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chr17:65,289,798-66,844,411

Best TWAS P=7.62e-09 · Best GWAS P=7.65e-09 conditioned to 0.0511

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LINC00674 0.12 0.13 enet 6 0.14 9.9e-12 5.3 5.8 7.6e-09 0.79 0.17 0.83 TRUE
2 GTEx Adipose Subcutaneous SH3GL1P3 0.08 0.06 lasso 5 0.04 2.5e-04 5.3 5.7 1.4e-08 0.80 0.04 0.93 FALSE
3 GTEx Brain Cortex C17orf58 0.34 0.09 lasso 6 0.13 2.4e-04 5.7 5.7 1.3e-08 0.95 0.03 0.95 FALSE
4 GTEx Cells Transformed fibroblasts LINC00674 0.30 0.31 enet 10 0.32 1.5e-24 5.3 5.3 9.2e-08 0.86 0.20 0.80 FALSE
5 GTEx Cells Transformed fibroblasts LRRC37A16P 0.50 0.46 lasso 8 0.47 1.1e-38 5.3 5.4 7.9e-08 0.84 0.20 0.80 FALSE
6 GTEx Cells Transformed fibroblasts SH3GL1P3 0.26 0.31 lasso 7 0.31 1.5e-23 5.3 5.6 1.8e-08 0.90 0.19 0.81 FALSE
7 GTEx Colon Sigmoid LINC00674 0.42 0.09 lasso 8 0.12 5.5e-05 4.8 5.3 9.0e-08 0.81 0.11 0.74 FALSE
8 GTEx Esophagus Muscularis LINC00674 0.11 0.04 lasso 6 0.07 7.9e-05 4.0 5.4 7.8e-08 0.77 0.16 0.82 FALSE
9 GTEx Heart Atrial Appendage LINC00674 0.14 0.08 lasso 17 0.09 1.1e-04 4.0 5.1 2.7e-07 0.73 0.07 0.84 FALSE
10 GTEx Nerve Tibial LRRC37A16P 0.09 0.08 lasso 4 0.06 2.7e-05 5.3 5.4 8.4e-08 0.84 0.08 0.82 FALSE
11 GTEx Spleen C17orf58 0.30 -0.01 lasso 8 -0.01 4.6e-01 4.3 5.2 2.2e-07 0.81 0.03 0.35 FALSE
12 The Cancer Genome Atlas Thyroid Carcinoma C17orf58 0.02 0.02 lasso 2 0.01 1.8e-02 5.7 5.7 1.1e-08 0.99 0.00 0.76 FALSE