Best TWAS P=2.47e-08 · Best GWAS P=5.62e-07 conditioned to 0.482
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Skin Sun Exposed Lower leg | KLC1 | 0.06 | 0.09 | enet | 19 | 0.08 | 2.2e-07 | 4.2 | 5.1 | 2.7e-07 | 0.68 | 0.10 | 0.85 | FALSE |
| 2 | GTEx | Spleen | KLC1 | 0.15 | 0.05 | lasso | 3 | 0.03 | 6.4e-02 | 4.8 | 5.4 | 7.2e-08 | 0.86 | 0.03 | 0.57 | FALSE |
| 3 | METSIM | Adipose | MARK3 | 0.03 | 0.02 | lasso | 6 | 0.03 | 6.3e-05 | 4.7 | -5.6 | 2.5e-08 | -0.83 | 0.02 | 0.96 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CKB | 0.03 | 0.00 | blup | 34 | 0.02 | 1.4e-03 | 4.7 | -5.2 | 1.9e-07 | -0.79 | 0.01 | 0.58 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CKB | 0.07 | 0.09 | blup | 32 | 0.10 | 1.1e-10 | 4.8 | -5.2 | 2.4e-07 | -0.90 | 0.01 | 0.99 | FALSE |