Hub : Traits :

Hearing difficulty/problems with background noise

66 significantly associated models · 21 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	204927136	206329620	4	1	2.8e-09	8.7e-09	0.0536	89	NUCKS1
2	5	72232417	73934274	2	3	7.9e-10	5.3e-13	0.0012	80	ARHGEF28 RGNEF
3	6	42611872	44034691	3	1	3.0e-15	1.5e-14	0.3360	98	ZNF318
4	10	103527782	105201577	4	1	1.5e-08	3.3e-07	0.1630	92	LOC100505761
5	14	103161201	104866687	3	1	2.5e-08	5.6e-07	0.4820	98	MARK3
6	15	74431715	75825337	1	1	2.3e-07	2.5e-07	0.0445	85	ULK3
7	17	42884538	43913030	3	1	8.1e-08	4.5e-06	0.8730	100	LRRC37A4P

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hearing difficulty/problems: Yes	19.92	5	3	6.7	0.95	0.0037	ARHGEF28 LOC100505761 LRRC37A4P RGNEF ZNF318
Hair/balding pattern: Pattern 4	9.68	1	1	2.2	0.00	1.0000	LRRC37A4P
Hearing aid user	7.44	2	1	2.2	0.00	1.0000	ARHGEF28 RGNEF
Vascular/heart problems diagnosed by doctor	6.50	3	2	4.4	0.00	1.0000	MARK3 ULK3 ZNF318
Relative age of first facial hair	6.42	1	1	2.2	0.00	1.0000	LRRC37A4P
High blood pressure	6.41	4	2	4.4	-0.09	0.9134	LOC100505761 LRRC37A4P ULK3 ZNF318
Hair/balding pattern: Pattern 3	6.31	2	1	2.2	0.00	1.0000	LRRC37A4P ULK3
Systolic Blood Pressure	6.10	3	3	6.7	0.00	1.0000	LRRC37A4P ULK3 ZNF318
Hypertension (Self-reported)	5.94	4	2	4.4	-0.09	0.9072	LOC100505761 LRRC37A4P ULK3 ZNF318
Medication: Blood pressure	5.82	3	2	4.4	0.00	1.0000	LRRC37A4P ULK3 ZNF318
Blood Red Count	5.80	4	2	4.4	0.33	0.6653	LOC100505761 LRRC37A4P MARK3 ULK3
Peak expiratory flow (PEF)	5.62	2	2	4.4	0.00	1.0000	LRRC37A4P NUCKS1
Heel T-Score	5.58	5	3	6.7	-0.25	0.6898	ARHGEF28 LRRC37A4P MARK3 RGNEF ZNF318
Cardiovascular Disease	5.56	5	2	4.4	-0.64	0.2406	MARK3 NUCKS1 RGNEF ULK3 ZNF318
Lung FVC	5.26	3	1	2.2	0.00	1.0000	LRRC37A4P NUCKS1 RGNEF
Neuroticism (Nagel 2018)	5.16	2	1	2.2	0.00	1.0000	LRRC37A4P ZNF318
Sensitivity / hurt feelings	5.14	1	1	2.2	0.00	1.0000	LRRC37A4P
Neuroticism score	5.13	2	1	2.2	0.00	1.0000	LRRC37A4P ZNF318
Diastolic blood pressure, automated reading	5.06	1	1	2.2	0.00	1.0000	ULK3
Neuroticism	4.86	2	1	2.2	0.00	1.0000	LRRC37A4P ZNF318
Mood swings	4.82	2	1	2.2	0.00	1.0000	LRRC37A4P NUCKS1
Forced expiratory volume in 1-second (FEV1)	4.52	2	1	2.2	0.00	1.0000	LRRC37A4P ZNF318
Medication: Ibuprofen (e.g. Nurofen)	4.29	1	0	0.0	0.00	1.0000	LRRC37A4P
Mouth/teeth dental problems	4.22	2	1	2.2	0.00	1.0000	LRRC37A4P MARK3
Medication: Paracetamol	4.20	2	1	2.2	0.00	1.0000	LRRC37A4P MARK3
Prostate Cancer	4.18	1	0	0.0	0.00	1.0000	NUCKS1
Depressed Affect (Nagel 2018)	4.14	2	1	2.2	0.00	1.0000	LRRC37A4P ZNF318
Forced vital capacity (FVC)	4.14	3	1	2.2	0.00	1.0000	LRRC37A4P RGNEF ZNF318
Hand grip strength (left)	4.11	2	2	4.4	0.00	1.0000	LRRC37A4P NUCKS1
Hand grip strength (right)	4.01	2	1	2.2	0.00	1.0000	LRRC37A4P NUCKS1
Forced expiratory volume in 1-second (FEV1), Best measure	3.94	1	1	2.2	0.00	1.0000	LRRC37A4P
