[Hub]/) : Traits : Hearing difficulty/problems with background noise :

chr1:204,927,136-206,329,620

Best TWAS P=2.79e-09 · Best GWAS P=8.66e-09 conditioned to 0.0536

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RAB7L1 0.07 0.03 enet 16 0.05 4.1e-07 4.0 -5.3 1.0e-07 -0.84 0.01 0.99 FALSE
2 GTEx Adipose Subcutaneous NUCKS1 0.11 0.10 lasso 3 0.08 9.4e-07 -5.3 5.3 8.8e-08 0.76 0.02 0.98 FALSE
3 GTEx Artery Aorta NUCKS1 0.14 0.11 lasso 3 0.08 3.7e-05 -5.5 5.7 1.2e-08 0.87 0.02 0.98 FALSE
4 GTEx Artery Aorta RAB7L1 0.43 0.20 lasso 8 0.29 1.9e-16 5.6 -5.3 9.0e-08 -0.88 0.01 0.99 FALSE
5 GTEx Artery Tibial RAB7L1 0.29 0.27 lasso 9 0.31 9.7e-25 5.6 -5.6 2.6e-08 -0.90 0.00 1.00 FALSE
6 GTEx Brain Caudate basal ganglia NUCKS1 0.25 0.24 lasso 3 0.25 8.1e-08 5.8 -5.7 1.4e-08 -0.99 0.00 0.99 FALSE
7 GTEx Brain Cerebellum SLC41A1 0.27 0.09 lasso 4 0.08 2.1e-03 -5.0 -5.3 1.3e-07 -0.70 0.04 0.67 FALSE
8 GTEx Brain Putamen basal ganglia NUCKS1 0.40 0.26 lasso 4 0.27 3.2e-07 -5.3 5.3 1.2e-07 0.75 0.02 0.95 FALSE
9 GTEx Breast Mammary Tissue NUCKS1 0.15 0.05 lasso 4 0.09 2.5e-05 -5.3 5.5 4.1e-08 0.73 0.02 0.98 FALSE
10 GTEx Colon Sigmoid NUCKS1 0.34 0.22 enet 20 0.21 8.3e-08 -5.5 5.5 4.7e-08 0.70 0.02 0.98 FALSE
11 GTEx Esophagus Mucosa NUCKS1 0.12 0.11 enet 6 0.06 7.2e-05 5.6 5.8 6.8e-09 0.97 0.00 1.00 FALSE
12 GTEx Esophagus Muscularis NUCKS1 0.21 0.22 lasso 5 0.20 3.6e-12 -5.0 5.3 1.2e-07 0.80 0.03 0.97 FALSE
13 GTEx Esophagus Muscularis RAB7L1 0.27 0.30 lasso 4 0.33 9.4e-21 3.9 -5.1 2.8e-07 -0.85 0.04 0.96 FALSE
14 GTEx Heart Atrial Appendage NUCKS1 0.12 0.14 enet 4 0.08 1.7e-04 5.6 5.8 7.5e-09 0.98 0.01 0.99 FALSE
15 GTEx Heart Atrial Appendage RAB7L1 0.20 0.17 enet 12 0.14 4.9e-07 5.6 -5.7 1.3e-08 -0.93 0.01 0.99 FALSE
16 GTEx Heart Left Ventricle NUCKS1 0.10 0.04 lasso 3 0.05 1.4e-03 -5.5 5.5 3.3e-08 0.74 0.02 0.92 FALSE
17 GTEx Lung NUCKS1 0.09 0.07 lasso 3 0.04 2.6e-04 -5.3 5.2 2.0e-07 0.75 0.02 0.98 FALSE
18 GTEx Nerve Tibial NUCKS1 0.25 0.21 enet 16 0.22 7.3e-16 -5.4 5.7 1.5e-08 0.79 0.02 0.98 FALSE
19 GTEx Nerve Tibial SLC41A1 0.12 0.02 lasso 4 0.05 2.5e-04 -4.6 -5.4 7.7e-08 -0.73 0.03 0.96 FALSE
20 GTEx Pancreas NUCKS1 0.16 0.00 lasso 4 0.00 4.5e-01 4.9 5.1 3.1e-07 0.86 0.03 0.76 FALSE
