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chr11:64,501,991-67,059,499

Best TWAS P=1.14e-10 · Best GWAS P=1.02e-07 conditioned to 0.0375

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Esophagus Muscularis	CTD-3074O7.5	0.22	0.02	enet	17	0.09	3.7e-06	-4.5	6.4	1.1e-10	-0.58	0.14	0.70	TRUE
19	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNX32	0.12	0.13	blup	60	0.13	1.2e-09	4.4	5.7	1.0e-08	0.02	0.02	0.93	TRUE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC87	0.03	0.02	blup	34	0.02	2.0e-03	-5.1	-5.7	1.3e-08	0.88	0.01	0.83	FALSE
6	GTEx	Nerve Tibial	SIPA1	0.17	0.01	enet	19	0.06	6.8e-05	-3.0	5.6	2.1e-08	0.02	0.19	0.36	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSF	0.05	0.04	blup	35	0.04	1.2e-05	-4.4	-5.5	3.2e-08	0.77	0.05	0.91	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	CCS	0.08	0.04	lasso	9	0.06	8.9e-08	-4.3	5.5	3.7e-08	-0.68	0.16	0.81	FALSE
5	GTEx	Heart Atrial Appendage	KLC2	0.10	0.04	lasso	8	0.09	1.1e-04	3.4	-5.5	4.9e-08	0.51	0.14	0.65	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	CTD-3074O7.5	0.14	0.03	lasso	8	0.04	1.8e-03	4.8	5.4	6.5e-08	-0.62	0.05	0.80	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	CTSF	0.07	0.08	blup	244	0.07	1.6e-09	-4.5	-5.4	7.3e-08	0.73	0.16	0.81	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	CTSW	0.06	0.03	bslmm	328	0.03	3.6e-05	4.4	-5.3	1.1e-07	0.01	0.18	0.65	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX32	0.15	0.17	blup	60	0.17	2.9e-34	4.9	5.3	1.3e-07	-0.03	0.00	0.99	FALSE
2	GTEx	Breast Mammary Tissue (Male)	NEAT1	0.27	0.01	enet	29	0.03	6.3e-02	4.0	5.3	1.4e-07	-0.04	0.04	0.25	FALSE
3	GTEx	Esophagus Gastroesophageal Junction	CTD-3074O7.12	0.11	0.00	enet	7	0.01	9.7e-02	4.7	5.2	1.5e-07	-0.64	0.10	0.55	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	ACTN3	0.14	0.14	enet	9	0.13	7.0e-14	4.8	-5.3	1.5e-07	0.55	0.03	0.96	FALSE
12	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DPP3	0.05	0.02	blup	41	0.02	2.8e-02	-4.5	5.2	1.8e-07	-0.77	0.02	0.61	FALSE
17	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ACTN3	0.23	0.06	enet	13	0.08	3.9e-06	4.8	-5.2	1.9e-07	0.51	0.06	0.92	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	SNX32	0.14	0.09	blup	60	0.13	8.8e-15	4.9	5.2	2.0e-07	0.00	0.01	0.97	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZDHHC24	0.03	0.03	blup	47	0.03	1.5e-04	-4.5	-5.2	2.5e-07	0.66	0.09	0.82	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CTSF	0.04	0.02	blup	259	0.03	8.1e-05	-4.5	-5.1	2.9e-07	0.59	0.11	0.80	FALSE