Best TWAS P=7.94e-10 · Best GWAS P=5.28e-13 conditioned to 0.00117
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | ARHGEF28 | 0.15 | 0.03 | lasso | 5 | 0.06 | 6.7e-05 | -5.6 | -6.1 | 7.9e-10 | -0.29 | 0.61 | 0.08 | TRUE |
| 2 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RGNEF | 0.16 | 0.04 | lasso | 4 | 0.06 | 1.0e-03 | -4.9 | 5.4 | 5.5e-08 | 0.23 | 0.28 | 0.03 | FALSE |
| 3 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RGNEF | 0.15 | 0.09 | lasso | 7 | 0.07 | 7.8e-04 | -5.8 | 5.9 | 2.9e-09 | 0.33 | 0.24 | 0.07 | FALSE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RGNEF | 0.20 | 0.14 | lasso | 4 | 0.20 | 1.3e-20 | -6.1 | -6.0 | 2.3e-09 | -0.23 | 0.94 | 0.06 | TRUE |
| 5 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RGNEF | 0.18 | 0.00 | blup | 254 | 0.08 | 3.7e-03 | 3.9 | 5.1 | 3.0e-07 | 0.63 | 0.07 | 0.31 | TRUE |