21 GTEx Pituitary NUCKS1 0.26 0.19 lasso 2 0.20 7.6e-06 -5.0 5.1 2.8e-07 0.76 0.03 0.91 FALSE
22 GTEx Skin Not Sun Exposed Suprapubic NUCKS1 0.20 0.14 lasso 4 0.13 2.0e-07 -5.3 5.2 1.6e-07 0.77 0.02 0.98 FALSE
23 GTEx Skin Sun Exposed Lower leg NUCKS1 0.20 0.26 lasso 5 0.26 1.5e-21 -5.3 5.4 6.0e-08 0.77 0.02 0.98 FALSE
24 GTEx Skin Sun Exposed Lower leg SLC45A3 0.08 0.00 lasso 5 0.00 3.6e-01 5.6 5.3 1.1e-07 0.85 0.01 0.91 FALSE
25 GTEx Stomach NUCKS1 0.21 0.11 lasso 8 0.15 1.1e-07 -5.0 5.2 1.8e-07 0.79 0.03 0.96 FALSE
26 GTEx Testis NUCKS1 0.16 0.16 enet 15 0.16 1.3e-07 -5.2 5.4 7.8e-08 0.78 0.03 0.97 FALSE
27 GTEx Thyroid NUCKS1 0.26 0.16 lasso 6 0.19 1.8e-14 -5.4 5.6 2.1e-08 0.90 0.02 0.98 FALSE
28 METSIM Adipose NUCKS1 0.05 0.02 lasso 6 0.01 4.3e-03 -5.2 5.2 1.7e-07 0.84 0.02 0.96 FALSE
29 YFS Blood NUCKS1 0.15 0.24 lasso 4 0.25 1.4e-80 -5.3 5.7 1.1e-08 0.89 0.02 0.98 FALSE
30 YFS Blood RAB7L1 0.06 0.07 lasso 6 0.06 1.1e-19 5.8 -5.9 3.4e-09 -0.97 0.00 1.00 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma RAB7L1 0.09 0.08 lasso 2 0.07 1.1e-08 5.8 -5.8 8.1e-09 -1.00 0.00 1.00 FALSE
32 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RAB7L1 0.06 0.06 blup 46 0.06 5.2e-05 -5.5 -5.5 3.4e-08 -0.81 0.02 0.98 FALSE
33 The Cancer Genome Atlas Pancreatic Adenocarcinoma RAB7L1 0.09 0.04 blup 46 0.04 1.2e-02 5.8 -5.7 1.1e-08 -0.90 0.00 0.96 FALSE
34 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RAB7L1 0.17 0.13 lasso 2 0.11 4.4e-05 5.6 -5.7 1.3e-08 -1.00 0.00 0.99 FALSE
35 The Cancer Genome Atlas Prostate Adenocarcinoma NUCKS1 0.04 0.05 lasso 2 0.03 1.5e-04 -5.5 5.9 2.8e-09 0.76 0.01 0.98 TRUE
36 The Cancer Genome Atlas Prostate Adenocarcinoma RAB7L1 0.12 0.12 lasso 2 0.12 3.8e-12 5.6 -5.5 3.9e-08 -0.98 0.00 1.00 FALSE
37 The Cancer Genome Atlas Stomach Adenocarcinoma RAB7L1 0.07 0.04 blup 46 0.07 1.2e-05 -4.3 -5.3 1.3e-07 -0.86 0.01 0.98 FALSE
38 The Cancer Genome Atlas Thyroid Carcinoma RAB7L1 0.13 0.17 enet 15 0.21 3.6e-20 5.6 -5.7 1.1e-08 -0.91 0.01 0.99 FALSE
39 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma NUCKS1 0.11 0.02 blup 58 0.09 1.9e-03 3.8 5.8 9.0e-09 0.81 0.02 0.59 FALSE