[Hub]/) : Traits : Overall health rating :

chr11:64,501,991-67,059,499

Best TWAS P=1.14e-10 · Best GWAS P=1.02e-07 conditioned to 0.0375

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CTSF 0.04 0.02 blup 259 0.03 8.1e-05 -4.5 -5.1 2.9e-07 0.59 0.11 0.80 FALSE
2 GTEx Breast Mammary Tissue (Male) NEAT1 0.27 0.01 enet 29 0.03 6.3e-02 4.0 5.3 1.4e-07 -0.04 0.04 0.25 FALSE
3 GTEx Esophagus Gastroesophageal Junction CTD-3074O7.12 0.11 0.00 enet 7 0.01 9.7e-02 4.7 5.2 1.5e-07 -0.64 0.10 0.55 FALSE
4 GTEx Esophagus Muscularis CTD-3074O7.5 0.22 0.02 enet 17 0.09 3.7e-06 -4.5 6.4 1.1e-10 -0.58 0.14 0.70 TRUE
5 GTEx Heart Atrial Appendage KLC2 0.10 0.04 lasso 8 0.09 1.1e-04 3.4 -5.5 4.9e-08 0.51 0.14 0.65 FALSE
6 GTEx Nerve Tibial SIPA1 0.17 0.01 enet 19 0.06 6.8e-05 -3.0 5.6 2.1e-08 0.02 0.19 0.36 FALSE
7 GTEx Skin Not Sun Exposed Suprapubic CTD-3074O7.5 0.14 0.03 lasso 8 0.04 1.8e-03 4.8 5.4 6.5e-08 -0.62 0.05 0.80 FALSE
8 ROSMAP Brain Pre-frontal Cortex CTSW 0.06 0.03 bslmm 328 0.03 3.6e-05 4.4 -5.3 1.1e-07 0.01 0.18 0.65 FALSE
9 ROSMAP Brain Pre-frontal Cortex CCS 0.08 0.04 lasso 9 0.06 8.9e-08 -4.3 5.5 3.7e-08 -0.68 0.16 0.81 FALSE
10 ROSMAP Brain Pre-frontal Cortex CTSF 0.07 0.08 blup 244 0.07 1.6e-09 -4.5 -5.4 7.3e-08 0.73 0.16 0.81 FALSE
11 The Cancer Genome Atlas Breast Invasive Carcinoma SNX32 0.15 0.17 blup 60 0.17 2.9e-34 4.9 5.3 1.3e-07 -0.03 0.00 0.99 FALSE
12 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma DPP3 0.05 0.02 blup 41 0.02 2.8e-02 -4.5 5.2 1.8e-07 -0.77 0.02 0.61 FALSE
13 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ZDHHC24 0.03 0.03 blup 47 0.03 1.5e-04 -4.5 -5.2 2.5e-07 0.66 0.09 0.82 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CCDC87 0.03 0.02 blup 34 0.02 2.0e-03 -5.1 -5.7 1.3e-08 0.88 0.01 0.83 FALSE
15 The Cancer Genome Atlas Brain Lower Grade Glioma CTSF 0.05 0.04 blup 35 0.04 1.2e-05 -4.4 -5.5 3.2e-08 0.77 0.05 0.91 FALSE
16 The Cancer Genome Atlas Lung Adenocarcinoma SNX32 0.14 0.09 blup 60 0.13 8.8e-15 4.9 5.2 2.0e-07 0.00 0.01 0.97 FALSE
17 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ACTN3 0.23 0.06 enet 13 0.08 3.9e-06 4.8 -5.2 1.9e-07 0.51 0.06 0.92 FALSE
18 The Cancer Genome Atlas Prostate Adenocarcinoma ACTN3 0.14 0.14 enet 9 0.13 7.0e-14 4.8 -5.3 1.5e-07 0.55 0.03 0.96 FALSE
19 The Cancer Genome Atlas Stomach Adenocarcinoma SNX32 0.12 0.13 blup 60 0.13 1.2e-09 4.4 5.7 1.0e-08 0.02 0.02 0.93 TRUE