[Hub]/) : Traits : Hearing difficulty/problems with background noise : →

chr1:204,927,136-206,329,620

Best TWAS P=2.79e-09 · Best GWAS P=8.66e-09 conditioned to 0.0536

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RAB7L1	0.07	0.03	enet	16	0.05	4.1e-07	4.0	-5.3	1.0e-07	-0.84	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	NUCKS1	0.11	0.10	lasso	3	0.08	9.4e-07	-5.3	5.3	8.8e-08	0.76	0.02	0.98	FALSE
3	GTEx	Artery Aorta	NUCKS1	0.14	0.11	lasso	3	0.08	3.7e-05	-5.5	5.7	1.2e-08	0.87	0.02	0.98	FALSE
4	GTEx	Artery Aorta	RAB7L1	0.43	0.20	lasso	8	0.29	1.9e-16	5.6	-5.3	9.0e-08	-0.88	0.01	0.99	FALSE
5	GTEx	Artery Tibial	RAB7L1	0.29	0.27	lasso	9	0.31	9.7e-25	5.6	-5.6	2.6e-08	-0.90	0.00	1.00	FALSE
6	GTEx	Brain Caudate basal ganglia	NUCKS1	0.25	0.24	lasso	3	0.25	8.1e-08	5.8	-5.7	1.4e-08	-0.99	0.00	0.99	FALSE
7	GTEx	Brain Cerebellum	SLC41A1	0.27	0.09	lasso	4	0.08	2.1e-03	-5.0	-5.3	1.3e-07	-0.70	0.04	0.67	FALSE
8	GTEx	Brain Putamen basal ganglia	NUCKS1	0.40	0.26	lasso	4	0.27	3.2e-07	-5.3	5.3	1.2e-07	0.75	0.02	0.95	FALSE
9	GTEx	Breast Mammary Tissue	NUCKS1	0.15	0.05	lasso	4	0.09	2.5e-05	-5.3	5.5	4.1e-08	0.73	0.02	0.98	FALSE
10	GTEx	Colon Sigmoid	NUCKS1	0.34	0.22	enet	20	0.21	8.3e-08	-5.5	5.5	4.7e-08	0.70	0.02	0.98	FALSE
11	GTEx	Esophagus Mucosa	NUCKS1	0.12	0.11	enet	6	0.06	7.2e-05	5.6	5.8	6.8e-09	0.97	0.00	1.00	FALSE
12	GTEx	Esophagus Muscularis	NUCKS1	0.21	0.22	lasso	5	0.20	3.6e-12	-5.0	5.3	1.2e-07	0.80	0.03	0.97	FALSE
13	GTEx	Esophagus Muscularis	RAB7L1	0.27	0.30	lasso	4	0.33	9.4e-21	3.9	-5.1	2.8e-07	-0.85	0.04	0.96	FALSE
14	GTEx	Heart Atrial Appendage	NUCKS1	0.12	0.14	enet	4	0.08	1.7e-04	5.6	5.8	7.5e-09	0.98	0.01	0.99	FALSE
15	GTEx	Heart Atrial Appendage	RAB7L1	0.20	0.17	enet	12	0.14	4.9e-07	5.6	-5.7	1.3e-08	-0.93	0.01	0.99	FALSE
16	GTEx	Heart Left Ventricle	NUCKS1	0.10	0.04	lasso	3	0.05	1.4e-03	-5.5	5.5	3.3e-08	0.74	0.02	0.92	FALSE
17	GTEx	Lung	NUCKS1	0.09	0.07	lasso	3	0.04	2.6e-04	-5.3	5.2	2.0e-07	0.75	0.02	0.98	FALSE
18	GTEx	Nerve Tibial	NUCKS1	0.25	0.21	enet	16	0.22	7.3e-16	-5.4	5.7	1.5e-08	0.79	0.02	0.98	FALSE
19	GTEx	Nerve Tibial	SLC41A1	0.12	0.02	lasso	4	0.05	2.5e-04	-4.6	-5.4	7.7e-08	-0.73	0.03	0.96	FALSE
20	GTEx	Pancreas	NUCKS1	0.16	0.00	lasso	4	0.00	4.5e-01	4.9	5.1	3.1e-07	0.86	0.03	0.76	FALSE
21	GTEx	Pituitary	NUCKS1	0.26	0.19	lasso	2	0.20	7.6e-06	-5.0	5.1	2.8e-07	0.76	0.03	0.91	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	NUCKS1	0.20	0.14	lasso	4	0.13	2.0e-07	-5.3	5.2	1.6e-07	0.77	0.02	0.98	FALSE
23	GTEx	Skin Sun Exposed Lower leg	NUCKS1	0.20	0.26	lasso	5	0.26	1.5e-21	-5.3	5.4	6.0e-08	0.77	0.02	0.98	FALSE
24	GTEx	Skin Sun Exposed Lower leg	SLC45A3	0.08	0.00	lasso	5	0.00	3.6e-01	5.6	5.3	1.1e-07	0.85	0.01	0.91	FALSE
25	GTEx	Stomach	NUCKS1	0.21	0.11	lasso	8	0.15	1.1e-07	-5.0	5.2	1.8e-07	0.79	0.03	0.96	FALSE
26	GTEx	Testis	NUCKS1	0.16	0.16	enet	15	0.16	1.3e-07	-5.2	5.4	7.8e-08	0.78	0.03	0.97	FALSE
27	GTEx	Thyroid	NUCKS1	0.26	0.16	lasso	6	0.19	1.8e-14	-5.4	5.6	2.1e-08	0.90	0.02	0.98	FALSE
28	METSIM	Adipose	NUCKS1	0.05	0.02	lasso	6	0.01	4.3e-03	-5.2	5.2	1.7e-07	0.84	0.02	0.96	FALSE
29	YFS	Blood	NUCKS1	0.15	0.24	lasso	4	0.25	1.4e-80	-5.3	5.7	1.1e-08	0.89	0.02	0.98	FALSE
30	YFS	Blood	RAB7L1	0.06	0.07	lasso	6	0.06	1.1e-19	5.8	-5.9	3.4e-09	-0.97	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB7L1	0.09	0.08	lasso	2	0.07	1.1e-08	5.8	-5.8	8.1e-09	-1.00	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RAB7L1	0.06	0.06	blup	46	0.06	5.2e-05	-5.5	-5.5	3.4e-08	-0.81	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RAB7L1	0.09	0.04	blup	46	0.04	1.2e-02	5.8	-5.7	1.1e-08	-0.90	0.00	0.96	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RAB7L1	0.17	0.13	lasso	2	0.11	4.4e-05	5.6	-5.7	1.3e-08	-1.00	0.00	0.99	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUCKS1	0.04	0.05	lasso	2	0.03	1.5e-04	-5.5	5.9	2.8e-09	0.76	0.01	0.98	TRUE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB7L1	0.12	0.12	lasso	2	0.12	3.8e-12	5.6	-5.5	3.9e-08	-0.98	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	RAB7L1	0.07	0.04	blup	46	0.07	1.2e-05	-4.3	-5.3	1.3e-07	-0.86	0.01	0.98	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	RAB7L1	0.13	0.17	enet	15	0.21	3.6e-20	5.6	-5.7	1.1e-08	-0.91	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	NUCKS1	0.11	0.02	blup	58	0.09	1.9e-03	3.8	5.8	9.0e-09	0.81	0.02	0.59	FALSE