Best TWAS P=1.44e-08 · Best GWAS P=7.53e-08 conditioned to 0.611
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MEI1 | 0.09 | 0.10 | blup | 343 | 0.10 | 3.1e-12 | 4.4 | 5.3 | 1.0e-07 | 0.84 | 0.34 | 0.65 | FALSE |
| 2 | GTEx | Artery Tibial | ACO2 | 0.06 | 0.02 | enet | 15 | 0.06 | 1.2e-05 | 5.0 | 5.2 | 1.6e-07 | 0.78 | 0.04 | 0.95 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | CYP2D7P1 | 0.32 | 0.00 | lasso | 8 | 0.02 | 9.7e-02 | 3.4 | -5.1 | 3.0e-07 | -0.36 | 0.03 | 0.04 | FALSE |
| 4 | GTEx | Nerve Tibial | ACO2 | 0.06 | 0.05 | lasso | 5 | 0.04 | 8.5e-04 | 5.2 | 5.7 | 1.5e-08 | 0.90 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Thyroid | ACO2 | 0.08 | 0.09 | lasso | 6 | 0.10 | 9.6e-08 | 5.4 | 5.3 | 9.2e-08 | 0.99 | 0.03 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POLR3H | 0.04 | 0.04 | blup | 22 | 0.04 | 6.8e-05 | 5.1 | -5.7 | 1.4e-08 | -0.91 | 0.01 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | POLR3H | 0.03 | 0.01 | blup | 26 | 0.01 | 6.4e-02 | 4.9 | -5.4 | 6.2e-08 | -0.92 | 0.01 | 0.86 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TOB2 | 0.03 | 0.00 | blup | 28 | 0.02 | 3.4e-03 | 5.1 | 5.4 | 7.9e-08 | 0.92 | 0.01 | 0.55 | FALSE |