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chr7:2,032,803-3,581,391

Best TWAS P=3.4e-37 · Best GWAS P=3.78e-34 conditioned to 0.0808

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	ROSMAP	Brain Pre-frontal Cortex	AMZ1	0.09	0.05	lasso	6	0.04	2.4e-06	-12.0	12.7	3.4e-37	-0.90	0.03	0.97	TRUE
4	GTEx	Cells EBV-transformed lymphocytes	GNA12	0.46	0.51	lasso	5	0.50	7.9e-19	-12.2	-12.1	1.5e-33	0.99	0.00	1.00	FALSE
16	GTEx	Whole Blood	GNA12	0.09	0.01	enet	4	0.00	3.3e-01	-11.7	-11.9	1.1e-32	0.94	0.02	0.91	FALSE
10	GTEx	Esophagus Muscularis	GNA12	0.32	0.31	lasso	3	0.34	2.1e-21	-12.0	-11.6	4.6e-31	0.94	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Esophageal Carcinoma	AMZ1	0.18	0.05	blup	69	0.05	1.4e-02	7.4	-10.8	3.5e-27	0.71	0.01	0.71	FALSE
9	GTEx	Esophagus Mucosa	GNA12	0.16	0.13	lasso	3	0.13	3.0e-09	-11.4	-10.3	7.5e-25	0.87	0.05	0.95	FALSE
3	GTEx	Artery Tibial	GNA12	0.24	0.13	enet	20	0.22	3.5e-17	-12.0	-10.1	7.3e-24	0.84	0.03	0.97	FALSE
6	GTEx	Colon Sigmoid	GNA12	0.14	0.05	lasso	3	0.03	3.6e-02	-6.5	-9.7	2.8e-22	0.87	0.02	0.94	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	GNA12	0.20	0.12	lasso	6	0.12	3.4e-05	-6.6	-9.7	3.9e-22	0.86	0.03	0.96	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	GNA12	0.03	0.01	enet	7	0.02	1.5e-03	4.4	-9.5	1.5e-21	0.78	0.06	0.75	FALSE
5	GTEx	Cells Transformed fibroblasts	GNA12	0.21	0.11	lasso	11	0.15	1.7e-11	-11.9	-9.3	1.9e-20	0.86	0.05	0.95	FALSE
13	GTEx	Skin Sun Exposed Lower leg	GNA12	0.17	0.16	lasso	3	0.18	1.3e-14	-6.7	-9.2	2.3e-20	0.87	0.13	0.87	FALSE
12	GTEx	Nerve Tibial	GNA12	0.31	0.34	lasso	7	0.36	9.6e-27	-6.7	-9.2	2.6e-20	0.86	0.66	0.34	FALSE
11	GTEx	Lung	GNA12	0.16	0.08	enet	21	0.12	1.2e-09	-11.3	-9.0	3.0e-19	0.78	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AMZ1	0.19	0.12	enet	22	0.13	5.7e-16	7.4	8.9	7.3e-19	-0.43	1.00	0.00	FALSE
18	NTR	Blood	GNA12	0.07	0.03	bslmm	597	0.06	1.3e-17	-7.9	-8.7	3.0e-18	0.63	0.87	0.13	FALSE
20	YFS	Blood	GNA12	0.23	0.15	bslmm	570	0.25	4.5e-82	6.9	-8.5	1.5e-17	0.52	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMZ1	0.04	0.04	lasso	3	0.02	1.3e-03	7.4	8.5	1.5e-17	-0.60	0.03	0.91	FALSE
2	GTEx	Adipose Subcutaneous	GNA12	0.11	0.08	lasso	4	0.07	1.3e-06	-6.6	-7.6	3.8e-14	0.76	0.06	0.94	FALSE
14	GTEx	Small Intestine Terminal Ileum	GNA12	0.34	0.20	lasso	5	0.16	2.4e-04	-6.6	-7.3	2.1e-13	0.72	0.04	0.85	FALSE
17	METSIM	Adipose	GNA12	0.07	0.05	lasso	3	0.05	3.3e-08	-6.6	-6.7	1.8e-11	0.72	0.22	0.78	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNA12	0.03	0.04	lasso	1	0.04	3.0e-05	-6.6	-6.7	3.0e-11	0.72	0.07	0.79	FALSE
15	GTEx	Stomach	GNA12	0.18	0.16	lasso	2	0.13	6.6e-07	-6.5	-6.6	3.2e-11	0.70	0.17	0.82	FALSE
7	GTEx	Colon Transverse	GNA12	0.19	0.08	lasso	4	0.10	2.3e-05	5.4	-6.2	7.0e-10	0.58	0.52	0.44	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMZ1	0.08	0.01	blup	71	0.05	1.3e-05	-6.6	5.5	4.9e-08	-0.60	0.06	0.72	FALSE