Best TWAS P=1.65e-08 · Best GWAS P=8.77e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | CPSF4 | 0.08 | 0.03 | lasso | 4 | 0.03 | 1.8e-03 | -5.2 | -5.2 | 1.6e-07 | 0.80 | 0.10 | 0.75 | FALSE |
| 2 | GTEx | Esophagus Mucosa | GS1-259H13.2 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.7e-04 | -5.1 | 5.3 | 1.3e-07 | -0.82 | 0.12 | 0.82 | FALSE |
| 3 | GTEx | Lung | ZKSCAN5 | 0.09 | 0.05 | lasso | 2 | 0.03 | 2.7e-03 | -5.2 | 5.2 | 2.5e-07 | -0.77 | 0.14 | 0.68 | FALSE |
| 4 | GTEx | Lung | GS1-259H13.2 | 0.09 | 0.07 | lasso | 4 | 0.05 | 8.4e-05 | -5.1 | 5.2 | 2.0e-07 | -0.78 | 0.16 | 0.80 | FALSE |
| 5 | GTEx | Thyroid | GS1-259H13.2 | 0.26 | 0.05 | enet | 30 | 0.08 | 7.6e-07 | -5.3 | 5.5 | 3.2e-08 | -0.69 | 0.16 | 0.83 | FALSE |
| 6 | METSIM | Adipose | GS1-259H13.2 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | -5.3 | 5.3 | 1.5e-07 | -0.78 | 0.10 | 0.88 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | GS1-259H13.2 | 0.07 | 0.05 | bslmm | 305 | 0.06 | 6.9e-08 | -5.5 | 5.2 | 1.8e-07 | -0.82 | 0.07 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZKSCAN5 | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.0e-04 | -5.6 | -5.6 | 1.6e-08 | 0.96 | 0.01 | 0.99 | TRUE |