Best TWAS P=4.88e-09 · Best GWAS P=7.17e-11 conditioned to 0.0468
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | RAC1 | 0.19 | 0.07 | enet | 28 | 0.09 | 6.2e-07 | 4.3 | 5.2 | 2.5e-07 | 0.60 | 0.11 | 0.88 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | KDELR2 | 0.07 | 0.05 | lasso | 2 | 0.05 | 1.4e-06 | -4.4 | 5.1 | 3.0e-07 | 0.27 | 0.86 | 0.06 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | DAGLB | 0.09 | 0.06 | lasso | 5 | 0.06 | 4.8e-08 | 6.0 | -5.8 | 4.9e-09 | -0.73 | 0.05 | 0.95 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAC1 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.8e-05 | 3.6 | 5.1 | 2.8e-07 | 0.64 | 0.04 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAC1 | 0.08 | 0.02 | blup | 63 | 0.06 | 7.0e-07 | 3.0 | 5.2 | 2.3e-07 | 0.42 | 0.63 | 0.35 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | DAGLB | 0.06 | 0.02 | blup | 71 | 0.03 | 7.4e-04 | 4.3 | -5.7 | 9.5e-09 | -0.61 | 0.04 | 0.36 | FALSE |