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chr7:76,609,573-78,122,616

Best TWAS P=1.07e-11 · Best GWAS P=1.56e-08 conditioned to 0.509

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RSBN1L	0.09	0.09	enet	9	0.09	2.0e-11	-5.1	-5.4	6.1e-08	0.94	0.06	0.94	FALSE
2	GTEx	Adipose Subcutaneous	TMEM60	0.08	0.05	lasso	4	0.05	7.3e-05	-5.5	-5.4	5.3e-08	0.96	0.04	0.96	FALSE
3	GTEx	Cells Transformed fibroblasts	TMEM60	0.25	0.20	lasso	4	0.20	1.5e-14	-5.7	-5.6	2.0e-08	1.00	0.01	0.99	FALSE
4	GTEx	Colon Sigmoid	RSBN1L	0.17	0.09	lasso	2	0.05	5.5e-03	-5.3	-5.1	2.9e-07	0.96	0.06	0.78	FALSE
5	GTEx	Esophagus Gastroesophageal Junction	RSBN1L-AS1	0.38	0.41	lasso	12	0.44	1.2e-17	-5.5	-5.3	9.2e-08	0.98	0.04	0.96	FALSE
6	GTEx	Esophagus Mucosa	TMEM60	0.06	0.04	lasso	2	0.04	1.0e-03	-5.7	-5.6	2.8e-08	1.00	0.02	0.98	FALSE
7	GTEx	Muscle Skeletal	TMEM60	0.11	0.12	lasso	4	0.12	4.6e-12	-5.7	5.7	9.0e-09	-0.99	0.02	0.98	FALSE
8	GTEx	Nerve Tibial	TMEM60	0.14	0.14	lasso	8	0.12	1.1e-08	-5.7	-5.6	1.9e-08	0.99	0.03	0.97	FALSE
9	GTEx	Pituitary	TMEM60	0.19	0.06	lasso	6	0.04	2.8e-02	4.9	-5.5	3.6e-08	0.86	0.04	0.88	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	TMEM60	0.14	0.08	lasso	4	0.03	1.4e-02	-5.7	-5.3	1.3e-07	0.97	0.02	0.97	FALSE
11	GTEx	Skin Sun Exposed Lower leg	TMEM60	0.10	0.10	lasso	3	0.09	1.4e-07	-5.7	-5.7	1.6e-08	1.00	0.01	0.99	FALSE
12	GTEx	Testis	RSBN1L-AS1	0.16	0.12	lasso	8	0.16	1.5e-07	-5.1	-5.1	2.7e-07	0.89	0.07	0.92	FALSE
13	METSIM	Adipose	TMEM60	0.10	0.07	enet	9	0.08	2.1e-12	5.5	-5.6	2.7e-08	0.87	0.02	0.98	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	RSBN1L	0.09	0.07	enet	42	0.08	9.9e-11	-4.9	-6.8	1.1e-11	0.77	0.07	0.93	TRUE
15	YFS	Blood	TMEM60	0.14	0.16	lasso	4	0.18	1.8e-55	-5.7	-5.2	1.9e-07	0.96	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM60	0.02	0.02	lasso	1	0.02	2.3e-05	5.5	-5.5	4.5e-08	0.93	0.01	0.98	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PHTF2	0.02	0.03	lasso	1	0.02	8.0e-04	5.1	-5.1	2.9e-07	0.56	0.06	0.81	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSBN1L	0.02	0.02	blup	58	0.02	3.4e-03	-5.7	5.9	4.2e-09	-0.91	0.01	0.87	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM60	0.02	0.03	blup	29	0.02	6.8e-03	5.5	-5.1	2.6e-07	0.94	0.01	0.84	FALSE
20	The Cancer Genome Atlas	Soft Tissue Sarcoma	PHTF2	0.06	0.04	blup	72	0.04	2.0e-03	5.0	-5.4	5.6e-08	0.73	0.03	0.76	FALSE