Relative age voice broke	3.91	1	1	2.2	0.00	1.0000	LRRC37A4P
Forced vital capacity (FVC), Best measure	3.82	2	1	2.2	0.00	1.0000	LRRC37A4P RGNEF
Headache pain in last month	3.72	1	1	2.2	0.00	1.0000	LRRC37A4P
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.72	1	1	2.2	0.00	1.0000	LRRC37A4P
Multivitamins +/- minerals	3.69	1	0	0.0	0.00	1.0000	NUCKS1
Neuroticism (2016)	3.67	1	1	2.2	0.00	1.0000	LRRC37A4P
Waist Hip Ratio (WHR)	3.63	2	2	4.4	0.00	1.0000	LRRC37A4P ZNF318
Medication: Paracetamol	3.60	1	0	0.0	0.00	1.0000	LRRC37A4P
Systolic blood pressure, automated reading	3.59	2	2	4.4	0.00	1.0000	LRRC37A4P ULK3
Handedness (chirality/laterality): Left-handed	3.59	1	1	2.2	0.00	1.0000	LRRC37A4P
Ovarian Cancer	3.56	1	1	2.2	0.00	1.0000	LRRC37A4P
Medication: Blood pressure	3.53	1	1	2.2	0.00	1.0000	ULK3
Schizophrenia (2014)	3.47	2	1	2.2	0.00	1.0000	MARK3 ZNF318
Sitting height	3.36	3	2	4.4	0.00	1.0000	LOC100505761 LRRC37A4P NUCKS1
Breast Cancer	3.30	2	2	4.4	0.00	1.0000	LRRC37A4P ULK3
Tinnitus: Yes, now most or all of the time	3.26	1	0	0.0	0.00	1.0000	ZNF318
Average weekly champagne plus white wine intake	3.24	1	0	0.0	0.00	1.0000	LRRC37A4P
Mineral and other dietary supplements	3.22	1	0	0.0	0.00	1.0000	NUCKS1
Pack years adult smoking proportion	3.21	1	0	0.0	0.00	1.0000	MARK3
Wheeze or whistling in the chest in last year	3.20	2	0	0.0	0.00	1.0000	RGNEF ZNF318
Medication for pain relief, constipation, heartburn	3.14	2	0	0.0	0.00	1.0000	LRRC37A4P NUCKS1
Pack years of smoking	3.13	1	0	0.0	0.00	1.0000	MARK3
Medication: Bendroflumethiazide	3.12	1	0	0.0	0.00	1.0000	ULK3
Comparative body size at age 10	3.09	2	1	2.2	0.00	1.0000	NUCKS1 RGNEF
Medication for cholesterol	3.09	1	0	0.0	0.00	1.0000	LRRC37A4P
Bipolar Disorder or Schizophrenia	3.08	1	1	2.2	0.00	1.0000	MARK3
Mouth/teeth dental problems: Mouth ulcers	3.07	1	1	2.2	0.00	1.0000	LRRC37A4P
Number of self-reported non-cancer illnesses	3.06	2	0	0.0	0.00	1.0000	MARK3 ZNF318
Worry (Nagel 2018)	3.03	2	1	2.2	0.00	1.0000	LRRC37A4P ZNF318
Supplements: Glucosamine	3.03	1	0	0.0	0.00	1.0000	ULK3
Smoking Status	2.97	2	0	0.0	0.00	1.0000	LOC100505761 MARK3
Risk taking	2.91	1	0	0.0	0.00	1.0000	MARK3
Medication: Ramipril	2.85	1	0	0.0	0.00	1.0000	ULK3
Vitamin and mineral supplements	2.83	1	0	0.0	0.00	1.0000	NUCKS1
Guilty feelings	2.83	1	1	2.2	0.00	1.0000	LRRC37A4P
BMI	2.82	5	1	2.2	0.31	0.6117	LOC100505761 MARK3 NUCKS1 ULK3 ZNF318
Frequency of tenseness / restlessness in last 2 weeks	2.82	1	1	2.2	0.00	1.0000	LRRC37A4P
Alcohol intake frequency.	2.81	2	1	2.2	0.00	1.0000	LRRC37A4P ULK3
Comparative height size at age 10	2.72	3	2	4.4	0.00	1.0000	LRRC37A4P MARK3 NUCKS1
Financial difficulties in last 2 years	2.70	1	0	0.0	0.00	1.0000	MARK3
Heel bone mineral density (BMD) T-score, automated (left)	2.69	2	1	2.2	0.00	1.0000	LRRC37A4P MARK3
Average weekly red wine intake	2.68	1	0	0.0	0.00	1.0000	ULK3
Medication: Amlodipine	2.66	1	0	0.0	0.00	1.0000	ZNF318
