Best TWAS P=3.4e-37 · Best GWAS P=3.78e-34 conditioned to 0.0808
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AMZ1 | 0.19 | 0.12 | enet | 22 | 0.13 | 5.7e-16 | 7.4 | 8.9 | 7.3e-19 | -0.43 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | GNA12 | 0.11 | 0.08 | lasso | 4 | 0.07 | 1.3e-06 | -6.6 | -7.6 | 3.8e-14 | 0.76 | 0.06 | 0.94 | FALSE |
| 3 | GTEx | Artery Tibial | GNA12 | 0.24 | 0.13 | enet | 20 | 0.22 | 3.5e-17 | -12.0 | -10.1 | 7.3e-24 | 0.84 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | GNA12 | 0.46 | 0.51 | lasso | 5 | 0.50 | 7.9e-19 | -12.2 | -12.1 | 1.5e-33 | 0.99 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | GNA12 | 0.21 | 0.11 | lasso | 11 | 0.15 | 1.7e-11 | -11.9 | -9.3 | 1.9e-20 | 0.86 | 0.05 | 0.95 | FALSE |
| 6 | GTEx | Colon Sigmoid | GNA12 | 0.14 | 0.05 | lasso | 3 | 0.03 | 3.6e-02 | -6.5 | -9.7 | 2.8e-22 | 0.87 | 0.02 | 0.94 | FALSE |
| 7 | GTEx | Colon Transverse | GNA12 | 0.19 | 0.08 | lasso | 4 | 0.10 | 2.3e-05 | 5.4 | -6.2 | 7.0e-10 | 0.58 | 0.52 | 0.44 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | GNA12 | 0.20 | 0.12 | lasso | 6 | 0.12 | 3.4e-05 | -6.6 | -9.7 | 3.9e-22 | 0.86 | 0.03 | 0.96 | FALSE |
| 9 | GTEx | Esophagus Mucosa | GNA12 | 0.16 | 0.13 | lasso | 3 | 0.13 | 3.0e-09 | -11.4 | -10.3 | 7.5e-25 | 0.87 | 0.05 | 0.95 | FALSE |
| 10 | GTEx | Esophagus Muscularis | GNA12 | 0.32 | 0.31 | lasso | 3 | 0.34 | 2.1e-21 | -12.0 | -11.6 | 4.6e-31 | 0.94 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Lung | GNA12 | 0.16 | 0.08 | enet | 21 | 0.12 | 1.2e-09 | -11.3 | -9.0 | 3.0e-19 | 0.78 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Nerve Tibial | GNA12 | 0.31 | 0.34 | lasso | 7 | 0.36 | 9.6e-27 | -6.7 | -9.2 | 2.6e-20 | 0.86 | 0.66 | 0.34 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | GNA12 | 0.17 | 0.16 | lasso | 3 | 0.18 | 1.3e-14 | -6.7 | -9.2 | 2.3e-20 | 0.87 | 0.13 | 0.87 | FALSE |
| 14 | GTEx | Small Intestine Terminal Ileum | GNA12 | 0.34 | 0.20 | lasso | 5 | 0.16 | 2.4e-04 | -6.6 | -7.3 | 2.1e-13 | 0.72 | 0.04 | 0.85 | FALSE |
| 15 | GTEx | Stomach | GNA12 | 0.18 | 0.16 | lasso | 2 | 0.13 | 6.6e-07 | -6.5 | -6.6 | 3.2e-11 | 0.70 | 0.17 | 0.82 | FALSE |
| 16 | GTEx | Whole Blood | GNA12 | 0.09 | 0.01 | enet | 4 | 0.00 | 3.3e-01 | -11.7 | -11.9 | 1.1e-32 | 0.94 | 0.02 | 0.91 | FALSE |
| 17 | METSIM | Adipose | GNA12 | 0.07 | 0.05 | lasso | 3 | 0.05 | 3.3e-08 | -6.6 | -6.7 | 1.8e-11 | 0.72 | 0.22 | 0.78 | FALSE |
| 18 | NTR | Blood | GNA12 | 0.07 | 0.03 | bslmm | 597 | 0.06 | 1.3e-17 | -7.9 | -8.7 | 3.0e-18 | 0.63 | 0.87 | 0.13 | FALSE |
| 19 | ROSMAP | Brain Pre-frontal Cortex | AMZ1 | 0.09 | 0.05 | lasso | 6 | 0.04 | 2.4e-06 | -12.0 | 12.7 | 3.4e-37 | -0.90 | 0.03 | 0.97 | TRUE |
| 20 | YFS | Blood | GNA12 | 0.23 | 0.15 | bslmm | 570 | 0.25 | 4.5e-82 | 6.9 | -8.5 | 1.5e-17 | 0.52 | 1.00 | 0.00 | FALSE |
| 21 | The Cancer Genome Atlas | Esophageal Carcinoma | AMZ1 | 0.18 | 0.05 | blup | 69 | 0.05 | 1.4e-02 | 7.4 | -10.8 | 3.5e-27 | 0.71 | 0.01 | 0.71 | FALSE |
| 22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GNA12 | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.0e-05 | -6.6 | -6.7 | 3.0e-11 | 0.72 | 0.07 | 0.79 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AMZ1 | 0.04 | 0.04 | lasso | 3 | 0.02 | 1.3e-03 | 7.4 | 8.5 | 1.5e-17 | -0.60 | 0.03 | 0.91 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Adenocarcinoma | GNA12 | 0.03 | 0.01 | enet | 7 | 0.02 | 1.5e-03 | 4.4 | -9.5 | 1.5e-21 | 0.78 | 0.06 | 0.75 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AMZ1 | 0.08 | 0.01 | blup | 71 | 0.05 | 1.3e-05 | -6.6 | 5.5 | 4.9e-08 | -0.60 | 0.06 | 0.72 | FALSE |