07 | 0.87 | 0.02 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LRRC14B | 0.08 | 0.04 | lasso | 5 | 0.03 | 6.7e-03 | 5.3 | 5.3 | 1.1e-07 | 0.97 | 0.01 | 0.96 | FALSE |
12 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | AHRR | 0.11 | 0.05 | lasso | 3 | 0.07 | 2.5e-04 | 5.5 | 5.3 | 1.1e-07 | 0.85 | 0.01 | 0.93 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | PDCD6 | 0.07 | 0.06 | enet | 5 | 0.07 | 2.0e-07 | 5.5 | -5.3 | 1.2e-07 | -0.91 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | SDHA | 0.06 | 0.09 | lasso | 13 | 0.08 | 1.8e-08 | 5.5 | 5.4 | 7.7e-08 | 0.99 | 0.01 | 0.99 | FALSE |