Hair/balding pattern: Pattern 2	2.64	1	0	0.0	0.00	1.0000	LRRC37A4P
Father's age at death	2.61	1	0	0.0	0.00	1.0000	ULK3
Worrier / anxious feelings	2.61	2	0	0.0	0.00	1.0000	LRRC37A4P ZNF318
Schizophrenia (2018)	2.55	1	1	2.2	0.00	1.0000	MARK3
Nervous feelings	2.55	1	1	2.2	0.00	1.0000	LRRC37A4P
Qualifications: O levels/GCSEs or equivalent	2.55	1	0	0.0	0.00	1.0000	ULK3
Miserableness	2.53	1	1	2.2	0.00	1.0000	LRRC37A4P
Number of treatments/medications taken	2.50	1	0	0.0	0.00	1.0000	NUCKS1
Illnesses of father: None of the above (group 1)	2.49	1	0	0.0	0.00	1.0000	NUCKS1
Fed-up feelings	2.48	1	0	0.0	0.00	1.0000	LRRC37A4P
Birth weight of first child	2.46	1	0	0.0	0.00	1.0000	ULK3
Mouth/teeth dental problems: Dentures	2.43	1	0	0.0	0.00	1.0000	RGNEF
Tense / 'highly strung'	2.43	1	0	0.0	0.00	1.0000	NUCKS1
Medication: Lisinopril	2.43	1	0	0.0	0.00	1.0000	ULK3
Impedance of leg (right)	2.41	5	1	2.2	-0.40	0.5032	LOC100505761 LRRC37A4P MARK3 NUCKS1 ZNF318
Impedance of whole body	2.36	4	1	2.2	-0.59	0.4127	LOC100505761 LRRC37A4P MARK3 NUCKS1
Primary Biliary Cirrhosis	2.32	1	0	0.0	0.00	1.0000	LRRC37A4P
Blood Eosinophil Count	2.32	3	1	2.2	0.00	1.0000	LRRC37A4P MARK3 RGNEF
Maternal smoking around birth	2.29	1	0	0.0	0.00	1.0000	MARK3
Age when periods started (menarche)	2.29	2	0	0.0	0.00	1.0000	LRRC37A4P NUCKS1
High blood pressure (mother)	2.29	1	0	0.0	0.00	1.0000	ZNF318
Heel bone mineral density (BMD) T-score, automated (right)	2.29	2	0	0.0	0.00	1.0000	LRRC37A4P MARK3
Medication: Seretide 50 evohaler	2.29	1	0	0.0	0.00	1.0000	RGNEF
Loneliness, isolation	2.27	1	0	0.0	0.00	1.0000	LRRC37A4P
Number of full brothers	2.24	1	0	0.0	0.00	1.0000	LRRC37A4P
Impedance of leg (left)	2.23	4	0	0.0	-0.60	0.3968	LOC100505761 LRRC37A4P MARK3 NUCKS1
Standing height	2.23	5	4	8.9	0.63	0.2569	LOC100505761 LRRC37A4P MARK3 NUCKS1 ZNF318
Taking other prescription medications	2.21	1	0	0.0	0.00	1.0000	ZNF318
Number of live births	2.21	1	0	0.0	0.00	1.0000	LRRC37A4P
Impedance of arm (left)	2.17	2	1	2.2	0.00	1.0000	LRRC37A4P NUCKS1
Medication for cholesterol, blood pressure or diabetes	2.17	1	0	0.0	0.00	1.0000	ULK3
Height	2.15	5	5	11.1	0.55	0.3335	LOC100505761 LRRC37A4P MARK3 NUCKS1 ZNF318
Irritability	2.14	1	0	0.0	0.00	1.0000	LRRC37A4P
Suffer from 'nerves'	2.07	1	0	0.0	0.00	1.0000	LRRC37A4P
Depression (Nagel 2018)	2.06	1	0	0.0	0.00	1.0000	LRRC37A4P
Osteoarthritis (self-reported)	2.06	1	0	0.0	0.00	1.0000	ULK3
Impedance of arm (right)	2.04	2	1	2.2	0.00	1.0000	LRRC37A4P NUCKS1
Back pain experienced in last month	2.03	1	0	0.0	0.00	1.0000	ZNF318
Seen a psychiatrist for nerves, anxiety, tension or depression	1.96	1	0	0.0	0.00	1.0000	NUCKS1
Worry too long after embarrassment	1.94	1	0	0.0	0.00	1.0000	LRRC37A4P
Leg pain on walking	1.89	1	0	0.0	0.00	1.0000	LRRC37A4P
Long-standing illness, disability or infirmity	1.89	1	0	0.0	0.00	1.0000	MARK3
Body Mass Index (BMI) (2010)	1.87	1	0	0.0	0.00	1.0000	NUCKS1
