Best TWAS P=3.84e-11 · Best GWAS P=2.2e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RERE | 0.20 | 0.23 | lasso | 2 | 0.24 | 1.7e-19 | 5.7 | 6.2 | 5.0e-10 | -0.77 | 0.05 | 0.95 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP5-1115A15.1 | 0.14 | 0.07 | enet | 20 | 0.10 | 2.6e-08 | -6.3 | 5.9 | 2.9e-09 | -0.88 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RERE | 0.22 | 0.17 | lasso | 5 | 0.17 | 5.2e-09 | -5.9 | 5.6 | 2.6e-08 | -0.90 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | RERE | 0.19 | 0.08 | enet | 10 | 0.14 | 8.0e-08 | 5.9 | 5.3 | 1.4e-07 | -0.71 | 0.05 | 0.94 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | RP5-1115A15.1 | 0.10 | 0.07 | lasso | 2 | 0.03 | 7.0e-03 | 5.7 | 5.7 | 1.3e-08 | -0.64 | 0.03 | 0.95 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | RERE | 0.12 | 0.08 | lasso | 4 | 0.05 | 6.0e-05 | 5.9 | 6.0 | 2.6e-09 | -0.67 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Esophagus Mucosa | RERE | 0.13 | 0.16 | lasso | 3 | 0.16 | 7.2e-11 | -5.9 | 5.9 | 2.8e-09 | -0.98 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Esophagus Mucosa | RP5-1115A15.1 | 0.06 | 0.06 | lasso | 4 | 0.05 | 3.0e-04 | -5.9 | 6.1 | 8.3e-10 | -0.95 | 0.01 | 0.97 | FALSE |
| 9 | GTEx | Lung | RERE | 0.07 | 0.05 | lasso | 4 | 0.05 | 2.0e-04 | -5.5 | 5.6 | 1.9e-08 | -0.87 | 0.06 | 0.93 | FALSE |
| 10 | GTEx | Lung | RP5-1115A15.1 | 0.05 | 0.08 | lasso | 1 | 0.07 | 1.0e-05 | -6.3 | 6.3 | 3.5e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Muscle Skeletal | RP5-1115A15.1 | 0.09 | 0.07 | enet | 10 | 0.06 | 1.5e-06 | -5.9 | 5.1 | 3.0e-07 | -0.87 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Pancreas | RERE | 0.11 | 0.12 | lasso | 4 | 0.07 | 5.9e-04 | 5.9 | 5.8 | 9.2e-09 | -0.64 | 0.02 | 0.93 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | RP5-1115A15.1 | 0.08 | 0.04 | enet | 8 | 0.04 | 3.0e-03 | -5.4 | 5.7 | 1.4e-08 | -0.95 | 0.02 | 0.94 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | RP5-1115A15.1 | 0.07 | 0.03 | enet | 13 | 0.03 | 1.5e-03 | -5.9 | 5.1 | 2.9e-07 | -0.87 | 0.01 | 0.98 | FALSE |
| 15 | GTEx | Thyroid | RP5-1115A15.1 | 0.09 | 0.12 | lasso | 2 | 0.09 | 1.5e-07 | -6.3 | 6.3 | 2.2e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Whole Blood | RERE | 0.19 | 0.15 | lasso | 4 | 0.13 | 2.7e-12 | -5.9 | 6.1 | 1.1e-09 | -0.98 | 0.01 | 0.99 | FALSE |
| 17 | METSIM | Adipose | RERE | 0.08 | 0.12 | lasso | 17 | 0.13 | 1.8e-19 | 5.6 | 5.9 | 3.5e-09 | -0.80 | 0.08 | 0.92 | FALSE |
| 18 | NTR | Blood | RERE | 0.04 | 0.04 | lasso | 8 | 0.03 | 2.0e-11 | -5.3 | 5.5 | 4.9e-08 | -0.88 | 0.09 | 0.91 | FALSE |
| 19 | ROSMAP | Brain Pre-frontal Cortex | RERE | 0.15 | 0.15 | lasso | 7 | 0.15 | 1.5e-18 | 5.8 | 6.0 | 1.7e-09 | -0.73 | 0.05 | 0.95 | FALSE |
| 20 | YFS | Blood | RERE | 0.09 | 0.15 | lasso | 4 | 0.16 | 5.7e-49 | -6.3 | 6.6 | 3.8e-11 | -0.98 | 0.00 | 1.00 | TRUE |
| 21 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RERE | 0.02 | 0.03 | lasso | 2 | 0.03 | 4.7e-07 | -6.3 | 6.2 | 4.5e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 22 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RERE | 0.22 | 0.04 | lasso | 10 | 0.08 | 4.1e-04 | -5.9 | 6.5 | 6.4e-11 | -0.90 | 0.01 | 0.97 | FALSE |