Best TWAS P=1.56e-10 · Best GWAS P=3e-10 conditioned to 0.0194
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | PDIA2 | 0.12 | 0.01 | enet | 13 | 0.06 | 4.4e-05 | -6.3 | 6.0 | 1.4e-09 | -0.87 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Nerve Tibial | ARHGDIG | 0.13 | 0.07 | lasso | 2 | 0.07 | 8.0e-06 | -5.7 | 5.5 | 4.2e-08 | -0.61 | 0.03 | 0.88 | FALSE |
| 3 | GTEx | Testis | AXIN1 | 0.36 | 0.29 | lasso | 3 | 0.28 | 4.3e-13 | -5.7 | -5.3 | 1.1e-07 | 0.70 | 0.04 | 0.96 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | PDIA2 | 0.15 | 0.07 | lasso | 8 | 0.10 | 5.2e-13 | -5.8 | -6.2 | 4.0e-10 | 0.85 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AXIN1 | 0.03 | 0.01 | blup | 88 | 0.01 | 7.7e-03 | -5.6 | 6.4 | 1.6e-10 | -0.74 | 0.01 | 0.76 | TRUE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100134368 | 0.05 | 0.00 | blup | 48 | 0.04 | 2.5e-05 | -4.0 | -5.6 | 2.1e-08 | 0.42 | 0.01 | 0.88 | FALSE |