Best TWAS P=4.07e-09 · Best GWAS P=2.38e-08 conditioned to 0.0799
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | TRPT1 | 0.16 | 0.05 | lasso | 5 | 0.04 | 3.0e-03 | -4.7 | -5.5 | 3.9e-08 | 0.60 | 0.07 | 0.46 | FALSE |
| 2 | GTEx | Esophagus Mucosa | PLCB3 | 0.28 | 0.24 | lasso | 6 | 0.23 | 1.1e-15 | -5.5 | 5.2 | 1.7e-07 | -0.94 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Esophagus Muscularis | TRPT1 | 0.20 | 0.12 | enet | 18 | 0.15 | 2.3e-09 | -4.8 | -5.3 | 9.7e-08 | 0.67 | 0.10 | 0.90 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | KCNK4 | 0.14 | 0.12 | bslmm | 334 | 0.11 | 3.0e-14 | -5.2 | -5.4 | 6.2e-08 | 0.96 | 0.00 | 1.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TEX40 | 0.25 | 0.23 | lasso | 3 | 0.23 | 2.5e-29 | -5.6 | 5.5 | 3.2e-08 | -1.00 | 0.00 | 1.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RP11-783K16.10 | 0.07 | 0.05 | lasso | 6 | 0.06 | 9.6e-08 | -5.6 | 5.5 | 5.1e-08 | -0.99 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C11orf20 | 0.06 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | -5.5 | 5.5 | 5.1e-08 | -0.94 | 0.00 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C11orf20 | 0.07 | 0.07 | lasso | 4 | 0.07 | 6.4e-08 | -5.6 | 5.5 | 2.8e-08 | -1.00 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C11orf20 | 0.04 | 0.03 | lasso | 2 | 0.03 | 4.2e-04 | -5.2 | 5.2 | 2.4e-07 | -0.96 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | VEGFB | 0.04 | 0.04 | blup | 47 | 0.02 | 8.9e-03 | -5.0 | 5.9 | 4.1e-09 | -0.75 | 0.02 | 0.62 | TRUE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | PRDX5 | 0.05 | 0.04 | lasso | 3 | 0.02 | 1.6e-03 | -5.5 | 5.5 | 2.9e-08 | -0.98 | 0.00 | 0.94 | FALSE |