Qualifications: College or University degree	1.87	1	1	2.2	0.00	1.0000	LRRC37A4P
Body mass index (BMI)	1.86	1	1	2.2	0.00	1.0000	MARK3
Lung FEV1/FVC ratio	1.84	1	1	2.2	0.00	1.0000	NUCKS1
Waist circumference	1.77	2	0	0.0	0.00	1.0000	MARK3 ULK3
Leg fat-free mass (right)	1.76	1	1	2.2	0.00	1.0000	NUCKS1
Leg predicted mass (right)	1.76	1	1	2.2	0.00	1.0000	NUCKS1
Birth weight	1.75	1	0	0.0	0.00	1.0000	NUCKS1
Mean time to correctly identify matches	1.74	1	0	0.0	0.00	1.0000	NUCKS1
Arm fat percentage (left)	1.73	1	1	2.2	0.00	1.0000	MARK3
Alzheimer’s Disease (including proxy)	1.71	1	0	0.0	0.00	1.0000	ZNF318
LDL Cholesterol	1.71	1	0	0.0	0.00	1.0000	ULK3
Arm predicted mass (right)	1.70	1	1	2.2	0.00	1.0000	NUCKS1
Arm fat percentage (right)	1.69	1	1	2.2	0.00	1.0000	MARK3
Overall health rating	1.68	1	0	0.0	0.00	1.0000	MARK3
Arm fat-free mass (right)	1.66	1	1	2.2	0.00	1.0000	NUCKS1
Trunk fat percentage	1.64	2	0	0.0	0.00	1.0000	LRRC37A4P MARK3
Leg fat-free mass (left)	1.63	1	1	2.2	0.00	1.0000	NUCKS1
Leg predicted mass (left)	1.63	1	1	2.2	0.00	1.0000	NUCKS1
Arm fat mass (left)	1.62	1	1	2.2	0.00	1.0000	MARK3
Arm fat mass (right)	1.59	1	1	2.2	0.00	1.0000	MARK3
Whole body fat-free mass	1.59	1	1	2.2	0.00	1.0000	NUCKS1
Basal metabolic rate	1.59	1	1	2.2	0.00	1.0000	NUCKS1
Whole body water mass	1.58	1	1	2.2	0.00	1.0000	NUCKS1
Angina	1.57	1	0	0.0	0.00	1.0000	MARK3
Trunk predicted mass	1.57	1	1	2.2	0.00	1.0000	NUCKS1
Trunk fat-free mass	1.55	1	1	2.2	0.00	1.0000	NUCKS1
Allergy or Eczema	1.54	1	0	0.0	0.00	1.0000	ULK3
Trunk fat mass	1.54	2	0	0.0	0.00	1.0000	LRRC37A4P MARK3
Arm predicted mass (left)	1.53	1	1	2.2	0.00	1.0000	NUCKS1
Allergy	1.51	1	0	0.0	0.00	1.0000	ULK3
Weight	1.49	2	1	2.2	0.00	1.0000	NUCKS1 ULK3
Hip circumference	1.49	1	0	0.0	0.00	1.0000	MARK3
Angina (self-reported)	1.49	1	0	0.0	0.00	1.0000	MARK3
Arm fat-free mass (left)	1.49	1	1	2.2	0.00	1.0000	NUCKS1
Hayfever, allergic rhinitis or eczema	1.47	1	0	0.0	0.00	1.0000	ULK3
Frequency of tiredness / lethargy in last 2 weeks	1.46	1	0	0.0	0.00	1.0000	MARK3
Pulse rate, automated reading	1.44	1	0	0.0	0.00	1.0000	NUCKS1
Age at first live birth	1.43	1	0	0.0	0.00	1.0000	LRRC37A4P
Whole body fat mass	1.42	1	0	0.0	0.00	1.0000	MARK3
Intelligence (Savage-Jansen 2018)	1.37	1	0	0.0	0.00	1.0000	LRRC37A4P
Verbal and Numeric Reasoning (VNR)	1.35	1	0	0.0	0.00	1.0000	LRRC37A4P
Fluid intelligence score	1.35	1	0	0.0	0.00	1.0000	LRRC37A4P
Body fat percentage	1.32	1	0	0.0	0.00	1.0000	MARK3
Leg fat mass (left)	1.32	1	0	0.0	0.00	1.0000	MARK3
Myopia	1.30	1	0	0.0	0.00	1.0000	LRRC37A4P
Reaction Time	1.28	1	0	0.0	0.00	1.0000	NUCKS1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.28	1	0	0.0	0.00	1.0000	NUCKS1
Blood White Count	1.21	3	0	0.0	0.00	1.0000	LOC100505761 LRRC37A4P MARK3
Leg fat mass (right)	1.16	1	0	0.0	0.00	1.0000	MARK3
HDL Cholesterol	1.14	1	0	0.0	0.00	1.0000	NUCKS1
Blood Platelet Count	0.96	2	1	2.2	0.00	1.0000	ULK3 ZNF318
Leg fat percentage (left)	0.96	1	0	0.0	0.00	1.0000	MARK3
Leg fat percentage (right)	0.78	1	0	0.0	0.00	1.0000	MARK3
Hair Pigment	0.61	4	2	4.4	-0.50	0.4981	ARHGEF28 MARK3 NUCKS1 RGNEF
Tanning	0.36	1	0	0.0	0.00	1.0000	ULK3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cortex	0	0.000	1.8
GTEx	Prostate	0	0.000	1.8
GTEx	Adipose Subcutaneous	1	0.029	1.7
GTEx	Artery Aorta	2	0.067	1.7
GTEx	Artery Coronary	2	0.169	1.7
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.7
GTEx	Breast Mammary Tissue	2	0.101	1.7
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.7
GTEx	Colon Transverse	0	0.000	1.7
GTEx	Esophagus Mucosa	1	0.030	1.7
GTEx	Esophagus Muscularis	2	0.062	1.7
GTEx	Liver	0	0.000	1.7
GTEx	Ovary	0	0.000	1.7
GTEx	Pancreas	1	0.061	1.7
GTEx	Pituitary	1	0.090	1.7
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.7
GTEx	Skin Sun Exposed Lower leg	3	0.082	1.7
GTEx	Small Intestine Terminal Ileum	0	0.000	1.7
GTEx	Spleen	2	0.142	1.7
GTEx	Stomach	1	0.069	1.7
GTEx	Testis	2	0.063	1.7
GTEx	Thyroid	2	0.050	1.7
GTEx	Uterus	1	0.176	1.7
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.7
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.7
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.197	1.7
GTEx	Adipose Visceral Omentum	0	0.000	1.6
GTEx	Adrenal Gland	0	0.000	1.6
GTEx	Artery Tibial	1	0.027	1.6
GTEx	Brain Caudate basal ganglia	1	0.109	1.6
GTEx	Brain Cerebellum	1	0.050	1.6
GTEx	Brain Frontal Cortex BA9	0	0.000	1.6
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.6
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.6
GTEx	Cells Transformed fibroblasts	0	0.000	1.6
GTEx	Colon Sigmoid	2	0.137	1.6
GTEx	Esophagus Gastroesophageal Junction	1	0.069	1.6
GTEx	Heart Atrial Appendage	2	0.127	1.6
GTEx	Heart Left Ventricle	1	0.065	1.6
GTEx	Lung	1	0.035	1.6
GTEx	Muscle Skeletal	0	0.000	1.6
GTEx	Nerve Tibial	4	0.093	1.6
GTEx	Vagina	0	0.000	1.6
GTEx	Whole Blood	0	0.000	1.6
METSIM	Adipose	2	0.043	1.6
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.6
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.6
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.6
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.6
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.6
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.6
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.6
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	2	0.151	1.6
The Cancer Genome Atlas	Prostate Adenocarcinoma	4	0.087	1.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.094	1.6
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.6
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.6
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Brain Putamen basal ganglia	1	0.160	1.5
NTR	Blood	1	0.042	1.5
YFS	Blood	2	0.043	1.5
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.5
GTEx	Brain Hippocampus	0	0.000	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.4